Strain

USA_FELINE_2005_NC_002306 (Region: USA;  Strain: Feline infectious peritonitis virus, complete genome.;  Date: 2005)

Gene

nucleocapsid protein

Description

Annotated in NCBI,  nucleocapsid protein

Location

NC_002306(+):27014-28147

GenBank Accession

YP_004070199.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGGCCACACAGGGACAACGCGTCAACTGGGGAGATGAACCTTCCAAAAGACGTGGTCGTTCTAACTCTCGTGGTCGGAAGAATAATGATATACCTTTGTCATTCTACAACCCCATTACCCTCGAACAAGGATCTAAATTTTGGAATTTATGTCCGAGAGACCTTGTTCCCAAAGGAATAGGTAATAAGGATCAACAAATTGGTTATTGGAATAGACAGATTCGTTATCGTATTGTAAAAGGCCAGCGTAAGGAACTCGCTGAGAGGTGGTTCTTTTACTTCTTAGGTACAGGACCTCATGCTGATGCTAAATTCAAAGACAAGATTGATGGAGTCTTCTGGGTTGCAAGGGATGGTGCCATGAACAAGCCCACAACGCTTGGCACTCGTGGAACCAATAACGAATCCAAACCACTGAGATTTGATGGTAAGATACCGCCACAGTTTCAGCTTGAAGTGAACCGTTCTAGGAACAATTCAAGGTCTGGTTCTCAGTCTAGATCTGTTTCAAGAAACAGATCTCAATCTAGAGGAAGACACCATTCCAATAACCAGAATAATAATGTTGAGGATACAATTGTAGCCGTGCTTGAAAAATTAGGTGTTACTGACAAACAAAGGTCACGTTCTAAACCTAGAGAACGTAGTGATTCCAAACCTAGGGACACAACACCTAAGAATGCCAACAAACACACCTGGAAGAAAACTGCAGGCAAGGGAGATGTGACAACTTTCTATGGTGCTAGAAGTAGTTCAGCTAACTTTGGTGATAGTGATCTCGTTGCCAATGGTAACGCTGCCAAATGCTACCCTCAGATAGCTGAATGTGTTCCATCAGTGTCTAGCATAATCTTTGGCAGTCAATGGTCTGCTGAAGAAGCTGGTGATCAAGTGAAAGTCACGCTCACTCACACCTACTACCTGCCAAAGGATGATGCCAAAACTAGTCAATTCCTAGAACAGATTGACGCTTACAAGCGACCTTCTGAAGTGGCTAAGGATCAGAGGCAAAGAAGATCCCGTTCTAAGTCTGCTGATAAGAAGCCTGAGGAGTTGTCTGTAACTCTTGTGGAGGCATACACAGATGTGTTTGATGACACACAGGTTGAGATGATTGATGAGGTTACGAACTAA

Protein

MATQGQRVNWGDEPSKRRGRSNSRGRKNNDIPLSFYNPITLEQGSKFWNLCPRDLVPKGIGNKDQQIGYWNRQIRYRIVKGQRKELAERWFFYFLGTGPHADAKFKDKIDGVFWVARDGAMNKPTTLGTRGTNNESKPLRFDGKIPPQFQLEVNRSRNNSRSGSQSRSVSRNRSQSRGRHHSNNQNNNVEDTIVAVLEKLGVTDKQRSRSKPRERSDSKPRDTTPKNANKHTWKKTAGKGDVTTFYGARSSSANFGDSDLVANGNAAKCYPQIAECVPSVSSIIFGSQWSAEEAGDQVKVTLTHTYYLPKDDAKTSQFLEQIDAYKRPSEVAKDQRQRRSRSKSADKKPEELSVTLVEAYTDVFDDTQVEMIDEVTN

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Similarity

Belongs to the alphacoronavirus nucleocapsid protein family.

Keywords

ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Reference proteome   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion  

Feature

chain  Nucleoprotein

Uniprot

V9PIY0   P25909   I0B0S5   A0A5K1VI92   A3DT41   K7Y4L7   + More
C5IGE5   A0A2H5ACK0   A0A2H5ACI4   A0A2H5ACL3   A0A2H5ACH4   C6GHD1   A0A2H5ACL4   A0A2H5ACI3   A0A2H5ACI7   A0A2H5ACK8   A0A2H5ACG7   A0A2H5ACJ4   A0A2H5ACH3   A0A2H5ACL2   A0A2H5ACK3   A0A2H5ACK5   E0AGW1   A0A2H5ACI2   B0LJR4   A0A2H5ACI1   A0A2H5BX35   C6GH90   Q8JVR0   C6GHF2   O12298   A0A2H5ACI5   A0A2H5ACH2   C5IGF4   E0AH03   T1SS38   D3KDK9   D3KDM0   A0A2H5ACH0   D3JBI0   A0A2H5ACL8   S6BUP8   D3JBI8   D3JBI9   G1FEY1   E3W5G3   E0AGX1   D3JBH5   C6GHG2   D3JBK1   Q8JVR2   C6GHH3   C6GHA1   J7FAM6   A0A515KYU4   D3JBJ4   C6GHJ5   C6GHI4   A0A125R5H7   D3JBH4   A0A0C5D0Q0   A0A2H4KI29   A0A0C5D0R1   A0A2H4KI40   D3JBH9   E3W5J5   C6GHE1   E3W5I5   A0A2H4KI13   C5IGH2   D3JBJ3   A0A0C5D0M5   S6CE24   C5IGI1   A0A2H5BX05   A0A125R5F5   A0A2H5BX39   D3JBI7   D3JBJ5   G1FEZ2   A0A0C5D0L5   D3JBI2   A0A2H5BX00   E3W5H4   S6BFI0   C5IGA1   D3JBI6   D3JBI5   E0AGZ2   D3JBH7   D3JBG8   A0A386YJD5   Q09PH0   D3JBI1   D3JBG9   D3JBH1   C6GHK6   D3JBG7   D3JBH6   D3JBH0  

Pubmed

23996606    1847259    16033972    22438554    18077720    8839428    + More
21213598    25180686    26822958    25667330   

EMBL

KC461235    KC461236    KC461237    AGZ84522.1    AGZ84532.1    AGZ84542.1    + More
X56496    DQ010921    AY994055    JQ408981    AFH55126.1    JQ408980    AFH55117.1    DQ286389    ABD33845.1    KC175339    AFX81086.1    FJ917525    ACR10338.1    KY587352    AUG69017.1    KY587351    AUG69016.1    KY587344    KY587356    KY587357    KY587358    KY587361    AUG69021.1    KY587349    AUG69014.1    FJ938055    ACT10901.1    KY587345    AUG69010.1    KY587359    AUG69024.1    KY587360    AUG69025.1    KY587362    AUG69027.1    KY587339    AUG69004.1    KY587342    KY587343    AUG69007.1    KY587338    AUG69003.1    KY587354    AUG69019.1    KY587346    AUG69011.1    KY587353    AUG69018.1    HQ012368    ADL71461.1    KY587348    AUG69013.1    EU186072    ABX60148.1    KY587350    AUG69015.1    KY566198    AUG98106.1    FJ938051    ACT10860.1    AB086903    BAC01159.1    FJ938057    ACT10922.1    AB086904    Y13921    BAC01161.1    CAA74230.1    KY587347    AUG69012.1    KY587341    AUG69006.1    FJ917526    ACR10347.1    HQ012372    ADL71503.1    KF530123    AGT52086.1    GU553361    ADC35467.1    GU553362    ADC35478.1    KY587340    AUG69005.1    GU017105    ADC34648.1    KY587355    AUG69020.1    AB781806    BAN67942.1    GU017113    ADC34656.1    GU017114    ADC34657.1    JN183882    AEK25516.1    HQ392469    ADO39823.1    HQ012369    ADL71471.1    GU017100    ADC34643.1    FJ938058    ACT10932.1    GU017126    ADC34669.1    AB086902    BAC01157.1    FJ938059    ACT10943.1    FJ938052    ACT10871.1    JN634064    AFH58015.1    MN165107    QDM36992.1    GU017119    ADC34662.1    FJ938061    ACT10965.1    FJ938060    ACT10954.1    KU215419    KU215420    KU215421    KU215422    KU215423    KU215426    KU215427    KU215428    AMD11136.1    AMD11148.1    AMD11159.1    AMD11170.1    AMD11181.1    AMD11214.1    AMD11225.1    AMD11236.1    GU017099    ADC34642.1    KP143510    KP143511    AJO27009.1    AJO27019.1    KX722530    ASU62505.1    KP143507    KP143512    AJO26979.1    AJO27029.1    KX722531    ASU62515.1    GU017104    ADC34647.1    HQ392472    ADO39855.1    FJ938056    ACT10911.1    HQ392471    ADO39845.1    KX722529    ASU62494.1    FJ917528    ACR10365.1    GU017118    ADC34661.1    KP143509    AJO26999.1    AB781789    BAN67915.1    FJ917529    ACR10374.1    KY566207    AUG98115.1    KU215424    KU215425    AMD11192.1    AMD11203.1    KY566208    AUG98116.1    GU017112    ADC34655.1    GU017120    ADC34663.1    JN183883    AEK25527.1    KP143508    AJO26989.1    GU017107    GU017108    GU017109    ADC34650.1    ADC34651.1    ADC34652.1    KY566205    AUG98113.1    HQ392470    ADO39834.1    AB781788    BAN67906.1    FJ917520    FJ917532    FJ917533    FJ917534    FJ917535    ACR10294.1    ACR10401.1    ACR10410.1    ACR10419.1    ACR10427.1    GU017111    ADC34654.1    GU017110    ADC34653.1    HQ012371    ADL71492.1    GU017102    ADC34645.1    GU017093    ADC34636.1    MH817484    AYF53099.1    DQ848678    ABI14451.1    GU017106    ADC34649.1    GU017094    ADC34637.1    GU017096    ADC34639.1    FJ938062    ACT10976.1    GU017092    ADC34635.1    GU017101    ADC34644.1    GU017095    ADC34638.1   

Proteomes

UP000131699    UP000156095    UP000169693    UP000000835    UP000140386    UP000180339    + More
UP000096172    UP000144800    UP000119918    UP000162682    UP000141579    UP000141821    UP000117062    UP000151137    UP000110620    UP000113324    UP000137357    UP000138585    UP000144443    UP000113038    UP000161789    UP000122558    UP000153160    UP000114363    UP000164655    UP000147290    UP000118118    UP000102801    UP000113596    UP000117806    UP000125896    UP000126919    UP000135072    UP000158395    UP000161862    UP000105943    UP000140032    UP000115718    UP000170923    UP000153548    UP000140550    UP000145457    UP000100168    UP000135717    UP000143834    UP000173564    UP000149467    UP000165438    UP000169984    UP000118215    UP000173643   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037179   Nucleocapsid_C
IPR001218   Corona_nucleocap
IPR042548   ALPHA_CORONA_NCAP
IPR037195   Nucleocapsid_N

SUPFAM

SSF110304   SSF110304
SSF103068   SSF103068

ProteinModelPortal

V9PIY0   P25909   I0B0S5   A0A5K1VI92   A3DT41   K7Y4L7   + More
C5IGE5   A0A2H5ACK0   A0A2H5ACI4   A0A2H5ACL3   A0A2H5ACH4   C6GHD1   A0A2H5ACL4   A0A2H5ACI3   A0A2H5ACI7   A0A2H5ACK8   A0A2H5ACG7   A0A2H5ACJ4   A0A2H5ACH3   A0A2H5ACL2   A0A2H5ACK3   A0A2H5ACK5   E0AGW1   A0A2H5ACI2   B0LJR4   A0A2H5ACI1   A0A2H5BX35   C6GH90   Q8JVR0   C6GHF2   O12298   A0A2H5ACI5   A0A2H5ACH2   C5IGF4   E0AH03   T1SS38   D3KDK9   D3KDM0   A0A2H5ACH0   D3JBI0   A0A2H5ACL8   S6BUP8   D3JBI8   D3JBI9   G1FEY1   E3W5G3   E0AGX1   D3JBH5   C6GHG2   D3JBK1   Q8JVR2   C6GHH3   C6GHA1   J7FAM6   A0A515KYU4   D3JBJ4   C6GHJ5   C6GHI4   A0A125R5H7   D3JBH4   A0A0C5D0Q0   A0A2H4KI29   A0A0C5D0R1   A0A2H4KI40   D3JBH9   E3W5J5   C6GHE1   E3W5I5   A0A2H4KI13   C5IGH2   D3JBJ3   A0A0C5D0M5   S6CE24   C5IGI1   A0A2H5BX05   A0A125R5F5   A0A2H5BX39   D3JBI7   D3JBJ5   G1FEZ2   A0A0C5D0L5   D3JBI2   A0A2H5BX00   E3W5H4   S6BFI0   C5IGA1   D3JBI6   D3JBI5   E0AGZ2   D3JBH7   D3JBG8   A0A386YJD5   Q09PH0   D3JBI1   D3JBG9   D3JBH1   C6GHK6   D3JBG7   D3JBH6   D3JBH0  

PDB

5N4K     E-value=5.60326e-28,     Score=309