Strain

GERMANY_ERINACEINAE_2012_NC_022643 (Region: Germany; Strain: Betacoronavirus Erinaceus/VMC/DEU/2012 isolate ErinaceusCoV/2012-216/GER/2012, complete genome.; Date: 2012)

Gene

Description

Annotated in NCBI, S

Location

NC_022643(+):21637-25629

GenBank Accession

YP_008719932.1

Full name

Spike glycoprotein

Alternative Name

E2
Peplomer protein

Sequence

CDS

ATGATACGCTCAGCGTGTCTACTGATGTGCTTGTTAATGTTTATAAAAGCAACCCCAAGCGAGGGAACATGTATATCTGTTGACATGCAGCCCTCATATTTTATCAAAAATTGGTCTATGCCAATTAATATGAGTAAAGCAGATGGTGTTTTATACCCTGTTGGGCGTACTTATTCTAATATCACAATAACGCTTGAAGGGTTATTTCCACACCAAGCAGATCGTGGTGATATGTATGTTTACTCACAATCTCATAAAGGCAGGCCTTTCATTTCTAATTATTCTCTCGTTACTAATGATTTTGGTAATGGCATAGTAATTAGAATAGGTTCTGCTGCTAATAAAACTGGTAGTCCTATTATTTCTAATATTGCTAGTAACTTTCAGATTATGAAGAAACTTTATCCAGCTTTGCTCTTTGGTAGTGCTGTTGGTAAATTTCCTGCTAATAATAAAACAGGTGCTTATTTTAATCATAGCCTCGTTATTTTGCCCGAAAAATGTGGCACTGTTATTACAGCACTTTATTGTGTTTTAGAGCCCAAGAATGATACCAATTGTACTGGTAGTTCTGGTTATGTTAGTTATGTGCTGTTTGAAAATTTTAGTTGTGATGCAACTACTGATGGTAACTTAAAAAATAGTTTACAGCAGTGGTTTAATATTAAGGATTGTCTTTTTGAGAAAAATTACAATGTTACTGATGATGAGAGGGAAGAGTGGTTTGGAATTATCCAAGATCAGCAAGGTGTCCACCTCTATACATCTCGGAAGAATGGATATTCAAACAATATGTTTTTGTTTGCTACTTTACCAATTTATGATCAGATACTATATTATACTGTTATGCCGCGCAGTATTAATGCTAGTAATTATGCATCATATCATGCTTTTTCTGCATTTTATATTTACAAGTTACACAAAATCAACTATATGGTTGACTTTGATGTAAATGGTTATATCACAAGGGCTGTCGATTGTGGTTATAATGATTATACACAATTGCAATGCTCTTATGGTCAATTTGATATGGATTCTGGTGTTTATTCAGCTTCGTATTTTAATGCCCGCTCTAGAGGTTATTACTATGAAGCTGCAGAACTCACAGAATGTGACTTAGATGTATTGTTTAAAAACGATGCTCCTATAATAGCTAATTACAGTAGGCGAGTTTTTACTAATTGTAATTATAATTTAACAAAACTCCTTTCTCTTGTGCAAGTAGATGAGTTTGTTTGTCATAAAACAACACCAGAAGCGCTTGCTACTGGCTGTTATTCCTCTCTAACGGTAGACTGGTTTGCGCTGCCTTTTAGTATGAAGTCAACATTAGCTATAGGATCAGCAGAAGCTATATCTATGTTTAATTATAATCAGGATTATTCCAATCCTACGTGTAGAATTCATGCAGCTGTAACAGCTAATGTTTCAACAGCGTTGAATTTTACTGCTAATGCTAATTATGCTTATATTTCCAGGTGCCAAGGTGTTGATGGTAAACCAATTCTATTACAACCAGGACAAATGACTAATATTGCTTGTCGTTCTGGTGTTTTGGCACGGCCATCAGATGCAGATTATTTTGGCTATTCATTTCAAGGACGCAACTATTATTTAGGGCGTAAATCTTATAAACCTAAAACCGATGAGGGCGACGTTCAAATGGTTTATGTAATAACGCCTAAATATGATAAAGGCCCTGATACTGTATGCCCTCTTAAAGATATGGGTGCTGCCTCTTCTAGTTTAGATGGCTTGTTAGGGCAGTGCATAGATTATGACATTCATGGAGTAGTAGGCCGTGGTGTTTTTCAAGTTTGCAATACCACAGGAATTGCTAGTCAAATTTTTGTCTATGACGGATTTGGTAATATCATAGGCTTTCATTCTAAAAATGGTACATACTATTGTATGGCACCATGCGTATCAGTACCTGTTTCTGTAATTTATGATAAAAGCAGTGATGTTCATGCTACGCTTTATAGTAGCGTTGAGTGCAATCATATAAAATCAGTTGCAACAGTTTTTAGTCGTCAAACTGAGTCTAAGCTTAGATCGAGTGATAACGGCCTTTTACAAACAGCTGTAGGCTGTGTTATTGGATTCCGTAACACAAGTGACACTGTTGAAGATTGTACCTTACCTTTAGGCCAATCTCTCTGTGCAAAACCACCTTCTTTTTCCAGTCGTAGTACCAATGTTAATAACACATTTGCTTTAGTGCATATGTTGTTCCAAAATCCATTAAAAGTTAGTGTTCTCAATTCAACTGAGTTTCAGGTTTCAATACCTCAGAATTTTAGTTTTGGTATTACTGAAGAATTTATAGAAACATCCATACAAAAGGTTACTGTTGATTGTAAGCAGTATGTTTGTAATGGATTTGAGCGTTGTGAACAATTGTTGGTGCAGTATGGCCAATTTTGTTCAAAAATTAATCAAGCATTACATGGTGTTAATTTGCGCCAAGATGATGCTACTAAGAGTCTTTTTGAGGACATTAAAGTACCCCAATCAGTACCCTTAATGACAAGCCTCACTGGTGATTATAATTTATCATTATTCGAGGCACCTAATATTGGCAGTGGTAATAATAACTACCGCAGTGCTTTAGAAGATCTGCTTTTTGATAAGGTTACATTATCAGATCCAGGTTATATGAAAGGATATGACGAGTGCATGAAAAAAGGACCACCTAGTGCTAGGGACCTAATTTGTGCACAATATGTATCTGGTTATAAAGTTTTACCGCCTTTGTATGATGCTAATATGGAGGCTATGTATACTGCTTCTTTAACTGGTAGTATAGCAGGTTCTTTTTGGACAGGAGGACTATCGTCTGCTGCTGCACTACCATTTGCACAGTCAATGTTTTATCGTATGAATGGTATTGGCATCACTCAAAATGTTCTTATGAAGAACCAGAGGGAGATAGCCAATAAGTTCAACCAGGCATTAGGTGCTATGCAAACAGGATTCACAGCTACCAATCAAGCTTTTCAGAAGGTTCAAGATGTTGTGAATGCCAATGCACAAGCATTATCTAAATTAGCTAGTGAATTAGCTAACACATTCGGTGCTATTTCCGCTTCTATAGGTGACATCTTAAAACGTTTGGATGTTTTAGAACAGGAAGTGCAAATAGACCGCCTTATTAACGGACGTCTTACATCGTTGAATGCGTTTGTAAGTCAGCAACTGGTGAGGAGTGAAGCTGCAGCTCGCTCATCTCAGTTGGCTAAAGAAAAAATTAATGAATGTGTCAAAGCTCAATCTACACGCAGTGGGTTTTGCGGACAAGGCACTCATATAGTGTCATTTGTTATTAATGCCCCTAATGGATTTTATTTTATACATGTGGGTTATCACCCACAGGATTATGTAAATCAAACAGCTGCTTATGGCCTGTGTGATTCTTCTTCTAAGAAATGTATTGCAGCCAAGAATGGCTATTTTGTTAAAAATGATTCTGATAGTGGTAGTTGGTCTTATACAGGCAGCAGTTTTTATCAGCCTGAACCTATCACCACTTTTAACTCAAGGTTTGTTGAACCTGAGGTAACTTTTCAAAATTTAAGCAACAACCTTCCACCTCCACTCTTAAGTAATAACACTGATATTACTTTTGAGGATGAGCTGGAAGAGTTTTATAAAAATATTACGTCTGAGATACCTAATTTTGGTTCTCTCAGTCAGATTAATACCACTATGCTTAACTTGTCTCAAGAAATGAGCACTTTACAGCAAGTGGTCAAAGATTTAAACAACTCTTATATAGAGCTTAAAGAATTAGGCAATCACACATACTACCAAAAATGGCCGTGGTATGTGTGGTTGGGTTTCATTGCTGGTCTTTTGGCACTAGCATTATGTTTATTTTTCATACTGTGTTGCACAGGGTGTGGCACTAGTTGTCTAGGAAAAATAAGTTGTACTCGTTGTTGTGATAAGTATGATGATTTTGAAATGCCGGACAAAGTTCACATACACTAA

Protein

MIRSACLLMCLLMFIKATPSEGTCISVDMQPSYFIKNWSMPINMSKADGVLYPVGRTYSNITITLEGLFPHQADRGDMYVYSQSHKGRPFISNYSLVTNDFGNGIVIRIGSAANKTGSPIISNIASNFQIMKKLYPALLFGSAVGKFPANNKTGAYFNHSLVILPEKCGTVITALYCVLEPKNDTNCTGSSGYVSYVLFENFSCDATTDGNLKNSLQQWFNIKDCLFEKNYNVTDDEREEWFGIIQDQQGVHLYTSRKNGYSNNMFLFATLPIYDQILYYTVMPRSINASNYASYHAFSAFYIYKLHKINYMVDFDVNGYITRAVDCGYNDYTQLQCSYGQFDMDSGVYSASYFNARSRGYYYEAAELTECDLDVLFKNDAPIIANYSRRVFTNCNYNLTKLLSLVQVDEFVCHKTTPEALATGCYSSLTVDWFALPFSMKSTLAIGSAEAISMFNYNQDYSNPTCRIHAAVTANVSTALNFTANANYAYISRCQGVDGKPILLQPGQMTNIACRSGVLARPSDADYFGYSFQGRNYYLGRKSYKPKTDEGDVQMVYVITPKYDKGPDTVCPLKDMGAASSSLDGLLGQCIDYDIHGVVGRGVFQVCNTTGIASQIFVYDGFGNIIGFHSKNGTYYCMAPCVSVPVSVIYDKSSDVHATLYSSVECNHIKSVATVFSRQTESKLRSSDNGLLQTAVGCVIGFRNTSDTVEDCTLPLGQSLCAKPPSFSSRSTNVNNTFALVHMLFQNPLKVSVLNSTEFQVSIPQNFSFGITEEFIETSIQKVTVDCKQYVCNGFERCEQLLVQYGQFCSKINQALHGVNLRQDDATKSLFEDIKVPQSVPLMTSLTGDYNLSLFEAPNIGSGNNNYRSALEDLLFDKVTLSDPGYMKGYDECMKKGPPSARDLICAQYVSGYKVLPPLYDANMEAMYTASLTGSIAGSFWTGGLSSAAALPFAQSMFYRMNGIGITQNVLMKNQREIANKFNQALGAMQTGFTATNQAFQKVQDVVNANAQALSKLASELANTFGAISASIGDILKRLDVLEQEVQIDRLINGRLTSLNAFVSQQLVRSEAAARSSQLAKEKINECVKAQSTRSGFCGQGTHIVSFVINAPNGFYFIHVGYHPQDYVNQTAAYGLCDSSSKKCIAAKNGYFVKNDSDSGSWSYTGSSFYQPEPITTFNSRFVEPEVTFQNLSNNLPPPLLSNNTDITFEDELEEFYKNITSEIPNFGSLSQINTTMLNLSQEMSTLQQVVKDLNNSYIELKELGNHTYYQKWPWYVWLGFIAGLLALALCLFFILCCTGCGTSCLGKISCTRCCDKYDDFEMPDKVHIH

Summary

Function

Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.
Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.

Subunit

Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes.

Similarity

Belongs to the betacoronaviruses spike protein family.

Feature

chain Spike protein S2

Uniprot

U5LMM7 U5LNM4 A0A4D6G1A4 A0A1W6ASU7 A0A2R2YRG8 U5NJG5 + More
A0A2I6PIX8 A0A2R4KP93 A0A2I6PIW5 A0A5H2WTJ3 A0A482DX17 A0A482DX85 A0A4P8L6Q6 A0A384YDC0 A0A0U2NE92 A0A2D0YM48 A3EXE8 A3EXF7 S4X278 A0A0A0Q4U5 A0A0U2IY58 A0A1C8EAZ2 A0A2P1IT40 A0A023VZD9 A0A2P1IT75 A0A2P1IT43 A0A493R163 A0A2H4TEF0 A0A291I635 A0A140AZ05 A0A2D0YAP4 A0A0U2NY03 A0A168DLI3 A0A2P1IT46 K0BRG7 A0A291I6E5 A0A411PBH3 A0A0U2NE84 A3EXD9 M4SVE7 A0A0H4JBS8 A0A0B5KTJ9 A0A0U2NXW5 A0A0A0Q4U2 A0A2D0YXA8 A0A2D0Y3M7 A0A2D0YUG7 A0A2H1YPP7 A0A384YDR2 A0A1L2DZI5 A0A2D0YCT4 A0A126G7T9 A0A0U2MMC5 A0A5C0PYB9 A0A0U2HTD9 A0A2D0YDA3 T2BBK5 A0A0A0Q7G4 A0A0U2NTX5 A0A384YG86 A0A140AZ15 T2B9T0 A0A140AYZ5 A0A141BR51 A0A2H4PWP1 A0A2D0YKN0 A0A0U2MS74 W6A8L9 A0A3T0I8D8 A0A0U2NQQ0 A0A2D0YT69 A0A1L2E0V8 A0A0U2J5U2 A0A0U2MMB6 A0A0U4AGH8 A0A0P0HJE7 A0A2D0YID8 A0A2D0YGK8 A0A0G2UN32 A0A0P0HBE6 W6A090 A0A1W5LIC4 A0A0A7E695 A0A1W5LGJ4 A0A2D0YGA8 A0A1W5LGD2 A0A0A0Q7F8 W6A0A7 A0A0U3SQE0 A0A2D0YCE0 A0A140AQ46 A0A0D3MU58 R9UCW7 A0A0U2MGJ8 A0A0U2P188 A0A291I6B7 A0A385AJU1 A0A291I6J0 A0A411PBG2 A0A1W5LGE4

Pubmed

24131722 28377531 29579103 24050621 25031349 29258555 + More
29116217 17121802 23720729 25323704 29507189 24781747 30753126 26933050 23170002 26391698 23903833 26079346 26678874 27999424 26814649 24055451 26691200 26839489 24549846 31022948 25989145 31553909 26981708 29239118 26281793 23782859

EMBL

KC545386 AGX27810.1 KC545383 AGX27799.1 MK679660 QCC20713.1 + More
KX574227 ARJ34226.1 MF593268 ATQ39390.1 KC869678 AGY29650.2 MG596803 AUM60024.1 MG021452 AVV62537.1 MG596802 AUM60014.1 LC469308 BBJ36008.1 MK564475 QBM11748.1 MK564474 QBM11737.1 MK858160 MK858161 MK858162 QCQ28832.1 QCQ28833.1 QCQ28834.1 MG912604 AVK87417.1 KT806010 ALJ54490.1 MF598638 ASU90406.1 EF065511 ABN10893.1 EF065512 ABN10902.1 KC522096 AGP04935.1 KM027284 MH013216 AID55095.1 AVV61900.1 KT805975 ALJ54455.1 KT877350 ALL26396.1 MG923468 AVN89313.1 KJ713299 AHY22565.1 MG923470 MG923471 AVN89334.1 AVN89344.1 MG923466 MG923467 AVN89291.1 AVN89302.1 MH978886 MH978887 QBF44113.1 QBF44114.1 MG366881 MG366882 MG366883 MG912595 MG912596 MG912598 MG912599 MG912600 MG912601 MG912602 MG912603 MG912605 MG366483 MH310910 MH310911 ATY74392.1 ATY74403.1 ATY74414.1 AVK87318.1 AVK87329.1 AVK87351.1 AVK87362.1 AVK87373.1 AVK87384.1 AVK87395.1 AVK87406.1 AVK87428.1 AXN73359.1 AXN92238.1 AXN92249.1 MG011347 MK858164 ATG84756.1 QCQ28836.1 KT868875 KX034094 KX034095 ALK80291.1 ANC28645.1 ANC28656.1 MF598679 ASU90857.1 KT806020 ALJ54500.1 KX034097 ANC28678.1 MG923469 AVN89324.1 JX869059 AFS88936.1 MG011357 ATG84866.1 MK462249 QBF80521.1 KT805994 ALJ54474.1 EF065510 ABN10884.1 KC776174 AGH58717.1 KP405225 KP405227 KT805988 MF598616 MG011341 MH822886 MK462250 AKO69634.1 AKO69636.1 ALJ54468.1 ASU90164.1 ATG84690.1 AYM48030.1 QBF80532.1 KP719931 KP719932 AJG44102.1 AJG44113.1 KT805972 KT806055 ALJ54452.1 ALW82753.1 KM027279 KT368824 AID55090.1 ALA49341.1 MF598648 MF598667 MF598696 ASU90516.1 ASU90725.1 ASU91043.1 KY673148 KY688114 MF598636 MF598639 MF598647 MF598681 AQZ41285.1 AQZ41306.1 ASU90384.1 ASU90417.1 ASU90505.1 ASU90879.1 MF598635 MF598637 ASU90373.1 ASU90395.1 MF598597 ASU89955.1 MG912597 AVK87340.1 KX108943 ANI69889.1 MF598641 ASU90439.1 KT374050 KT374051 ALB08246.1 ALB08257.1 KT805992 KY688119 ALJ54472.1 AQZ41322.1 MN365232 MN365233 QEJ82215.1 QEJ82226.1 KT805968 KT805985 KT805986 ALJ54448.1 ALJ54465.1 ALJ54466.1 MF598651 ASU90549.1 KF600634 AGV08492.1 KM027288 AID55099.1 KT806028 ALJ54508.1 MG912606 AVK87439.1 KT868872 KT868876 ALK80261.1 ALK80301.1 KF600652 KT806040 AGV08584.1 ALJ54520.1 KT182954 KT182955 KT326819 KT374052 KT374053 KT374054 KT374055 KT868865 KT868866 KT868867 KT868868 KT868869 KT868873 KT868874 KU308549 KX034096 KX034098 KX034099 KX034100 AKN11072.1 AKN11073.1 AKS48062.1 ALB08267.1 ALB08278.1 ALB08289.1 ALB08300.1 ALK80192.1 ALK80202.1 ALK80212.1 ALK80222.1 ALK80232.1 ALK80271.1 ALK80281.1 AML60270.1 ANC28667.1 ANC28689.1 ANC28700.1 ANC28711.1 KT182956 KT182957 AKN11074.1 AKN11075.1 MF679173 ATW75479.1 MF598674 ASU90802.1 KT805971 ALJ54451.1 KJ156881 AHI48550.1 MK280984 AZU90731.1 KT805966 ALJ54446.1 MF598693 ASU91010.1 KX108944 ANI69900.1 KT806038 ALJ54518.1 KT805976 ALJ54456.1 KT806049 ALW82691.1 KR912196 ALJ76286.1 MF598614 ASU90142.1 MF598608 MF598650 MF598700 ASU90076.1 ASU90538.1 ASU91087.1 KR011263 KR011264 KR011265 KR011266 KT805961 KT805962 KT805963 AKI29255.1 AKI29265.1 AKI29275.1 AKI29284.1 ALJ54441.1 ALJ54442.1 ALJ54443.1 KT368828 KT368843 KT368844 KT368845 KT368849 KT368850 KT368851 KT368855 KT368887 KT368888 KT805995 KT805997 KT805998 KT805999 KT806000 KT806013 KR912189 KR912190 KR912191 KR912192 KR912193 KR912194 KT877351 ALA49385.1 ALA49550.1 ALA49561.1 ALA49572.1 ALA49616.1 ALA49627.1 ALA49638.1 ALA49682.1 ALA50034.1 ALA50045.1 ALJ54475.1 ALJ54477.1 ALJ54478.1 ALJ54479.1 ALJ54480.1 ALJ54493.1 ALJ76282.1 ALL26409.1 KJ156876 KU242423 KU242424 MF598663 AHI48672.1 ALT66870.1 ALT66880.1 ASU90681.1 KX154689 MG757604 ANF29217.1 AXN73514.1 KP209306 KP209308 KP209309 KP209310 KP209311 KP209313 KY673147 KY581686 KY581688 KY581689 KY581690 KY581691 KY581692 KY581696 KY581697 KY581700 AIY60518.1 AIY60538.1 AIY60548.1 AIY60558.1 AIY60568.1 AIY60588.1 AQZ41283.1 ASU45719.1 ASU45741.1 ASU45752.1 ASU45763.1 ASU45774.1 ASU45785.1 ASU45829.1 ASU45840.1 ASU45873.1 KX154690 MG011345 MG011351 ANF29228.1 ATG84734.1 ATG84800.1 MF598629 MF598640 MF598658 MF598689 ASU90307.1 ASU90428.1 ASU90626.1 ASU90966.1 KX154686 KX154692 ANF29184.1 ANF29250.1 KM027273 AID55084.1 KJ156905 AHI48692.1 KT806054 ALW82742.1 MF598631 ASU90329.1 KT374056 ALB08311.1 KJ361503 AIZ74450.1 KF192507 AGN52936.1 KT806016 ALJ54496.1 KT806021 ALJ54501.1 MG011354 ATG84833.1 MH310909 AXN92228.1 MG011358 ATG84877.1 MK462251 QBF80543.1 KX154687 ANF29195.1

Proteomes

UP000095937 UP000101546 UP000202992 UP000145931 UP000143769 UP000100668 + More
UP000105499 UP000145271 UP000167218 UP000129370 UP000112279 UP000164987 UP000108469 UP000131416 UP000174176 UP000117213 UP000138672 UP000103178 UP000113724 UP000096281 UP000148810 UP000097149 UP000098933 UP000105311 UP000106595 UP000109122 UP000126763 UP000128076 UP000140611 UP000147342 UP000105272 UP000146591 UP000102098 UP000110604 UP000120083 UP000165587 UP000098431 UP000104003 UP000112676 UP000126955 UP000128936 UP000136645 UP000137287 UP000146604 UP000151733 UP000159793 UP000120625 UP000174530 UP000110817 UP000118636 UP000130850 UP000142709 UP000144516 UP000159028 UP000171389 UP000149108 UP000096629 UP000104220

Pfam

PF09408 Spike_rec_bind
PF01601 Corona_S2

Interpro

IPR018548   Spike_rcpt-bd
IPR002552   Corona_S2
IPR036326   Spike_rcpt-bd_sf
IPR027400   S_HR2
IPR042578   BETA_CORONA_SPIKE
IPR043002   Spike_N_sf

SUPFAM

SSF143587 SSF143587

Gene 3D

1.20.5.790 2.60.120.960

ProteinModelPortal

PDB

5X5F E-value=0, Score=3563

Ontologies

GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0061025  P:membrane fusion
GO:0046813  P:receptor-mediated virion attachment to host cell
GO:0019064  P:fusion of virus membrane with host plasma membrane
GO:0020002  C:host cell plasma membrane
GO:0075509  P:endocytosis involved in viral entry into host cell
GO:0039654  P:fusion of virus membrane with host endosome membrane
GO:0009405  P:pathogenesis
GO:0055036  C:virion membrane
GO:0044173  C:host cell endoplasmic reticulum-Golgi intermediate compartment membrane

Subcellular Location

From MSLVP

Capsid

From Uniprot

Virion membrane   Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion.   With evidence from 1 publications.
Host endoplasmic reticulum-Golgi intermediate compartment membrane   Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion.   With evidence from 1 publications.
Host cell membrane   Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion.   With evidence from 1 publications.

Topology

Length:

1330

Number of predicted TMHs:

Exp number of AAs in TMHs:

25.98302

Exp number, first 60 AAs:

0.18167

Total prob of N-in:

0.01923

outside

1 - 1273

TMhelix

1274 - 1296

inside

1297 - 1330

Population Genetic Test Statistics

0.3929321

Theta

0.4414017

Tajima's D

-0.6712777

CLR

14.80375

Interpretation

No evidence of Selection

Genomic alignment in the CDS region

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
CHINA_HS_2019_MN908947
CHINA_AVIAN_2008_NC_016995
CHINA_AVIAN_2007_NC_016991
CHINA_MURINE_2015_NC_035191
CANADA_AVIAN_2007_NC_010800
USA_PIG_2000_NC_038861
CHINA_AVIAN_2007_NC_011549
ITALY_PIG_2009_NC_028806
GERMANY_PIG_2012_LT545990
CHINA_AVIAN_2007_NC_016992
CHINA_BAT_2005_NC_009657
CANADA_HS_2003_NC_004718
CHINA_BAT_2014_NC_030886
CHINA_BAT_2005_NC_018871
USA_MURINE_2009_NC_012936
CHINA_RABBIT_2006_NC_017083
UK_PIG_2000_NC_003436
ROMANIA_PIG_2015_LT898435
ROMANIA_PIG_2015_LT898436
GERMANY_PIG_2015_LT898444
GERMANY_PIG_2015_LT898414
GERMANY_PIG_2015_LT898439
GERMANY_PIG_2015_LT898413
GERMANY_PIG_2015_LT898412
GERMANY_PIG_2015_LT898411
GERMANY_PIG_2015_LT898416
GERMANY_PIG_2015_LT898443
GERMANY_PIG_2015_LT898420
GERMANY_PIG_2015_LT898408
GERMANY_PIG_2015_LT898423
GERMANY_PIG_2015_LT898432
GERMANY_PIG_2015_LT898409
GERMANY_PIG_2015_LT898425
GERMANY_PIG_2015_LT898446
GERMANY_PIG_2014_LT898438
GERMANY_PIG_2014_LT898440
GERMANY_PIG_2014_LT900501
GERMANY_PIG_2014_LT898427
GERMANY_PIG_2014_LT898415
GERMANY_PIG_2014_LT898421
GERMANY_PIG_2014_LT898431
GERMANY_PIG_2014_LT898410
GERMANY_PIG_2014_LT900498
GERMANY_PIG_2014_LT898430
GERMANY_PIG_1978_LT897799
GERMANY_PIG_2014_LT898447
GERMANY_PIG_2014_LT898426
GERMANY_PIG_2014_LT898417
GERMANY_PIG_2014_LT900500
GERMANY_PIG_2014_LT898445
AUSTRIA_PIG_2015_LT898418
AUSTRIA_PIG_2015_LT898441
AUSTRIA_PIG_2015_LT898433
AUSTRIA_PIG_2015_LT900502
GERMANY_PIG_2015_LT900499
BELGIUM_PIG_1980_LT906620
BELGIUM_PIG_1977_LT905450
SWITZERLAND_PIG_2003_LT905451
BELGIUM_PIG_1978_LT906581
UK_PIG_1987_LT906582
CHINA_PIG_2009_NC_016990
CHINA_PIG_2010_NC_039208
KENYA_BAT_2010_KY073745
KENYA_BAT_2010_NC_032107
CHINA_AVIAN_2007_NC_016994
EUROPE_MURINE_2004_AY700211
CHINA_AVIAN_2007_NC_011550
USA_MURINE_1997_NC_001846
USA_MURINE_1998_NC_023760
MID_EAST_HS_2012_NC_019843
CHINA_AVIAN_2007_NC_016993
CHINA_MURINE_2013_NC_032730
USA_HS_2004_AY585228
NETHERLAND_HS_2004_NC_005831
CHINA_HS_2004_NC_006577
EUROPE_HS_2000_NC_002645
NETHERLAND_FERRET_2010_NC_030292
JAPAN_FERRET_2013_LC119077
USA_FELINE_2005_NC_002306
CHINA_MURINE_2011_NC_034972
CHINA_AVIAN_2007_NC_016996
ARABIA_CAMEL_2015_NC_028752
CHINA_AVIAN_2007_NC_011547
CHINA_BAT_2012_NC_028824
CHINA_BAT_2013_NC_028814
CHINA_BAT_2013_NC_028833
CHINA_BAT_2011_NC_028811
USA_BOVIN_2001_NC_003045
CHINA_MURINE_2012_NC_026011
GERMANY_ERINACEINAE_2012_NC_022643	Protein	YP_008719932.1
GERMANY_ERINACEINAE_2012_NC_039207	Protein	YP_009513010.1
UK_HS_2012_NC_038294
AMERICA_WHALE_2007_NC_010646
CHINA_BAT_2013_NC_025217
UGANDA_BAT_2013_NC_034440
CHINA_BAT_2006_NC_009021
CHINA_BAT_2008_NC_010438
CHINA_BAT_2006_NC_009020
CHINA_BAT_2006_NC_009019
CHINA_BAT_2006_NC_009988
USA_BAT_2006_NC_022103
BULGARIA_BAT_2008_NC_014470
CHINA_BAT_2008_NC_010437
USA_AVIAN_2004_NC_001451