Strain

USA_AVIAN_2004_NC_001451 (Region: USA: Beaudette;  Strain: Avian infectious bronchitis virus, complete genome.;  Date: 2004)

Gene

nucleocapsid protein

Description

Annotated in NCBI,  nucleocapsid protein

Location

NC_001451(+):25873-27102

GenBank Accession

NP_040838.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGGCAAGCGGTAAAGCAGCTGGAAAAACAGACGCCCCAGCGCCAGTCATTAAACTAGGAGGACCAAAACCACCTAAAGTCGGTTCTTCTGGAAATGCATCTTGGTTTCAAGCAATAAAAGCCAAGAAGTTAAATACACCTCCGCCCAAGTTTGAAGGTAGCGGTGTTCCTGATAACGAAAACATTAAGCCAAGCCAGCAACATGGATACTGGAGACGCCAAGCCAGGTTTAAGCCAGGCAAAGGTGGAAGAAAACCAGTCCCAGATGCTTGGTACTTTTACTATACTGGAACAGGACCTGCCGCTGACCTGAACTGGGGTGATACTCAAGATGGTATAGTGTGGGTTGCTGCTAAGGGTGCTGATACTAAATCTAGATCCAATCAGGGTACAAGAGATCCTGATAAGTTTGACCAATACCCACTACGATTCTCGGATGGCGGACCTGATGGTAATTTCCGTTGGGACTTCATTCCCCTGAACCGTGGTAGGAGTGGAAGATCAACAGCAGCTTCATCAGCAGCAGCTAGTAGAGCACCATCACGTGAAGGTTCGCGTGGTCGTAGAAGTGATTCTGGAGATGACCTTATTGCTCGTGCAGCAAAGATAATCCAGGATCAGCAGAAAAAGGGCTCTCGCATTACCAAGGCAAAGGCAGATGAAATGGCTCATCGCCGGTATTGCAAGCGCACTATCCCACCTAATTATAGGGTTGATCAAGTGTTTGGTCCCCGTACTAAAGGTAAGGAGGGGAATTTTGGTGATGACAAGATGAATGAGGAAGGTATTAAGGATGGGCGTGTTACAGCAATGCTCAACCTAGTCCCTAGCAGCCATGCTTGTCTTTTTGGAAGTAGAGTGACACCCAAACTTCAACTAGATGGGCTTCACTTGAGATTTGAATTTACTACTGTGGTCCCATGTGATGACCCGCAGTTTGATAATTATGTGAAAATTTGTGATCAGTGTGTCGATGGTGTAGGAACGCGTCCAAAAGATGACGAACCAAAACCAAAGTCACGCTCAAGTTCAAGACCTGCTACAAGAGGAAATTCTCCAGCGCCAAGACAACAGCGCCCAAAGAAGGAGAAAAAGCTAAAGAAGCAGGATGATGAAGCAGATAAAGCATTGACCTCAGATGAGGAGAGGAACAATGCACAGCTGGAATTTTATGATGAGCCCAAGGTAATTAACTGGGGGGATGCAGCTCTAGGAGAGAATGAACTTTGA

Protein

MASGKAAGKTDAPAPVIKLGGPKPPKVGSSGNASWFQAIKAKKLNTPPPKFEGSGVPDNENIKPSQQHGYWRRQARFKPGKGGRKPVPDAWYFYYTGTGPAADLNWGDTQDGIVWVAAKGADTKSRSNQGTRDPDKFDQYPLRFSDGGPDGNFRWDFIPLNRGRSGRSTAASSAAASRAPSREGSRGRRSDSGDDLIARAAKIIQDQQKKGSRITKAKADEMAHRRYCKRTIPPNYRVDQVFGPRTKGKEGNFGDDKMNEEGIKDGRVTAMLNLVPSSHACLFGSRVTPKLQLDGLHLRFEFTTVVPCDDPQFDNYVKICDQCVDGVGTRPKDDEPKPKSRSSSRPATRGNSPAPRQQRPKKEKKLKKQDDEADKALTSDEERNNAQLEFYDEPKVINWGDAALGENEL

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Similarity

Belongs to the gammacoronavirus nucleocapsid protein family.

Keywords

3D-structure   ADP-ribosylation   Disulfide bond   Host Golgi apparatus   Phosphoprotein   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion   Reference proteome  

Feature

chain  Nucleoprotein

Uniprot

P69598   P69597   P69596   B5LSW1   Q4ZJT5   F4MIZ3   + More
Q5MNY5   A0A516UWE3   A0A172Q3Q7   V9QGE1   G3C7F3   V9QGD8   V9QGR6   A0MNZ2   Q6UQG9   A4ZCS7   Q8JMI5   A0A0D4CFP1   F4MIX3   A0A172Q3S6   A0A0N9Q6T2   A0A4Y5SY57   V9QFQ9   A0A346T2W1   C1IY02   Q80AG5   A0A172Q3U7   C9DSU5   F4MIQ3   A0A172Q3Q4   A7Y2U6   E5D0B9   Q6UQG8   A0A5J6RBP4   F4MIR3   I6YVZ4   Q5MBP6   Q8JMI7   Q98Y32   Q6DV48   J7I3T6   A0A1X9Y2S3   A0A172Q3W7   Q8JMI6   A0A5J6RGJ4   A0A0K1RMW2   A0A1X9Y2N3   A4ZCQ3   B5LSW3   I6YVZ0   B3TD70   Q82616   V9QGK3   G4XMR4   G3C7E1   V9QGR3   A0A172Q3U2   I6YAW4   Q4G2X4   M4I9Y4   F6KSZ3   I6YAV9   Q66V98   D3Y2R0   F4MIY3   V9QGJ7   I6Y078   A0A0C5GWH7   A0A5J6RDW7   U5S076   Q4G2X6   E5D0A8   Q80AG6   D3Y283   A0A346M364   A0A0E3SVG4   B2MWM6   Q6UQG7   A5Z0W5   T2AZ92   V9QFR1   A4ZCP0   A0A2K8GJ29   C6K2F7   Q5XL97   Q2PZJ3   B3VN14   G3C777   I6Y081   A0A172Q3X7   M4I7F3   G3C7A3   Q2I1A9   A0A1P8SFN3   A0A3G6IQA9   A0A172Q3U6   A0A286LPM4   A0A4Y5QCU0   Q20CB2   A0A0D4CFA5  

Pubmed

11711626    2983001    3027249    16137658    11119619    11533198    + More
15613344    16338414    21539870    15661153    21994806    15187369    18045937    26262637    20022075    24613433    26482289    30526618    21909766    31561498    23065112    18295413    19102764    19219402    17629993    23202499    28116527    18514348    16934878    23178317    16025240    23203570    15722532    25667323    21049275    22542436    25721384    29337625    16990149    19781572    27793730    31439703   

EMBL

AJ311362    AJ311317    M95169    M28565    DQ001339    EU889031    + More
ACG70922.1    DQ001338    AAY24430.1    FJ904722    ADA83564.1    AY692454    AAV98213.1    MK581202    QDQ69130.1    KU253618    AND76841.1    KF826875    AHC28326.1    GU393337    ADV71801.1    KF826870    AHC28321.1    KF826876    AHC28327.1    EF025537    ABK30933.1    AY363966    AAR15908.1    DQ490216    ABF61554.1    AY121093    AY167729    AAM82282.1    KP118885    AJT47894.1    FJ904720    ADA83544.1    KU253619    AND76849.1    KR231009    ALH21120.1    MK937828    QDA76298.1    KF826872    AHC28323.1    MG233398    AXT92422.1    FJ008695    ACM45236.1    AY278110    AAP32083.1    KU253622    AND76873.1    GQ427174    ACV87246.1    FJ904713    FJ904716    FJ904718    FJ904719    KC506155    KF696629    KJ425485    KF996283    KR265092    ADA83474.1    ADA83504.1    ADA83524.1    ADA83534.1    AGJ98444.1    AHB79530.1    AHX25900.1    AIB54176.1    ART35356.1    KU253617    KU253620    AND76833.1    AND76857.1    EU116941    KJ425504    MH539771    ABV03163.1    AHX26071.1    AZP23938.1    GQ504724    ADP06497.1    AY363967    AAR15909.1    MK887124    QEY95729.1    FJ904714    ADA83482.1    JQ964084    AFN61252.1    AY839145    EF602442    EU418976    AAV88464.1    ABQ84789.1    ACB59379.1    AY121091    AY167731    FJ904723    MH539772    MK728875    MK937830    AAM82280.1    ADA83574.1    AZP23948.1    QCE31541.1    QDA76316.1    AF352310    AY044185    AY641576    AAT70080.1    JQ977697    AFQ31007.1    KU900743    ARS22457.1    KU253624    AND76889.1    AY121092    AY167730    MK887126    QEY95731.1    KR902510    AKV63212.1    KU900739    ARS22417.1    DQ490213    ABF61530.1    EU889032    ACG70924.1    JQ964079    AFN61247.1    EU022526    ABW75147.1    M28566    DQ834384    AY851295    KF826878    AHC28329.1    JF828980    AEP84743.1    GU393336    ADV71788.1    KF826871    AHC28322.1    KU253616    AND76825.1    JQ964080    AFN61248.1    AY790348    AAX19436.1    JQ693047    AFZ88842.1    HQ607366    AEF98429.1    JQ964073    JQ964075    JQ964076    JQ964078    MK937832    AFN61241.1    AFN61243.1    AFN61244.1    AFN61246.1    QDA76334.1    AY702085    KJ435286    AAU09497.1    AHX26179.1    GU391029    ADC55279.1    FJ904721    ADA83554.1    KF826868    AHC28319.1    JQ964077    AFN61245.1    KP036504    AJP16737.1    MK887118    QEY95723.1    KF360987    AGY78355.1    AY790346    AAX19434.1    GQ504723    ADP06485.1    AY277721    AAP32046.1    GU386375    ADC79658.1    MG913343    AXQ05208.1    KM658210    KM658212    KM658213    AKB91482.1    AKB91484.1    AKB91485.1    EU637854    ACC94333.1    AY363968    AAR15910.1    EF602440    ABQ84773.1    KC478653    AGV02020.1    KF826877    AHC28328.1    DQ490211    JN983807    KF460437    KF931628    ABF61517.1    AFK30961.1    AIG54292.1    AIG54303.1    KU949746    ARI46299.1    GQ149079    ACS34956.1    AY761141    AAV28729.1    DQ287910    EF213582    EF602445    EF602446    ABC02824.1    ABN04183.1    ABQ84813.1    ABQ84821.1    EU780081    KF377577    KP118880    KP118881    KP118884    KP118887    KP118888    KP118891    KP118892    KP118893    MK032179    MK032180    MK887115    ACE88710.1    AGY56147.1    AJT47849.1    AJT47858.1    AJT47885.1    AJT47912.1    AJT47921.1    AJT47948.1    AJT47957.1    AJT47966.1    AZA07849.1    AZA07858.1    QEY95720.1    GU393331    ADV71725.1    JQ964082    AFN61250.1    KU253621    AND76865.1    JQ693045    AFZ88840.1    GU393333    ADV71751.1    DQ352151    EF602457    KX236001    ABC75297.1    ABQ84908.1    APY26752.1    KX272465    APY20703.1    MK032178    AZA07840.1    KU253623    AND76881.1    MF462335    ASU92403.1    MK878536    QCX19628.1    DQ377138    ABD34800.1    KP118882    AJT47867.1   

Proteomes

UP000114388    UP000006717    UP000180341    UP000101586    UP000107149    UP000119508    + More
UP000105510    UP000165485    UP000097758    UP000098674    UP000119721    UP000121579    UP000124016    UP000130162    UP000145806    UP000155805    UP000167075    UP000117985    UP000107291    UP000133571    UP000102335    UP000098752    UP000104400    UP000096390    UP000151562    UP000099410    UP000007642    UP000096468    UP000149491    UP000160333    UP000161686    UP000169726    UP000124537    UP000132955    UP000130254    UP000123393    UP000128029    UP000100522    UP000109170    UP000117109    UP000121165    UP000136129    UP000142905    UP000147307    UP000149934    UP000170218    UP000138275    UP000146844    UP000111271   

PRIDE

P69596    Q8JMI6   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037195   Nucleocapsid_N
IPR001218   Corona_nucleocap
IPR037179   Nucleocapsid_C
IPR042547   GAMMA_CORONA_NCAP

SUPFAM

SSF103068   SSF103068
SSF110304   SSF110304

ProteinModelPortal

P69598   P69597   P69596   B5LSW1   Q4ZJT5   F4MIZ3   + More
Q5MNY5   A0A516UWE3   A0A172Q3Q7   V9QGE1   G3C7F3   V9QGD8   V9QGR6   A0MNZ2   Q6UQG9   A4ZCS7   Q8JMI5   A0A0D4CFP1   F4MIX3   A0A172Q3S6   A0A0N9Q6T2   A0A4Y5SY57   V9QFQ9   A0A346T2W1   C1IY02   Q80AG5   A0A172Q3U7   C9DSU5   F4MIQ3   A0A172Q3Q4   A7Y2U6   E5D0B9   Q6UQG8   A0A5J6RBP4   F4MIR3   I6YVZ4   Q5MBP6   Q8JMI7   Q98Y32   Q6DV48   J7I3T6   A0A1X9Y2S3   A0A172Q3W7   Q8JMI6   A0A5J6RGJ4   A0A0K1RMW2   A0A1X9Y2N3   A4ZCQ3   B5LSW3   I6YVZ0   B3TD70   Q82616   V9QGK3   G4XMR4   G3C7E1   V9QGR3   A0A172Q3U2   I6YAW4   Q4G2X4   M4I9Y4   F6KSZ3   I6YAV9   Q66V98   D3Y2R0   F4MIY3   V9QGJ7   I6Y078   A0A0C5GWH7   A0A5J6RDW7   U5S076   Q4G2X6   E5D0A8   Q80AG6   D3Y283   A0A346M364   A0A0E3SVG4   B2MWM6   Q6UQG7   A5Z0W5   T2AZ92   V9QFR1   A4ZCP0   A0A2K8GJ29   C6K2F7   Q5XL97   Q2PZJ3   B3VN14   G3C777   I6Y081   A0A172Q3X7   M4I7F3   G3C7A3   Q2I1A9   A0A1P8SFN3   A0A3G6IQA9   A0A172Q3U6   A0A286LPM4   A0A4Y5QCU0   Q20CB2   A0A0D4CFA5  

PDB

2C86     E-value=9.47774e-68,     Score=653