Strain
USA_AVIAN_2004_NC_001451
(Region: USA: Beaudette; Strain: Avian infectious bronchitis virus, complete genome.; Date: 2004)
Gene
ORF1ab polyprotein
Description
Annotated in NCBI,
ORF1ab polyprotein
Location
GenBank Accession
Full name
Replicase polyprotein 1ab
Alternative Name
ORF1ab polyprotein
Sequence
CDS
ATGGCTTCAAGCCTAAAACAGGGAGTATCTCCCAAACCACGGGATGTCATTCTTGTGTCCAAAGACATCCCTGAACAACTTTGTGACGCTTTGTTTTTCTATACGTCACATAACCCTAAGGATTACGCTGATGCTTTTGCAGTTAGGCAGAAGTTTGACCGTAGTCTCCAGACTGGGAAACAGTTCAAATTTGAAACTGTGTGTGGTCTCTTCCTCTTGAAGGGAGTTGACAAAATAACACCTGGCGTCCCAGCAAAAGTTTTAAAAGCCACTTCTAAGTTGGCAGATTTAGAAGACATCTTTGGTGTCTCTCCTTTAGCGCGGAAGTACCGTGAATTGTTGAAAACAGCGTGTCAGTGGTCTCTTACTGTAGAAGCACTGGATGTTCGTGCACAAACTCTCGATGAAATTTTTGACCCCACTGAAATACTTTGGCTTCAGGTGGCTGCAAAAATTCATGTTTCATCTATGGCAATGCGCAGGCTTGTTGGAGAAGTAACTGCAAAAGTCATGGATGCTCTGGGCTCAAACTTGAGTGCTCTTTTTCAAATTGTTAAACAACAAATAGCCAGAATCTTTCAAAAGGCACTGGCTATTTTTGAGAATGTGAATGAATTACCACAGCGTATTGCAGCACTTAAGATGGCTTTTGCCAAGTGTGCTAGGTCAATTACTGTTGTGGTTGTTGAAAGAACTCTAGTTGTTAAAGAGTTCGCAGGAACTTGTCTTGCAAGCATTAATGGTGCTGTCGCAAAATTCTTTGAAGAGTTGCCAAACGGCTTCATGGGTTCTAAGATTTTCACAACACTTGCCTTCTTTAAAGAGGCAGCTGTGAGAGTTGTGGAGAACATACCAAATGCACCGAGAGGTACTAAGGGATTTGAAGTTGTTGGCAATGCCAAAGGCACACAGGTAGTTGTGCGCGGCATGCGAAATGACTTAACATTGCTTGACCAAAAAGCTGATATTCCTGTTGAACCAGAAGGTTGGTCTGCAATTTTGGATGGACATCTTTGCTATGTCTTTAGGAGTGGTGATCGCTTTTATGCTGCACCTCTTTCAGGAAATTTTGCTTTGAGTGATGTTCATTGCTGTGAGCGTGTAGTCTGTCTATCTGATGGTGTAACACCGGAGATAAATGATGGACTCATTCTAGCTGCAATCTACTCTTCTTTTAGTGTCTCTGAGCTTGTAACAGCTCTTAAAAAGGGTGAACCATTCAAGTTCTTGGGCCATAAATTCGTGTATGCGAAGGATGCAGCAGTGTCTTTTACTTTAGCGAAGGCTGCCACTATTGCAGATGTCTTGAGGCTGTTTCAATCAGCTCGTGTGATAGCAGAAGATGTTTGGTCTTCATTTACTGAAAAGTCTTTTGAATTCTGGAAGCTTGCATATGGAAAAGTGCGCAACCTTGAAGAATTTGTGAAGACCTATGTTTGTAAGGCTCAAATGTCGATTGTGATTCTAGCAGCAGTGCTTGGAGAGGACATTTGGCATCTTGTCTCACAAGTCATCTATAAATTAGGTGTTCTTTTTACTAAAGTCGTTGACTTTTGTGACAAACACTGGAAAGGTTTTTGTGTACAGTTGAAAAGAGCTAAGCTCATTGTCACCGAAACCTTCTGTGTTTTAAAAGGAGTTGCACAGCATTGTTTTCAACTGCTGCTAGATGCAATACACTCTTTGTACAAGAGTTTTAAGAAGTGTGCACTTGGTAGAATCCATGGAGATTTGCTCTTCTGGAAAGGAGGTGTGCATAAAATTGTTCAAGATGGCGATGAAATATGGTTTGACGCCATTGATAGTGTTGATGTTGAAGATCTGGGTGTTGTTCAGGAAAAATCGATTGATTTTGAGGTTTGCGATGACGTGACACTTCCAGAAAACCAACCTGGTCATATGGTTCAAATAGAGGATGATGGTAAGAACTACATGTTCTTCCGTTTTAAAAAGGATGAGAACATTTATTATACACCAATGTCTCAACTTGGTGCTATTAATGTGGTTTGCAAAGCAGGCGGTAAGACTGTCACCTTTGGAGAAACTACAGTACAAGAGATACCACCACCTGATGTCGTGCCTATTAAGGTTAGCATAGAATGTTGTGGTGAACCATGGAATACGATCTTCAAGAAGGCTTATAAAGAGCCTATAGAAGTAGATACAGACCTCACAGTAGAACAATTGCTCTCTGTGATCTATGAGAAAATGTGTGACGACCTTAAATTGTTTCCAGAGGCACCAGAGCCTCCACCATTTGAGAATGTCGCACTTGTTGATAAGAACGGTAAAGATTTGGATTGTATAAAATCTTGCCATTTGATCTATCGTGACTATGAGAGCGATGATGACATCGAGGAGGAAGATGCTGAGGAGTGTGACACAGACTCAGGTGAAGCTGAGGAGTGTGACACTAATTCAGAATGTGAAGAAGAGGATGAGGATACTAAAGTGTTGGCTCTTATACAAGACCCGGCAAGTATTAAATACCCTCTGCCTCTTGATGAAGATTATAGCGTCTATAATGGATGTATTGTACACAAGGACGCTCTTGATGTTGTGAATTTACCATCTGGTGAAGAAACTTTTGTTGTCAATAACTGTTTTGAGGGAGCTGTTAAACCACTTCCACAGAAGGTAGTTGATGTTCTTGGTGACTGGGGAGAGGCTGTTGATGCGCAAGAACAACTGTGTCAACAAGAGCCTCTGCAACATACCTTTGAAGAACCAGTCGAAAATTCTACTGGTAGTTCTAAGACAATGACTGAACAAGTCGTTGTAGAAGATCAAGAACTACCTGTTGTTGAACAAGATCAGGATGTAGTTGTTTATACACCTACAGATCTTGAAGTTGCAAAAGAAACAGCAGAAGAGGTTGATGAGTTTATTCTCATTTTTGCTGTTCCTAAAGAAGAAGTTGTGTCCCAGAAAGATGGGGCACAGATTAAACAAGAGCCTATTCAAGTTGTTAAACCACAACGTGAGAAGAAGGCTAAAAAGTTCAAAGTTAAACCAGCCACATGTGAGAAACCTAAATTTTTGGAGTATAAAACATGTGTGGGTGATTTGACTGTTGTAATTGCCAAAGCATTGGATGAGTTTAAAGAGTTCTGCATTGTAAATGCTGCAAATGAGCATATGACTCATGGTAGTGGCGTTGCAAAGGCAATTGCAGACTTTTGTGGACTGGATTTTGTTGAATATTGTGAGGACTATGTTAAGAAACATGGGCCACAACAGAGACTTGTTACACCTTCGTTTGTCAAAGGCATTCAATGTGTGAATAATGTTGTAGGACCCCGCCATGGAGACAACAACTTGCATGAGAAGCTTGTTGCTGCCTACAAGAATGTGCTTGTAGATGGCGTAGTCAATTATGTTGTGCCAGTTCTTTCATTAGGAATTTTTGGTGTAGATTTTAAAATGTCAATAGACGCAATGCGTGAAGCTTTTGAAGGTTGCACCATACGCGTTCTTTTGTTTTCTCTGAGCCAAGAACACATCGATTATTTCGATGTAACTTGCAAACAGAAGACAATTTATCTTACGGAGGATGGTGTTAAATACCGCTCCATTGTTCTAAAACCTGGTGACTCATTGGGTCAATTTGGACAGGTTTATGCTAAAAACAAGATAGTTTTTACAGCCGATGATGTTGAGGACAAAGAAATTCTCTACGTCCCCACGACTGATAAAAGCATTCTTGAATACTATGGTTTAGATGCGCAAAAGTATGTAATATATTTGCAAACGCTTGCGCAGAAATGGAATGTCCAATATAGGGACAATTTTCTTATACTAGAGTGGCGCGATGGAAATTGTTGGATTAGTTCAGCAATAGTTCTCCTTCAAGCTGCTAAAATTAGGTTTAAAGGTTTTCTAACAGAAGCGTGGGCTAAACTGTTAGGTGGAGATCCTACAGACTTTGTTGCCTGGTGTTATGCAAGTTGTACTGCTAAAGTAGGTGATTTCTCAGATGCTAATTGGCTTTTAGCGAATTTAGCAGAACATTTTGACGCAGATTACACAAATGCGTTTCTTAAGAAGCGCGTTTCGTGTAACTGTGGTATTAAGAGCTATGAGCTTAGAGGCCTTGAAGCTTGTATTCAGCCAGTTCGGGCAACTAATCTGCTACATTTTAAGACGCAATATTCAAATTGCCCAACCTGTGGCGCAAATAATACGGATGAAGTAATAGAAGCTTCGTTACCGTACTTATTGCTTTTTGCTACTGATGGTCCTGCTACAGTTGATTGTGATGAAGATGCTGTGGGGACTGTCGTGTTTGTTGGTTCTACTAATAGTGGCCATTGTTATACACAAGCTGCAGGGCAAGCTTTTGATAATCTTGCTAAAGATAGAAAATTTGGAAAGAAGTCGCCTTACATTACTGCAATGTATACGCGATTCGCTTTTAAGAATGAAACCTCTTTGCCTGTTGCTAAACAGAGCAAGGGTAAGTCTAAGTCGGTAAAGGAAGATGTTTCTAACCTTGCTACTAGTTCTAAGGCCAGTTTTGATAATCTTACTGACTTCGAACAGTGGTATGATAGTAACATCTATGAAAGTCTTAAAGTGCAGGAATCACCTGATAACTTTGATAAATATGTGTCATTCACAACAAAGGAAGATTCTAAGTTGCCATTGACACTTAAGGTTAGAGGTATTAAATCAGTTGTTGACTTTAGATCGAAGGATGGTTTTATTTATAAGTTAACACCTGATACTGATGAAAATTCAAAAGCACCAGTCTACTACCCAGTCTTGGACGCTATTAGTCTTAAGGCAATATGGGTGGAAGGTAATGCTAACTTTGTTGTTGGTCATCCAAATTATTATAGTAAGTCTCTTCATATTCCTACTTTTTGGGAAAATGCTGAGAATTTTGTTAAAATGGGTGATAAAATTGGTGGTGTAACTATGGGACTTTGGCGTGCAGAACACCTTAATAAACCTAATTTGGAGAGAATTTTCAACATTGCTAAGAAAGCCATTGTTGGATCTAGTGTTGTTACTACACAATGCGGTAAATTAATAGGTAAAGCAGCTACATTCATTGCTGATAAAGTAGGTGGTGGTGTAGTTCGCAATATTACAGATAGCATTAAGGGTCTTTGTGGAATTACACGAGGGCATTTTGAAAGAAAAATGTCTCCACAATTCCTAAAGACGCTTATGTTCTTTTTATTCTATTTCTTGAAGGCTAGTGTTAAGAGTGTTGTCGCTAGCTATAAGACCGTGTTATGTAAGGTGGTACTTGCTACTTTACTTATAGTTTGGTTTGTCTACACAAGTAACCCAGTAATGTTTACAGGAATACGTGTGTTAGATTTTCTATTCGAGGGTTCTTTGTGTGGTCCTTATAAAGACTATGGTAAAGATTCTTTTGATGTGTTACGATATTGTGCAGATGATTTTATTTGTCGTGTGTGTTTACATGACAAAGATTCACTTCATTTGTACAAACACGCTTATAGTGTAGAGCAGGTCTATAAAGATGCAGCTTCTGGTTTTATTTTTAATTGGAATTGGCTTTATTTGGTCTTTCTAATATTATTTGTTAAACCAGTGGCAGGTTTTGTTATTATTTGCTATTGTGTTAAGTATTTGGTATTGAATTCAACTGTGCTGCAAACTGGTGTTTGTTTTTTAGATTGGTTTGTACAAACAGTTTTTAGTCACTTTAATTTTATGGGAGCAGGGTTTTATTTCTGGCTCTTTTACAAGATATATATACAGGTGCATCATATACTGTATTGTAAGGATGTAACATGTGAAGTGTGCAAAAGGGTTGCACGCAGCAACAGGCAAGAGGTTAGCGTGGTTGTTGGTGGACGCAAGCAGATAGTGCATGTTTACACTAACTCTGGCTATAACTTTTGTAAGAGACATAATTGGTATTGTAGAAATTGTGATGATTATGGTCACCAAAATACATTTATGTCTCCTGAAGTTGCTGGCGAGCTCTCTGAAAAGCTTAAGCGCCATGTTAAACCTACAGCATACGCTTACCACGTTGTGGATGAGGCATGCTTAGTTGATGATTTTGTCAATTTAAAATATAAAGCTGCAACTCCTGGTAAGGATAGTGCATCTTCAGCTGTTAAGTGTTTCAGTGTTACAGATTTCTTGAAGAAAGCTGTTTTTCTTAAGGAAGCACTGAAATGTGAACAAATATCTAATGATGGTTTTATAGTGTGTAATACACAGAGTGCTCATGCATTAGAGGAAGCAAAGAATGCAGCCATCTATTATGCGCAATATCTGTGTAAGCCAATACTTATACTTGACCAGGCACTTTATGAGCAATTAGTAGTAGAGCCTGTGTCTAAGAGTGTTATAGATAAAGTGTGTAGCATTTTGTCTAGTATAATATCTGTAGATACTGCAGCTTTAAATTATAAGGCAGGCACACTTCGTGATGCTCTGCTTTCTATTACTAAAGACGAAGAGGCCGTAGATATGGCTATATTCTGTCATAATCATGATGTGGATTACACTGGTGATGGTTTTACTAATGTGATACCGTCATATGGTATAGACACTGGCAAGTTAACACCTCGTGATAGAGGGTTTTTGATAAATGCAGATGCTTCTATTGCTAACTTAAGAGTTAAAAATGCTCCGCCGGTAGTATGGAAGTTTTCTGAGCTTATTAAGTTGTCTGACAGTTGTCTTAAATATTTAATTTCGGCTACTGTTAAGTCAGGTGTTCGTTTCTTTATAACAAAGTCTGGTGCTAAACAAGTTATTGCTTGTCATACACAGAAGTTGTTAGTAGAGAAAAAGGCAGGTGGTATTGTTAGCGGCACCTTTAAGTGTTTTAAGAGTTATTTTAAATGGCTCTTGATCTTTTACATACTTTTTACAGCATGTTGTTCGGGTTATTACTATATGGAGGTGAGTAAAAGTTTTGTTCACCCCATGTATGATGTAAACTCCACACTGCATGTTGAAGGTTTTAAAGTTATAGATAAAGGTGTTCTTAGGGAAATTGTACCAGAAGATACATGTTTCTCTAATAAATTTGTTAATTTTGATGCTTTTTGGGGCAGACCATATGATAATAGTAGAAACTGTCCAATTGTCACAGCTGTTATAGATGGTGATGGGACAGTAGCTACAGGTGTTCCTGGTTTTGTGTCCTGGGTTATGGATGGTGTTATGTTTATACATATGACACAGACTGAGAGAAAACCGTGGTACATTCCTACTTGGTTTAATAGAGAAATTGTCGGTTACACTCAGGATTCAATTATTACTGAGGGTAGTTTTTATACATCTATAGCGTTATTTTCCGCTAGGTGTTTATATTTAACAGCCAGCAATACACCTCAATTGTATTGCTTTAATGGTGATAATGATGCACCTGGGGCTTTGCCATTTGGTAGTATTATTCCTCATAGAGTTTATTTCCAACCCAATGGTGTTAGGCTTATAGTTCCACAACAAATACTGCACACACCCTACGTAGTAAAGTTTGTATCAGACAGCTATTGTAGGGGTAGTGTGTGTGAGTACACTAGACCAGGTTACTGTGTGTCATTAAACCCACAATGGGTTTTGTTTAATGACGAATACACAAGTAAACCCGGTGTTTTCTGTGGTTCTACTGTTAGAGAACTTATGTTTAGTATGGTTAGTACATTCTTTACTGGTGTTAACCCCAATATCTATATGCAATTAGCAACTATGTTTTTAATACTAGTTGTTGTTGTATTAATCTTTGCAATGGTTATAAAGTTTCAAGGTGTTTTTAAAGCTTATGCAACCACTGTTTTTATAACAATGTTAGTTTGGGTAATTAACGCATTTATTTTGTGTGTACATAGTTACAACAGTGTTTTAGCTGTTATATTACTAGTACTCTATTGCTATGCGTCATTGGTTACAAGTCGCAATACTGTTATAATAATGCATTGTTGGCTTGTTTTTACCTTTGGTTTAATAGTACCCACATGGTTGGCTTGTTGCTACCTGGGATTTATTATTTATATGTATACACCGTTGTTTTTATGGTGTTATGGTACTACAAAAAACACTCGTAAGCTGTATGATGGCAATGAGTTTGTTGGTAATTATGATCTTGCTGCGAAGAGCACTTTTGTTATTCGCGGCTCTGAATTTGTTAAGCTTACTAATGAGATAGGTGATAAATTTGAGGCCTACCTTTCAGCGTATGCTAGATTAAAGTACTATTCAGGCACTGGCAGTGAACAAGATTATTTGCAAGCTTGTCGTGCATGGTTAGCTTATGCTTTGGACCAATATAGAAATAGTGGTGTGGAAATTGTTTATACTCCGCCACGTTACTCTATTGGTGTTAGTAGATTACAATCTGGTTTTAAGAAACTGGTTTCTCCTAGTAGTGCTGTTGAAAAGTGCATTGTTAGTGTCTCTTATAGAGGTAATAATCTTAATGGACTGTGGCTAGGTGACACTATCTACTGTCCTCGTCATGTATTGGGTAAGTTTTCAGGTGACCAATGGAATGATGTACTTAATCTTGCTAATAATCATGAGTTTGAAGTTACAACTCAACATGGTGTTACTTTGAATGTTGTCAGTAGGCGTTTAAAAGGTGCAGTTTTAATTTTACAAACTGCTGTTGCTAATGCTGAAACTCCAAAGTATAAGTTTATTAAAGCTAATTGTGGTGATAGTTTCACTATAGCTTGTGCTTATGGTGGTACAGTTGTAGGACTCTACCCTGTTACTATGCGTTCTAATGGTACTATTAGAGCATCTTTTCTTGCGGGAGCCTGTGGTTCAGTTGGTTTTAATATAGAAAAGGGTGTAGTTAATTTCTTTTATATGCACCATCTTGAGTTACCTAATGCATTACACACTGGAACTGACCTAATGGGTGAATTCTATGGTGGTTATGTTGATGAAGAGGTTGCACAAAGAGTGCCACCAGATAATTTAGTTACTAACAATATTGTAGCATGGCTCTATGCGGCAATTATTAGTGTTAAGGAGAGTAGTTTCTCGCTGCCTAAATGGTTGGAGAGTACTACTGTTAGTGTTGATGATTATAATAAGTGGGCTGGTGACAATGGTTTTACACCATTTTCTACTAGTACCGCTATTACTAAATTAAGTGCTATAACTGGAGTTGATGTTTGTAAGCTCCTTCGCACTATTATGGTAAAAAATAGCCAGTGGGGTGGTGACCCCATTTTAGGGCAATATAATTTTGAAGATGAATTGACACCGGAGTCTGTATTTAATCAGATTGGTGGTGTTAGATTACAATCTTCTTTTGTAAGAAAAGCTACATCTTGGTTTTGGAGTAGATGTGTGTTAGCTTGCTTCTTATTTGTGTTGTGTGCTATTGTCTTGTTTACGGCAGTGCCACTTAAATTTTATGTATATGCAGCTGTTATTTTGTTAATGGCTGTACTTTTTATTTCTTTTACTGTTAAACATGTTATGGCATATATGGATACTTTTCTATTGCCAACATTGATTACAGTTATTATTGGAGTTTGTGCTGAAGTGCCTTTCATCTACAATACTCTAATTAGTCAAGTTGTTATTTTCTTAAGTCAATGGTATGACCCAGTAGTCTTTGATACTATGGTACCATGGATGTTCTTGCCACTAGTGTTGTATACTGCTTTTAAGTGTGTACAAGGTTGCTATATGAATTCTTTCAATACTTCTTTGTTAATGCTGTATCAGTTTGTGAAGTTAGGTTTTGTTATTTACACCTCTTCTAATACTCTTACTGCATACACAGAAGGTAATTGGGAGTTATTCTTCGAGTTGGTGCACACTACTGTGTTGGCTAATGTTAGTAGTAATTCTTTAATTGGTTTATTTGTTTTTAAGTGTGCTAAATGGATGTTGTATTATTGTAATGCAACATACTTAAACAATTATGTACTAATGGCAGTTATGGTTAACTGCATTGGCTGGCTCTGCACTTGTTACTTTGGGTTGTATTGGTGGGTTAATAAGGTTTTTGGTTTAACCTTAGGTAAATACAATTTTAAAGTTTCAGTAGATCAATATAGGTATATGTGTTTGCACAAGATAAACCCACCTAAAACTGTGTGGGAAGTCTTTTCGACAAATATACTTATACAAGGAATTGGTGGTGACCGTGTGTTGCCTATTGCTACAGTTCAAGCTAAATTGAGTGATGTAAAGTGTACAACTGTTGTTTTAATGCAGCTTTTGACTAAGCTTAATGTTGAAGCAAATTCAAAAATGCATGTTTATCTTGTTGAGTTACACAATAAAATTCTTGCTTCTGATGATGTTGGAGAGTGCATGGATAATTTGTTGGGTATGCTTATAACACTATTTTGTATAGATTCTACTATTGATTTGAGTGAGTATTGTGATGACATACTTAAGAGGTCAACTGTATTACAATCGGTTACTCAAGAATTCTCACATATACCCTCTTATGCTGAATATGAAAGGGCTAAGAATCTTTATGAAAAGGTTTTAGTTGATTCTAAAAATGGTGGTGTTACACAGCAAGAGCTTGCTGCATATCGTAAAGCTGCCAATATTGCAAAGTCAGTTTTTGATAGAGACTTGGCTGTCCAAAAGAAGTTAGATAGCATGGCAGAGCGTGCTATGACAACAATGTATAAAGAGGCGCGTGTAACAGATAGACGAGCAAAATTAGTCTCATCACTACATGCGTTACTTTTCTCAATGCTTAAGAAAATAGATTCTGAAAAGCTTAATGTCTTGTTTGACCAGGCTAGTAGTGGTGTTGTGCCCCTAGCGACTGTTCCAATTGTTTGTAGTAATAAGCTTACACTTGTAATACCAGACCCAGAAACGTGGGTCAAGTGTGTGGAAGGTGTGCATGTTACATATTCAACAGTTGTTTGGAATATAGACACTGTTATTGATGCCGATGGCACAGAGTTACACCCAACTTCTACAGGTAGTGGATTGACATACTGTATAAGTGGTGCTAATATAGCATGGCCTTTAAAGGTTAACTTGACTAGGAATGGGCATAATAAGGTTGATGTTGTTTTGCAAAATAATGAGCTTATGCCACATGGTGTTAAAACAAAGGCTTGCGTAGCAGGTGTAGATCAAGCACATTGTAGCGTAGAGTCTAAATGTTATTATACAAATATTAGTGGCAATTCAGTTGTAGCTGCTATTACTTCTTCAAATCCAAATCTGAAAGTAGCTTCGTTTTTGAATGAGGCAGGCAATCAGATTTATGTAGACTTAGACCCACCATGTAAATTTGGCATGAAAGTGGGTGTCAAGGTTGAGGTTGTTTACTTGTATTTTATAAAGAATACAAGGTCGATTGTTAGGGGTATGGTACTTGGTGCTATATCTAATGTTGTTGTCTTACAGTCTAAAGGGCATGAAACAGAGGAAGTGGATGCTGTTGGCATTCTTTCACTATGTTCATTTGCAGTAGATCCCGCGGACACATATTGTAAATATGTGGCAGCAGGTAATCAACCTTTAGGTAACTGTGTTAAAATGTTGACAGTGCATAATGGTAGTGGTTTTGCTATAACTTCAAAGCCAAGTCCTACTCCTGACCAGGATTCTTATGGAGGAGCTTCTGTGTGTCTCTATTGTAGAGCACACATAGCACATCCAGGAAGTGTAGGAAATTTAGATGGACGTTGTCAATTTAAAGGTTCTTTTGTGCAAATACCTACTACGGAGAAAGACCCCGTTGGATTCTGTCTACGTAATAAGGTTTGCACTGTTTGCCAGTGTTGGATTGGTTATGGATGTCAGTGTGATTCACTTAGACAACCAAAATCTTCTGTTCAATCAGTTGCTGGAGCATCTGATTTTGATAAGAATTATTTAAACGGGTACGGGGTAGCAGTGAGGCTCGGCTGATACCCCTTGCTAGTGGATGTGATCCTGATGTTGTAAAGCGAGCCTTTGATGTTTGTAATAAGGAATCAGCTGGTATGTTTCAAAATTTGAAGCGTAACTGCGCTAGATTCCAGGAACTACGCGATACTGAAGATGGAAATCTTGAGTATCTTGATTCTTACTTTGTAGTTAAACAAACCACTCCTAGTAATTATGAACATGAAAAATCTTGTTACGAAGACTTAAAGTCAGAAGTAACAGCTGACCATGACTTCTTTGTGTTCAATAAGAACATTTACAATATTAGTAGGCAACGGCTTACTAAATATACTATGATGGACTTCTGCTATGCTTTGAGACATTTCGACCCAAAGGATTGTGAAGTTCTTAAAGAAATACTTGTCACTTATGGTTGTATAGAAGACTATCACCCTAAGTGGTTTGAGGAGAATAAGGATTGGTACGACCCAATAGAAAACTCAAAATATTATGTCATGTTGGCTAAAATGGGACCTATTGTACGACGTGCTTTATTGAATGCTATTGAGTTCGGAAACCTTATGGTTGAAAAAGGTTATGTTGGTGTTATTACACTCGATAACCAAGACCTTAATGGCAAATTTTATGATTTTGGTGATTTTCAGAAGACGGCACCTGGTGCTGGTGTTCCTGTTTTTGATACGTATTATTCTTACATGATGCCCATCATAGCCATGACGGATGCTTTAGCACCTGAGAGGTACTTTGAATATGATGTGCACAAGGGTTATAAATCTTATGATCTCCTCAAGTATGATTATACTGAGGAGAAACAAGAATTGTTTCAGAAGTACTTTAAGTACTGGGATCAAGAGTATCATCCTAACTGCCGTGACTGTAGTGATGACAGGTGTTTGATACATTGTGCAAACTTCAATATCTTGTTTTCTACACTTATACCGCAGACTTCTTTCGGTAATTTGTGTAGAAAAGTTTTTGTTGATGGTGTACCATTTATAGCTACTTGTGGCTATCATTCTAAGGAACTTGGTGTTATTATGAATCAAGATAACACCATGTCTTTTTCAAAAATGGGTTTAAGTCAACTCATGCAGTTTGTTGGAGATCCTGCTTTGTTAGTGGGAACATCCAATAATTTAGTTGATCTTAGAACGTCTTGTTTTAGTGTTTGTGCGTTAACATCTGGTATTACTCATCAAACGGTAAAGCCAGGTCACTTTAACAAGGATTTCTATGATTTTGCAGAGAAGGCTGGTATGTTTAAGGAGGGTTCGTCTATACCACTTAAACATTTTTTCTATCCTCAAACTGGTAATGCTGCTATAAACGATTATGATTATTATCGTTATAACAGGCCTACCATGTTTGACATATGTCAACTTCTATTTTGTTTAGAAGTGACTTCTAAATACTTTGAGTGTTATGAAGGCGGCTGTATACCAGCTAGCCAAGTTGTAGTTAACAACTTAGATAAGAGTGCAGGCTATCCATTTAATAAGTTTGGAAAAGCCCGCCTCTATTATGAAATGAGTCTAGAGGAACAGGACCAACTCTTCGAGATTACGAAGAAGAATGTCCTACCCACTATAACTCAAATGAATTTAAAATATGCCATATCCGCGAAAAATAGAGCGCGTACAGTGGCAGGTGTGTCTATCCTTTCTACTATGACTAATAGGCAGTTTCATCAGAAGATTCTTAAGTCTATAGTCAACACTAGAAATGCTTCTGTAGTTATTGGAACAACCAAGTTTTATGGCGGTTGGGACAACATGTTGAGAAACCTGATTCAGGGTGTTGAAGACCCAATTCTTATGGGTTGGGATTATCCTAAGTGTGATAGAGCAATGCCTAATTTGTTGCGTATAGCAGCATCCTTAGTACTTGCTCGCAAACACACTAACTGTTGTAGTTGGTCTGAACGCATTTATAGGTTGTATAATGAATGCGCCCAGGTCTTATCTGAAACTGTACTTGCTACAGGTGGTATTTATGTTAAACCTGGTGGCACTAGCAGTGGTGATGCTACTACTGCTTATGCAAACAGTGTTTTTAACATAATACAAGCCACATCTGCTAATGTTGCGCGTCTTTTGAGTGTTATAACGCGTGATATTGTCTATGATAATATTAAGAGCTTGCAGTATGAATTGTATCAGCAGGTCTACAGGCGAGTTAATTTTGACCCAGCCTTTGTTGAAAAGTTTTATTCTTACTTATGTAAGAATTTTTCGTTGATGATCTTGTCTGACGACGGTGTTGTTTGTTACAACAACACATTAGCCAAACAAGGTCTTGTAGCAGATATTTCTGGTTTTAGAGAGGTTCTCTACTATCAGAATAATGTTTTTATGGCTGATTCTAAATGTTGGGTTGAACCAGATTTAGAAAAAGGCCCACATGAGTTTTGTTCACAACACACAATGCTAGTGGAGGTTGATGGTGAGCCTAAGTATTTGCCATACCCAGACCCTTCACGCATTTTGGGTGCATGTGTTTTTGTAGATGACGTGGATAAGACAGAACCTGTGGCTGTTATGGAGCGTTATATAGCTCTTGCCATAGATGCTTATCCACTAGTACATCATGAAAATGAAGAGTACAAGAAGGTATTCTTTGTTCTCCTTGCATATATCAGAAAACTCTATCAAGAGCTTTCTCAGAATATGCTTATGGACTACTCTTTTGTAATGGATATAGACAAGGGTAGTAAATTTTGGGAACAGGAGTTCTATGAGAATATGTATAGAGCTCCTACGACTTTACAATCTTGTGGCGTTTGTGTAGTTTGTAATAGTCAAACTATACTACGCTGCGGTAATTGTATTCGTAAACCGTTTTTGTGTTGTAAGTGTTGCTATGACCACGTCATGCATACGGACCACAAAAATGTTTTATCTATAAATCCTTATATTTGCTCACAGCTAGGTTGCGGTGAAGCAGATGTTACTAAATTGTACCTCGGGGGTATGTCGTACTTCTGTGGTAATCATAAACCGAAATTGTCAATACCGTTAGTATCTAATGGTACTGTTTTTGGAATTTACAGGGCTAATTGTGCTGGTAGTGAAAATGTTGATGATTTTAATCAACTAGCTACTACTAATTGGTCCATTGTCGAACCTTATATTTTAGCAAATCGCTGTAGTGATTCATTGAGACGTTTTGCTGCAGAGACAGTAAAAGCCACAGAAGAATTACATAAGCAACAATTTGCTAGTGCAGAAGTGCGAGAAGTATTCTCAGATCGTGAATTGATTCTATCATGGGAACCAGGAAAAACCAGGCCGCCATTGAATAGAAATTATGTTTTCACAGGTTATCACTTTACAAGAACTAGTAAGGTGCAGCTTGGTGATTTTACATTTGAAAAAGGTGAAGGTAAGGATGTTGTCTATTATAAAGCAACGTCTACTGCTAAATTGTCTGTAGGAGACATTTTTGTTTTAACCTCACACAATGTTGTTTCTCTCGTAGCGCCAACATTGTGTCCACAACAAACCTTTTCTAGGTTTGTAAATTTAAGACCTAATGTAATGGTACCTGAATGTTTTGTAAATAACATTCCACTTTACCATTTAGTAGGTAAACAGAAGCGTACTACAGTACAAGGTCCTCCTGGCAGTGGTAAATCCCACTTTGCTATAGGCCTTGCAGTATACTTTAGTAGCGCTCGTGTTGTTTTTACTGCATGTTCTCATGCAGCTGTTGATGCTTTATGTGAAAAAGCTTTTAAGTTTCTTAAAGTTGATGATTGCACTCGTATAGTACCCCAAAGGACTACTGTCGATTGCTTCTCAAAATTTAAAGCTAATGACACAGGCAAAAAGTACATTTTTAGTACTATTAATGCCTTGCCGGAAGTTAGTTGTGATATTCTTTTGGTTGACGAGGTTAGTATGTTGACCAATTACGAATTGTCCTTTATTAATGGTAAGATAAATTACCAATATGTTGTGTATGTAGGTGATCCGGCTCAATTACCGGCACCCCGCACTTTACTTAATGGTTCACTTTCTCCAAAGGATTATAATGTTGTCACAAACCTTATGGTTTGTGTTAAACCTGATATTTTCCTTGCAAAGTGTTATCGTTGTCCTAAGGAAATTGTAGACACTGTGTCTACTCTTGTTTATGATGGAAAGTTTATTGCAAATAACCCAGAATCACGTGAGTGTTTCAAGGTTATAGTTAATAATGGCAATTCTGATGTAGGACATGAAAGTGGTTCAGCCTACAACACAACACAATTGGAATTTGTGAAAGACTTTGTTTGTCGCAATAAACAATGGCGGGAAGCAATATTTATTTCACCTTACAATGCTATGAACCAGAGAGCTTACCGTATGCTTGGACTTAATGTTCAAACAGTAGATTCTTCTCAAGGTTCAGAGTATGATTATGTCATCTTCTGTGTTACTGCAGATTCGCAGCATGCACTGAATATTAATAGATTTAATGTGGCGCTTACAAGAGCTAAGCGTGGTATACTAGTTGTCATGCGCCAGCGTGATGAATTGTATTCTGCTCTTAAGTTTACAGAGCTAGATAGTGAAACAAGTCTGCAAGGTACAGGTTTGTTTAAAATTTGCAACAAAGAATTTAGTGGTGTCCATCCTGCTTATGCAGTCACAACTAAGGCTCTTGCTGCAACCTATAAAGTTAATGATGAACTTGCTGCACTTGTTAATGTGGAAGCTGGTTCAGAAATAACATATAAACATCTTATTTCTCTGTTAGGATTCAAGATGAGTGTTAATGTTGAAGGCTGCCACAACATGTTTATAACACGTGATGAGGCAATCCGCAATGTAAGAGGTTGGGTAGGTTTTGATGTAGAAGCAACACATGCTTGTGGCACTAACATTGGTACTAACCTGCCTTTTCAAGTAGGTTTCTCTACTGGTGCAGACTTTGTAGTCACGCCTGAGGGACTTGTAGATACTTCAATAGGCAATAATTTTGAGCCTGTGAATTCTAAAGCACCTCCAGGTGAACAATTTAACCACTTGAGAGTGTTATTTAAAAGTGCTAAACCTTGGCATGTTATAAGACCAAGGATAGTGCAGATGTTAGCAGACAATCTATGCAACGTTTCAGATTGTGTAGTGTTTGTCACATGGTGTCATGGCCTAGAACTAACTACTTTGCGCTATTTTGTTAAAATAGGCAAGGAACAAGTTTGTTCTTGTGGTTCTAGAGCTACAACTTTTAATTCTCATACTCAAGCTTATGCTTGTTGGAAGCATTGTTTGGGTTTTGATTTTGTTTATAACCCACTTCTAGTGGATATTCAACAGTGGGGTTACTCGGGTAACCTACAGTTTAATCATGATTTGCACTGTAATGTGCATGGCCACGCTCATGTAGCTTCTGTTGACGCTATAATGACTCGTTGTCTTGCAATTAACAATGCATTTTGTCAAGATGTCAACTGGGATTTGACATACCCTCACATTGCAAATGAGGATGAAGTCAATTCTAGTTGTAGATATCTACAACGCATGTATCTTAATGCGTGTGTTGATGCTCTTAAAGTTAATGTTGTCTATGATATAGGCAACCCTAAAGGTATTAAATGTGTTAGGCGTGGGGATGTTAATTTTAGATTCTATGATAAGAATCCAATAGTACGCAACGTCAAGCAGTTTGAGTATGACTATAATCAGCACAAAGATAAGTTTGCTGATGGTCTTTGTATGTTTTGGAATTGTAATGTGGATTGTTATCCTGATAATTCCTTGGTTTGTAGGTATGACACACGAAATTTGAGTGTGTTTAACCTACCAGGCTGTAATGGTGGTAGTCTGTACGTTAACAAACATGCATTCTACACACCTAAATTTGACCGCATTAGCTTCCGCAATTTGAAAGCTATGCCATTCTTTTTTTATGACTCATCGCCTTGTGAAACCATTCAAGTGGATGGAGTTGCGCAAGACCTTGTGTCTCTAGCTACGAAAGACTGTATCACAAAGTGCAACATTGGTGGCGCTGTTTGTAAGAAACATGCCCAGATGTATGCAGAATTTGTGACTTCTTACAATGCAGCTGTCACAGCTGGCTTTACTTTCTGGGTAACTAATAAACTTAACCCTTATAACTTATGGAAAAGTTTTTCAGCTCTCCAGTCTATCGACAATATTGCTTATAATATGTATAAGGGTGGTCATTATGATGCTATTGCTGGAGAAATGCCCACTGTCATAACTGGAGACAAAGTTTTTGTTATTGATCAAGGTGTAGAAAAGGCAGTTTTTGTTAATCAAACAACTCTACCTACATCTGTGGCGTTTGAGCTATATGCAAAGAGAAATATTCGCACACTGCCAAACAACCGTATTTTGAAAGGTTTAGGTGTAGACGTAACCAATGGATTTGTAATTTGGGATTATGCTAACCAAACACCATTGTATCGTAATACCGTCAAGGTATGTGCATATACAGATATTGAGCCAAATGGCCTAGTAGTTCTGTATGATGATAGATATGGTGATTACCAGTCTTTTCTTGCTGCTGATAATGCTGTTCTAGTTTCTACACAGTGTTATAAGCGATATTCATACGTAGAAATACCATCTAATTTGCTCGTTCAGAATGGTATGCCATTAAAAGATGGAGCGAACCTGTATGTTTATAAGCGTGTTAATGGTGCGTTTGTTACACTACCTAACACAATAAACACCCAGGGTCGAAGTTATGAAACTTTTGAACCTCGTAGTGACATTGAGCGTGATTTTCTCGCTATGTCAGAGGAGAGTTTTGTAGAAAGGTATGGTAAAGACTTAGGCCTACAACACATACTGTATGGTGAAGTTGATAAGCCCCAATTAGGTGGTTTACACACTGTTATAGGTATGTACAGACTCTTACGTGCGAATAAGTTGAACGCAAAGTCTGTAACTAATTCGGATTCTGATGTCATGCAAAATTACTTTGTATTGTCGGACAATGGTTCTTACAAGCAAGTGTGTACTGTTGTGGATTTACTGCTTGATGATTTCTTAGAACTTCTTAGAAACATACTTAAGGAGTATGGTACTAATAAGTCAAAAGTTGTAACAGTGTCAATTGATTACCATAGCATAAATTTTATGACTTGGTTTGAAGATGGCAGTATTAAAACATGTTATCCACAGCTTCAATCAGCATGGACGTGTGGTTATAATATGCCTGAACTTTATAAAGTTCAGAATTGTGTTATGGAACCTTGCAACATTCCTAATTATGGTGTTGGAATAACGTTGCCTAGCGGTATTCTTATGAATGTGGCAAAGTATACACAACTTTGTCAATACCTTTCGAAAACAACAATTTGTGTACCGCATAACATGCGAGTAATGCATTTCGGAGCAGGAAGCGACAAAGGAGTGGCGCCAGGTAGTACTGTTCTTAAACAATGGCTCCCAGAAGGGACACTCCTTGTCGATAATGATATTGTAGACTATGTGTCTGATGCACATGTTTCTGTGCTTTCAGATTGCAATAAATATAATACAGAGCACAAGTTTGATCTTGTGATATCTGATATGTATACAGATAATGATTCAAAAAGAAAGCATGAAGGCGTGATAGCCAATAATGGCAATGATGACGTTTTCATATATCTCTCAAGTTTTCTTCGTAACAATTTGGCTCTAGGTGGTAGTTTTGCTGTAAAAGTGACAGAGACAAGTTGGCACGAAGTTTTATATGACATTGCACAGGATTGTGCATGGTGGACAATGTTTTGTACAGCAGTGAATGCCTCTTCTTCAGAAGCATTCTTGATTGGTGTTAATTATTTGGGTGCAAGTGAAAAGGTTAAGGTTAGTGGAAAAACGCTGCACGCAAATTATATATTTTGGAGGAATTGTAATTATTTACAAACCTCTGCTTATAGTATATTTGACGTTGCTAAGTTTGATTTGAGATTGAAAGCAACGCCAGTTGTTAATTTGAAAACTGAACAAAAGACAGACTTAGTCTTTAATTTAATTAAGTGTGGTAAGTTACTGGTAAGAGATGTTGGTAACACCTCTTTTACTAGTGACTCTTTTGTGTGCACTATGTAG
Protein
MASSLKQGVSPKPRDVILVSKDIPEQLCDALFFYTSHNPKDYADAFAVRQKFDRSLQTGKQFKFETVCGLFLLKGVDKITPGVPAKVLKATSKLADLEDIFGVSPLARKYRELLKTACQWSLTVEALDVRAQTLDEIFDPTEILWLQVAAKIHVSSMAMRRLVGEVTAKVMDALGSNLSALFQIVKQQIARIFQKALAIFENVNELPQRIAALKMAFAKCARSITVVVVERTLVVKEFAGTCLASINGAVAKFFEELPNGFMGSKIFTTLAFFKEAAVRVVENIPNAPRGTKGFEVVGNAKGTQVVVRGMRNDLTLLDQKADIPVEPEGWSAILDGHLCYVFRSGDRFYAAPLSGNFALSDVHCCERVVCLSDGVTPEINDGLILAAIYSSFSVSELVTALKKGEPFKFLGHKFVYAKDAAVSFTLAKAATIADVLRLFQSARVIAEDVWSSFTEKSFEFWKLAYGKVRNLEEFVKTYVCKAQMSIVILAAVLGEDIWHLVSQVIYKLGVLFTKVVDFCDKHWKGFCVQLKRAKLIVTETFCVLKGVAQHCFQLLLDAIHSLYKSFKKCALGRIHGDLLFWKGGVHKIVQDGDEIWFDAIDSVDVEDLGVVQEKSIDFEVCDDVTLPENQPGHMVQIEDDGKNYMFFRFKKDENIYYTPMSQLGAINVVCKAGGKTVTFGETTVQEIPPPDVVPIKVSIECCGEPWNTIFKKAYKEPIEVDTDLTVEQLLSVIYEKMCDDLKLFPEAPEPPPFENVALVDKNGKDLDCIKSCHLIYRDYESDDDIEEEDAEECDTDSGEAEECDTNSECEEEDEDTKVLALIQDPASIKYPLPLDEDYSVYNGCIVHKDALDVVNLPSGEETFVVNNCFEGAVKPLPQKVVDVLGDWGEAVDAQEQLCQQEPLQHTFEEPVENSTGSSKTMTEQVVVEDQELPVVEQDQDVVVYTPTDLEVAKETAEEVDEFILIFAVPKEEVVSQKDGAQIKQEPIQVVKPQREKKAKKFKVKPATCEKPKFLEYKTCVGDLTVVIAKALDEFKEFCIVNAANEHMTHGSGVAKAIADFCGLDFVEYCEDYVKKHGPQQRLVTPSFVKGIQCVNNVVGPRHGDNNLHEKLVAAYKNVLVDGVVNYVVPVLSLGIFGVDFKMSIDAMREAFEGCTIRVLLFSLSQEHIDYFDVTCKQKTIYLTEDGVKYRSIVLKPGDSLGQFGQVYAKNKIVFTADDVEDKEILYVPTTDKSILEYYGLDAQKYVIYLQTLAQKWNVQYRDNFLILEWRDGNCWISSAIVLLQAAKIRFKGFLTEAWAKLLGGDPTDFVAWCYASCTAKVGDFSDANWLLANLAEHFDADYTNAFLKKRVSCNCGIKSYELRGLEACIQPVRATNLLHFKTQYSNCPTCGANNTDEVIEASLPYLLLFATDGPATVDCDEDAVGTVVFVGSTNSGHCYTQAAGQAFDNLAKDRKFGKKSPYITAMYTRFAFKNETSLPVAKQSKGKSKSVKEDVSNLATSSKASFDNLTDFEQWYDSNIYESLKVQESPDNFDKYVSFTTKEDSKLPLTLKVRGIKSVVDFRSKDGFIYKLTPDTDENSKAPVYYPVLDAISLKAIWVEGNANFVVGHPNYYSKSLHIPTFWENAENFVKMGDKIGGVTMGLWRAEHLNKPNLERIFNIAKKAIVGSSVVTTQCGKLIGKAATFIADKVGGGVVRNITDSIKGLCGITRGHFERKMSPQFLKTLMFFLFYFLKASVKSVVASYKTVLCKVVLATLLIVWFVYTSNPVMFTGIRVLDFLFEGSLCGPYKDYGKDSFDVLRYCADDFICRVCLHDKDSLHLYKHAYSVEQVYKDAASGFIFNWNWLYLVFLILFVKPVAGFVIICYCVKYLVLNSTVLQTGVCFLDWFVQTVFSHFNFMGAGFYFWLFYKIYIQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYTNSGYNFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVDEACLVDDFVNLKYKAATPGKDSASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHALEEAKNAAIYYAQYLCKPILILDQALYEQLVVEPVSKSVIDKVCSILSSIISVDTAALNYKAGTLRDALLSITKDEEAVDMAIFCHNHDVDYTGDGFTNVIPSYGIDTGKLTPRDRGFLINADASIANLRVKNAPPVVWKFSELIKLSDSCLKYLISATVKSGVRFFITKSGAKQVIACHTQKLLVEKKAGGIVSGTFKCFKSYFKWLLIFYILFTACCSGYYYMEVSKSFVHPMYDVNSTLHVEGFKVIDKGVLREIVPEDTCFSNKFVNFDAFWGRPYDNSRNCPIVTAVIDGDGTVATGVPGFVSWVMDGVMFIHMTQTERKPWYIPTWFNREIVGYTQDSIITEGSFYTSIALFSARCLYLTASNTPQLYCFNGDNDAPGALPFGSIIPHRVYFQPNGVRLIVPQQILHTPYVVKFVSDSYCRGSVCEYTRPGYCVSLNPQWVLFNDEYTSKPGVFCGSTVRELMFSMVSTFFTGVNPNIYMQLATMFLILVVVVLIFAMVIKFQGVFKAYATTVFITMLVWVINAFILCVHSYNSVLAVILLVLYCYASLVTSRNTVIIMHCWLVFTFGLIVPTWLACCYLGFIIYMYTPLFLWCYGTTKNTRKLYDGNEFVGNYDLAAKSTFVIRGSEFVKLTNEIGDKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYRNSGVEIVYTPPRYSIGVSRLQSGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPRHVLGKFSGDQWNDVLNLANNHEFEVTTQHGVTLNVVSRRLKGAVLILQTAVANAETPKYKFIKANCGDSFTIACAYGGTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFYMHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFSLPKWLESTTVSVDDYNKWAGDNGFTPFSTSTAITKLSAITGVDVCKLLRTIMVKNSQWGGDPILGQYNFEDELTPESVFNQIGGVRLQSSFVRKATSWFWSRCVLACFLFVLCAIVLFTAVPLKFYVYAAVILLMAVLFISFTVKHVMAYMDTFLLPTLITVIIGVCAEVPFIYNTLISQVVIFLSQWYDPVVFDTMVPWMFLPLVLYTAFKCVQGCYMNSFNTSLLMLYQFVKLGFVIYTSSNTLTAYTEGNWELFFELVHTTVLANVSSNSLIGLFVFKCAKWMLYYCNATYLNNYVLMAVMVNCIGWLCTCYFGLYWWVNKVFGLTLGKYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQAKLSDVKCTTVVLMQLLTKLNVEANSKMHVYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTIDLSEYCDDILKRSTVLQSVTQEFSHIPSYAEYERAKNLYEKVLVDSKNGGVTQQELAAYRKAANIAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLFDQASSGVVPLATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDTVIDADGTELHPTSTGSGLTYCISGANIAWPLKVNLTRNGHNKVDVVLQNNELMPHGVKTKACVAGVDQAHCSVESKCYYTNISGNSVVAAITSSNPNLKVASFLNEAGNQIYVDLDPPCKFGMKVGVKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCSFAVDPADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAHPGSVGNLDGRCQFKGSFVQIPTTEKDPVGFCLRNKVCTVCQCWIGYGCQCDSLRQPKSSVQSVAGASDFDKNYLNRVRGSSEARLIPLASGCDPDVVKRAFDVCNKESAGMFQNLKRNCARFQELRDTEDGNLEYLDSYFVVKQTTPSNYEHEKSCYEDLKSEVTADHDFFVFNKNIYNISRQRLTKYTMMDFCYALRHFDPKDCEVLKEILVTYGCIEDYHPKWFEENKDWYDPIENSKYYVMLAKMGPIVRRALLNAIEFGNLMVEKGYVGVITLDNQDLNGKFYDFGDFQKTAPGAGVPVFDTYYSYMMPIIAMTDALAPERYFEYDVHKGYKSYDLLKYDYTEEKQELFQKYFKYWDQEYHPNCRDCSDDRCLIHCANFNILFSTLIPQTSFGNLCRKVFVDGVPFIATCGYHSKELGVIMNQDNTMSFSKMGLSQLMQFVGDPALLVGTSNNLVDLRTSCFSVCALTSGITHQTVKPGHFNKDFYDFAEKAGMFKEGSSIPLKHFFYPQTGNAAINDYDYYRYNRPTMFDICQLLFCLEVTSKYFECYEGGCIPASQVVVNNLDKSAGYPFNKFGKARLYYEMSLEEQDQLFEITKKNVLPTITQMNLKYAISAKNRARTVAGVSILSTMTNRQFHQKILKSIVNTRNASVVIGTTKFYGGWDNMLRNLIQGVEDPILMGWDYPKCDRAMPNLLRIAASLVLARKHTNCCSWSERIYRLYNECAQVLSETVLATGGIYVKPGGTSSGDATTAYANSVFNIIQATSANVARLLSVITRDIVYDNIKSLQYELYQQVYRRVNFDPAFVEKFYSYLCKNFSLMILSDDGVVCYNNTLAKQGLVADISGFREVLYYQNNVFMADSKCWVEPDLEKGPHEFCSQHTMLVEVDGEPKYLPYPDPSRILGACVFVDDVDKTEPVAVMERYIALAIDAYPLVHHENEEYKKVFFVLLAYIRKLYQELSQNMLMDYSFVMDIDKGSKFWEQEFYENMYRAPTTLQSCGVCVVCNSQTILRCGNCIRKPFLCCKCCYDHVMHTDHKNVLSINPYICSQLGCGEADVTKLYLGGMSYFCGNHKPKLSIPLVSNGTVFGIYRANCAGSENVDDFNQLATTNWSIVEPYILANRCSDSLRRFAAETVKATEELHKQQFASAEVREVFSDRELILSWEPGKTRPPLNRNYVFTGYHFTRTSKVQLGDFTFEKGEGKDVVYYKATSTAKLSVGDIFVLTSHNVVSLVAPTLCPQQTFSRFVNLRPNVMVPECFVNNIPLYHLVGKQKRTTVQGPPGSGKSHFAIGLAVYFSSARVVFTACSHAAVDALCEKAFKFLKVDDCTRIVPQRTTVDCFSKFKANDTGKKYIFSTINALPEVSCDILLVDEVSMLTNYELSFINGKINYQYVVYVGDPAQLPAPRTLLNGSLSPKDYNVVTNLMVCVKPDIFLAKCYRCPKEIVDTVSTLVYDGKFIANNPESRECFKVIVNNGNSDVGHESGSAYNTTQLEFVKDFVCRNKQWREAIFISPYNAMNQRAYRMLGLNVQTVDSSQGSEYDYVIFCVTADSQHALNINRFNVALTRAKRGILVVMRQRDELYSALKFTELDSETSLQGTGLFKICNKEFSGVHPAYAVTTKALAATYKVNDELAALVNVEAGSEITYKHLISLLGFKMSVNVEGCHNMFITRDEAIRNVRGWVGFDVEATHACGTNIGTNLPFQVGFSTGADFVVTPEGLVDTSIGNNFEPVNSKAPPGEQFNHLRVLFKSAKPWHVIRPRIVQMLADNLCNVSDCVVFVTWCHGLELTTLRYFVKIGKEQVCSCGSRATTFNSHTQAYACWKHCLGFDFVYNPLLVDIQQWGYSGNLQFNHDLHCNVHGHAHVASVDAIMTRCLAINNAFCQDVNWDLTYPHIANEDEVNSSCRYLQRMYLNACVDALKVNVVYDIGNPKGIKCVRRGDVNFRFYDKNPIVRNVKQFEYDYNQHKDKFADGLCMFWNCNVDCYPDNSLVCRYDTRNLSVFNLPGCNGGSLYVNKHAFYTPKFDRISFRNLKAMPFFFYDSSPCETIQVDGVAQDLVSLATKDCITKCNIGGAVCKKHAQMYAEFVTSYNAAVTAGFTFWVTNKLNPYNLWKSFSALQSIDNIAYNMYKGGHYDAIAGEMPTVITGDKVFVIDQGVEKAVFVNQTTLPTSVAFELYAKRNIRTLPNNRILKGLGVDVTNGFVIWDYANQTPLYRNTVKVCAYTDIEPNGLVVLYDDRYGDYQSFLAADNAVLVSTQCYKRYSYVEIPSNLLVQNGMPLKDGANLYVYKRVNGAFVTLPNTINTQGRSYETFEPRSDIERDFLAMSEESFVERYGKDLGLQHILYGEVDKPQLGGLHTVIGMYRLLRANKLNAKSVTNSDSDVMQNYFVLSDNGSYKQVCTVVDLLLDDFLELLRNILKEYGTNKSKVVTVSIDYHSINFMTWFEDGSIKTCYPQLQSAWTCGYNMPELYKVQNCVMEPCNIPNYGVGITLPSGILMNVAKYTQLCQYLSKTTICVPHNMRVMHFGAGSDKGVAPGSTVLKQWLPEGTLLVDNDIVDYVSDAHVSVLSDCNKYNTEHKFDLVISDMYTDNDSKRKHEGVIANNGNDDVFIYLSSFLRNNLALGGSFAVKVTETSWHEVLYDIAQDCAWWTMFCTAVNASSSEAFLIGVNYLGASEKVKVSGKTLHANYIFWRNCNYLQTSAYSIFDVAKFDLRLKATPVVNLKTEQKTDLVFNLIKCGKLLVRDVGNTSFTSDSFVCTM
Summary
Function
The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity).
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK.
The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G) (By similarity).
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK.
The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G) (By similarity).
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.
Catalytic Activity
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
ATP + H2O = ADP + H(+) + phosphate
ATP + H2O = ADP + H(+) + phosphate
Subunit
3CL-PRO exists as monomer and homodimer. The three peptides nsp2, nsp3 and nsp4 may form a complex. Nsp9 is a dimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp10 forms a dodecamer (By similarity). Interacts with DDX1 (via C-terminus).
Miscellaneous
Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Similarity
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
3D-structure
Activation of host autophagy by virus
ATP-binding
Endonuclease
Exonuclease
Helicase
Host cytoplasm
Host membrane
Host-virus interaction
Hydrolase
Membrane
Metal-binding
Methyltransferase
Nuclease
Nucleotide-binding
Nucleotidyltransferase
Protease
Reference proteome
Repeat
Ribosomal frameshifting
RNA-binding
RNA-directed RNA polymerase
Thiol protease
Transferase
Transmembrane
Transmembrane helix
Viral RNA replication
Zinc
Zinc-finger
Feature
chain Non-structural protein 2
Uniprot
Pubmed
Proteomes
PRIDE
Pfam
Interpro
IPR037227
EndoU-like
IPR007094 RNA-dir_pol_PSvirus
IPR037204 NSP7_sf
IPR009003 Peptidase_S1_PA
IPR042515 Nsp15_N
IPR040795 Nsp1a_N
IPR013016 Peptidase_C30/C16
IPR038123 NSP4_C_sf
IPR009461 Coronavirus_NSP16
IPR014828 NSP7
IPR027352 CV_ZBD
IPR036333 NSP10_sf
IPR002589 Macro_dom
IPR029063 SAM-dependent_MTases
IPR008740 Peptidase_C30
IPR009466 NSP11
IPR014829 NSP8
IPR027417 P-loop_NTPase
IPR014827 Viral_protease
IPR001205 RNA-dir_pol_C
IPR027351 (+)RNA_virus_helicase_core_dom
IPR036499 NSP9_sf
IPR003593 AAA+_ATPase
IPR037230 NSP8_sf
IPR009469 RNA_pol_N_coronovir
IPR018995 RNA_synth_NSP10_coronavirus
IPR032505 Corona_NSP4_C
IPR014822 NSP9
IPR007094 RNA-dir_pol_PSvirus
IPR037204 NSP7_sf
IPR009003 Peptidase_S1_PA
IPR042515 Nsp15_N
IPR040795 Nsp1a_N
IPR013016 Peptidase_C30/C16
IPR038123 NSP4_C_sf
IPR009461 Coronavirus_NSP16
IPR014828 NSP7
IPR027352 CV_ZBD
IPR036333 NSP10_sf
IPR002589 Macro_dom
IPR029063 SAM-dependent_MTases
IPR008740 Peptidase_C30
IPR009466 NSP11
IPR014829 NSP8
IPR027417 P-loop_NTPase
IPR014827 Viral_protease
IPR001205 RNA-dir_pol_C
IPR027351 (+)RNA_virus_helicase_core_dom
IPR036499 NSP9_sf
IPR003593 AAA+_ATPase
IPR037230 NSP8_sf
IPR009469 RNA_pol_N_coronovir
IPR018995 RNA_synth_NSP10_coronavirus
IPR032505 Corona_NSP4_C
IPR014822 NSP9
SUPFAM
ProteinModelPortal
PDB
6NUS
E-value=0,
Score=3073
Ontologies
GO
GO:0039520 P:induction by virus of host autophagy
GO:0039694 P:viral RNA genome replication
GO:0008168 F:methyltransferase activity
GO:0016896 F:exoribonuclease activity, producing 5'-phosphomonoesters
GO:0008270 F:zinc ion binding
GO:0003678 F:DNA helicase activity
GO:0006351 P:transcription, DNA-templated
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0032259 P:methylation
GO:0044172 C:host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0019082 P:viral protein processing
GO:0004519 F:endonuclease activity
GO:0008242 F:omega peptidase activity
GO:0033644 C:host cell membrane
GO:0003723 F:RNA binding
GO:0005524 F:ATP binding
GO:0003724 F:RNA helicase activity
GO:0004197 F:cysteine-type endopeptidase activity
GO:0016021 C:integral component of membrane
GO:0039694 P:viral RNA genome replication
GO:0008168 F:methyltransferase activity
GO:0016896 F:exoribonuclease activity, producing 5'-phosphomonoesters
GO:0008270 F:zinc ion binding
GO:0003678 F:DNA helicase activity
GO:0006351 P:transcription, DNA-templated
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0032259 P:methylation
GO:0044172 C:host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0019082 P:viral protein processing
GO:0004519 F:endonuclease activity
GO:0008242 F:omega peptidase activity
GO:0033644 C:host cell membrane
GO:0003723 F:RNA binding
GO:0005524 F:ATP binding
GO:0003724 F:RNA helicase activity
GO:0004197 F:cysteine-type endopeptidase activity
GO:0016021 C:integral component of membrane
Subcellular Location
From MSLVP
Capsid
From Uniprot
Host membrane
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 5 publications.
Host endoplasmic reticulum-Golgi intermediate compartment The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA. With evidence from 5 publications.
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 5 publications.
Host endoplasmic reticulum-Golgi intermediate compartment The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA. With evidence from 5 publications.
Topology
Length:
6629
Number of predicted TMHs:
18
Exp number of AAs in TMHs:
410.395389999997
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00064
outside
1 - 1724
TMhelix
1725 - 1744
inside
1745 - 1750
TMhelix
1751 - 1773
outside
1774 - 1841
TMhelix
1842 - 1864
inside
1865 - 1868
TMhelix
1869 - 1888
outside
1889 - 1897
TMhelix
1898 - 1920
inside
1921 - 2276
TMhelix
2277 - 2299
outside
2300 - 2557
TMhelix
2558 - 2580
inside
2581 - 2584
TMhelix
2585 - 2607
outside
2608 - 2610
TMhelix
2611 - 2630
inside
2631 - 2642
TMhelix
2643 - 2665
outside
2666 - 2887
TMhelix
2888 - 2905
inside
2906 - 3095
TMhelix
3096 - 3118
outside
3119 - 3122
TMhelix
3123 - 3140
inside
3141 - 3152
TMhelix
3153 - 3175
outside
3176 - 3189
TMhelix
3190 - 3212
inside
3213 - 3223
TMhelix
3224 - 3246
outside
3247 - 3255
TMhelix
3256 - 3278
inside
3279 - 3297
TMhelix
3298 - 3320
outside
3321 - 6629
Population Genetic Test Statistics
Pi
0.0547137
Theta
0.132592
Tajima's D
-1.6975872
CLR
5.957995
Interpretation
No evidence of Selection
Genomic alignment in the CDS region
Multiple alignment of Orthologues
Orthologous in Strains
| Strain | Availability | Status | Gene |
|---|---|---|---|
| CHINA_HS_2019_MN908947 | |||
| CHINA_AVIAN_2008_NC_016995 | |||
| CHINA_AVIAN_2007_NC_016991 | |||
| CHINA_MURINE_2015_NC_035191 | |||
| CANADA_AVIAN_2007_NC_010800 |
Protein Protein |
YP_001941164.2 YP_001941165.1 |
|
| USA_PIG_2000_NC_038861 | |||
| CHINA_AVIAN_2007_NC_011549 | |||
| ITALY_PIG_2009_NC_028806 | |||
| GERMANY_PIG_2012_LT545990 | |||
| CHINA_AVIAN_2007_NC_016992 | |||
| CHINA_BAT_2005_NC_009657 | |||
| CANADA_HS_2003_NC_004718 | |||
| CHINA_BAT_2014_NC_030886 | |||
| CHINA_BAT_2005_NC_018871 | |||
| USA_MURINE_2009_NC_012936 | |||
| CHINA_RABBIT_2006_NC_017083 | |||
| UK_PIG_2000_NC_003436 | |||
| ROMANIA_PIG_2015_LT898435 | |||
| ROMANIA_PIG_2015_LT898436 | |||
| GERMANY_PIG_2015_LT898444 | |||
| GERMANY_PIG_2015_LT898414 | |||
| GERMANY_PIG_2015_LT898439 | |||
| GERMANY_PIG_2015_LT898413 | |||
| GERMANY_PIG_2015_LT898412 | |||
| GERMANY_PIG_2015_LT898411 | |||
| GERMANY_PIG_2015_LT898416 | |||
| GERMANY_PIG_2015_LT898443 | |||
| GERMANY_PIG_2015_LT898420 | |||
| GERMANY_PIG_2015_LT898408 | |||
| GERMANY_PIG_2015_LT898423 | |||
| GERMANY_PIG_2015_LT898432 | |||
| GERMANY_PIG_2015_LT898409 | |||
| GERMANY_PIG_2015_LT898425 | |||
| GERMANY_PIG_2015_LT898446 | |||
| GERMANY_PIG_2014_LT898438 | |||
| GERMANY_PIG_2014_LT898440 | |||
| GERMANY_PIG_2014_LT900501 | |||
| GERMANY_PIG_2014_LT898427 | |||
| GERMANY_PIG_2014_LT898415 | |||
| GERMANY_PIG_2014_LT898421 | |||
| GERMANY_PIG_2014_LT898431 | |||
| GERMANY_PIG_2014_LT898410 | |||
| GERMANY_PIG_2014_LT900498 | |||
| GERMANY_PIG_2014_LT898430 | |||
| GERMANY_PIG_1978_LT897799 | |||
| GERMANY_PIG_2014_LT898447 | |||
| GERMANY_PIG_2014_LT898426 | |||
| GERMANY_PIG_2014_LT898417 | |||
| GERMANY_PIG_2014_LT900500 | |||
| GERMANY_PIG_2014_LT898445 | |||
| AUSTRIA_PIG_2015_LT898418 | |||
| AUSTRIA_PIG_2015_LT898441 | |||
| AUSTRIA_PIG_2015_LT898433 | |||
| AUSTRIA_PIG_2015_LT900502 | |||
| GERMANY_PIG_2015_LT900499 | |||
| BELGIUM_PIG_1980_LT906620 | |||
| BELGIUM_PIG_1977_LT905450 | |||
| SWITZERLAND_PIG_2003_LT905451 | |||
| BELGIUM_PIG_1978_LT906581 | |||
| UK_PIG_1987_LT906582 | |||
| CHINA_PIG_2009_NC_016990 | |||
| CHINA_PIG_2010_NC_039208 | |||
| KENYA_BAT_2010_KY073745 | |||
| KENYA_BAT_2010_NC_032107 | |||
| CHINA_AVIAN_2007_NC_016994 | |||
| EUROPE_MURINE_2004_AY700211 | |||
| CHINA_AVIAN_2007_NC_011550 | |||
| USA_MURINE_1997_NC_001846 | |||
| USA_MURINE_1998_NC_023760 | |||
| MID_EAST_HS_2012_NC_019843 | |||
| CHINA_AVIAN_2007_NC_016993 | |||
| CHINA_MURINE_2013_NC_032730 | |||
| USA_HS_2004_AY585228 | |||
| NETHERLAND_HS_2004_NC_005831 | |||
| CHINA_HS_2004_NC_006577 | |||
| EUROPE_HS_2000_NC_002645 | |||
| NETHERLAND_FERRET_2010_NC_030292 | |||
| JAPAN_FERRET_2013_LC119077 | |||
| USA_FELINE_2005_NC_002306 | |||
| CHINA_MURINE_2011_NC_034972 | |||
| CHINA_AVIAN_2007_NC_016996 | |||
| ARABIA_CAMEL_2015_NC_028752 | |||
| CHINA_AVIAN_2007_NC_011547 | |||
| CHINA_BAT_2012_NC_028824 | |||
| CHINA_BAT_2013_NC_028814 | |||
| CHINA_BAT_2013_NC_028833 | |||
| CHINA_BAT_2011_NC_028811 | |||
| USA_BOVIN_2001_NC_003045 | |||
| CHINA_MURINE_2012_NC_026011 | |||
| GERMANY_ERINACEINAE_2012_NC_022643 | |||
| GERMANY_ERINACEINAE_2012_NC_039207 | |||
| UK_HS_2012_NC_038294 | |||
| AMERICA_WHALE_2007_NC_010646 | |||
| CHINA_BAT_2013_NC_025217 | |||
| UGANDA_BAT_2013_NC_034440 | |||
| CHINA_BAT_2006_NC_009021 | |||
| CHINA_BAT_2008_NC_010438 | |||
| CHINA_BAT_2006_NC_009020 | |||
| CHINA_BAT_2006_NC_009019 | |||
| CHINA_BAT_2006_NC_009988 | |||
| USA_BAT_2006_NC_022103 | |||
| BULGARIA_BAT_2008_NC_014470 | |||
| CHINA_BAT_2008_NC_010437 | |||
| USA_AVIAN_2004_NC_001451 |
Protein Protein |
NP_066134.1 NP_040829.1 |
Copyright@ 2018-2023
Any Comments and suggestions mail to:
zhuzl@cqu.edu.cn,
mg@cau.edu.cn
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