Strain

CHINA_BAT_2012_NC_028824 (Region: China;  Strain: BtRf-AlphaCoV/YN2012, complete genome.;  Date: 2012)

Gene

nucleocapsid protein

Description

Annotated in NCBI,  nucleocapsid protein

Location

NC_028824(+):25283-26410

GenBank Accession

YP_009200739.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGGCCACAGTTAATTGGGGTGACGCCGTTGAGGCTGAATCTCGTGGTCGTAAACCTAGAATACCCCTTTCACTCTTTGCGCCTTTGCGTGTTACGAGTGATAAAAACTTCTGGAATGTTATGCCTAGGAATGGAGTTCCAACAGGCAAAGGCAATTCAGAGCAACAGATTGGTTATTGGGTTGAACAGAAACGCTGGCGCATGCAAAAGGGCCAACGTAAGGATCAGCCTTCTAACTGGCATTTTTACTACCTTGGTACTGGTCCTCATGCAGAAGCTCCTTTTAGAAAGCGCATTCAGGGCGTCCATTGGGTTGCTATTGATGGTGCTAAAACTAACCCCACAGGTCTTGGTGTGCGGAATCGTAATAGGGAACCTATTACACCGCAGTTTGGCTTTCAGTTACCTTCAGACCTGATGATTGTTGAATCAACTTCTAGAAGTGCTTCACGTTCTCAGTCTAGATCTCGTAACCAAAGTCAGAGCCGCAGTGGTCAGCAAACACCTAGATTCCAACAACAGTCTCAATCTGTTGACATTGTTGCTGCAGTTAAACAGGCTTTAGCTGACTTAGGTATTTCAGGCACCCAGAATAAACCCCAGAGTGGTCGTAATACACCAAAACAAAAGAGCAGAGCTGTTTCACCTGCACCGAGCCCTAAACAGACTCGTAAGCAGATGGACAAACCTGAGTGGAAGCGTGTTCCAAATTCTGATGAAGATGTTAAGAAATGCTTTGGACCACGTTCTGTCGCTAGGAATTTTGGTGACAGTGATTTGATCCAGAATGGCGTTGAGGCTAAGCATTTTCCAACAATTGCTGAGCTACTTCCAACTCAGGCTGCTATAGCTTTTGGTAGCGAAATTACCACCAAAGAGGCGGGTGATTTTGTTGAGATCACATATCATTATGTGATGAAGGTTCCTAAAACTGACAAGAACCTTCCGAGGTTCCTTGAGCAAGTTTCGGCTTACTCTAAACCAAGTCAGATTAGAAGGTCTCAGTCCCAACAGGATCTAAATGTTGATGCCCTAGTCTTTACCCCAGCACCTCCTACTACTCCAACTGTGCAGAGCCCTTCTTTCCTAGAGGAAGAAGTGGAAATGGTTGATGAGATTATCAATTAG

Protein

MATVNWGDAVEAESRGRKPRIPLSLFAPLRVTSDKNFWNVMPRNGVPTGKGNSEQQIGYWVEQKRWRMQKGQRKDQPSNWHFYYLGTGPHAEAPFRKRIQGVHWVAIDGAKTNPTGLGVRNRNREPITPQFGFQLPSDLMIVESTSRSASRSQSRSRNQSQSRSGQQTPRFQQQSQSVDIVAAVKQALADLGISGTQNKPQSGRNTPKQKSRAVSPAPSPKQTRKQMDKPEWKRVPNSDEDVKKCFGPRSVARNFGDSDLIQNGVEAKHFPTIAELLPTQAAIAFGSEITTKEAGDFVEITYHYVMKVPKTDKNLPRFLEQVSAYSKPSQIRRSQSQQDLNVDALVFTPAPPTTPTVQSPSFLEEEVEMVDEIIN

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Miscellaneous

Bat coronavirus 512/2005 is highly similar to porcine epidemic diarrhea virus (PEDV).

Similarity

Belongs to the alphacoronavirus nucleocapsid protein family.

Keywords

ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Reference proteome   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion  

Feature

chain  Nucleoprotein

Uniprot

A0A0U1WHF9   A0A2R3NG38   A0A2P1G6H8   A0A2P1G6P9   A0A2P1G6J5   A0A2P1G6K4   + More
A0A3G1II26   A0A2P1G739   A0A410N738   A0A5B9Y683   A0A2D1BNM3   A0A2S1WCF9   A0A4Y5WWA6   A8JNZ6   A8JP12   A8JP04   A0A0U1WHF4   A0A0U1UZD2   F1DAY0   B1PHJ9   F1DB11   Q0Q0A2   A0A0U1WHB1   A0A0U1WHB5   A0A4Y5QL74   Q0Q0A1   A0A3G3NGR2   K4JZT7   A0A3G3NHI8   A0A3G3NH65   A0A3G3NGQ8   A0A3G3NGV8   A0A3G3NGV1   A0A3G3NHI7   A0A3G3NHJ5   A0A3G3NHM0   A0A3G3NGN9   B1PHJ2   A0A3G3NGH7   A0A3G3NGW5   A0A3G3NGR8   Q0Q462   A0A3G3NHH2   A0A3G3NGY6   A0A4Y6GL31   A0A3G3NGS1   A0A4Y6GL32   A0A4Y6GNG7   A0A3G3NGS4   A0A3G3NGJ1   A0A3G3NGJ4   A0A4Y6GNF9   A0A3G3NH92   A0A219TUM0   I1VWF9   A0A0U2GMI4   A0A0U2GR32   A0A1C8YZ39   A0A0U2GMT2   A0A0U2GMD8   A0A0U2GNG7   A0A0U2GRP0   A0A0U2GRD7   A0A0U2GN51   A0A1C8YZ17   A0A0U2GMP7   A0A1C8YZ40   A0A0U2GQA6   A0A1B3TNB1   A0A384VGQ5   A4UII9   A0A222UC65   A0A1B4X966   A0A0K2SF49  

Pubmed

29618817    28654418    30171801    30103259    31419711    29704627    + More
31207129    17617433    19239771    22561208    18420807    16894183    27125516    31067830    22933277    16840328    26678874    27528677    17267506   

EMBL

KJ473808    AIA62263.1    MF094702    AVM80791.1    MF094686    AVM80488.1    + More
MF094685    AVM80479.1    MF094687    AVM80496.1    MF094688    AVM80504.1    MF167434    ASK51721.1    MG557844    MF094681    MF094682    MF094683    MF094684    MF769416    MF769417    MF769418    MF769419    MF769420    MF769421    MF769422    MF769423    MF769424    MF769425    MF769426    MF769427    MF769428    MF769429    MF769430    MF769431    MF769432    MF769433    MF769434    MF769435    MF769436    MF769437    MF769438    MF769439    MF769440    MF769441    MF769442    MF769443    MF769444    MH615810    MG605087    MG605088    MG605089    MG605090    MG605091    MG775251    MG775253    AVM41574.1    AVM80443.1    AVM80452.1    AVM80461.1    AVM80470.1    AVM80528.1    AVM80537.1    AVM80546.1    AVM80555.1    AVM80564.1    AVM80573.1    AVM80582.1    AVM80591.1    AVM80600.1    AVM80609.1    AVM80618.1    AVM80627.1    AVM80636.1    AVM80645.1    AVM80654.1    AVM80663.1    AVM80672.1    AVM80681.1    AVM80690.1    AVM80699.1    AVM80708.1    AVM80717.1    AVM80726.1    AVM80735.1    AVM80744.1    AVM80753.1    AVM80762.1    AVM80771.1    AVM80780.1    AXP98443.1    AXY04078.1    AXY04079.1    AXY04080.1    AXY04087.1    AXY04096.1    MH539766    MH697599    QAS69032.1    QBP43304.1    MK977618    QEH62673.1    MF370205    ATN23893.1    MG742313    AWJ64267.1    MK651076    QDE12101.1    EF203064    ABQ57212.1    EF203066    EF203067    ABQ57228.1    ABQ57236.1    EF203065    ABQ57220.1    KJ473807    AIA62256.1    KJ473810    AIA62275.1    HQ728480    ADX59455.1    EU420138    ACA52168.1    HQ728484    ADX59486.1    DQ666341    ABG75576.1    KJ473795    AIA62204.1    KJ473796    AIA62210.1    MK720945    MK720946    QCX35174.1    QCX35185.1    DQ666342    ABG75577.1    MH687940    AYR18440.1    JQ989270    AFU92108.1    MH687936    MH687939    AYR18416.1    AYR18434.1    MH687935    MH687949    MH687962    AYR18410.1    AYR18491.1    AYR18565.1    MH687950    MH687951    AYR18497.1    AYR18503.1    MH687959    AYR18547.1    MH687960    MH687961    AYR18553.1    AYR18559.1    MH687938    AYR18428.1    MH687955    AYR18523.1    MH687965    AYR18583.1    MH687946    AYR18477.1    EU420137    ACA52161.1    MH687937    AYR18422.1    MH687941    AYR18446.1    MH687958    AYR18541.1    DQ648858    MH687934    AYR18404.1    MH687948    AYR18485.1    MK211370    QDF43798.1    MH687956    AYR18529.1    MK211372    QDF43808.1    MK211371    QDF43803.1    MH687954    AYR18517.1    MH687945    AYR18471.1    MH687943    AYR18459.1    MK211369    QDF43793.1    MH687963    MH687964    MH687967    AYR18571.1    AYR18577.1    AYR18595.1    KT346372    ANV78634.1    JQ410000    AFI49435.1    KT368901    ALA50155.1    KT368892    KT368893    KT368894    ALA50092.1    ALA50099.1    ALA50106.1    KT253327    AOI28287.1    KT368900    KT368904    KT368905    KT368908    KT368916    ALA50148.1    ALA50176.1    ALA50183.1    ALA50204.1    ALA50260.1    KT368898    KT368899    ALA50134.1    ALA50141.1    KT368915    ALA50253.1    KT368907    ALA50197.1    KT368911    ALA50225.1    KT368895    KT368896    KT368897    KT368902    KT368906    KT368909    KT368910    KT368913    KT368914    MF593473    ALA50113.1    ALA50120.1    ALA50127.1    ALA50162.1    ALA50190.1    ALA50211.1    ALA50218.1    ALA50239.1    ALA50246.1    ATI09441.1    KT253325    KT253326    AOI28271.1    AOI28279.1    KT368912    ALA50232.1    KT253324    KT253328    AOI28262.1    AOI28294.1    KT368903    ALA50169.1    KU291449    AOG74793.1    KX900411    ASV64443.1    EF192157    ABO88143.1    KX512809    ASR18942.1    LC119077    BAV31353.1    LC029423    BAS25720.1   

Proteomes

UP000104963    UP000166619    UP000130662    UP000152921    UP000096660    UP000106394    + More
UP000144177    UP000100808    UP000137012    UP000157060    UP000155419    UP000147155    UP000113079    UP000146121    UP000173458    UP000108758    UP000110675    UP000115399    UP000103248    UP000104585    UP000120649    UP000136940    UP000152663    UP000116691    UP000136947    UP000153625    UP000151210    UP000100137    UP000101679    UP000115199    UP000124352    UP000128900    UP000147133    UP000152773    UP000169049    UP000171347    UP000173795    UP000153580    UP000103783    UP000272061   

PRIDE

Q0Q462   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037195   Nucleocapsid_N
IPR037179   Nucleocapsid_C
IPR001218   Corona_nucleocap
IPR042548   ALPHA_CORONA_NCAP

SUPFAM

SSF103068   SSF103068
SSF110304   SSF110304

ProteinModelPortal

A0A0U1WHF9   A0A2R3NG38   A0A2P1G6H8   A0A2P1G6P9   A0A2P1G6J5   A0A2P1G6K4   + More
A0A3G1II26   A0A2P1G739   A0A410N738   A0A5B9Y683   A0A2D1BNM3   A0A2S1WCF9   A0A4Y5WWA6   A8JNZ6   A8JP12   A8JP04   A0A0U1WHF4   A0A0U1UZD2   F1DAY0   B1PHJ9   F1DB11   Q0Q0A2   A0A0U1WHB1   A0A0U1WHB5   A0A4Y5QL74   Q0Q0A1   A0A3G3NGR2   K4JZT7   A0A3G3NHI8   A0A3G3NH65   A0A3G3NGQ8   A0A3G3NGV8   A0A3G3NGV1   A0A3G3NHI7   A0A3G3NHJ5   A0A3G3NHM0   A0A3G3NGN9   B1PHJ2   A0A3G3NGH7   A0A3G3NGW5   A0A3G3NGR8   Q0Q462   A0A3G3NHH2   A0A3G3NGY6   A0A4Y6GL31   A0A3G3NGS1   A0A4Y6GL32   A0A4Y6GNG7   A0A3G3NGS4   A0A3G3NGJ1   A0A3G3NGJ4   A0A4Y6GNF9   A0A3G3NH92   A0A219TUM0   I1VWF9   A0A0U2GMI4   A0A0U2GR32   A0A1C8YZ39   A0A0U2GMT2   A0A0U2GMD8   A0A0U2GNG7   A0A0U2GRP0   A0A0U2GRD7   A0A0U2GN51   A0A1C8YZ17   A0A0U2GMP7   A0A1C8YZ40   A0A0U2GQA6   A0A1B3TNB1   A0A384VGQ5   A4UII9   A0A222UC65   A0A1B4X966   A0A0K2SF49  

PDB

5N4K     E-value=8.0852e-34,     Score=360