Strain

GERMANY_ERINACEINAE_2012_NC_039207 (Region: Germany;  Strain: Betacoronavirus Erinaceus/VMC/DEU/2012 isolate ErinaceusCoV/2012-174/GER/2012, complete genome.;  Date: 2012)

Gene

S

Description

Annotated in NCBI,  S

Location

NC_039207(+):21610-25602

GenBank Accession

YP_009513010.1

Full name

Spike glycoprotein      

Alternative Name

E2
Peplomer protein

CDS

ATGATACGCTCAGCGTGTCTACTGATGTGCTTGTTAATGTTTATAAAAGCAACCCCAAGCGAGGGAACATGTATATCTGTTGACATGCAGCCCTCATATTTTATCAAAAATTGGTCTATGCCAATTAATATGAGTAAAGCAGATGGTGTTTTATACCCTGTTGAGCGTACTTATTCTAATATCACAATAACGCTTGAAGGGTTATTTCCACACCAAGCAGATCGTGGTGATATGTATGTTTACTCACAATCTCATAAAGGCAGGCCTTTCATTTCTAATTATTCTCTCGTTACTAATGATTTTGGTAATGGCATAGTAATTAGAATAGGTTCTGCTGCTAATAAAACTGGTAGTCCTATTATTTCTAATATTGCTAGTAACTTTCAGATTATGAAGAAACTTTATCCAGCTTTGCTCTTTGGTAGTGCTGTTGGTAAATTTCCTGCTAATAATAAAACAGGTGCTTATTTTAATCATAGCCTCGTTATTTTGCCCGAAAAATGTGGCACTGTTATTACAGCACTTTATTGTGTTTTAGAGCCCAAGAATGATACCAATTGTACTGGTAGTTCTGGTTATGTTAGTTATGTGCTGTTTGAAAATTTTAGTTGTGATGCAACTACTGATGGTAACTTAAAAAATAGTTTACAGCAGTGGTTTAATATTAAGGATTGTCTTTTTGAGAAAAATTACAATGTTACTGATGATGAGAGGGAAGAGTGGTTTGGAATTATCCAAGATCAGCAAGGTGTCCACCTCTATACATCTCGGAAGAATGGATATTCAAACAATATGTTTTTGTTTGCTACTTTACCAATTTATGATCAGATACTATATTATACTGTTATGCCGCGCAGTATTAATGCTAGTAATTATGCATCATATCATGCTTTTTCTGCATTTTATATTTACAAGTTACACAAAATCAACTATATGGTTGACTTTGATGTAAATGGTTATATCACAAGGGCTGTCGATTGTGGTTATAATGATTATACACAATTGCAATGCTCTTATGGTCAATTTGATATGGATTCTGGTGTTTATTCAGCTTCGTATTTTAATGCCCGCTCTAGAGGTTATTACTATGAAGCTGCAGAACTCACAGAATGTGACTTAGATGTATTGTTTAAAAACGATGCTCCTATAATAGCTAATTACAGTAGGCGAGTTTTTACTAATTGTAATTATAATTTAACAAAACTCCTTTCTCTTGTGCAAGTAGATGAGTTTGTTTGTCATAAAACAACACCAGAAGCGCTTGCTACTGGCTGTTATTCCTCTCTAACGGTAGACTGGTTTGCGCTGCCTTTTAGTATGAAGTCAACATTAGCTATAGGATCAGCAGAAGCTATATCTATGTTTAATTATAATCAGGATTATTCCAATCCTACGTGTAGAATTCATGCAGCTGTAACAGCTAATGTTTCAACAGCGTTGAATTTTACTGCTAATGCTAATTATGCTTATATTTCCAGGTGCCAAGGTGTTGATGGTAAACCAATTCTATTACAACCAGGACAAATGACTAATATTGCTTGTCGTTCTGGTGTTTTGGCACGGCCATCAGATGCAGATTATTTTGGCTATTCATTTCAAGGACGCAACTATTATTTAGGGCGTAAATCTTATAAACCTAAAACCGATGAGGGCGACGTTCAAATGGTTTATGTAATAACGCCTAAATATGATAAAGGCCCTGATACTGTATGCCCTCTTAAAGATATGGGTGCTGCCTCTTCTAGTTTAGATGGCTTGTTAGGGCAGTGCATAGATTATGACATTCATGGAGTAGTAGGCCGTGGTGTTTTTCAAGTTTGCAATACCACAGGAATTGCTAGTCAAATTTTTGTCTATGACGGATTTGGTAATATCATAGGCTTTCATTCTAAAAATGGTACATACTATTGTATGGCACCATGCGTATCAGTACCTGTTTCTGTAATTTATGATAAAAGCAGTGATGTTCATGCTACGCTTTATAGTAGCGTTGAGTGCAATCATATAAAATCAGTTGCAACAGTTTTTAGTCGTCAAACTGAGTCTAAGCTTAGATCGAGTGATAACGGCCTTTTACAAACAGCTGTAGGCTGTGTTATTGGATTCCGTAACACAAGTGACACTGTTGAAGATTGTACCTTACCTTTAGGCCAATCTCTCTGTGCAAAACCACCTTCTTTTTCCAGTCGTAGTACCAATGTTAATAACACATTTGCTTTAGTGCATATGTTGTTCCAAAATCCATTAAAAGTTAGTGTTCTCAATTCAACTGAGTTTCAGGTTTCAATACCTCAGAATTTTAGTTTTGGTATTACTGAAGAATTTATAGAAACATCCATACAAAAGGTTACTGTTGATTGTAAGCAGTATGTTTGTAATGGATTTGAGCGTTGTGAACAATTGTTGGTGCAGTATGGCCAATTTTGTTCAAAAATTAATCAAGCATTACATGGTGTTAATTTGCGCCAAGATGATGCTACTAAGAGTCTTTTTGAGGACATTAAAGTACCCCAATCAGTACCCTTAATGACAAGCCTCACTGGTGATTATAATTTATCATTATTCGAGGCACCTAATATTGGCAGTGGTAATAATAACTACCGCAGTGCTTTAGAAGATCTGCTTTTTGATAAGGTTACATTATCAGATCCAGGTTATATGAAAGGATATGACGAGTGCATGAAAAAAGGACCACCTAGTGCTAGGGACCTAATTTGTGCACAATATGTATCTGGTTATAAAGTTTTACCGCCTTTGTATGATGCTAATATGGAGGCTATGTATACTGCTTCTTTAACTGGTAGTATAGCAGGTTCTTTTTGGACAGGAGGACTATCGTCTGCTGCTGCACTACCATTTGCACAGTCAATGTTTTATCGTATGAATGGTATTGGCATCACTCAAAATGTTCTTATGAAGAACCAGAGGGAGATAGCCAATAAGTTCAACCAGGCATTAGGTGCTATGCAAACAGGATTCACAGCTACCAATCAAGCTTTTCAGAAGGTTCAAGATGTTGTGAATGCCAATGCACAAGCATTATCTAAATTAGCTAGTGAATTAGCTAACACATTCGGTGCTATTTCCTCTTCTATAGGCGACATCTTAAAACGCTTGGATGTTTTAGAACAGGAAGTGCAAATAGACCGCCTTATTAACGGACGTCTCACATCGTTGAATGCGTTTGTAAGTCAGCAACTGGTGAGAAGCGAAGCTGCTGCCCGCTCATCTCAGTTAGCTAAAGAGAAAATTAATGAATGTGTCAAAGCTCAATCCACACGTAGTGGGTTTTGCGGACAAGGCACTCATATAGTGTCATTTGTTATTAATGCTCCTAATGGGTTCTATTTTATACATGTGGGTTATCACCCGCAGGATTATGTGAATCAAACAGCTGCATATGGTCTGTGTGATTCTTCTTCTTCTAAATGCATAGCCGCCAAGAACGGCTATTTTGTTAAAAATGATTCTGATAGTGATAGTTGGTCTTATACAGGCAGTAGTTTTTATCAACCTGAACCTATCACTAGTTTTAACTCGCGCTTTGTTCAGCCTGAGTTTACATTTCAAAATCTAACTAATAACCTTCCACCTCCACTCCTAAGTAATAATAGTGATGTTACTTTTGAGGATGAGCTGGAAGAGTTTTATAAAAATATTACGTCTGAGATACCTAATTTTGGTTCTATCAGCCAGATCAATACCACTATGCTTAACTTGAGTCGAGAAATGAGCATTTTACAACAAGTGGTAAAAGATTTAAACAACTCTTATATAGAGCTTAAAGAATTAGGTAACTACACATACTATCAAAAATCGCCGTGGTATGTGTGGTTAGGTTTCATTGCTGGTCTTGTTGCACTAGCACTATGCTTATTTTTCATACTGTGTTGCACAGGATGTGGCACTAGCTGCCTTGGAAAAATAAATTGTACTCGTTGTTGTGATAAGTATGATGATTTTGACATGCCAGAGAAAATTCACATACATTAA

Protein

MIRSACLLMCLLMFIKATPSEGTCISVDMQPSYFIKNWSMPINMSKADGVLYPVERTYSNITITLEGLFPHQADRGDMYVYSQSHKGRPFISNYSLVTNDFGNGIVIRIGSAANKTGSPIISNIASNFQIMKKLYPALLFGSAVGKFPANNKTGAYFNHSLVILPEKCGTVITALYCVLEPKNDTNCTGSSGYVSYVLFENFSCDATTDGNLKNSLQQWFNIKDCLFEKNYNVTDDEREEWFGIIQDQQGVHLYTSRKNGYSNNMFLFATLPIYDQILYYTVMPRSINASNYASYHAFSAFYIYKLHKINYMVDFDVNGYITRAVDCGYNDYTQLQCSYGQFDMDSGVYSASYFNARSRGYYYEAAELTECDLDVLFKNDAPIIANYSRRVFTNCNYNLTKLLSLVQVDEFVCHKTTPEALATGCYSSLTVDWFALPFSMKSTLAIGSAEAISMFNYNQDYSNPTCRIHAAVTANVSTALNFTANANYAYISRCQGVDGKPILLQPGQMTNIACRSGVLARPSDADYFGYSFQGRNYYLGRKSYKPKTDEGDVQMVYVITPKYDKGPDTVCPLKDMGAASSSLDGLLGQCIDYDIHGVVGRGVFQVCNTTGIASQIFVYDGFGNIIGFHSKNGTYYCMAPCVSVPVSVIYDKSSDVHATLYSSVECNHIKSVATVFSRQTESKLRSSDNGLLQTAVGCVIGFRNTSDTVEDCTLPLGQSLCAKPPSFSSRSTNVNNTFALVHMLFQNPLKVSVLNSTEFQVSIPQNFSFGITEEFIETSIQKVTVDCKQYVCNGFERCEQLLVQYGQFCSKINQALHGVNLRQDDATKSLFEDIKVPQSVPLMTSLTGDYNLSLFEAPNIGSGNNNYRSALEDLLFDKVTLSDPGYMKGYDECMKKGPPSARDLICAQYVSGYKVLPPLYDANMEAMYTASLTGSIAGSFWTGGLSSAAALPFAQSMFYRMNGIGITQNVLMKNQREIANKFNQALGAMQTGFTATNQAFQKVQDVVNANAQALSKLASELANTFGAISSSIGDILKRLDVLEQEVQIDRLINGRLTSLNAFVSQQLVRSEAAARSSQLAKEKINECVKAQSTRSGFCGQGTHIVSFVINAPNGFYFIHVGYHPQDYVNQTAAYGLCDSSSSKCIAAKNGYFVKNDSDSDSWSYTGSSFYQPEPITSFNSRFVQPEFTFQNLTNNLPPPLLSNNSDVTFEDELEEFYKNITSEIPNFGSISQINTTMLNLSREMSILQQVVKDLNNSYIELKELGNYTYYQKSPWYVWLGFIAGLVALALCLFFILCCTGCGTSCLGKINCTRCCDKYDDFDMPEKIHIH

Function

Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.
Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.
mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.

Subunit

Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes.

Similarity

Belongs to the betacoronaviruses spike protein family.

Keywords

3D-structure   Coiled coil   Disulfide bond   Fusion of virus membrane with host endosomal membrane   Fusion of virus membrane with host membrane   Glycoprotein   Host cell membrane   Host membrane   Host-virus interaction   Lipoprotein   Membrane   Palmitate   Reference proteome   Signal   Transmembrane   Transmembrane helix   Viral attachment to host cell   Viral envelope protein   Viral penetration into host cytoplasm   Virion   Virulence   Virus entry into host cell  

Feature

chain  Spike protein S2

Uniprot

U5LNM4   U5LMM7   A0A4D6G1A4   A0A1W6ASU7   A0A2R2YRG8   U5NJG5   + More
A0A2I6PIX8   A0A2R4KP93   A0A2I6PIW5   A0A5H2WTJ3   A3EXE8   A3EXF7   A3EXD9   S4X278   S4WYD2   S4WWS3   A0A4P8L6Q6   A0A0U2IY58   A0A384YDC0   A0A2P1IT46   A0A0U1WHM0   S4WYD6   A0A0A0Q4U5   A0A0U2NE92   A0A291I635   A0A140AZ05   A0A0U2NY03   A0A2P1IT40   A0A168DLI3   A0A023VZD9   A0A2D0YM48   A0A2D0YAP4   A0A0U2NE84   K0BRG7   A0A0H4JBS8   A0A2P1IT43   A0A493R163   A0A2H4TEF0   A0A140AYZ5   A0A0A0Q4U2   A0A5C0PYB9   A3EXD0   A0A291I6E5   A0A1C8EAZ2   M4SVE7   A0A2P1IT75   A0A0U2MMC5   A0A0B5KTJ9   A0A0U2NXW5   A0A2D0YXA8   A0A141BR51   A0A411PBH3   A0A1L2DZI5   A0A0U2J5U2   A0A2D0YCT4   A0A140AZ15   A0A126G7T9   T2B9T0   A0A0U2GMX5   A0A2D0YGK8   A0A2D0Y3M7   A0A0U2HTD9   S4WWQ3   S4WZQ1   A0A2H1YPP7   A0A384YDR2   A0A0U2MS74   A0A2D0YDA3   A0A0A0Q7G4   A0A0U2NTX5   A0A1L2E0V8   A0A0S1TQ87   A0A0U4AGH8   A0A411PBG2   A0A0P0HJE7   S4WZR0   A0A0G2UN32   A0A0P0HBE6   A0A1W5LIC4   A0A1W5LGJ4   A0A2D0YUG7   A0A1W5LGD2   A0A2H4PWP1   T2BBH7   T2BBK5   A0A2D0YT69   R9UCW7   A0A291I5Y3   A0A0U2P188   A0A0U2MMB6   A0A384YG86   A0A291I6B7   A0A482DX85   A0A2D0Y305   A3EXA3   W6A028   W6A090   A0A411PBL8   A0A0B5L4G8   A0A2D0YGA8  

Pubmed

24131722    28377531    29579103    24050621    25031349    29258555    + More
17121802    23720729    29507189    25323704    26933050    24781747    29116217    23170002    26391698    26079346    30753126    26691200    26814649    26839489    26678874    23903833    27999424    24055451    23782859    24549846    26584223    26272560    26981770    25989145    31553909   

EMBL

KC545383    AGX27799.1    KC545386    AGX27810.1    MK679660    QCC20713.1    + More
KX574227    ARJ34226.1    MF593268    ATQ39390.1    KC869678    AGY29650.2    MG596803    AUM60024.1    MG021452    AVV62537.1    MG596802    AUM60014.1    LC469308    BBJ36008.1    EF065511    ABN10893.1    EF065512    ABN10902.1    EF065510    ABN10884.1    KC522096    AGP04935.1    KC522049    AGP04916.1    KC522103    AGP04942.1    MK858160    MK858161    MK858162    QCQ28832.1    QCQ28833.1    QCQ28834.1    KT805975    ALJ54455.1    MG912604    AVK87417.1    MG923469    AVN89324.1    KJ473820    AIA62343.1    KC522051    KC522052    KC522053    KC522054    KC522055    KC522056    KC522058    KC522059    KC522060    KC522061    AGP04918.1    AGP04919.1    AGP04920.1    AGP04921.1    AGP04922.1    AGP04923.1    AGP04925.1    AGP04926.1    AGP04927.1    AGP04928.1    KM027284    MH013216    AID55095.1    AVV61900.1    KT806010    ALJ54490.1    MG011347    MK858164    ATG84756.1    QCQ28836.1    KT868875    KX034094    KX034095    ALK80291.1    ANC28645.1    ANC28656.1    KT806020    ALJ54500.1    MG923468    AVN89313.1    KX034097    ANC28678.1    KJ713299    AHY22565.1    MF598638    ASU90406.1    MF598679    ASU90857.1    KT805994    ALJ54474.1    JX869059    AFS88936.1    KP405225    KP405227    KT805988    MF598616    MG011341    MH822886    MK462250    AKO69634.1    AKO69636.1    ALJ54468.1    ASU90164.1    ATG84690.1    AYM48030.1    QBF80532.1    MG923466    MG923467    AVN89291.1    AVN89302.1    MH978886    MH978887    QBF44113.1    QBF44114.1    MG366881    MG366882    MG366883    MG912595    MG912596    MG912598    MG912599    MG912600    MG912601    MG912602    MG912603    MG912605    MG366483    MH310910    MH310911    ATY74392.1    ATY74403.1    ATY74414.1    AVK87318.1    AVK87329.1    AVK87351.1    AVK87362.1    AVK87373.1    AVK87384.1    AVK87395.1    AVK87406.1    AVK87428.1    AXN73359.1    AXN92238.1    AXN92249.1    KT182954    KT182955    KT326819    KT374052    KT374053    KT374054    KT374055    KT868865    KT868866    KT868867    KT868868    KT868869    KT868873    KT868874    KU308549    KX034096    KX034098    KX034099    KX034100    AKN11072.1    AKN11073.1    AKS48062.1    ALB08267.1    ALB08278.1    ALB08289.1    ALB08300.1    ALK80192.1    ALK80202.1    ALK80212.1    ALK80222.1    ALK80232.1    ALK80271.1    ALK80281.1    AML60270.1    ANC28667.1    ANC28689.1    ANC28700.1    ANC28711.1    KM027279    KT368824    AID55090.1    ALA49341.1    MN365232    MN365233    QEJ82215.1    QEJ82226.1    EF065509    MG011357    ATG84866.1    KT877350    ALL26396.1    KC776174    AGH58717.1    MG923470    MG923471    AVN89334.1    AVN89344.1    KT805992    KY688119    ALJ54472.1    AQZ41322.1    KP719931    KP719932    AJG44102.1    AJG44113.1    KT805972    KT806055    ALJ54452.1    ALW82753.1    MF598648    MF598667    MF598696    ASU90516.1    ASU90725.1    ASU91043.1    KT182956    KT182957    AKN11074.1    AKN11075.1    MK462249    QBF80521.1    KX108943    ANI69889.1    KT806038    ALJ54518.1    MF598641    ASU90439.1    KT868872    KT868876    ALK80261.1    ALK80301.1    KT374050    KT374051    ALB08246.1    ALB08257.1    KF600652    KT806040    AGV08584.1    ALJ54520.1    KT368880    KT368881    ALA49957.1    ALA49968.1    MF598608    MF598650    MF598700    ASU90076.1    ASU90538.1    ASU91087.1    KY673148    KY688114    MF598636    MF598639    MF598647    MF598681    AQZ41285.1    AQZ41306.1    ASU90384.1    ASU90417.1    ASU90505.1    ASU90879.1    KT805968    KT805985    KT805986    ALJ54448.1    ALJ54465.1    ALJ54466.1    KC522050    AGP04917.1    KC522057    AGP04924.1    MF598597    ASU89955.1    MG912597    AVK87340.1    KT805971    ALJ54451.1    MF598651    ASU90549.1    KM027288    AID55099.1    KT806028    ALJ54508.1    KX108944    ANI69900.1    KT003530    ALM26400.1    KT806049    ALW82691.1    MK462251    QBF80543.1    KR912196    ALJ76286.1    KC522095    AGP04934.1    KR011263    KR011264    KR011265    KR011266    KT805961    KT805962    KT805963    AKI29255.1    AKI29265.1    AKI29275.1    AKI29284.1    ALJ54441.1    ALJ54442.1    ALJ54443.1    KT368828    KT368843    KT368844    KT368845    KT368849    KT368850    KT368851    KT368855    KT368887    KT368888    KT805995    KT805997    KT805998    KT805999    KT806000    KT806013    KR912189    KR912190    KR912191    KR912192    KR912193    KR912194    KT877351    ALA49385.1    ALA49550.1    ALA49561.1    ALA49572.1    ALA49616.1    ALA49627.1    ALA49638.1    ALA49682.1    ALA50034.1    ALA50045.1    ALJ54475.1    ALJ54477.1    ALJ54478.1    ALJ54479.1    ALJ54480.1    ALJ54493.1    ALJ76282.1    ALL26409.1    KX154689    MG757604    ANF29217.1    AXN73514.1    KX154690    MG011345    MG011351    ANF29228.1    ATG84734.1    ATG84800.1    MF598635    MF598637    ASU90373.1    ASU90395.1    KX154686    KX154692    ANF29184.1    ANF29250.1    MF679173    ATW75479.1    KF600630    AGV08467.1    KF600634    AGV08492.1    MF598693    ASU91010.1    KF192507    AGN52936.1    MG011342    ATG84701.1    KT806021    ALJ54501.1    KT805976    ALJ54456.1    MG912606    AVK87439.1    MG011354    ATG84833.1    MK564474    QBM11737.1    MF598617    ASU90175.1    EF065506    ABN10848.1    KJ156934    KJ156873    KJ713295    KJ713296    KM015348    KM027281    KM210278    KP966104    KT006149    KT026453    KT026454    KT026455    KT026456    KT036372    KT036373    KT036374    KT182953    KT275306    KT275307    KT275308    KT368833    KT368868    KT368870    KT368871    KT368872    KT368873    KT368874    KT368876    KT368877    KT368878    KT368882    KT368883    KT368884    KT368885    KT368886    KT368889    KT805964    KT805965    KT805967    KT805969    KT805974    KT805977    KT805979    KT805980    KT805982    KT805984    KT805989    KT805990    KT805993    KT805996    KT806002    KT806005    KT806007    KT806009    KT806012    KT806014    KT806018    KT806019    KT806023    KT806024    KT806025    KT806026    KT806027    KT806029    KT806030    KT806031    KT806033    KT806034    KT806035    KT806039    KT868870    KU233362    KU233363    KU233364    KT806044    KT806045    KT806046    KT806047    KT806048    KT806050    KT806051    KT806052    KT806053    KU851859    KU851860    KU851861    KU851862    KU851863    KU851864    KX154684    KX108945    KY688118    KY688120    KY688121    KY688122    KY688123    KY688124    MF598594    MF598595    MF598603    MF598604    MF598606    MF598607    MF598611    MF598612    MF598613    MF598615    MF598620    MF598625    MF598627    MF598628    MF598633    MF598643    MF598644    MF598645    MF598646    MF598652    MF598654    MF598657    MF598660    MF598661    MF598662    MF598664    MF598665    MF598666    MF598668    MF598670    MF598677    MF598680    MF598682    MF598684    MF598685    MF598686    MF598687    MF598688    MF598691    MF598692    MF598694    MF598695    MF598697    MF598698    MF598701    MF741837    MF741825    MF741826    MF741828    MF741829    MF741831    MF741833    MF741834    MF741835    MF741836    MG011343    MG011352    MG011353    MG011355    MF679172    MG366880    MG912608    MH306207    MH371127    MH432120    MG757593    MG757594    MG757595    MG757596    MG757598    MG757599    MG757600    MG757601    MG757602    MG757603    MH029552    MK129253    MH978888    MK462248    MH259486    MK858156    MK858158    MK858163    AHI48572.1    AHI48662.1    AHY22525.1    AHY22535.1    AID50418.1    AID55092.1    AJD81451.1    AKA63509.1    AKJ80137.2    AKK52582.1    AKK52592.1    AKK52602.1    AKK52612.1    AKL80593.1    AKL80604.1    AKL80615.1    AKN11071.1    AKQ21055.1    AKQ21064.1    AKQ21073.1    ALA49440.1    ALA49825.1    ALA49847.1    ALA49858.1    ALA49869.1    ALA49880.1    ALA49891.1    ALA49913.1    ALA49924.1    ALA49935.1    ALA49979.1    ALA49990.1    ALA50001.1    ALA50012.1    ALA50023.1    ALA50056.1    ALJ54444.1    ALJ54445.1    ALJ54447.1    ALJ54449.1    ALJ54454.1    ALJ54457.1    ALJ54459.1    ALJ54460.1    ALJ54462.1    ALJ54464.1    ALJ54469.1    ALJ54470.1    ALJ54473.1    ALJ54476.1    ALJ54482.1    ALJ54485.1    ALJ54487.1    ALJ54489.1    ALJ54492.1    ALJ54494.1    ALJ54498.1    ALJ54499.1    ALJ54503.1    ALJ54504.1    ALJ54505.1    ALJ54506.1    ALJ54507.1    ALJ54509.1    ALJ54510.1    ALJ54511.1    ALJ54513.1    ALJ54514.1    ALJ54515.1    ALJ54519.1    ALK80242.1    ALT66802.1    ALT66813.1    ALT66824.1    ALW82636.1    ALW82647.1    ALW82658.1    ALW82669.1    ALW82680.1    ALW82702.1    ALW82709.1    ALW82720.1    ALW82731.1    AMQ49015.1    AMQ49026.1    AMQ49037.1    AMQ49048.1    AMQ49059.1    AMQ49070.1    ANF29162.1    ANI69911.1    AQZ41311.1    AQZ41332.1    AQZ41343.1    AQZ41354.1    AQZ41365.1    AQZ41376.1    ASU89921.1    ASU89933.1    ASU90021.1    ASU90032.1    ASU90054.1    ASU90065.1    ASU90109.1    ASU90120.1    ASU90131.1    ASU90153.1    ASU90208.1    ASU90263.1    ASU90285.1    ASU90295.1    ASU90351.1    ASU90461.1    ASU90472.1    ASU90483.1    ASU90494.1    ASU90560.1    ASU90582.1    ASU90615.1    ASU90648.1    ASU90659.1    ASU90670.1    ASU90692.1    ASU90703.1    ASU90714.1    ASU90736.1    ASU90758.1    ASU90835.1    ASU90868.1    ASU90890.1    ASU90912.1    ASU90923.1    ASU90934.1    ASU90945.1    ASU90956.1    ASU90988.1    ASU90999.1    ASU91021.1    ASU91032.1    ASU91054.1    ASU91065.1    ASU91098.1    ASY99778.1    ASY99789.1    ASY99800.1    ASY99820.1    ASY99831.1    ASY99853.1    ASY99873.1    ASY99884.1    ASY99895.1    ASY99906.1    ATG84712.1    ATG84811.1    ATG84822.1    ATG84844.1    ATW75478.1    ATY74381.1    AVK87461.1    AWM99582.1    AXG21643.1    AXG21665.1    AXN73393.1    AXN73404.1    AXN73415.1    AXN73426.1    AXN73448.1    AXN73459.1    AXN73470.1    AXN73481.1    AXN73492.1    AXN73503.1    AYO86699.1    AZK15900.1    QBF44115.1    QBF80510.1    QCI31480.1    QCQ28828.1    QCQ28830.1    QCQ28835.1    KJ156876    KU242423    KU242424    MF598663    AHI48672.1    ALT66870.1    ALT66880.1    ASU90681.1    MK462253    MK462254    MK462255    QBF80565.1    QBF80576.1    QBF80587.1    KP719929    KX108937    AJG44080.1    ANI69824.1    MF598629    MF598640    MF598658    MF598689    ASU90307.1    ASU90428.1    ASU90626.1    ASU90966.1   

Proteomes

UP000101546    UP000095937    UP000202992    UP000145931    UP000143769    UP000100668    + More
UP000164987    UP000148908    UP000145271    UP000167218    UP000129370    UP000105499    UP000112279    UP000097149    UP000098933    UP000105311    UP000106595    UP000109122    UP000126763    UP000128076    UP000140611    UP000147342    UP000138672    UP000007451    UP000108469    UP000131416    UP000174176    UP000117213    UP000103178    UP000113724    UP000148810    UP000113143    UP000152659    UP000146591    UP000102098    UP000110604    UP000120083    UP000165587    UP000098431    UP000104003    UP000112676    UP000126955    UP000128936    UP000136645    UP000137287    UP000146604    UP000151733    UP000159793    UP000143263    UP000096281    UP000104220    UP000163538    UP000095864    UP000096875    UP000102966    UP000104540    UP000109666    UP000112022    UP000115322    UP000118563    UP000119223    UP000121965    UP000122049    UP000125198    UP000128184    UP000128186    UP000128651    UP000142239    UP000144056    UP000144472    UP000147538    UP000151795    UP000153269    UP000157492    UP000158935    UP000159306    UP000161565    UP000163035    UP000163895    UP000170921    UP000171516    UP000171892    UP000174054    UP000174558    UP000180347    UP000180348    UP000120625    UP000174530    UP000136957   

PRIDE

A3EXD0   

Pfam

PF09408   Spike_rec_bind
PF01601   Corona_S2

Interpro

IPR027400   S_HR2
IPR002552   Corona_S2
IPR018548   Spike_rcpt-bd
IPR036326   Spike_rcpt-bd_sf
IPR042578   BETA_CORONA_SPIKE
IPR043002   Spike_N_sf

SUPFAM

SSF143587   SSF143587

Gene 3D

1.20.5.790     2.60.120.960    

ProteinModelPortal

U5LNM4   U5LMM7   A0A4D6G1A4   A0A1W6ASU7   A0A2R2YRG8   U5NJG5   + More
A0A2I6PIX8   A0A2R4KP93   A0A2I6PIW5   A0A5H2WTJ3   A3EXE8   A3EXF7   A3EXD9   S4X278   S4WYD2   S4WWS3   A0A4P8L6Q6   A0A0U2IY58   A0A384YDC0   A0A2P1IT46   A0A0U1WHM0   S4WYD6   A0A0A0Q4U5   A0A0U2NE92   A0A291I635   A0A140AZ05   A0A0U2NY03   A0A2P1IT40   A0A168DLI3   A0A023VZD9   A0A2D0YM48   A0A2D0YAP4   A0A0U2NE84   K0BRG7   A0A0H4JBS8   A0A2P1IT43   A0A493R163   A0A2H4TEF0   A0A140AYZ5   A0A0A0Q4U2   A0A5C0PYB9   A3EXD0   A0A291I6E5   A0A1C8EAZ2   M4SVE7   A0A2P1IT75   A0A0U2MMC5   A0A0B5KTJ9   A0A0U2NXW5   A0A2D0YXA8   A0A141BR51   A0A411PBH3   A0A1L2DZI5   A0A0U2J5U2   A0A2D0YCT4   A0A140AZ15   A0A126G7T9   T2B9T0   A0A0U2GMX5   A0A2D0YGK8   A0A2D0Y3M7   A0A0U2HTD9   S4WWQ3   S4WZQ1   A0A2H1YPP7   A0A384YDR2   A0A0U2MS74   A0A2D0YDA3   A0A0A0Q7G4   A0A0U2NTX5   A0A1L2E0V8   A0A0S1TQ87   A0A0U4AGH8   A0A411PBG2   A0A0P0HJE7   S4WZR0   A0A0G2UN32   A0A0P0HBE6   A0A1W5LIC4   A0A1W5LGJ4   A0A2D0YUG7   A0A1W5LGD2   A0A2H4PWP1   T2BBH7   T2BBK5   A0A2D0YT69   R9UCW7   A0A291I5Y3   A0A0U2P188   A0A0U2MMB6   A0A384YG86   A0A291I6B7   A0A482DX85   A0A2D0Y305   A3EXA3   W6A028   W6A090   A0A411PBL8   A0A0B5L4G8   A0A2D0YGA8  

PDB

5X5F     E-value=0,     Score=3563