Coronavirus Database

Strain

Bat_DQ412042 (Region: China: Hubei; Strain: Bat SARS coronavirus Rf1, complete genome.; Date: 15/11/2004)

Gene

P1a

Description

Annotated in NCBI, P1a

Location

DQ412042(+):261-13394

GenBank Accession

ABD75321.1

Full name

Replicase polyprotein 1a

Alternative Name

ORF1a polyprotein

CDS

ATGGAGAGCCTTGTTCTTGGTGTCAACGAGAAAACACACGTCCAACTCAGTTTACCTGTTCTTCAGGTTAGTGACGTGTTAGTGCGTGGTTTCGGGGATACTGTGGAAGAAGCCCTAGCGGAAGCACGTGAACATCTTAAAAATGGCACTTGTGGCCTAGTAGAGCTGGAAAAAGGTGTTTTACGCCAGCTTGAAGAGCCCTATGTGTTCATTAAACGATCTGAAGCCTTAAGCACCACTCATGGCCATAAGGTTGTTGAATTGGTGGCTGAAATGAATGGCATTCAGTTCGGTCGTAGCGGTACAACACTGGGAGTTCTCGTGCCACATGTGGGCGAAACCCCAATTGCGTACCGCAATGTTCTTCTTCGCAAGAACGGTAATAAGGGAGCTGGTGGTCATAGCTACGGCATCGATCTAAAGTCTTATGACTTAGGTGACGAGCTTAACACTGATCCCATTGAAGATTATGAACAAAAATGGAACACTAAGCATGGCAGGGGTGCTCTCCGTGAACTCATTCGTGAGCTTAATGGAGGTGCAGTCACTCGCTATGTTGATAACAACTTCTGTGGCCCTGATGGGTATCCTCTTGACTGCATTAAAGATCTTCTCGCTCGTGCGGGTAAGTCGATGTGCACTCTTTCCGAACAACTTGATTTCATTGAATCGAAGCGCGGTGTCTATTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACTGAGCGCTCAGACAAGAGTTATGAGCACCAGACACCATTCGAGGTTAAGAGTGCCAAGAAATTTGACACTTTTAAAGGGGAATGCCCGAAGTTCGTATTTCCTCTCAACTCTAAAGTCAAAGTCATTCAACCACGTGTTGAAAAGAAAAAGACTGAAGGTTTCATGGGGCGTATACGCTCTGTGTACCAAGTTGCCACTCCAAATGAATGCAACGACATGCACTTGTCTGTCTTTATGAAGTGCAATCATTGTGATGAAGCTTCTTGGCAGACGTGTGATTTTCTCAAAGCCACTTGTGAATATTGTGGCACTGAAAATCCAGTGAGTGGAGGACCTACTACATGTGGGTACCTACCTACTAATGCTGTAGTAAAGATGCCCTGTCCTGCTTGTCAGAATAAAGAAGTGGGACCTGAGCATAGTGTTGCAGACTACCACAATCACTCAAACATTGAAACTCGACTCCGCAAGGGAGGTAGGACTAAATGTTTTGGAGGCTGTGTGTTTTCCTATGTTGGCTGCTATAACAAGCGTGCTTACTGGGTTCCTCGTGCTAGTGCCGATATAGGTTCAAACCATACTGGCATTACCGGTGACAATGTAGAAGTTCTTAATGAAGACCTCCTTGAGATACTGAATCGTGAACGTGTTAATATTAACATTGTTGGCGATTTTCAGTTGAATGAAGAGATTGCCATCATTTTAGCGTCTCTTTCTGCTTCTACGAGTGCTTTTGTTGACACTGTAAAGAGTCTTGATTACAAGTCTTTTAAAGCCATTGTTGAGTCTTGCGGAAACTACGAAGTTACCAAGGGCAAGCCTGTGAAAGGTGCTTGGAACATTGGACAACAAAAATCTATTCTGACACCACTGTGTGGATTTCCATCACAGGCTGCTGGTGTTATTAGATCTATTTTCTCTCGCACACTAGATGCAGCAAATAATTCTATCCCAGATTTACAAAGAGCAGCTGTCACCATCCTCGGTGACATTTCCGAACAGTCACTGCGTCTTGTTGATGCAATGGTGTGTACATCAGACTTGATTACCAACAGTGTTATCATCATGGCATATGTTACTGGTGGTCTTGTACAGCAAACAGTGCAATGGTTGTCTAATGTGTTAGGCACCACAGTCGACAAACTCAAACCTGTATTTACATGGCTTGAGACTAAGCTTAATGCAGGAATAGAGTTTCTCAAGGATGCTTGGGAAATTCTTAAATTCCTAGTTACAGGTGTGTTTGACATTGTTAAAGGTCAAATACGGGTGTTTTCGGACAACCTCAAAGAATGTGTAAAAACTTTTGTTGGTGTTGTCAACAAAGCGCTTGAAATGTGCATTGACCAAGTCACAATCGCAGGCACCAAGGTGAGATCACTCAACCTTGGGGAGGTTTTTATTGCGCAAAGCAAGGGCCTCTACCGTCAGTGTGTTCGTGGCAAGGAGCAGCTGCAACTACTCATGCCTTTGAAGGCACCTAAAGAAGTCACTTTCCTTGAAGGAGACTCACATGATACAGTACTAATCTCCGAAGAGGTTGTTCTTAAAAATGGTGAGCTTGAAGCACTCGAGACACCAGTTGACAGTTTCACAAATGGAGCCGTCGTAGGCACTCCAGTTTGTGTCAATGGCCTCATGCTCTTGGAGCTCAAAGATAAGGAACAGTATTGTGCTTTATCTCCAGGCTTATTAGCTACAAACAATGTCTTCCGTCTAAATGGAGGTGCACCGGTTAAAGGTGTAACCTTTGGAGAAAACACTGTTTTAGAAGTTCAAGGTTACAAGAATGTGAAAATCACATTTGAGCTTGATGAGCGTGTAGACAAAGTGCTTAACGAGAAGTGTTCTGTCTACACTGTTGAATCCGGTACAGAGGTTACTGAATTCGCATGTGTTGTTGCAGAAGCCGTTGTAAAAGCTTTGCAACCAGTTTCTGACCTTCTTACTAAGATGGGTATTGACCTTGATGAGTGGAGTGTAGCTACATTCTACTTGTTTGATGATGCTGGTGAAGAAAAACTTTCATCACGCATGTACTGTTCCTTCTACCCTCCTGATGAGGAAGAAGACTGCGAAGAGTATGAGGATGAGGAAGAAGTTCCTGATGAAACCTGTGAACACGAATACGGCACAGAGGATGACTATAAAGGTCTTCCTCTTGAGTTTGGTTCGTCAACAGAAATACAACAGGTTGAAGATGAAGAGGAAGACTGGCTTGATGATGTTGGTGAAGCAGAACCTGAACCAGAACCTCTACCTGCAGAACCAGTTAATCAGTTTACTGGTTACTTTAAACTTACTGACAATGTTGCCATTAAATGTGTTGACATCGTTAAGGAAGCGCAAAGTGCCAAACCTGCGGTTATTGTTAATGCTGCTAACATTCACCTAAAACATGGTGGTGGTGTAGCAGGTGCACTCAACAAAGCAACCAATGGTGCCATGCAACAGGAGAGTGATGATTACATTAAACGAAATGGACCACTCACAGTAGGTGGTTCATGTTTGCTTTCTGGACACAATTTGGCTAAGAAGTGTATGCATGTTGTTGGCCCAAACCTAAATGCTGGTGAGGATGTCCAACTACTTAAAGCTGCATATGACAACTTTAATTCACAGGACGTATTACTTGCACCACTACTGTCAGCAGGCATATTTGGTGCTAAACCACTTCAGTCTTTAAAGATGTGTGTTGAAGTAGTTCGCACACAAGTTTACCTCGCGGTCAATGATAGGAGTCTTTATGATCAGGTTGTATTAGATTATCTGGACAGTTTGAAACCTAAAGTGGAGTCTCCCAAAAAGGAGGAGAATCCAAAATTGGAAGAGCATAAAGCGAAACAGCCAGCTGAAAAACCTGTTGACGTCAAACCTAAAATTAAGGCTTGTGTCGAAGAGGTTACTACAACATTGGAAGAAACTAAACTTCTCACCCAAAATCTGCTTCTTTTTGCTGATATCAATGGTAAACTTTACCCGGATTCTCAGAATATGCTAAGAGGTGAAGACATGTCTTTTCTAGAAAAGGACGCACCATATGTAGTAGGTGATGTCATCACTAGTGGTGATATTACTTGTGTTATAATACCTGCTAAGAAGGCTGGTGGTACTACAGAAATGCTTGCAAAGGCATTAAAGAAAGTGCCAGTGTGTGAGTATATAACTACATATCCCGGACAAGGATGTGCTGGTTATACACTCGAAGAAGCAAAGACTGCGCTTAAAAGGTGCAAATCTGCATGCTATGTATTACCTTCAAAAACACCTAATGTAAAAGATGAAATCCTTGGAACGGTGTCTTGGAATTTAAGGGAAATGCTTGCTCATGCTGAAGAGACAAGAAAATTAATGCCTATTTGCATGGACATTAGAGCCATAATGGCTACAATCCAACGTAAGTATAAAGGTATTAAGATTCAAGAAGGAATCGTTGACTATGGTGTTCGGTTCTTTTTCTATACTAGCAAAGAGCCTGTAGCTTCTATTATTACAAAACTCAATTCTTTAAATGAACCACTTATCACAATGCCGATAGGTTATGTGACACATGGTTTTAACCTGGAAGAAGCTGCGCGTTGTATGCGCTCTCTTAAAGCTCCTGCTGTAGTCTCAGTGTCTTCACCAGACGCAGTTACTACATACAATGGATACCTCACATCATCTTCAAAGACACCTGAGGAACACTTCATAGAGACCATCTCCCTTGCGGGTACGTATAGAGACTGGTCTTACTCTGGACAACGTACAGAATTAGGTGTTGAATTTCTCAAGCGTGGAGATAAGATTGTCTACCACACTATTGAAAAACCCACCGAGTTCTATCTTGACGGTGAGGTTCTCCCACTTGACAAGCTCAAGAGTCTTTTGTCTCTTCGTGAGGTTAAGACTATTAAAGTGTTTACTACTGTAGACAATACTAACCTCCACACACAACTTGTGGACATGTCTATGACATATGGACAGCACTTTGGTCCAACCTATTTGGACGGTGCTGATGTCACCAAGGTTAAGCCTCATGTTAATCATGAGGGTAAGACCTTCTTTGTACTACCTAGTGATGACACACTGCGTAGTGAAGCATTTGAATATTACCACACTCTCGACGAGAGTTTTCTCGGTAGATACATGTCTGCTTTGAATCACACAAAGAAATGGAAATTTCCTCAAGTTGGTGGTTTAACTTCAATCAAATGGGCTGACAATAACTGTTATTTGTCCAGTGTTTTATTAGCACTTCAGCAGATTGAGGTGAAGTTTAATGCACCCGCACTACAAGAGGCCTATTATAGAGCTCGTGCTGGTGATGCTGCTAATTTTTGTGCGCTCATACTCGCTTACAGTAATAAAACTGTGGGTGAGTTGGGTGATGTTAGGGAAACTATGACCCATCTTCTACAACATGCCAACTTGGAATCCGCTAAGAGGGTTCTTAATTTGGTGTGTAAGCATTGCGGACAGAAAACTACCACCTTAATGGGTGTAGAAGCCGTGATGTATATGGGTACTTTGTCTTATGATGAGCTTAAGGCAGGTGTTTCAATTCCTTGTGTGTGTGGTCGTGATGCTACACAATATCTAGTACAACAAGAGTCTTCTTTTGTTATGATGTCTGCACCTCCTGCTGAGTACAAGTTGCAGCAGGGTACATTTTTATGCGCTAATGAGTACACTGGTAATTATCAGTGTGGTCATTACACTCACATAACTGCCAAGGAAACGCTCTATCGTATAGATGGAGCTCACCTTACAAAAATGTCAGAATATAAAGGACCAGTGACTGATGTTTTCTATAAAGAAACATCTTACACTACAACTATTAAGCCTGTGTCATACAAACTCGACGGAGTTACTTACACAGAGATTGAACCTAAATTAGATGGGTATTATAAAAAGGATAATGCTTACTACACTGAGCAGCCTATTGATCTTGTGCCAACTCAACCATTGCCAAATGCGAGTTTTGACAATTTCAAACTCACATGCTCTAACATTAAGTTTGCTGATGACCTTAATCAAATGACAGGCTTTAAAAAGCCAGCTTCACGTGAGCTATCTGTCACATTCTTTCCAGACTTGAATGGCGATGTAGTGGCTATTGACTATAGACATTACTCAGCGAGTTTCAAGAAAGGTGCTAAACTGCTACATAAGCCAATTATTTGGCATATCAATCAGACTACAAACAAGACAACTTACAAGCCAAACATTTGGTGTTTACGTTGTCTTTGGAGTACAAAGCCAGTTGAAACCTCAAATTCATTTGAAGTTCTGGAAGTAGAAGGCACACAAGGAATGGATAATCTTGCTTGTGAAAGCCAACCACTAACCTCTGAAGAAGTAGTGGAAAATCCTACCGTACAGAAGGAAGTAATAGAGTGTGACGTGAAAACTACCGAAGTTGTAGGCAATGTCATACTAAAACCATCAGACGAAGGTGTCAAAGTGACACAAGAGTTAGGCCATGAAGATCTAATGGCTGCTTATGTAGAAAATACAAGCATTACCATTAAGAAACCTAATGAGCTCTCGTTGGCCTTAGGTTTAAAAACACTTGCCACTCATGGTGCTGCTGCAATCAATAGTGTCCCTTGGAGTAAGGTTTTGGCTTATGTTAAGCCTTTTCTAGGACAAGCAACAGTCACAACATCCAACTGCATGAAGAAATGTGTGCAGCGCATTTTTAACAACTATATGCCTTATGTCATTACATTATTATTCCAGTTGTGCACTTTCACAAAGGGCACCAACTCAAGAATTAGAGCATCACTTCCTACAACTATTGCTAAAAATAGTGTTAAGAGTGTTGCAAAATTATGTTTGGACGTTTGCATTGATTATGTGAAATCTCCTAAATCTTCTAAATTGTTCACAATTGCAATGTGGCTATTGTTGTTAAGCATTTGCTTGGGTTCATTAATCTATGTGACTGCAGCTTTTGGGGTGCTTTTATCTAATTTAGGCATCCCTTCTTATTGTGGTGGTGTTAGAGATTTGTATATCAATTCCTCTAATGTCACCATTATGGACTTCTGTGAGGGCTCTTTTCCTTGTAGTGTTTGTTTAAGTGGACTAGATTCTCTTGATTCTTACCCCGCTTTAGAAACTATTCAGGTTACGATTTCATCGTATAAGTTGGACCTAACATTTTTAGGTTTAGCAGCTGAATGGTTTTTGGCATACATGTTGTTTACAAAATTTTTCTACTTACTTGGTCTCTCTGCTATAATGCAGGTGTTCTTTGGCTACTTTGCTAGTCATTTCATCAGCAATTCATGGCTTATGTGGTTTATCATTAGCATTGTACAAATGGCGCCTGTTTCTGCTATGGTCAGGATGTACATTTTCTTTGCTTCTTTCTATTATATATGGAAAAGCTATGTTCATATTATGGATGGTTGCACTTCTTCAACGTGCATGATGAGCTACAAGCGCAATCGTGCTACGCGCGTTGAGTGTACAACTATAGTTAATGGCATGAAAAGATCTTTCTATGTCTATGCAAACGGAGGCCGTGGCTTCTGTAAGGCTCACAATTGGAACTGTCTTAATTGTGATACATTCTGTACTGGTAGTACTTTCATTAGCGACGAAGTAGCTCATGATTTGTCACTCCAGTTTAAGAGACCAATTAATCCTACAGACCAGTCTTCTTATGTTGTTGATAGTGTTGCTGTGAAGAACGGTGCACTCCACCTCTACTTTGATAAGGCTGGTCAGAAGACTTACGAGAGACACCCACTTTCTCATTTTGTCAATTTGGACAATCTGAGAGCTAACAACACTAAGGGTTCATTACCTATTAATGTTATTGTCTTTGACGGCAAGTCCAAGTGCGAAGAGTCTGCCGCCAAGTCTGCATCTGTTTATTACAGTCAGCTTATGTGCCAACCTATTCTGTTACTTGACCAAGCTCTTGTTTCGGATGTTGGTGATAGTACCGAGGTTTCTGTCAAGATGTTTGATGCTTATGTCGACACCTTTTCAGCAACTTTTAGTGTTCCTATGGAAAAACTTAAGGCACTAGTGGCCACGGCTCATAGTGAGTTGGCTAAGGGTGTTGCTTTGGATGGTGTCTTATCCACATTTATTTCAGCTGCCCGTCAAGGCGTTGTTGATACTGATGTTGATACAAAGGACGTCATTGAATGTCTCAAGCTTTCTCATCACTCTGACTTAGAAGTGACAGGTGACAGCTGTAATAACTTCATGCTCACCTATAACAAAGTTGAAAACATGACGCCCAGAGATCTTGGTGCATGTATTGATTGTAATGCAAGGCATATTAATGCCCAAGTAGCAAAAAGTCACAATGTCTCGCTCATCTGGAACGTCAAAGACTATATGTCATTGTCTGAACAGTTGCGCAAGCAAATTCGTGGTGCTGCTAAAAAGAACAACATACCCTTTAGGCTCACTTGTGCTACTACTAGGCAAGTTTTAAACGTCATAACTACTAAAATTTCACTCAAGGGTGGTAAGGTTGTTAGTACTTGGTTTAAATTTATGCTGAAAGTCACACTTTTGTGTGTTCTATCTGCATTATTCTGTTACATCATTATGCCAGTACACTCATTGTCTGTTCATGATGGTTATACAAATGAAATCATTGGATACAAAGCTATCCAGGACGGTGTCACTCGTGACATAGTGTCTACTGATGATTGTTTTGCAAACAAACATGCTGGTTTCGACTCTTGGTTTAGCCAGCGTGGTGGTTCTTATAGGAATGATAAGAGCTGCCCTGTTGTAGCTGCCATCATTACTAGGGAGATTGGTTTCATCGTGCCTGGATTACCTGGTACTGTGTTAAGAACAATTAATGGTGACTTTTTGCATTTTCTACCTCGCGTTTTTAGTGCCGTTGGCAACATTTGCTACACACCATCAAAACTTATTGAGTATAGTGATTTTGCTACTTCTGCTTGCGTCTTGGCTGCGGAATGTACCATTTTTAAGGACGCTATGGGTAAGCCTGTGCCATATTGTTATGACACTAACTTACTAGAGGGTTCTATTTCTTACAGTGAGCTGCGTCCTGACACTCGTTATGTGCTTATGGATGGCTCTATCATACAATTCCCTAACACCTACCTAGAAGGTTCTGTTAGAGTGGTTACAACTTTTGATGCAGAATACTGCCGTCATGGCACATGTGAGAGGTCAGAAGCTGGTATTTGCCTGTCTACTAGTGGTAGATGGGTTCTTAATAATGAACACTATAGGGCTTTGCCAGGAGTCTTTTGTGGTGTTGATGCCATGAATCTTATTGCTAACATCTTCACACCTCTTGTTCAACCTGTTGGTGCTTTAGATGTATCTGCTTCTGTAGTGGCGGGTGGTATTATTGCCATATTGGTGACTTGTGCTGCTTACTACTTTATGAAATTCAGGCGTGCATTTGGTGAGTACAACCATGTTGTAGCTGCTAATGCATTACTGTTTTTGATGTCTTTCACTATACTCTGTTTGGCACCTGCCTATAGCTTTTTGCCAGGAGTTTATTCTGTCTTTTACTTGTACTTGACATTCTATTTTACTAATGATGTTTCATTTTTAGCTCACCTTCAATGGTTTGCTATGTTTTCTCCCATTGTGCCTTTCTGGATAACAGCCATTTATGTGTTCTGCATCTCCTTGAAGCACTGCCACTGGTTCTTTAATAACTACCTTAAGAGAAGAGTCATGTTTAATGGAGTTACATTTAGCACCTTTGAGGAGGCTGCTTTATGTACCTTTTTACTTAACAAGGAAATGTACCTCAAATTGCGTAGTGAGACACTCTTGCCACTTACACAGTACAACAGGTACCTTGCTCTCTATAACAAGTACAAGTATTTCAGTGGGGCCTTGGACACAACCAGCTATCGTGAAGCAGCTTGCTGCCACTTAGCAAAGGCTCTTAATGACTTCAGTAACTCCGGTGCTGATGTCCTCTACCAACCACCACAAACTTCAATCACATCTGCAGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCGTCTGGTAAGGTTGAAGGGTGCATGGTTCAAGTCACTTGTGGAACCACAACTCTTAACGGATTGTGGTTAGATGACACAGTATATTGTCCAAGACATGTTATTTGCACAGCAGAAGACATGCTTAATCCAAACTATGAAGACCTGCTCATCCGTAAGTCTAACCATAGCTTCCTTGTCCAGGCTGGTAATGTCCAACTTCGTGTCATCGGCCATTCCATGCAAAATTGTCTGCTTAGGCTTAAAGTTGATACCTCTAACCCTAAGACACCAAAGTATAAATTTGTCCGTATCCAACCAGGTCAGACATTTTCAGTCTTAGCTTGTTACAATGGTTCACCATCAGGAGTTTACCAGTGTGCCATGAGACCTAACTACACCATTAAGGGTTCTTTCCTCAATGGGTCATGTGGTAGTGTTGGTTTTAACATTGACTATGATTGCGTGTCCTTTTGCTATATGCATCACATGGAGCTTCCAACTGGAGTACACGCTGGCACCGACTTAGAAGGTAAATTCTATGGTCCCTTTGTTGACAGACAAACTGCACAGGCTGCAGGCACAGACACAACCATTACATTGAACGTTTTGGCTTGGCTCTATGCTGCTGTTATTAATGGAGATAGATGGTTCCTTAATAGGTTTACCACAACTCTGAATGATTTTAACCTTGTGGCAATGAAATACAACTATGAGCCACTGACACAAGATCATGTTGACATACTGGGACCCCTTTCTGCACAAACAGGAATAGCTGTCTTAGATATGTGTGCTGCTCTAAAAGAGCTTCTACAGAATGGTATGAATGGTCGTACTATTCTTGGTAGCACTATTCTAGAAGATGAGTTTACGCCTTTCGATGTTGTTAGACAATGTTCTGGTGTGACTTTTCAAGGTAAGTTCAAGAAAATAGTTAAGGGCACTCATCATTGGATGCTCCTTACTTTCTTGACATCACTTTTAATTCTCGTTCAAAGTACACAGTGGTCACTGTTTTTCTTTGTTTATGAGAATGCTTTCTTGCCATTTACTTTTGGTATTATGGCTATTGCTGCTTGTGCTATGCTTCTGGTCAAGCATAAACATGCCTTCCTGTGCTTGTTTCTGTTACCTTCTCTTGCAACAGTTGCTTATTTCAATATGGTCTACATGCCTGCTAGCTGGGTGATGCGTATTATGACATGGCTCGAATTGGCTGATACTAGCTTGTCTGGTTATCGGCTTAAAGACTGTGTTATGTATGCGTCAGCCTTAGTACTACTCACCCTCATGACTGCTCGTACTGTCTATGATGATGCTGCTAGGCGTGTATGGACATTGATGAATGTCATTACACTTGTTTATAAAGTCTATTATGGTAATTCCTTAGATCAAGCTATTTCCATGTGGGCTCTTGTTATTTCTGTAACCTCTAACTATTCTGGTGTCGTTACGACTATCATGTTCTTAGCTAGAGCTATAGTTTTTGTGTGTGTTGAGTATTACCCTTTCTTGTTCATTACTGGCAACACCTTACAGTGTATTATGCTTGTCTATTGTTTCTTAGGCTATTGTTGCTGTTGCTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTTACTCTTGGTGTTTATGACTATTTGGTCTCCACACAGGAGTTTAGATATATGAACTCACAAGGGCTTTTGCCACCTAAGAGTAGTATTGATGCATTCAAGCTTAACATTAAATTGCTGGGCATTGGAGGAAAACCATGCATAAAAGTTGCTACTGTTCAGTCTAAAATGTCTGACGTGAAGTGCACTTCTGTTGTACTACTTTCTGTTCTTCAACAACTTAGAGTAGAATCATCTTCTAAATTGTGGGCACAATGTGTGCAATTGCACAATGACATTTTATTGGCTAAAGACACAACTGAAGCCTTTGAAAAGATGGTTTCTCTTCTGTCTGTTCTGCTATCTATGCAAGGTGCTGTAGACATCAACAAACTGTGCGAGGAAATGCTCGACAACCGCGCTACCCTGCAGGCTATTGCTTCAGAATTTAGTTCTTTACCATCATATGCTGCCTATGCTACAGCTCAAGAGGCTTATGAGCAGGCGGTAGCAAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTAAAGAAATCTTTGAATGTGGCTAAATCTGAGTTTGACCGTGATGCTGCCATGCAACGTAAGTTGGAGAAGATGGCGGATCAGGCTATGACCCAAATGTACAAACAGGCAAGATCTGAAGACAAGAGGGCAAAAGTTACTAGTGCAATGCAGACAATGCTTTTCACTATGCTTAGGAAGCTAGATAATGATGCACTTAACAACATTATCAACAATGCACGTGATGGTTGTGTACCACTCAACATCATACCACTTACAACAGCAGCTAAACTCATGGTTGTTGTACCTGATTATGGAACCTACAAGAATACTTGTGATGGTAACACTTTTACATATGCATCTGCTCTCTGGGAAATTCAGCAAGTTGTTGATGCAGATAGTAAAATTGTCCCGCTTAGTGAAATTAATATGGATAATTCACCAAATCTAGCTTGGCCTCTTATTGTTACTGCACTAAGAGCCAACTCAGCTGTCAAACTACAGAATAATGAACTGAGTCCAGTAGCACTACGACAGATGTCTTGTGCAGCTGGTACTACACAAACAGCTTGTACTGATGACAATGCACTTGCCTATTACAACAACTCTAAGGGAGGTAGGTTTGTGCTTGCATTACTATCAGACCATCAAGATCTCAAGTGGGCTAGATTCCCTAAGAGTGACGGAACAGGTACTATTTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACCCCAAAAGGACCTAAAGTGAAATACTTGTATTTCATTAAGGGCTTAAACAACCTAAATAGAGGTATGGTATTGGGCAGTTTAGCTGCTACAGTACGTCTTCAGGCTGGTAATGCAACTGAAGTGCCAGCCAACTCAACTGTGCTTTCTTTCTGCGCCTTTGCTGTTGATCCAGCTAAAGCATACAAAGATTACCTATCAAGTGGAGGACAACCAATCACCAATTGCGTGAAGATGCTGTGCACACACACTGGTACAGGACAGGCAATTACCGTAACACCCGAAGCCAATATGGATCAAGAGTCCTTTGGTGGTGCTTCATGTTGTCTGTATTGTAGATGCCACATTGATCATCCAAATCCTAAGGGATTTTGTGACCTGAAAGGTAAGTATGTTCAAATACCTACCACCTGTGCTAATGACCCAGTGGGTTTCACACTTAGAAACACAGTCTGTACTGTCTGCGGAATGTGGAAAGGTTATGGTTGTAGTTGTGACCAACTCCGCGAACCCATGATGCAGTCGGCGGATGCGTCACCGTTTTTAAACGGGTTTGCGGTGTAA

Protein

MESLVLGVNEKTHVQLSLPVLQVSDVLVRGFGDTVEEALAEAREHLKNGTCGLVELEKGVLRQLEEPYVFIKRSEALSTTHGHKVVELVAEMNGIQFGRSGTTLGVLVPHVGETPIAYRNVLLRKNGNKGAGGHSYGIDLKSYDLGDELNTDPIEDYEQKWNTKHGRGALRELIRELNGGAVTRYVDNNFCGPDGYPLDCIKDLLARAGKSMCTLSEQLDFIESKRGVYCCREHEHEIAWYTERSDKSYEHQTPFEVKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYQVATPNECNDMHLSVFMKCNHCDEASWQTCDFLKATCEYCGTENPVSGGPTTCGYLPTNAVVKMPCPACQNKEVGPEHSVADYHNHSNIETRLRKGGRTKCFGGCVFSYVGCYNKRAYWVPRASADIGSNHTGITGDNVEVLNEDLLEILNRERVNINIVGDFQLNEEIAIILASLSASTSAFVDTVKSLDYKSFKAIVESCGNYEVTKGKPVKGAWNIGQQKSILTPLCGFPSQAAGVIRSIFSRTLDAANNSIPDLQRAAVTILGDISEQSLRLVDAMVCTSDLITNSVIIMAYVTGGLVQQTVQWLSNVLGTTVDKLKPVFTWLETKLNAGIEFLKDAWEILKFLVTGVFDIVKGQIRVFSDNLKECVKTFVGVVNKALEMCIDQVTIAGTKVRSLNLGEVFIAQSKGLYRQCVRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLISEEVVLKNGELEALETPVDSFTNGAVVGTPVCVNGLMLLELKDKEQYCALSPGLLATNNVFRLNGGAPVKGVTFGENTVLEVQGYKNVKITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKALQPVSDLLTKMGIDLDEWSVATFYLFDDAGEEKLSSRMYCSFYPPDEEEDCEEYEDEEEVPDETCEHEYGTEDDYKGLPLEFGSSTEIQQVEDEEEDWLDDVGEAEPEPEPLPAEPVNQFTGYFKLTDNVAIKCVDIVKEAQSAKPAVIVNAANIHLKHGGGVAGALNKATNGAMQQESDDYIKRNGPLTVGGSCLLSGHNLAKKCMHVVGPNLNAGEDVQLLKAAYDNFNSQDVLLAPLLSAGIFGAKPLQSLKMCVEVVRTQVYLAVNDRSLYDQVVLDYLDSLKPKVESPKKEENPKLEEHKAKQPAEKPVDVKPKIKACVEEVTTTLEETKLLTQNLLLFADINGKLYPDSQNMLRGEDMSFLEKDAPYVVGDVITSGDITCVIIPAKKAGGTTEMLAKALKKVPVCEYITTYPGQGCAGYTLEEAKTALKRCKSACYVLPSKTPNVKDEILGTVSWNLREMLAHAEETRKLMPICMDIRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLITMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTPEEHFIETISLAGTYRDWSYSGQRTELGVEFLKRGDKIVYHTIEKPTEFYLDGEVLPLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQHFGPTYLDGADVTKVKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQIEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNLVCKHCGQKTTTLMGVEAVMYMGTLSYDELKAGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNIKFADDLNQMTGFKKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIIWHINQTTNKTTYKPNIWCLRCLWSTKPVETSNSFEVLEVEGTQGMDNLACESQPLTSEEVVENPTVQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTLATHGAAAINSVPWSKVLAYVKPFLGQATVTTSNCMKKCVQRIFNNYMPYVITLLFQLCTFTKGTNSRIRASLPTTIAKNSVKSVAKLCLDVCIDYVKSPKSSKLFTIAMWLLLLSICLGSLIYVTAAFGVLLSNLGIPSYCGGVRDLYINSSNVTIMDFCEGSFPCSVCLSGLDSLDSYPALETIQVTISSYKLDLTFLGLAAEWFLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMSYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKAHNWNCLNCDTFCTGSTFISDEVAHDLSLQFKRPINPTDQSSYVVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFISAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRGAAKKNNIPFRLTCATTRQVLNVITTKISLKGGKVVSTWFKFMLKVTLLCVLSALFCYIIMPVHSLSVHDGYTNEIIGYKAIQDGVTRDIVSTDDCFANKHAGFDSWFSQRGGSYRNDKSCPVVAAIITREIGFIVPGLPGTVLRTINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEAGICLSTSGRWVLNNEHYRALPGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANALLFLMSFTILCLAPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLKRRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNYTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTFGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLTLMTARTVYDDAARRVWTLMNVITLVYKVYYGNSLDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPFLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVPLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLSSGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPMMQSADASPFLNGFAV

Function

The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.

Catalytic Activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.

Subunit

Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer.

Miscellaneous

Produced by conventional translation.

Similarity

Belongs to the coronaviruses polyprotein 1ab family.

Keywords

3D-structure Activation of host autophagy by virus Decay of host mRNAs by virus Endonuclease Eukaryotic host gene expression shutoff by virus Eukaryotic host translation shutoff by virus Host cytoplasm Host gene expression shutoff by virus Host membrane Host mRNA suppression by virus Host-virus interaction Hydrolase Inhibition of host innate immune response by virus Inhibition of host interferon signaling pathway by virus Inhibition of host IRF3 by virus Inhibition of host ISG15 by virus Inhibition of host RLR pathway by virus Membrane Metal-binding Modulation of host ubiquitin pathway by viral deubiquitinase Modulation of host ubiquitin pathway by virus Nuclease Protease Reference proteome Repeat Ribosomal frameshifting RNA-binding Thiol protease Transmembrane Transmembrane helix Ubl conjugation pathway Viral immunoevasion Zinc Zinc-finger

Feature

chain Replicase polyprotein 1a

Uniprot

P0C6U8

Pubmed

12730500 12730501 12853594 12958366 12876307 12781537 + More
14527350 14645828 12917450 15331731 15564471 17024178 17692280 19369340 22174690 23035226 12746549 12925794 15007178 14962394 16228002 16271890 16581910 16873246 16873247 17202208

EMBL

AY278741 AY274119 AY278554 AY282752 AY304495 AY304486 + More
AY304488 AY278491 AY283794 AY283795 AY283796 AY283797 AY283798 AY286320 AY278488 AY278490 AY279354 AY278489 AY291451 AY310120 AY291315 AY323977 AY321118 AY338174 AY338175 AY348314 AP006557 AP006558 AP006559 AP006560 AP006561 AY427439 AY322205 AY322206 AY463059

Proteomes

UP000000354 UP000103670 UP000109640 UP000116947 UP000121636 UP000131569 + More
UP000131955 UP000137377 UP000138690 UP000143093 UP000145651 UP000146108 UP000146181 UP000146296 UP000148194 UP000153467 UP000160648 UP000164441 UP000172416

PRIDE

P0C6U8

Pfam

PF08716   nsp7
PF08717   nsp8
PF11633   SUD-M
PF08715   Viral_protease
PF09401   NSP10
PF16251   NAR
PF12379   DUF3655
PF01661   Macro
PF11501   Nsp1
PF05409   Peptidase_C30
PF08710   nsp9
PF12124   Nsp3_PL2pro
PF16348   Corona_NSP4_C

Interpro

IPR036499   NSP9_sf
IPR014829   NSP8
IPR024358   SARS-CoV_Nsp3_N
IPR014827   Viral_protease
IPR038166   Nsp3_PL2pro_sf
IPR002589   Macro_dom
IPR024375   Nsp3_coronavir
IPR038400   Nsp3_coronavir_sf
IPR042570   NAR_sf
IPR022733   Nsp3_PL2pro
IPR018995   RNA_synth_NSP10_coronavirus
IPR038083   R1a/1ab
IPR038030   NSP1_sf
IPR021590   NSP1
IPR009003   Peptidase_S1_PA
IPR014822   NSP9
IPR013016   Peptidase_C30/C16
IPR037230   NSP8_sf
IPR038123   NSP4_C_sf
IPR032592   NAR_dom
IPR014828   NSP7
IPR036333   NSP10_sf
IPR032505   Corona_NSP4_C
IPR008740   Peptidase_C30
IPR037204   NSP7_sf

SUPFAM

SSF101816   SSF101816
SSF143076   SSF143076
SSF140367   SSF140367
SSF159936   SSF159936
SSF144246   SSF144246
SSF50494   SSF50494
SSF160099   SSF160099

Gene 3D

1.10.150.420 1.10.8.370 2.30.30.590 2.40.10.250 2.40.10.290 3.10.20.350 3.40.220.20 3.40.50.11020

ProteinModelPortal

P0C6U8

PDB

5B6O E-value=0.0 Score= 665 Identity=99.37% Cov(Q)=7.22% Cov(P)=100.00%

3D Structure

View Sequence and Structure Alignments

GO

GO:0003968  F:RNA-directed 5'-3' RNA polymerase activity
GO:0039502  P:suppression by virus of host type I interferon-mediated signaling pathway
GO:0003723  F:RNA binding
GO:0044220  C:host cell perinuclear region of cytoplasm
GO:0039714  C:cytoplasmic viral factory
GO:0039579  P:suppression by virus of host ISG15 activity
GO:0008242  F:omega peptidase activity
GO:0039648  P:modulation by virus of host protein ubiquitination
GO:0004197  F:cysteine-type endopeptidase activity
GO:0039520  P:induction by virus of host autophagy
GO:0039595  P:induction by virus of catabolism of host mRNA
GO:0004519  F:endonuclease activity
GO:0019079  P:viral genome replication
GO:0036459  F:thiol-dependent ubiquitinyl hydrolase activity
GO:0019082  P:viral protein processing
GO:0008270  F:zinc ion binding
GO:0039548  P:suppression by virus of host IRF3 activity
GO:0016021  C:integral component of membrane
GO:0033644  C:host cell membrane

From MSLVP

Capsid

From Uniprot

Host membrane
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 23 publications.

Length:

4377

Number of predicted TMHs:

14

Exp number of AAs in TMHs:

364.66715

Exp number, first 60 AAs:

0.0002

Total prob of N-in:

0.00005

outside

1 - 2203

TMhelix

2204 - 2226

inside

2227 - 2308

TMhelix

2309 - 2331

outside

2332 - 2335

TMhelix

2336 - 2358

inside

2359 - 2747

TMhelix

2748 - 2770

outside

2771 - 3014

TMhelix

3015 - 3037

inside

3038 - 3049

TMhelix

3050 - 3072

outside

3073 - 3099

TMhelix

3100 - 3122

inside

3123 - 3549

TMhelix

3550 - 3572

outside

3573 - 3581

TMhelix

3582 - 3601

inside

3602 - 3605

TMhelix

3606 - 3628

outside

3629 - 3653

TMhelix

3654 - 3673

inside

3674 - 3679

TMhelix

3680 - 3699

outside

3700 - 3718

TMhelix

3719 - 3741

inside

3742 - 3753

TMhelix

3754 - 3776

outside

3777 - 4377

Sequence

Summary

Ontologies

Subcellular Location

Topology