Strain

CHINA_MURINE_2012_NC_026011 (Region: China;  Strain: Betacoronavirus HKU24 strain HKU24-R05005I, complete genome.;  Date: 2012)

Gene

membrane protein

Description

Annotated in NCBI,  membrane protein

Location

NC_026011(+):28908-29603

GenBank Accession

YP_009113029.1

Full name

Membrane protein      

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

CDS

ATGAGTGGTCAAGCAACAACCCCAGAGCCAATCTATAGCTGGACTGCGGATGAGGCAATTAGATTCCTAAAAGAATGGAATTTCTCTTTGGGTATCATACTACTTGTAATCACAATCATACTACAGTTCGGTTATACGAGCCGTAGCATGTTTGTCTATGTCATCAAGATGATAATTCTCTGGCTCATGTGGCCTCTGACTATCATTTTGGTTATTTTTAATTGCGTTTACGCATTGAATAATGTGTATCTTGGATTTTCTATAGTGTTTGCTATAGTGTCCATTATTATGTGGATTGTGTATTTTGTGAATAGTATTAGGTTGTTTATTAGAACGGGAAGTTGGTGGAGTTTCAACCCCGAAACAAACAACCTGATGTGTATAGATATGAAAGGGAGAATGTTTGTTAGGCCCATAATTGAGGACTATCATACCCTTACGGTCACAATAATACGTGGCCACCTTTACATTCAGGGTATAAAGCTTGGTACCGGCTATACTCTATCTGACCTTCCCGCTTATGTGACTGTAGCAAAAGTTACACACATTTGCACGTATAAGCGGGCATTTTTGGATAAGATAGGCGATATCAGTGGTTTTGCAGTATATGTGAAGTCCAAAGTCGGCAATTACCGGCTGCCATCCTCTCAAAAAGGGAATGGCATGGATACCGCATTGTTGAGAAATAATGTCTAA

Protein

MSGQATTPEPIYSWTADEAIRFLKEWNFSLGIILLVITIILQFGYTSRSMFVYVIKMIILWLMWPLTIILVIFNCVYALNNVYLGFSIVFAIVSIIMWIVYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGRMFVRPIIEDYHTLTVTIIRGHLYIQGIKLGTGYTLSDLPAYVTVAKVTHICTYKRAFLDKIGDISGFAVYVKSKVGNYRLPSSQKGNGMDTALLRNNV

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the betacoronaviruses M protein family.
Belongs to the alphacoronaviruses M protein family.

Keywords

Glycoprotein   Host Golgi apparatus   Host membrane   Host-virus interaction   Membrane   Transmembrane   Transmembrane helix   Viral envelope protein   Viral immunoevasion   Viral matrix protein   Virion   Reference proteome  

Feature

chain  Membrane protein

Uniprot

A0A0A7V404   A0A2H4MZ01   A0A3G3NH59   A0A096XNF0   A0A3G3NGZ2   A0A2H4MWZ4   + More
A0A5J6NRK8   H9AA47   A0A5J6NRN4   A0A5J6NUI0   H9AA58   H9AA37   D0EY98   B7U2S0   B7U2N8   B7U2M7   C6GHL8   B7U2L6   Q0PL34   Q4U3R0   A0A191URC8   B7U2Q9   P69600   P69599   A3FEW1   A3FEW0   A0A3S7GYH1   Q6W359   A0A2P1IQA5   X2JFA7   A0A0U2GR22   P69705   P69704   P69703   C6GHN0   A4ZU79   C6GHP2   A4ZU13   A4ZU68   C6GHQ3   A4ZTY0   B7U2P8   A4ZU46   A4ZTZ1   A4ZU35   Q06BD5   A4ZU57   A4ZU02   Q4U3R5   Q8V433   A0A5J6NWV2   C6GHR5   Q91A23   Q4U3R7   A0A2H4MX17   Q9QAR9   A4ZU24   A8HB21   Q2QKM9   Q8BB24   A0A1V0JAZ7   P26021   Q4U3Q9   A7BKC7   Q4U3Q8   D0EY88   A0A3G3NH91   Q8JSP5   B8RIR2   A0A2R4STQ1   A3E2F6   A0A1S6KXR4   A0A0C5B155   A0A1Z3FR08   A0A1V0IGA2   A0A411D599   A0A3Q9K3V9   A0A1V0IGB5   A0A166MX93   U3M7X5   D0EY78   A0A2R4KSQ9   U3M790   U3M7A7   A0A1V0IG90   B5M8W0   U3M7H9   U3M750   U3M7I1   U3M771   A0A0B4UEX4   A0A513ZT13   Q01455   A0A3G3NH08   A0A096XNH8   A0A3T0IBJ5   Q4VID2   A8R4D6   A0A2H4MWZ9   A0A2H4MXY2  

Pubmed

25552712    30285857    25463600    31534035    22398294    18842722    + More
16604443    27274850    9778786    29508550    24655427    26678874    11774548    3029965    3434434    7966615    9371586    1706882    17344285    17434558    17459444    11714968    17916374    16809333    12237422    1856695    17374765    23405345    19162098    17092595    24756345    25530469    1402806    15280490    15650185    15914223    21849456    17706262    26271151   

EMBL

KM349742    KM349743    KM349744    AJA91200.1    AJA91211.1    AJA91221.1    + More
KY370047    ATP66752.1    MH687971    MH687972    MH687973    MH687974    MH687975    MH687976    MH687977    MH687978    AYR18629.1    AYR18638.1    AYR18647.1    AYR18656.1    AYR18665.1    AYR18674.1    AYR18683.1    AYR18692.1    KF294357    AID16633.1    MH687969    AYR18611.1    KY370046    ATP66746.1    MN514963    QEY10636.1    JN874560    AFE48808.1    MN514966    QEY10660.1    MN514964    MN514965    MN514967    QEY10644.1    QEY10652.1    QEY10668.1    JN874561    AFE48820.1    JN874559    JN874562    AFE48798.1    AFE48830.1    GQ918143    ACX46865.1    FJ425189    ACJ67005.1    FJ425186    ACJ66966.1    FJ425185    ACJ66958.1    FJ938063    ACT10988.1    FJ425184    ACJ66952.1    DQ811784    ABG89282.1    AH014871    AH014873    KU886219    AAY33945.1    AAY33951.1    ANJ04979.1    KU558922    KU558923    ANJ04722.1    ANJ04733.1    FJ425188    FJ425190    ACJ66992.1    AF058944    AF058943    EF371516    ABN49621.1    EF371515    ABN49620.1    MG757138    MG757139    MG757140    MG757141    MG757142    AVI15005.1    AVI15016.1    AVI15027.1    AVI15038.1    AVI15049.1    AY316299    FJ415324    AAQ67201.1    ACJ35488.1    MG518518    AVN88327.1    KF906249    KF906250    KF906251    AHN64777.1    AHN64786.1    AHN64795.1    KT368891    MF593476    ALA50083.1    ATI09452.1    AF220295    M27474    U00735    FJ938064    ACT11000.1    EF424624    ABP38331.1    FJ938065    ACT11012.1    EF424618    ABP38270.1    EF424623    ABP38325.1    FJ938066    ACT11023.1    EF424615    ABP38238.1    FJ425187    ACJ66984.1    EF424621    ABP38305.1    EF424616    ABP38250.1    EF424620    ABP38285.1    DQ915164    ABI94002.1    EF424622    ABP38308.1    EF424617    ABP38255.1    DQ016129    DQ016130    DQ016131    DQ016132    DQ016134    AAY33933.1    AAY33936.1    AAY33939.1    AAY33942.1    AAY33948.1    AF391542    MN514962    QEY10628.1    FJ938067    ACT11035.1    AF391541    AH014866    AAY33930.1    KY370052    ATP66781.1    AF058942    EF424619    ABP38278.1    EU019216    ABV74059.1    DQ011855    KY419103    AAY68301.1    ARC95206.1    AY078417    KX982264    ARD06004.1    AH014874    AAY33954.1    AB354579    BAF75636.1    AH014875    AAY33957.1    GQ918142    JX860640    ACX46855.1    AFW97365.1    MH687970    AYR18620.1    AF481863    EU999954    ACL13000.1    MH043952    MH043953    MH043954    MH043955    MK095148    MK095149    MK095150    MK095151    MK095152    MK095153    MK095154    MK095155    MK095158    MK095159    MK095160    AVZ61104.1    AVZ61114.1    AVZ61124.1    AVZ61134.1    AZS64195.1    AZS64196.1    AZS64197.1    AZS64198.1    AZS64199.1    AZS64200.1    AZS64201.1    AZS64202.1    AZS64205.1    AZS64206.1    AZS64207.1    DQ682406    ABG78752.1    KX432213    AQT26503.1    KM985633    AJL33726.1    KY348417    KY994645    ASC42971.1    AUF40279.1    KY419104    KY419105    KY419110    KY419112    ARC95214.1    ARC95222.1    ARC95254.1    ARC95270.1    MH249786    QAY30025.1    MK095156    MK095157    AZS64203.1    AZS64204.1    KY419107    KY419109    KY419111    KY419113    ARC95238.1    ARC95246.1    ARC95262.1    ARC95277.1    KU127229    ANA52020.1    KF530064    KF530072    KF530078    KF530080    AGT51454.1    AGT51534.1    AGT51593.1    AGT51613.1    GQ918141    ACX46845.1    MF083115    AVV64338.1    KF530059    KF530062    KF530074    KF530075    KF530085    KF530087    KF530090    KF530093    KF530097    AGT51405.1    AGT51434.1    AGT51554.1    AGT51564.1    AGT51663.1    AGT51683.1    AGT51713.1    AGT51743.1    AGT51783.1    KF530092    KU131570    KY967360    KY014281    KY014282    MF314143    MK327281    AGT51733.1    AMK59680.1    ARK08673.1    ATP16760.1    ATP16770.1    AVQ05267.1    QBP84762.1    KY419106    ARC95230.1    FJ009233    ACH72649.1    KF530060    KF530077    KF530083    KF530086    AGT51415.1    AGT51583.1    AGT51643.1    AGT51673.1    KF530067    KF530071    KF530076    KF530079    KF530088    KF530089    KF530091    KF530094    KF530095    KF530096    AGT51484.1    AGT51524.1    AGT51573.1    AGT51603.1    AGT51693.1    AGT51703.1    AGT51723.1    AGT51753.1    AGT51763.1    AGT51773.1    KF530061    KF530065    KF530066    KF530073    AGT51425.1    AGT51464.1    AGT51474.1    AGT51544.1    KF530082    AGT51633.1    KP198610    KP198611    AJC98130.1    AJC98138.1    MN026165    QDH43729.1    M93390    AY585229    AY585228    AY391777    MH687968    AYR18602.1    KF294371    AID16657.1    MH810163    AZU96329.1    AY903459    AY903460    JN129834    JN129835    KF530063    KF530068    KF530069    KF530070    KF530081    KF530084    KF530098    KF530099    MK303625    MN306043    AAX85672.1    AAX85681.1    AEN19361.1    AEN19369.1    AGT51444.1    AGT51494.1    AGT51504.1    AGT51514.1    AGT51623.1    AGT51653.1    AGT51793.1    AGT51803.1    QBQ01842.1    QEG03780.1    EF446615    LC061272    ABP87994.1    BAS18849.1    KY370048    ATP66758.1    KY370049    ATP66764.1   

Proteomes

UP000144342    UP000153628    UP000174571    UP000124585    UP000125269    UP000107676    + More
UP000145001    UP000133443    UP000140344    UP000104294    UP000172225    UP000174569    UP000147981    UP000102696    UP000148210    UP000158296    UP000121258    UP000145507    UP000149260    UP000158231    UP000008572    UP000007554    UP000136745    UP000147178    UP000139966    UP000173415    UP000163913    UP000162935    UP000121953    UP000158327    UP000136116    UP000127099    UP000170940    UP000154814    UP000139235    UP000151273    UP000008571    UP000164707    UP000008570    UP000134650    UP000125924    UP000007546    UP000168103    UP000137675    UP000007543    UP000100971    UP000115705    UP000154668    UP000165185    UP000105266    UP000147585    UP000149594    UP000149702    UP000165173    UP000170317    UP000126877    UP000147591    UP000096360    UP000136788    UP000159503    UP000167348    UP000097333    UP000104124    UP000109543    UP000119922    UP000122365    UP000140040    UP000143194    UP000150595    UP000158566    UP000160021    UP000106834    UP000143333    UP000147052    UP000168172    UP000114034    UP000133796    UP000134871    UP000007552    UP000100580    UP000180344    UP000100004    UP000109321    UP000117387    UP000119762    UP000130586    UP000140401    UP000155676    UP000159995    UP000161137    UP000168290    UP000172586    UP000173822    UP000103372    UP000166748   

Pfam

PF01635   Corona_M

Interpro

IPR002574   Corona_M

ProteinModelPortal

A0A0A7V404   A0A2H4MZ01   A0A3G3NH59   A0A096XNF0   A0A3G3NGZ2   A0A2H4MWZ4   + More
A0A5J6NRK8   H9AA47   A0A5J6NRN4   A0A5J6NUI0   H9AA58   H9AA37   D0EY98   B7U2S0   B7U2N8   B7U2M7   C6GHL8   B7U2L6   Q0PL34   Q4U3R0   A0A191URC8   B7U2Q9   P69600   P69599   A3FEW1   A3FEW0   A0A3S7GYH1   Q6W359   A0A2P1IQA5   X2JFA7   A0A0U2GR22   P69705   P69704   P69703   C6GHN0   A4ZU79   C6GHP2   A4ZU13   A4ZU68   C6GHQ3   A4ZTY0   B7U2P8   A4ZU46   A4ZTZ1   A4ZU35   Q06BD5   A4ZU57   A4ZU02   Q4U3R5   Q8V433   A0A5J6NWV2   C6GHR5   Q91A23   Q4U3R7   A0A2H4MX17   Q9QAR9   A4ZU24   A8HB21   Q2QKM9   Q8BB24   A0A1V0JAZ7   P26021   Q4U3Q9   A7BKC7   Q4U3Q8   D0EY88   A0A3G3NH91   Q8JSP5   B8RIR2   A0A2R4STQ1   A3E2F6   A0A1S6KXR4   A0A0C5B155   A0A1Z3FR08   A0A1V0IGA2   A0A411D599   A0A3Q9K3V9   A0A1V0IGB5   A0A166MX93   U3M7X5   D0EY78   A0A2R4KSQ9   U3M790   U3M7A7   A0A1V0IG90   B5M8W0   U3M7H9   U3M750   U3M7I1   U3M771   A0A0B4UEX4   A0A513ZT13   Q01455   A0A3G3NH08   A0A096XNH8   A0A3T0IBJ5   Q4VID2   A8R4D6   A0A2H4MWZ9   A0A2H4MXY2  

KEGG

vg:22807885     vg:11948237     vg:921686    

GO

GO:0019031  C:viral envelope
GO:0039660  F:structural constituent of virion
GO:0019058  P:viral life cycle
GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane
GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0044178  C:host cell Golgi membrane

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Host Golgi apparatus membrane  
Virion membrane  

Length:

231

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

64.8691200000001

Exp number, first 60 AAs:

27.30924

Total prob of N-in:

0.56148

POSSIBLE N-term signal

sequence

inside

1  -  25

TMhelix

26  -  45

outside

46  -  49

TMhelix

50  -  72

inside

73  -  78

TMhelix

79  -  101

outside

102  -  231

 

 

Pi

0.2851873

Theta

0.3638959

Tajima's D

-0.8934838

CLR

6.086995

Interpretation

No evidence of Selection