Strain

USA_PIG_2000_NC_038861 (Region: USA:Indiana;  Strain: Transmissible gastroenteritis virus complete genome, genomic RNA.;  Date: 2000)

Gene

nucleoprotein

Description

Annotated in NCBI,  nucleoprotein

Location

NC_038861(+):26917-28065

GenBank Accession

NP_058428.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGGCCAACCAGGGACAACGTGTCAGTTGGGGAGATGAATCTACCAAAACACGTGGTCGTTCCAATTCCCGTGGTCGGAAGAATAATAACATACCTCTTTCATTCTTCAACCCCATAACCCTCCAACAAGGTTCAAAATTTTGGAACTTATGTCCGAGAGACTTTGTACCCAAAGGAATAGGTAACAGGGATCAACAGATTGGTTATTGGAATAGACAAACTCGCTATCGCATGGTGAAGGGCCAACGTAAAGAGCTTCCTGAAAGGTGGTTCTTCTACTACTTAGGTACTGGACCTCATGCAGATGCCAAATTTAAAGATAAATTAGATGGAGTTGTCTGGGTTGCCAAGGATGGTGCCATGAACAAACCAACCACGCTTGGTAGTCGTGGTGCTAATAATGAATCCAAAGCTTTGAAATTCGATGGTAAAGTGCCAGGCGAATTTCAACTTGAAGTTAATCAATCAAGAGACAATTCAAGGTCACGCTCTCAATCTAGATCTCGGTCTAGAAATAGATCTCAATCTAGAGGCAGGCAACAATTCAATAACAAGAAGGATGACAGTGTAGAACAAGCTGTTCTTGCCGCACTTAAAAAGTTAGGTGTTGACACAGAAAAACAACAGCAACGCTCTCGTTCTAAATCTAAAGAACGTAGTAACTCTAAGACAAGAGATACTACACCTAAGAATGAAAACAAACACACCTGGAAGAGAACTGCAGGTAAAGGTGATGTGACAAGATTTTATGGAGCTAGAAGCAGTTCAGCCAATTTTGGTGACACTGACCTCGTTGCCAATGGGAGCAGTGCCAAGCATTACCCACAACTGGCTGAATGTGTTCCATCTGTGTCTAGCATTCTGTTTGGAAGCTATTGGACTTCAAAGGAAGATGGCGACCAGATAGAAGTCACGTTCACACACAAATACCACTTGCCAAAGGATGATCCTAAGACTGGACAATTCCTTCAGCAGATTAATGCCTATGCTCGTCCATCAGAAGTGGCAAAAGAACAGAGAAAAAGAAAATCTCGTTCTAAATCTGCAGAAAGGTCAGAGCAAGATGTGGTACCTGATGCATTAATAGAAAATTATACAGATGTGTTTGATGACACACAGGTTGAGATAATTGATGAGGTAACGAACTAA

Protein

MANQGQRVSWGDESTKTRGRSNSRGRKNNNIPLSFFNPITLQQGSKFWNLCPRDFVPKGIGNRDQQIGYWNRQTRYRMVKGQRKELPERWFFYYLGTGPHADAKFKDKLDGVVWVAKDGAMNKPTTLGSRGANNESKALKFDGKVPGEFQLEVNQSRDNSRSRSQSRSRSRNRSQSRGRQQFNNKKDDSVEQAVLAALKKLGVDTEKQQQRSRSKSKERSNSKTRDTTPKNENKHTWKRTAGKGDVTRFYGARSSSANFGDTDLVANGSSAKHYPQLAECVPSVSSILFGSYWTSKEDGDQIEVTFTHKYHLPKDDPKTGQFLQQINAYARPSEVAKEQRKRKSRSKSAERSEQDVVPDALIENYTDVFDDTQVEIIDEVTN

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Similarity

Belongs to the alphacoronavirus nucleocapsid protein family.

Keywords

ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Reference proteome   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion   Host nucleus  

Feature

chain  Nucleoprotein

Uniprot

Q0PKZ9   A0A1L6BQB7   F1CNZ2   P04134   M4I828   A0A1B1IJL6   + More
I3QKR2   Q0PKZ0   A0A0E3M3T7   A0A384VI14   C8CAL8   A0A1B1IJK8   Q1W2N6   A0A1B1IJM5   K7WUV5   A0A1B1IJL2   Q0PL25   Q9DY21   M4I906   Q0PL16   Q7T712   P05991   A0A1I9UVL9   C8CAL7   A0A1B1IJL3   A0A1B1IJL8   A0A1B1IJL0   Q88515   A0A1B1IJL5   A0A1B1IJN1   A0A1I9UVM4   A0A1B1IJL4   A0A384V9J2   A0A1I9UVM2   B7T4B4   A0A1B1IJL1   K7X1B6   Q6PQ03   A0A1B1IJN3   C8CAM4   A0A1I9UVL7   Q8JVB2   C8CAL6   D3XKB3   A0A384VI73   A0A384V9R5   B7T4C3   C8CAL4   A0A384VGQ5   Q0PL08   A0A1B1IJM1   F6M1R5   A0A1B1IJM4   A0A1B1IJM2   G8J7H0   Q0ZVX0   Q80IQ7   K7XKS8   A0A1L7NS54   C8CAL5   E7E041   A0A0U2UGH8   G8A506   A0A166IHH5   D3XKB1   S6BPJ1   E7E032   Q6TPK9   H9TEX7   A0A1D8ELQ5   Q6TPK8   P24411   P33463   Q9YRA4   B7T077   S6BPJ6   S6BFL6   Q6T523   A4UII9   A4UIJ0   A1DS39   Q04700   A0A1I9UVL8   S6BPH9   A0A3S6JM63   A0A0K1RLP0   S6CE38   S6BUP2   D2WXM3   S6B921   S6CE41   D3XKB2   S6BFM2   Q7T6S8   P36298  

Pubmed

17023013    23043168    25890036    2825819    3008432    10805807    + More
2841792    1645905    15507657    16033973    20414714    20229183    2835592    11533198    8546012    19036814    22002680    22609354    16704791    17275120    25953186    27840394    21481551    22542271    27084706    25180686    27619563    2174956    1662846    10365166    17267506    18306032    1329312    26250391    15177889    1431811   

EMBL

DQ811788    ABG89327.1    KX083668    APQ31247.1    HQ462571    HM776941    + More
KC962433    KU729220    KU981075    KX499468    KX900394    ADY39745.1    AEM55571.1    AGM75131.1    AML22779.1    APA05106.1    AQT01354.1    ASV64291.1    X06371    M14878    AJ271965    M21627    JQ693058    AFZ88853.1    KU500157    KX900402    ANR94928.1    ASV64363.1    JQ700302    AFK10484.1    DQ811789    ABG89328.1    KP202848    AKA60059.1    KX900393    ASV64282.1    GQ374559    ACU56726.1    KU500153    ANR94924.1    DQ443743    ABD97840.1    KU500169    ANR94940.1    JX827600    AFX69274.1    KU500156    ANR94927.1    DQ811785    ABG89293.1    AF302264    EU074218    FJ755618    GQ374566    JX827601    JX827602    JX827603    JX827604    JX827605    JX827606    JX827607    KT696544    KU500154    KU500163    KU981076    KU981078    AAG30228.1    ABU49664.1    ACN71201.1    ACU56733.1    AFX69275.1    AFX69276.1    AFX69277.1    AFX69278.1    AFX69279.1    AFX69280.1    AFX69281.1    AMB66493.1    ANR94925.1    ANR94934.1    APA05107.1    APA05109.1    JQ693057    JQ693059    JQ693060    AFZ88852.1    AFZ88854.1    AFZ88855.1    DQ811786    ABG89310.1    AY335549    DQ201447    AAQ02627.1    ABC72419.1    Y00542    KU981074    APA05105.1    GQ374558    ACU56725.1    KU500160    ANR94931.1    KU500155    ANR94926.1    KU500152    ANR94923.1    Z35758    CAA84811.1    KU500161    ANR94932.1    KU500166    KU500167    ANR94937.1    ANR94938.1    KU981079    APA05110.1    KU500159    ANR94930.1    KX900401    ASV64354.1    KU981077    APA05108.1    EU924790    ACJ64181.1    KU500158    ANR94929.1    JX827599    AFX69273.1    AY587884    AAT00647.1    KU500164    ANR94935.1    GQ374565    KX900395    KX900396    KX900397    KX900398    KX900399    KX900400    KX900404    KX900405    KX900406    KX900407    ACU56732.1    ASV64300.1    ASV64309.1    ASV64318.1    ASV64327.1    ASV64336.1    ASV64344.1    ASV64380.1    ASV64389.1    ASV64398.1    ASV64407.1    KU981072    APA05103.1    AF298213    AAM97563.1    GQ374557    GQ374561    GQ374562    ACU56724.1    ACU56728.1    ACU56729.1    GU356398    ADC53234.1    KX900403    ASV64372.1    KX900408    KX900409    KX900410    ASV64416.1    ASV64425.1    ASV64434.1    EU924791    ACJ64190.1    GQ374555    ACU56722.1    KX900411    ASV64443.1    DQ811787    ABG89315.1    KU500168    ANR94939.1    JF682842    AEE69328.1    KU500162    ANR94933.1    KU500165    ANR94936.1    JN856008    AEQ61973.1    DQ112226    EU856361    KP981644    AAZ91442.1    ACJ63237.1    AKA65835.1    JQ404409    AB105373    AFG19729.1    BAC65328.1    KC175340    KC175341    AFX81103.1    AFX81113.1    LC190907    BAW32708.1    GQ374556    GQ374560    GQ374563    GQ374564    ACU56723.1    ACU56727.1    ACU56730.1    ACU56731.1    HQ450377    ADU17740.1    KR061459    ALR84919.1    GU146061    ADB10855.1    KT852997    ANA11063.1    GU356396    ADC53232.1    AB781797    AB781798    BAN67933.1    BAN67934.1    HQ450376    ADU17731.1    AY390345    AAQ96369.1    JQ404410    KY063616    KY063617    KY063618    AFG19745.1    ASB15744.1    ASB15754.1    ASB15762.1    KX689261    AOT21924.1    AY390346    AAQ96370.1    Z24675    X60056    AF104420    AAC96008.1    EU856362    ACJ63248.1    AB781803    BAN67939.1    AB781800    BAN67936.1    AY436636    AAR11076.1    EF192157    ABO88143.1    EF192158    ABO88144.1    EF056485    ABK79895.1    X66717    KU981073    APA05104.1    AB781790    BAN67924.1    KY406735    ASV45153.1    KR270796    AKV62760.1    AB781799    BAN67935.1    AB781801    BAN67937.1    GQ477367    ADB28913.1    AB781802    BAN67938.1    AB781804    BAN67940.1    GU356397    ADC53233.1    AB781805    BAN67941.1    AY342160    D13096   

Proteomes

UP000137024    UP000113525    UP000123026    UP000131894    UP000166047    UP000001440    + More
UP000158285    UP000098772    UP000158504    UP000145148    UP000111647    UP000121388    UP000166023    UP000156732    UP000149523    UP000153699    UP000115330    UP000119169    UP000155481    UP000165378    UP000125818    UP000106470    UP000129150    UP000129066   

PRIDE

Q7T6S8    P36298   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037179   Nucleocapsid_C
IPR001218   Corona_nucleocap
IPR042548   ALPHA_CORONA_NCAP
IPR037195   Nucleocapsid_N

SUPFAM

SSF110304   SSF110304
SSF103068   SSF103068

ProteinModelPortal

Q0PKZ9   A0A1L6BQB7   F1CNZ2   P04134   M4I828   A0A1B1IJL6   + More
I3QKR2   Q0PKZ0   A0A0E3M3T7   A0A384VI14   C8CAL8   A0A1B1IJK8   Q1W2N6   A0A1B1IJM5   K7WUV5   A0A1B1IJL2   Q0PL25   Q9DY21   M4I906   Q0PL16   Q7T712   P05991   A0A1I9UVL9   C8CAL7   A0A1B1IJL3   A0A1B1IJL8   A0A1B1IJL0   Q88515   A0A1B1IJL5   A0A1B1IJN1   A0A1I9UVM4   A0A1B1IJL4   A0A384V9J2   A0A1I9UVM2   B7T4B4   A0A1B1IJL1   K7X1B6   Q6PQ03   A0A1B1IJN3   C8CAM4   A0A1I9UVL7   Q8JVB2   C8CAL6   D3XKB3   A0A384VI73   A0A384V9R5   B7T4C3   C8CAL4   A0A384VGQ5   Q0PL08   A0A1B1IJM1   F6M1R5   A0A1B1IJM4   A0A1B1IJM2   G8J7H0   Q0ZVX0   Q80IQ7   K7XKS8   A0A1L7NS54   C8CAL5   E7E041   A0A0U2UGH8   G8A506   A0A166IHH5   D3XKB1   S6BPJ1   E7E032   Q6TPK9   H9TEX7   A0A1D8ELQ5   Q6TPK8   P24411   P33463   Q9YRA4   B7T077   S6BPJ6   S6BFL6   Q6T523   A4UII9   A4UIJ0   A1DS39   Q04700   A0A1I9UVL8   S6BPH9   A0A3S6JM63   A0A0K1RLP0   S6CE38   S6BUP2   D2WXM3   S6B921   S6CE41   D3XKB2   S6BFM2   Q7T6S8   P36298  

PDB

5N4K     E-value=5.60326e-28,     Score=309