Strain

EUROPE_MURINE_2004_AY700211 (Region: Europe;  Strain: Murine hepatitis virus strain A59, complete genome.;  Date: 2004)

Gene

membrane protein

Description

Annotated in NCBI,  membrane protein

Location

AY700211(+):28969-29655

GenBank Accession

AAU06360.1

Full name

Membrane protein      

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

CDS

ATGAGTAGTACTACTCAGGCCCCAGAGCCCGTCTATCAATGGACCGCCGACGAGGCAGTTCAATTCCTTAAGGAATGGAACTTCTCGTTGGGCATTATACTACTCTTTATTACTATCATACTACAGTTCGGTTACACGAGCCGTAGCATGTTTATTTATGTTGTGAAAATGATAATCTTGTGGTTAATGTGGCCACTGACTATTGTTTTGTGTATTTTCAATTGCGTGTATGCGCTAAATAATGTGTATCTTGGATTTTCTATAGTGTTTACTATAGTGTCCATTGTAATCTGGATTATGTATTTTGTTAATAGCATAAGGTTGTTTATCAGGACTGGTAGCTGGTGGAGCTTCAACCCCGAAACAAACAACCTTATGTGTATAGATATGAAAGGTACCGTGTATGTTAGACCCATTATTGAGGATTACCATACACTAACAGCCACTATTATTCGTGGCCACCTCTACATGCAAGGTGTTAAGCTAGGCACCGGTTTCTCTTTGTCTGACTTGCCCGCTTATGTTACAGTTGCTAAGGTGTCACACCTTTGCACTTATAAGCGCGCATTCTTAGACAAGGTAGACGGTGTTAGCGGTTTTGCTGTTTATGTGAAGTCCAAGGTCGGAAATTACCGACTGCCCTCAAACAAACCGAGTGGCGCGGACACCGCATTGTTGAGAACCTAA

Protein

MSSTTQAPEPVYQWTADEAVQFLKEWNFSLGIILLFITIILQFGYTSRSMFIYVVKMIILWLMWPLTIVLCIFNCVYALNNVYLGFSIVFTIVSIVIWIMYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGTVYVRPIIEDYHTLTATIIRGHLYMQGVKLGTGFSLSDLPAYVTVAKVSHLCTYKRAFLDKVDGVSGFAVYVKSKVGNYRLPSNKPSGADTALLRT

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.
Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus (By similarity).

Similarity

Belongs to the betacoronaviruses M protein family.
Belongs to the coronaviruses M protein family.
Belongs to the alphacoronaviruses M protein family.

Keywords

Glycoprotein   Host Golgi apparatus   Host membrane   Host-virus interaction   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Viral envelope protein   Viral immunoevasion   Viral matrix protein   Virion  

Feature

chain  Membrane protein

Uniprot

C0KYT4   C0KYR4   C0KYY2   C0KZ03   Q9J3E3   S5YGC7   + More
A7U548   C0KYW5   Q77NM8   A0A2D1CEC5   C3VPF2   P03415   A0A2S0SZ14   C0KYX3   A0A2D1CEF4   H9BZY2   D7PJY4   Q5ICW8   C0KYZ3   C0KYS5   C0KYU4   C0KYV5   A0A513RAU2   Q9J3F0   D4QFK5   Q9JEB4   Q7TG51   I7AB50   P08549   Q9QD00   I7AB57   A0A513RAU4   C6GHS5   I1TMG6   Q9IKC7   V5N7E5   Q9WCD2   I1TMH6   Q9WCD1   A0A2H4MXA4   A0A096XNI0   A0A2H4MWZ9   A0A2H4N019   A0A096XNG2   A0A096XNH8   A0A2H4MXY2   A0A3G3NH91   A0A3G3NH08   A0A2P1IQA5   A0A2H4MZ01   A0A3G3NH59   C6GHN0   A4ZU79   C6GHP2   A4ZU13   A4ZU68   C6GHQ3   A4ZTY0   B7U2P8   A4ZU46   A4ZTZ1   A4ZU35   Q06BD5   A4ZU57   A4ZU02   Q4U3R5   Q8V433   B7U2S0   B7U2N8   B7U2M7   C6GHL8   B7U2L6   A3FEW1   Q0PL34   A3FEW0   Q4U3R0   A0A191URC8   B7U2Q9   P69600   P69599   A0A0A7V404   Q91A23   A0A3S7GYH1   Q6W359   Q4U3R7   A4ZU24   H9AA58   A0A096XNF0   A0A0C5B155   B8RIR2   D0EY98   A0A3G3NGZ2   H9AA37   X2JFA7   A0A0U2GR22   P69705   P69704   P69703   C6GHR5   A7BKC7  

Pubmed

10438865    15709029    17079303    11582515    16341254    20631137    + More
17041219    8392595    6325918    6331107    9426441    1400501    10438834    10799570    1629209    20519394    15507445    12970410    12663803    10725548    11502093    12784855    3748812    10544100    10933723    10882653    10551451    30285857    25463600    29508550    17344285    17434558    18842722    17459444    16604443    11714968    27274850    9778786    25552712    22398294    19162098    24655427    26678874    11774548    3029965    3434434    7966615    9371586    1706882    17374765   

EMBL

FJ647220    ACN89707.1    FJ647218    ACN89692.1    FJ647225    ACN89755.1    + More
FJ647227    ACN89781.1    AF208067    AY700211    AAF69348.1    AAU06360.1    KF268336    KF268337    KF268338    KF268339    AGT17720.1    AGT17731.1    AGT17742.1    AGT17753.1    EF682498    ABS87268.1    FJ647223    ACN89740.1    AF207902    AAF68927.1    MF618252    ATN37891.1    FJ884686    FJ884687    ACO72887.1    X00509    M25894    AF029248    MF416379    AWB14617.1    FJ647224    ACN89749.1    MF618253    ATN37901.1    JQ173883    AFD97611.1    GU593319    ADI59792.1    AY771998    AAW47244.1    FJ647226    ACN89768.1    FJ647219    ACN89700.1    FJ647221    ACN89721.1    FJ647222    ACN89725.1    MH687884    MH687885    QCI55925.1    QCI55926.1    AF208066    AAF69337.1    AB551247    BAJ04700.1    AF126508    AF201929    AY102934    AAM55466.1    JX169866    AFO11511.1    X04223    AF190407    AAF05705.1    JX169867    AFO11521.1    MH687886    MH687887    MH687888    QCI55927.1    QCI55928.1    QCI55929.1    FJ938068    ACT11045.1    JF792616    AFG25754.1    AF207551    KF850449    AHA83611.1    AF088986    AAD33106.1    JF792617    AFG25764.1    AF088985    KY370043    ATP66729.1    KF294372    AID16663.1    KY370048    ATP66758.1    KY370051    ATP66775.1    KF294370    AID16651.1    KF294371    AID16657.1    KY370049    ATP66764.1    MH687970    AYR18620.1    MH687968    AYR18602.1    MG518518    AVN88327.1    KY370047    ATP66752.1    MH687971    MH687972    MH687973    MH687974    MH687975    MH687976    MH687977    MH687978    AYR18629.1    AYR18638.1    AYR18647.1    AYR18656.1    AYR18665.1    AYR18674.1    AYR18683.1    AYR18692.1    FJ938064    ACT11000.1    EF424624    ABP38331.1    FJ938065    ACT11012.1    EF424618    ABP38270.1    EF424623    ABP38325.1    FJ938066    ACT11023.1    EF424615    ABP38238.1    FJ425187    ACJ66984.1    EF424621    ABP38305.1    EF424616    ABP38250.1    EF424620    ABP38285.1    DQ915164    ABI94002.1    EF424622    ABP38308.1    EF424617    ABP38255.1    DQ016129    DQ016130    DQ016131    DQ016132    DQ016134    AAY33933.1    AAY33936.1    AAY33939.1    AAY33942.1    AAY33948.1    AF391542    FJ425189    ACJ67005.1    FJ425186    ACJ66966.1    FJ425185    ACJ66958.1    FJ938063    ACT10988.1    FJ425184    ACJ66952.1    EF371516    ABN49621.1    DQ811784    ABG89282.1    EF371515    ABN49620.1    AH014871    AH014873    KU886219    AAY33945.1    AAY33951.1    ANJ04979.1    KU558922    KU558923    ANJ04722.1    ANJ04733.1    FJ425188    FJ425190    ACJ66992.1    AF058944    AF058943    KM349742    KM349743    KM349744    AJA91200.1    AJA91211.1    AJA91221.1    AF391541    MG757138    MG757139    MG757140    MG757141    MG757142    AVI15005.1    AVI15016.1    AVI15027.1    AVI15038.1    AVI15049.1    AY316299    FJ415324    AAQ67201.1    ACJ35488.1    AH014866    AAY33930.1    EF424619    ABP38278.1    JN874561    AFE48820.1    KF294357    AID16633.1    KM985633    AJL33726.1    EU999954    ACL13000.1    GQ918143    ACX46865.1    MH687969    AYR18611.1    JN874559    JN874562    AFE48798.1    AFE48830.1    KF906249    KF906250    KF906251    AHN64777.1    AHN64786.1    AHN64795.1    KT368891    MF593476    ALA50083.1    ATI09452.1    AF220295    M27474    U00735    FJ938067    ACT11035.1    AB354579    BAF75636.1   

Proteomes

UP000098534    UP000151686    UP000119015    UP000138757    UP000113498    UP000155907    + More
UP000112338    UP000164259    UP000171340    UP000171975    UP000159025    UP000163097    UP000180349    UP000180350    UP000007192    UP000167944    UP000118088    UP000117254    UP000148943    UP000158592    UP000133456    UP000142874    UP000143567    UP000154289    UP000139707    UP000114687    UP000007193    UP000149957    UP000173347    UP000175084    UP000161770    UP000136745    UP000147178    UP000139966    UP000173415    UP000163913    UP000162935    UP000121953    UP000158327    UP000136116    UP000127099    UP000170940    UP000154814    UP000139235    UP000151273    UP000008571    UP000133443    UP000140344    UP000104294    UP000172225    UP000174569    UP000147981    UP000102696    UP000148210    UP000144342    UP000153628    UP000174571    UP000008570    UP000158296    UP000134650    UP000125269    UP000107676    UP000145001    UP000121258    UP000145507    UP000149260    UP000158231    UP000008572    UP000007554    UP000164707    UP000168103   

PRIDE

Q9JEB4   

Pfam

PF01635   Corona_M

Interpro

IPR002574   Corona_M

ProteinModelPortal

C0KYT4   C0KYR4   C0KYY2   C0KZ03   Q9J3E3   S5YGC7   + More
A7U548   C0KYW5   Q77NM8   A0A2D1CEC5   C3VPF2   P03415   A0A2S0SZ14   C0KYX3   A0A2D1CEF4   H9BZY2   D7PJY4   Q5ICW8   C0KYZ3   C0KYS5   C0KYU4   C0KYV5   A0A513RAU2   Q9J3F0   D4QFK5   Q9JEB4   Q7TG51   I7AB50   P08549   Q9QD00   I7AB57   A0A513RAU4   C6GHS5   I1TMG6   Q9IKC7   V5N7E5   Q9WCD2   I1TMH6   Q9WCD1   A0A2H4MXA4   A0A096XNI0   A0A2H4MWZ9   A0A2H4N019   A0A096XNG2   A0A096XNH8   A0A2H4MXY2   A0A3G3NH91   A0A3G3NH08   A0A2P1IQA5   A0A2H4MZ01   A0A3G3NH59   C6GHN0   A4ZU79   C6GHP2   A4ZU13   A4ZU68   C6GHQ3   A4ZTY0   B7U2P8   A4ZU46   A4ZTZ1   A4ZU35   Q06BD5   A4ZU57   A4ZU02   Q4U3R5   Q8V433   B7U2S0   B7U2N8   B7U2M7   C6GHL8   B7U2L6   A3FEW1   Q0PL34   A3FEW0   Q4U3R0   A0A191URC8   B7U2Q9   P69600   P69599   A0A0A7V404   Q91A23   A0A3S7GYH1   Q6W359   Q4U3R7   A4ZU24   H9AA58   A0A096XNF0   A0A0C5B155   B8RIR2   D0EY98   A0A3G3NGZ2   H9AA37   X2JFA7   A0A0U2GR22   P69705   P69704   P69703   C6GHR5   A7BKC7  

KEGG

vg:1489756     vg:11273172     vg:22807885     vg:921686     vg:11948237    

GO

GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0039660  F:structural constituent of virion
GO:0055036  C:virion membrane
GO:0044178  C:host cell Golgi membrane
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0019058  P:viral life cycle
GO:0044177  C:host cell Golgi apparatus

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Virion membrane   Largely embedded in the lipid bilayer.   With evidence from 1 publications.
Host Golgi apparatus membrane   Largely embedded in the lipid bilayer.   With evidence from 1 publications.

Length:

228

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

64.7462799999999

Exp number, first 60 AAs:

26.28326

Total prob of N-in:

0.55612

POSSIBLE N-term signal

sequence

inside

1  -  25

TMhelix

26  -  45

outside

46  -  49

TMhelix

50  -  72

inside

73  -  78

TMhelix

79  -  101

outside

102  -  228

 

 

Pi

0.2132888

Theta

0.3348037

Tajima's D

-1.0476155

CLR

3.554251

Interpretation

No evidence of Selection