Strain

CHINA_BAT_2006_NC_009988 (Region: China: Hong Kong;  Strain: Bat coronavirus HKU2, complete genome.;  Date: 2006)

Gene

nucleocapsid phosphoprotein

Description

Annotated in NCBI,  nucleocapsid phosphoprotein

Location

NC_009988(+):25469-26596

GenBank Accession

YP_001552240.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGGCCACTGTTAATTGGGGTGACGCTGTTGAACAGGCGGAATCTCGTGGTCGTAAAAGAATTCCATTGTCACTCTTTGCGCCTTTGCGTGTTACAGATGGCAAAAACTTTTGGAATGTCATGCCTAGAAATGGAGTTCCAACAGGCAGAGGCAATCCAGATCAACAGATTGGTTATTGGGTTGAACAAAAACGCTGGCGAATGCAAAAAGGCCAACGTAAAGATCAGCCTTCTAACTGGCATTTTTATTACCTTGGTACTGGTCCTCACGCAGATGCTCCTTTCAGGAAACGGATTCAGGGTGTGCATTGGGTTGCTGTTGATGGTGCTAAAACTAGCCCCACAGGTCTTGGTGTTCGCAATCGTAATAAAGAACCTGCTACACCTCAGTTTGGGTTTCAATTACCAGCTGACGTAACTGTTGTTGAGGCTACTTCTAGAAGTGCTTCACGTTCACAGTCTCGTTCTCGCAATCAAAGCCAAAGCCGCAGCGGTGCTCAGACACCTCGTGTTCAACAATCGTCTCAGGCTGTTGACATCGTAGCTGCAGTTAAACAAGCTTTGGCAGACTTGGGCATAGCTTCTAGCCAGTCCAAGTCGCAGAGCGGTAAGAATACACCCAAACCAAGAAGCAGAGCTGTTTCTCCTGCACCAGCCCCTAAACCGGCTCGTAAGCAGATGGATAAACCTGAATGGAAGCGCGTTCCTAATTCTGAAGAGGACGTGCGTAAGTGCTTTGGTCCTCGATCAGCTTCTAGAAATTTTGGTGACAGTGATCTTGTTCAGCATGGTGTTGAAGCTAAGCATTTTCCAACAATTGCGGAGCTGCTTCCTACTCAGGCTGCATTAGCCTTTGGTAGTGAAATTACCACCAAAGAAGCTGGTGATTTTGTTGAAGTCACCTATCATTATGTAATGAAGGTTTCTAAGACTGATAAAAATCTACCTAGATTTCTTGAGCAAGTTGCTGCTTACTCTAAACCTAGCCAGATTAGGAGGTCCCAATCTCAACAGGATTTGAATGTTGATGCGCCTGCGTTCACCCCAGCACCCCCAGCTACTCCAGTTTCCCGAAATCCTGATTTTCCTGAGGAAGAGGTTGAGATGGTGGATGAGATTATTAATTAG

Protein

MATVNWGDAVEQAESRGRKRIPLSLFAPLRVTDGKNFWNVMPRNGVPTGRGNPDQQIGYWVEQKRWRMQKGQRKDQPSNWHFYYLGTGPHADAPFRKRIQGVHWVAVDGAKTSPTGLGVRNRNKEPATPQFGFQLPADVTVVEATSRSASRSQSRSRNQSQSRSGAQTPRVQQSSQAVDIVAAVKQALADLGIASSQSKSQSGKNTPKPRSRAVSPAPAPKPARKQMDKPEWKRVPNSEEDVRKCFGPRSASRNFGDSDLVQHGVEAKHFPTIAELLPTQAALAFGSEITTKEAGDFVEVTYHYVMKVSKTDKNLPRFLEQVAAYSKPSQIRRSQSQQDLNVDAPAFTPAPPATPVSRNPDFPEEEVEMVDEIIN

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Similarity

Belongs to the alphacoronavirus nucleocapsid protein family.

Keywords

3D-structure   ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion  

Feature

chain  Nucleoprotein

Uniprot

A8JNZ6   A8JP12   A0A2P1G6H8   A0A2P1G6P9   A0A2R3NG38   A8JP04   + More
A0A2P1G6J5   A0A2P1G6K4   A0A3G1II26   A0A2P1G739   A0A410N738   A0A5B9Y683   A0A2D1BNM3   A0A4Y5WWA6   A0A2S1WCF9   A0A0U1WHF9   B1PHJ9   B1PHJ2   Q06XQ3   U3M7G3   A0A384RBU9   A0A2U8JDM2   Q06Y06   A0A5B9MVD7   A0A384RBV1   A0A127AV50   A0A127ATV7   A0A127AX00   A0A127AU27   A0A127ATQ0   A0A127AX58   A0A127ATT3   A0A127ATP0   A0A127AV25   A0A127ATS9   A0A127ATT5   A0A127AU18   A0A127ATQ1   I7DJE7   A0A127ATS5   A0A5B9BGU8   A0A127ATY8   A0A127ATR0   Q06Y12   U3M6A0   H9EJA4   H9EJ69   Q6Q1R8   A0A2P1E971   A0A2P1E945   A0A2P1E959   A0A1Y0EV18   A0A2P1E948   Q06XQ5   A0A127AX50   Q0GMF2   A0A2L0WQF7   H9EJ76   A0A127ATR3   A0A2P1E938   A0A384R2N5   A0T2T5   A0A127ATW4   A0A127ATU8   A0A127AUA1   A0A127ATQ8   A0A127ATS0   A0A127AV68   A0A127AV38   A0A127AU90   A0A127ATX3   A0A127ATR7   A0A127ATQ4   A0A127ATS6   A0A127ATV6   A0A127AU23   A0A127ATQ7   A0A127ATR6   A0A127ATY7   A0A127AU79   A0A127ATT9   A0A127AX15   A0A127ATX8   A0A127ATW2   A0A127AU68   H9EJ20   Q06XQ8   Q06XQ0   Q06XQ4   Q06XQ6   Q06XQ7   Q06XQ1   Q06XQ2   A0A5B9BJR5   A0A127ATS3   A0A127ATY1   A0A0N7J131   A0A1L2KGF4  

Pubmed

17617433    29618817    28654418    30171801    30103259    31419711    + More
31207129    29704627    18420807    17054987    29741740    26928836    22879617    27799635    15073334    22837419    15034574    25700263    17889596    26378164   

EMBL

EF203064    ABQ57212.1    EF203066    EF203067    ABQ57228.1    ABQ57236.1    + More
MF094686    AVM80488.1    MF094685    AVM80479.1    MF094702    AVM80791.1    EF203065    ABQ57220.1    MF094687    AVM80496.1    MF094688    AVM80504.1    MF167434    ASK51721.1    MG557844    MF094681    MF094682    MF094683    MF094684    MF769416    MF769417    MF769418    MF769419    MF769420    MF769421    MF769422    MF769423    MF769424    MF769425    MF769426    MF769427    MF769428    MF769429    MF769430    MF769431    MF769432    MF769433    MF769434    MF769435    MF769436    MF769437    MF769438    MF769439    MF769440    MF769441    MF769442    MF769443    MF769444    MH615810    MG605087    MG605088    MG605089    MG605090    MG605091    MG775251    MG775253    AVM41574.1    AVM80443.1    AVM80452.1    AVM80461.1    AVM80470.1    AVM80528.1    AVM80537.1    AVM80546.1    AVM80555.1    AVM80564.1    AVM80573.1    AVM80582.1    AVM80591.1    AVM80600.1    AVM80609.1    AVM80618.1    AVM80627.1    AVM80636.1    AVM80645.1    AVM80654.1    AVM80663.1    AVM80672.1    AVM80681.1    AVM80690.1    AVM80699.1    AVM80708.1    AVM80717.1    AVM80726.1    AVM80735.1    AVM80744.1    AVM80753.1    AVM80762.1    AVM80771.1    AVM80780.1    AXP98443.1    AXY04078.1    AXY04079.1    AXY04080.1    AXY04087.1    AXY04096.1    MH539766    MH697599    QAS69032.1    QBP43304.1    MK977618    QEH62673.1    MF370205    ATN23893.1    MK651076    QDE12101.1    MG742313    AWJ64267.1    KJ473808    AIA62263.1    EU420138    ACA52168.1    EU420137    ACA52161.1    DQ462768    ABE73425.1    KF530105    AGT51335.1    KM055598    AIW52795.1    MG428705    AWK59971.1    DQ445912    ABE97134.1    MN306040    QEG03752.1    KM055608    AIW52805.1    KT359858    AMM42617.1    KT359853    AMM42612.1    KT359835    AMM42594.1    KT359871    AMM42630.1    KT359839    AMM42598.1    KT359865    AMM42624.1    KT359864    AMM42623.1    KT359829    AMM42588.1    KT359838    AMM42597.1    KT359866    AMM42625.1    KT359862    AMM42621.1    KT359851    AMM42610.1    KT359836    AMM42595.1    JX104161    JX524171    KM055599    KM055600    KM055601    KM055603    KM055604    KM055605    KM055606    KM055607    KM055609    KM055610    KT266906    KX179497    KX179498    KX179499    KY862059    KY862063    MG428699    MG428700    MG428701    MG428702    MG428703    MG428704    MG428706    MG428707    MK334043    MK334044    MK334045    MN306018    AFO70495.1    AFQ55888.1    AIW52796.1    AIW52797.1    AIW52798.1    AIW52800.1    AIW52801.1    AIW52802.1    AIW52803.1    AIW52804.1    AIW52806.1    AIW52807.1    AKT07956.1    APF29065.1    APF29067.1    APF29069.1    AVL25597.1    AVL25601.1    AWK59935.1    AWK59941.1    AWK59947.1    AWK59953.1    AWK59959.1    AWK59965.1    AWK59977.1    AWK59983.1    QED88016.1    QED88023.1    QED88030.1    QEG03735.1    KT359854    AMM42613.1    MK334046    QED88037.1    KT359870    AMM42629.1    KT359846    AMM42605.1    DQ445911    ABE97141.1    KF530106    KF530110    AGT51342.1    AGT51370.1    AY518894    JQ765568    JQ765572    JQ765573    JQ765574    JQ765575    JX504050    KF530104    KF530107    KF530108    KF530109    KF530111    KF530113    KF530114    KY554969    KY554971    KY829118    KY862073    KY862074    AAS89771.1    AFD98789.1    AFD98817.1    AFD98824.1    AFD98831.1    AFD98838.1    AFV53152.1    AGT51328.1    AGT51349.1    AGT51356.1    AGT51363.1    AGT51377.1    AGT51391.1    AGT51398.1    ARE29975.1    ARE29987.1    ARK08631.1    AVL25611.1    AVL25612.1    JQ765564    JQ765565    JQ765566    JQ765567    JQ765569    JQ765570    KF530112    KM055591    KM055592    KM055593    KM055595    KM055597    KM055602    KT381875    KU521535    KX179500    KY674915    KY674916    KY554967    KY554968    KY554970    KY862055    KY862058    KY862060    KY862061    KY862062    KY862065    KY862067    KY862068    KY862069    KY862070    KY862072    AFD98761.1    AFD98768.1    AFD98775.1    AFD98782.1    AFD98796.1    AFD98803.1    AGT51384.1    AIW52788.1    AIW52789.1    AIW52790.1    AIW52792.1    AIW52794.1    AIW52799.1    ALJ53435.1    ANU06088.1    APF29075.1    ARB07403.1    ARB07410.1    ARE29963.1    ARE29969.1    ARE29981.1    AVL25593.1    AVL25596.1    AVL25598.1    AVL25599.1    AVL25600.1    AVL25603.1    AVL25605.1    AVL25606.1    AVL25607.1    AVL25608.1    AVL25610.1    AY567487    KY862071    AVL25609.1    KY862057    AVL25595.1    KY862064    AVL25602.1    KY983586    ARU07598.1    KY862066    AVL25604.1    DQ462766    ABE73423.1    KT359855    AMM42614.1    DQ846901    KM055611    ABI20791.1    AIW52808.1    MG772808    AVA26877.1    JQ765571    AFD98810.1    KT359844    AMM42603.1    KY862056    AVL25594.1    KM055594    KM055596    AIW52791.1    AIW52793.1    EF081296    ABK63972.1    KT359863    AMM42622.1    KT359843    AMM42602.1    KT359867    AMM42626.1    KT359849    AMM42608.1    KT359856    AMM42615.1    KT359868    AMM42627.1    KT359848    AMM42607.1    KT359857    AMM42616.1    KT359850    AMM42609.1    KT359842    AMM42601.1    KT359834    AMM42593.1    KT359852    AMM42611.1    KT359830    AMM42589.1    KT359861    AMM42620.1    KT359832    AMM42591.1    KT359859    AMM42618.1    KT359841    AMM42600.1    KT359847    AMM42606.1    KT359833    AMM42592.1    KT359845    AMM42604.1    KT359831    AMM42590.1    KT359840    AMM42599.1    KT359837    AMM42596.1    JQ765563    AFD98754.1    DQ462763    ABE73420.1    DQ462771    ABE73428.1    DQ462767    ABE73424.1    DQ462765    ABE73422.1    DQ462764    ABE73421.1    DQ462770    ABE73427.1    DQ462769    ABE73426.1    MK334047    QED88044.1    KT359869    AMM42628.1    KT359860    AMM42619.1    KT253271    ALK28791.1    KY073747    APD51503.1   

Proteomes

UP000166619    UP000130662    UP000152921    UP000096660    UP000104963    UP000100808    + More
UP000147155    UP000171901    UP000138462    UP000098690    UP000141634    UP000158277    UP000115484    UP000143818    UP000146557    UP000100468    UP000103541    UP000106901    UP000110792    UP000129674    UP000134798    UP000140530    UP000144638    UP000153644    UP000161757    UP000162862    UP000167796    UP000168590    UP000174240    UP000105969    UP000108941    UP000125140    UP000130385    UP000136929    UP000145724    UP000151180    UP000151840    UP000008573    UP000141321    UP000173136    UP000096398   

PRIDE

Q6Q1R8   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037179   Nucleocapsid_C
IPR001218   Corona_nucleocap
IPR037195   Nucleocapsid_N
IPR042548   ALPHA_CORONA_NCAP

SUPFAM

SSF110304   SSF110304
SSF103068   SSF103068

ProteinModelPortal

A8JNZ6   A8JP12   A0A2P1G6H8   A0A2P1G6P9   A0A2R3NG38   A8JP04   + More
A0A2P1G6J5   A0A2P1G6K4   A0A3G1II26   A0A2P1G739   A0A410N738   A0A5B9Y683   A0A2D1BNM3   A0A4Y5WWA6   A0A2S1WCF9   A0A0U1WHF9   B1PHJ9   B1PHJ2   Q06XQ3   U3M7G3   A0A384RBU9   A0A2U8JDM2   Q06Y06   A0A5B9MVD7   A0A384RBV1   A0A127AV50   A0A127ATV7   A0A127AX00   A0A127AU27   A0A127ATQ0   A0A127AX58   A0A127ATT3   A0A127ATP0   A0A127AV25   A0A127ATS9   A0A127ATT5   A0A127AU18   A0A127ATQ1   I7DJE7   A0A127ATS5   A0A5B9BGU8   A0A127ATY8   A0A127ATR0   Q06Y12   U3M6A0   H9EJA4   H9EJ69   Q6Q1R8   A0A2P1E971   A0A2P1E945   A0A2P1E959   A0A1Y0EV18   A0A2P1E948   Q06XQ5   A0A127AX50   Q0GMF2   A0A2L0WQF7   H9EJ76   A0A127ATR3   A0A2P1E938   A0A384R2N5   A0T2T5   A0A127ATW4   A0A127ATU8   A0A127AUA1   A0A127ATQ8   A0A127ATS0   A0A127AV68   A0A127AV38   A0A127AU90   A0A127ATX3   A0A127ATR7   A0A127ATQ4   A0A127ATS6   A0A127ATV6   A0A127AU23   A0A127ATQ7   A0A127ATR6   A0A127ATY7   A0A127AU79   A0A127ATT9   A0A127AX15   A0A127ATX8   A0A127ATW2   A0A127AU68   H9EJ20   Q06XQ8   Q06XQ0   Q06XQ4   Q06XQ6   Q06XQ7   Q06XQ1   Q06XQ2   A0A5B9BJR5   A0A127ATS3   A0A127ATY1   A0A0N7J131   A0A1L2KGF4  

PDB

5N4K     E-value=8.0852e-34,     Score=360