Strain

CHINA_HS_2004_NC_006577 (Region: China: Hong Kong;  Strain: Human coronavirus HKU1, complete genome.;  Date: 2004)

Gene

membrane glycoprotein

Description

Annotated in NCBI,  membrane glycoprotein

Location

NC_006577(+):27633-28304

GenBank Accession

YP_173241.1

Full name

Membrane protein      

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

CDS

ATGAATAAATCTTTTCTTCCTCAATTTACTTCTGATCAAGCTGTTACATTCTTAAAAGAATGGAATTTCTCTTTGGGTGTAATACTACTTTTTATTACTATCATATTGCAGTTCGGTTATACGAGCCGTAGTATGTTTGTTTATCTTATCAAGATGATTATTCTTTGGCTTATGTGGCCATTGACTATCACCTTGACTATATTTAATTGTTTTTATGCTTTGAATAATGCTTTTCTTGCATTTTCTATAGTGTTTACTATTATTTCTATTGTTATATGGATTCTTTATTTTGTTAATAGTATTCGGCTTTTTATTAGAACTGGCAGTTGGTGGAGTTTTAATCCAGAGACCAATAATCTTATGTGTATTGATATGAAAGGCAAGATGTTTGTTAGGCCAGTTATTGAGGACTATCACACATTAACTGCTACTGTTATTCGTGGTCATCTTTATATACAGGGTGTCAAACTTGGCACTGGTTATACTCTTTCAGATTTGCCCGTATATGTTACTGTAGCTAAGGTGCAAGTACTTTGTACCTATAAACGTGCCTTTTTAGATAAGTTAGATGTTAATAGTGGTTTTGCTGTTTTTGTTAAGTCTAAAGTTGGTAACTATCGTTTACCGTCTAGTAAACCTAGTGGTATGGATACTGCCTTGTTAAGAGCTTAA

Protein

MNKSFLPQFTSDQAVTFLKEWNFSLGVILLFITIILQFGYTSRSMFVYLIKMIILWLMWPLTITLTIFNCFYALNNAFLAFSIVFTIISIVIWILYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGKMFVRPVIEDYHTLTATVIRGHLYIQGVKLGTGYTLSDLPVYVTVAKVQVLCTYKRAFLDKLDVNSGFAVFVKSKVGNYRLPSSKPSGMDTALLRA

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Miscellaneous

Isolate N1 belongs to genotype A.
Isolate N5 belongs to genotype C. Genotype C probably arose from recombination between genotypes A and B.
Isolate N2 belongs to genotype B.

Similarity

Belongs to the betacoronaviruses M protein family.

Keywords

Glycoprotein   Host Golgi apparatus   Host membrane   Host-virus interaction   Membrane   Transmembrane   Transmembrane helix   Viral envelope protein   Viral immunoevasion   Viral matrix protein   Virion   Reference proteome  

Feature

chain  Membrane protein

Uniprot

Q0ZJH0   Q5MQC7   Q0ZJM6   Q0ZJ82   Q0ZJD0   Q0ZJD8   + More
Q0ZJ90   Q0ZME4   Q0ZJA6   Q14EA7   A0A3Q9JNI0   A0A2H4N019   A0A096XNI0   Q9J3F0   Q9JEB4   D4QFK5   Q7TG51   Q9QD00   A8R4D6   A0A1V0IGA2   Q2QKM9   Q8BB24   A0A1V0IGB5   A0A0K2RVN4   Q8JSP5   A0A1Z3FR08   A0A166MX93   A0A2P1IQA5   B7U2S0   B7U2N8   B7U2M7   C6GHL8   B7U2L6   Q0PL34   Q4U3R0   A0A191URC8   B7U2Q9   P69600   P69599   A3FEW1   A3FEW0   Q6W351   A0A2R4KSQ9   A0A3S7GYH1   Q6W359   A0A1V0IG90   A0A1V0JAZ7   C6GHN0   A4ZU79   C6GHP2   A4ZU13   A4ZU68   C6GHQ3   A4ZTY0   B7U2P8   A4ZU46   A4ZTZ1   A4ZU35   Q06BD5   A4ZU57   A4ZU02   Q4U3R5   Q8V433   A4ZU24   Q4U3R7   C6GHR5   Q91A23   A0A0C5B155   Q4U3Q8   A8HB21   B5M8W0   Q4U3Q9   A0A3Q9K3V9   A0A3G3NH91   A0A2H4MXA4   A0A2R4STQ1   A0A3G3NH08   A0A096XNG2   A0A096XNH8   A0A2H4MWZ9   A0A2H4MXY2   A0A3T0IBJ5   A0A2S0SZ14   A7U548   C0KYW5   C0KYT4   C0KYR4   C0KYY2   C0KZ03   Q9J3E3   S5YGC7   Q77NM8   A0A2D1CEC5   C3VPF2   P03415   H9BZY2   D7PJY4   Q5ICW8   A0A513RAU2  

Pubmed

16809319    15613317    20719951    24394697    29217279    30285857    + More
25463600    10725548    11502093    12784855    17706262    26271151    16809333    12237422    29508550    18842722    16604443    27274850    9778786    17344285    17434558    17459444    11714968    17916374    24756345    20631137    17041219    10438865    15709029    17079303    11582515    16341254    8392595    6325918    6331107    9426441    1400501    10438834    10799570    1629209    20519394    15507445   

EMBL

DQ415903    ABD75556.1    AY597011    DQ415896    HM034837    ABD75500.1    + More
ADN03342.1    DQ415900    DQ415901    DQ415904    DQ415905    DQ415906    DQ415909    DQ415910    DQ415914    KF430201    KF686340    KF686342    KF686343    KF686346    KT779555    KT779556    KY674941    KY674942    KY674943    KY983584    LC315650    ABD75532.1    ABD75540.1    ABD75564.1    ABD75572.1    ABD75580.1    ABD75604.1    ABD75612.1    ABD75644.1    AGT17772.1    AGW27839.1    AGW27857.1    AGW27866.1    AGW27884.1    AMN88689.1    AMN88697.1    ARB07602.1    ARB07611.1    ARB07620.1    ARU07580.1    BBA20985.1    DQ415908    ABD75596.1    DQ415907    KF686341    KF686344    ABD75588.1    AGW27848.1    AGW27875.1    DQ415897    DQ415898    DQ415899    DQ415912    DQ415913    ABD75508.1    ABD75516.1    ABD75524.1    ABD75628.1    ABD75636.1    DQ339101    DQ415902    DQ415911    KY674921    MH940245    LC315651    ABD75548.1    ABD75620.1    ARB07441.1    AYN64564.1    BBA20988.1    AY884001    MK167038    AZS52621.1    KY370051    ATP66775.1    KF294372    AID16663.1    AF208066    AAF69337.1    AF126508    AF201929    AB551247    BAJ04700.1    AY102934    AAM55466.1    AF190407    AAF05705.1    EF446615    LC061272    ABP87994.1    BAS18849.1    KY419104    KY419105    KY419110    KY419112    ARC95214.1    ARC95222.1    ARC95254.1    ARC95270.1    DQ011855    KY419103    AAY68301.1    ARC95206.1    AY078417    KY419107    KY419109    KY419111    KY419113    ARC95238.1    ARC95246.1    ARC95262.1    ARC95277.1    LC061273    LC061274    BAS18859.1    BAS18869.1    AF481863    KY348417    KY994645    ASC42971.1    AUF40279.1    KU127229    ANA52020.1    MG518518    AVN88327.1    FJ425189    ACJ67005.1    FJ425186    ACJ66966.1    FJ425185    ACJ66958.1    FJ938063    ACT10988.1    FJ425184    ACJ66952.1    DQ811784    ABG89282.1    AH014871    AH014873    KU886219    AAY33945.1    AAY33951.1    ANJ04979.1    KU558922    KU558923    ANJ04722.1    ANJ04733.1    FJ425188    FJ425190    ACJ66992.1    AF058944    AF058943    EF371516    ABN49621.1    EF371515    ABN49620.1    AY316300    AAQ67209.1    MF083115    AVV64338.1    MG757138    MG757139    MG757140    MG757141    MG757142    AVI15005.1    AVI15016.1    AVI15027.1    AVI15038.1    AVI15049.1    AY316299    FJ415324    AAQ67201.1    ACJ35488.1    KY419106    ARC95230.1    KX982264    ARD06004.1    FJ938064    ACT11000.1    EF424624    ABP38331.1    FJ938065    ACT11012.1    EF424618    ABP38270.1    EF424623    ABP38325.1    FJ938066    ACT11023.1    EF424615    ABP38238.1    FJ425187    ACJ66984.1    EF424621    ABP38305.1    EF424616    ABP38250.1    EF424620    ABP38285.1    DQ915164    ABI94002.1    EF424622    ABP38308.1    EF424617    ABP38255.1    DQ016129    DQ016130    DQ016131    DQ016132    DQ016134    AAY33933.1    AAY33936.1    AAY33939.1    AAY33942.1    AAY33948.1    AF391542    EF424619    ABP38278.1    AH014866    AAY33930.1    FJ938067    ACT11035.1    AF391541    KM985633    AJL33726.1    AH014875    AAY33957.1    EU019216    ABV74059.1    FJ009233    ACH72649.1    AH014874    AAY33954.1    MK095156    MK095157    AZS64203.1    AZS64204.1    MH687970    AYR18620.1    KY370043    ATP66729.1    MH043952    MH043953    MH043954    MH043955    MK095148    MK095149    MK095150    MK095151    MK095152    MK095153    MK095154    MK095155    MK095158    MK095159    MK095160    AVZ61104.1    AVZ61114.1    AVZ61124.1    AVZ61134.1    AZS64195.1    AZS64196.1    AZS64197.1    AZS64198.1    AZS64199.1    AZS64200.1    AZS64201.1    AZS64202.1    AZS64205.1    AZS64206.1    AZS64207.1    MH687968    AYR18602.1    KF294370    AID16651.1    KF294371    AID16657.1    KY370048    ATP66758.1    KY370049    ATP66764.1    MH810163    AZU96329.1    MF416379    AWB14617.1    EF682498    ABS87268.1    FJ647223    ACN89740.1    FJ647220    ACN89707.1    FJ647218    ACN89692.1    FJ647225    ACN89755.1    FJ647227    ACN89781.1    AF208067    AY700211    AAF69348.1    AAU06360.1    KF268336    KF268337    KF268338    KF268339    AGT17720.1    AGT17731.1    AGT17742.1    AGT17753.1    AF207902    AAF68927.1    MF618252    ATN37891.1    FJ884686    FJ884687    ACO72887.1    X00509    M25894    AF029248    JQ173883    AFD97611.1    GU593319    ADI59792.1    AY771998    AAW47244.1    MH687884    MH687885    QCI55925.1    QCI55926.1   

Proteomes

UP000148743    UP000008170    UP000108760    UP000118444    UP000098016    UP000098607    + More
UP000102058    UP000103177    UP000120443    UP000122230    UP000123677    UP000134208    UP000139452    UP000143896    UP000147573    UP000161305    UP000168247    UP000173725    UP000174991    UP000164754    UP000107950    UP000127413    UP000173897    UP000107997    UP000134743    UP000143869    UP000156925    UP000168964    UP000001985    UP000124867    UP000162514    UP000006551    UP000143567    UP000139707    UP000154289    UP000103372    UP000166748    UP000125924    UP000007546    UP000130220    UP000155347    UP000007543    UP000133443    UP000140344    UP000104294    UP000172225    UP000174569    UP000147981    UP000102696    UP000148210    UP000158296    UP000136745    UP000147178    UP000139966    UP000173415    UP000163913    UP000162935    UP000121953    UP000158327    UP000136116    UP000127099    UP000170940    UP000154814    UP000139235    UP000151273    UP000008571    UP000134650    UP000164707    UP000008570    UP000159025    UP000098534    UP000151686    UP000119015    UP000138757    UP000113498    UP000155907    UP000112338    UP000164259    UP000171340    UP000171975    UP000163097    UP000180349    UP000180350    UP000007192    UP000118088    UP000117254   

PRIDE

Q9JEB4   

Pfam

PF01635   Corona_M

Interpro

IPR002574   Corona_M

ProteinModelPortal

Q0ZJH0   Q5MQC7   Q0ZJM6   Q0ZJ82   Q0ZJD0   Q0ZJD8   + More
Q0ZJ90   Q0ZME4   Q0ZJA6   Q14EA7   A0A3Q9JNI0   A0A2H4N019   A0A096XNI0   Q9J3F0   Q9JEB4   D4QFK5   Q7TG51   Q9QD00   A8R4D6   A0A1V0IGA2   Q2QKM9   Q8BB24   A0A1V0IGB5   A0A0K2RVN4   Q8JSP5   A0A1Z3FR08   A0A166MX93   A0A2P1IQA5   B7U2S0   B7U2N8   B7U2M7   C6GHL8   B7U2L6   Q0PL34   Q4U3R0   A0A191URC8   B7U2Q9   P69600   P69599   A3FEW1   A3FEW0   Q6W351   A0A2R4KSQ9   A0A3S7GYH1   Q6W359   A0A1V0IG90   A0A1V0JAZ7   C6GHN0   A4ZU79   C6GHP2   A4ZU13   A4ZU68   C6GHQ3   A4ZTY0   B7U2P8   A4ZU46   A4ZTZ1   A4ZU35   Q06BD5   A4ZU57   A4ZU02   Q4U3R5   Q8V433   A4ZU24   Q4U3R7   C6GHR5   Q91A23   A0A0C5B155   Q4U3Q8   A8HB21   B5M8W0   Q4U3Q9   A0A3Q9K3V9   A0A3G3NH91   A0A2H4MXA4   A0A2R4STQ1   A0A3G3NH08   A0A096XNG2   A0A096XNH8   A0A2H4MWZ9   A0A2H4MXY2   A0A3T0IBJ5   A0A2S0SZ14   A7U548   C0KYW5   C0KYT4   C0KYR4   C0KYY2   C0KZ03   Q9J3E3   S5YGC7   Q77NM8   A0A2D1CEC5   C3VPF2   P03415   H9BZY2   D7PJY4   Q5ICW8   A0A513RAU2  

KEGG

vg:3200428     vg:921686     vg:1489756    

GO

GO:0039660  F:structural constituent of virion
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane
GO:0019058  P:viral life cycle
GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0044178  C:host cell Golgi membrane
GO:0044177  C:host cell Golgi apparatus

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Virion membrane   Largely embedded in the lipid bilayer.   With evidence from 1 publications.
Host Golgi apparatus membrane   Largely embedded in the lipid bilayer.   With evidence from 1 publications.

Length:

223

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

64.41361

Exp number, first 60 AAs:

31.73317

Total prob of N-in:

0.63867

POSSIBLE N-term signal

sequence

outside

1  -  19

TMhelix

20  -  39

inside

40  -  45

TMhelix

46  -  68

outside

69  -  77

TMhelix

78  -  100

inside

101  -  223