Strain
Avian_FJ904722
(Region: USA; Strain: Infectious bronchitis virus strain Mass41 1979, complete genome.; Date: 1979)
Gene
replicase polyprotein 1a
Description
Annotated in NCBI,
replicase polyprotein 1a
Location
GenBank Accession
Full name
Replicase polyprotein 1a
Alternative Name
ORF1a polyprotein
Sequence
CDS
ATGGCTTCAAGCCTAAAACAGGGAGTATCTCCCAAACCACGGGATGTCATTCTTGTGTCCAAAGACATCCCTGAACAACTTTGTGACGCTTTGTTTTTCTATACGTCACATAACCCTAAGGATTACGCTGATGCTTTTGCAGTTAGGCAGAAGTTTGACCGTAGTCTCCAGACTGGGAAACAGTTCAAATTTGAAACTGTGTGTGGTCTCTTCCTCTTGAAGGGAGTTGACAAAATAACACCTGGCGTCCCAGCAAAAGTTTTAAAAGCCACTTCTAAGTTGGCAGATTTAGAAGACATCTTTGGTGTCTCTCCTTTAGCGCGGAAGTACCGTGAATTGTTGAAAACAGCGTGTCAGTGGTCTCTTACTGTAGAAGCACTGGATGTTCGTGCACAAACTCTCGATGAAATTTTTGACCCCACTGAAATACTTTGGCTTCAGGTGGCTGCAAAAATTCATGTTTCATCTATGGCAATGCGCAGGCTTGTTGGAGAAGTAACTGCAAAAGTCATGGATGCTCTGGGCTCAAACTTGAGTGCTCTTTTTCAAATTGTTAAACAACAAATAGCCAGAATCTTTCAAAAGGCACTGGCTATTTTTGAGAATGTGAATGAATTACCACAGCGTATTGCAGCACTTAAGATGGCTTTTGCCAAGTGTGCTAGGTCAATTACTGTTGTGGTTGTTGAARGAACTCTAGTTGTTAAAGAGTTCGCAGGAACTTGTCTTGCAAGCATTAATGGTGCTGTCGCAAAATTCTTTGAAGAGTTGCCAAACGGCTTCATGGGTTCTAAGATTTTCACAACACTTGCCTTCTTTAAAGAGGCAGCTGTGAGAGTTGTGGAAAACATACCAAATGCACCGAGAGGTACTAAGGGATTTGAAGTTGTTGGCAATGCCAAAGGCACACAGGTAGTTGTGCGCGGCATGCGAAATGACTTAACATTGCTTGACCAAAAAGCTGATATTCCTGTTGAACCAGAAGGTTGGTCTGCAATTTTGGATGGACATCTTTGCTATGTCTTTAGGAGTGGTGATCGCTTTTATGCTGCACCTCTTTCAGGAAATTTTGCTTTGAGTGATGTTCATTGCTGTGAGCGTGTAGTCTGTCTATCTGATGGTGTAACACCGGAGATAAATGATGGACTCATTCTAGCTGCAATCTACTCTTCTTTTAGTGTCTCTGAGCTTGTAACAGCTCTTAAAAAGGGTGAACCATTCAAGTTCTTGGGCCATAAATTCGTGTATGCGAAGGATGCAGCAGTGTCTTTTACTTTAGCGAAGGCTGCCACTATTGCAGATGTCTTGAGGCTGTTCCAATCAGCTCGTGTGATAGCAGAAGATGTTTGGTCTTCATTTACTGAAAAGTCTTTTGAATTCTGGAAGCTTGCATATGGAAAAGTGCGCAACCTTGAAGAATTTGTGAAGACCTATGTTTGTAAGGCTCAAATGTCGATTGTGATTCTAGCAGCAGTGCTTGGAGAGGGCATTTGGCATCTTGTCTCACAAGTCATCTATAAATTAGGTGTTCTTTTTACTAAAGTCGTTGACTTTTGTGACAAACACTGGAAAGGTTTTTGTGTACAGTTGAAAAGAGCTAAGCTCATTGTCACCGAAACCTTCTGTGTTTTAAAAGGAGTTGCACAGCATTGTTTTCAACTGCTGCTAGATGCAATACACTCTTTGTACAAGAGTTTTAAGAAGTGTGCACTTGGTAGAATCCATGGAGATTTGCTCTTCTGGAAAGGAGGTGTGCATAAAATTGTTCAAGATGGCGATGAAATATGGTTTGACGCCATTGATAGTGTTGATGTTGAAGATCTGGGTGTTGTTCAGGAAAAATCGATTGATTTTGAGGTTTGCGATGACGTGACACTTCCAGAAAACCAACCTGGTCATATGGTTCAAATTGAGGATGATGGTAAGAACTACATGTTCTTCCGTTTTAAAAAGGATGAGAACATTTATTATACACCAATGTCACAGCTTGGTGCTATTAATGTGGTTTGCAAAGCAGGCGGTAAGACTGTCACCTTTGGAGAAACTACAGTACAAGAGATACCACCACCTGATGTCGTGCCTATTAAGGTTAGCATAGAATGTTGTGGTGAACCATGGAATACGATCTTCAAGAAGGCTTATAAAGAGCCTATAGAAGTAGATACAGACCTCACAGTAGAACAATTGCTCTCTGTGATCTATGAGAAAATGTGTGACGACCTTAAATTGTTTCCAGAGGCACCAGAGCCTCCACCATTTGAGAATGTCGCACTTGTTGATAAGAACGGTAAAGATTTGGATTGTATAAAATCTTGCCATTTGATCTATCGTGACTATGAGAGCGATGATGCCATCGAGGAGGAAGATGCTGAGGAGTGTGACACAGACTCAGGTGAAGCTGAGGAGTGTGACACTAATTCAGAATGTGAAGAAGAGGATGAGGATACTAAAGTGTTGGCTCTTATACAAGACCCGGCAAGTATTAAATACCCTCTGCCTCTTGATGAAGATTATAGCGTCTATAATGGATGTATTGTACACAAGGACGCTCTTGATGTTGTGAATTTACCATCTGGTGAAGAAACTTTTGTTGTCAATAACTGTTTTGAGGGAGCTGTTAAACCACTTCCACAGAAGGTTGTTGATGTTCTTGGTGACTGGGGAGAGGCTGTTGATGCGCAAGAACAACTGTGTCAACAAGAGCCTCTGCAACATACCTTTGAAGAACCAGTCGAAAATTCTACTGGTAGTTCTGAGACAATGACTGAACAAGTCGTTGTAGAAGATCAAGAAATACCTGTTGTTGAACAAGATCAGGATGTAGTTGTTTATACACCTACAGATCTTGAAGTTGCAAAAGAAACAGCAGAAGAGGTTGATGAGTTTATTCTCATTTTTGATGTTCCTAAAGAAGAAGTTGTGTCCCAGAAAGATGGGGCACAGATTAAACAAGAGCCTATTCAAGTTGTTAAACCACAACGTGAGAAGAAGGCTAAAAAGTTCAAAGTTAAACCAGCCACATGTGAGAAACCTAAATTTTTGGAGTATAAAACATGTGTGGGTGATTTGACTGTTGTAATTGCCAAAGCATTGGATGAGTTTAAAGAGTTCTGCATTGTAAATGCTGCAAATGAGCATATGACTCATGGTAGTGGCGTTGCAAAGGCAATTGCAGACTTTTGTGGACTGGATTTTGTTGAATATTGTGAGGACTATGTTAAGAAACATGGGCCACAACAGAGACTTGTTACACCTTCGTTTGTCAAAGGCATTCAATGTGTGAATAATGTTGTAGGACCCCGCCATGGAGACAACAACTTGCATGAGAAGCTTGTTGCTGCCTACAAGAATGTGCTTGTAGATGGCGTAGTCAATTATGTTGTGCCAGTTCTTTCATTAGGAATTTTTGGTGTAGATTTTAAAATGTCAATAGACGCAATGCGTGAAGCTTTTGAAGGTTGCACCATACGCGTTCTTTTGTTTTCTCTGAGCCAAGAACACATCGATTATTTCGATGTAACTTGCAAACAGAAGACAATTTATCTTACGGAGGATGGTGTTAAATACCGCTCCATTGTTCTAAAACCTGGTGACTCATTGGGTCAATTTGGACAGGTTTATGCTAAAAACAAGATAGTTTTTACAGCCGATGATGTTGAGGACAAAGAAATTCTCTACGTCCCCACGACTGATAAAAGCATTCTTGAATACTATGGTTTAGATGCGCAAAAGTATGTAATATATTTGCAAACGCTTGCGCAGAAATGGAATGTCCAATATAGGGACAATTTTCTTATACTAGAGTGGCGTGACGGAAATTGCTGGATTAGTTCAGCAATAGTTCTCCTTCAAGCTGCTAAAATTAGGTTTAAAGGTTTTCTAACAGAAGCGTGGGCTAAACTGTTAGGTGGAGATCCTACAGACTTTGTTGCCTGGTGTTATGCAAGTTGTAATGCTAAAGTAGGTGATTTCTCAGATGCTAATTGGCTTTTAGCGAATTTAGCAGAACATTTTGACGCAGATTACACAAATGCGTTTCTTAAGAAGCGCGTTTCGTGTAACTGTGGTATTAAGAGCTATGAGCTTAGAGGCCTTGAAGCTTGTATTCAGCCAGTTCGGGCAACTAATCTGCTACATTTTAAGACGCAATATTCAAATTGCCCAACCTGTGGCGCAAATAATACGGATGAAGTAATAGAAGCTTCGTTACCGTACTTATTGCTTTTTGCTACTGATGGTCCTGCTACAGTTGATTGTGATGAAGATGCTGTGGGGACTGTCGTGTTTGTTGGTTCTACTAATAGTGGCCATTGTTATACACAAGCTGCAGGGCAAGCTTTTGATAATCTTGCTAAAGATAGAAAATTTGGAAAGAAGTCGCCTTACATTACTGCAATGTATACGCGATTCGCTTTTAAGAATGAAACCTCTTTGCCTGTTGCTAAACAGAGCAAGGGTAAGTCTAAGTCGGTAAAGGAAGATGTTTCTAACCTTGCTACTAGTTCTAAGGCCAGTTTTGATAATCTTACTGACTTCGAACAGTGGTATGATAGTAACATCTATGAAAGTCTTAAAGTGCAGGAATCACCTGATAACTTTGATAAATATGTGTCATTCACAACAAAGGAAGATTCTAAGTTGCCATTGACACTTAAGGTTAGAGGTATTAAATCAGTTGTTGACTTTAGATCGAAGGATGGTTTTATTTATAAGTTAACACCTGATACTGATGAAAATTCAAAAGCACCAGTCTACTACCCAGTCTTGGACGCTATTAGTCTTAAGGCAATATGGGTGGAAGGTAATGCTAACTTTGTTGTTGGTCATCCAAATTATTATAGTAAGTCTCTTCATATTCCTACTTTTTGGGAAAATGCTGAGAATTTTGTTAAAATGGGTGATAAAATTGGTGGTGTAACTATGGGACTTTGGCGTGCAGAACACCTTAATAAACCTAATTTGGAGAGAATTTTCAACATTGCTAAGAAAGCCATTGTTGGATCTAGTGTTGTTACTACACAATGCGGTAAATTAATAGGTAAAGCAGCTACATTCATTGCTGATAAAGTAGGTGGTGGTGTAGTTCGCAATATTACAGATAGCATTAAGGGTCTTTGTGGAATTACACGAGGGCATTTTGAAAGAAAAATGTCTCCACAATTCCTAAAGACGCTCATGTTCTTTTTATTCTATTTCTTGAAGGCTAGTGTTAAGAGTGTTGTCGCTAGCTATAAGACCGTGTTATGTAAGGTGGTATTTGCTACTTTACTTATAGTTTGGTTTGTCTACACAAGTAACCCAGTAATGTTTACAGGAATACGTGTGTTAGATTTTCTATTCGAGGGTTCTTTGTGTGGTCCTTATAAAGACTATGGTAAAGATTCTTTTGATGTGTTACGATATTGTGCAGATGATTTTATTTGTCGTGTGTGTTTACATGACAAAGATTCACTTCATTTGTACAAACACGCTTATAGTGTAGAGCAGGTCTATAAAGATGCAGCTTCTGGTTTTATTTTTAATTGGAATTGGCTTTATTTGGTCTTTCTAATATTATTTGTTAAACCAGTGGCAGGTTTTGTTATTATTTGCTATTGTGTTAAGTATTTGGTATTGAATTCAACTGTGCTGCAAACTGGTGTTTGTTTTTTAGATTGGTTTGTACAAACAGTTTTTAGTCACTTTAATTTTATGGGAGCAGGATTTTATTTCTGGCTCTTTTACAAGATATATATACAGGTGCATCATATACTGTATTGTAAGGATGTAACATGTGAAGTGTGCAAAAGGGTTGCACGCAGCAACAGGCAAGAGGTTAGCGTGGTTGTTGGTGGACGCAAGCAGATAGTGCATGTTTACACTAACTCTGGCTATAACTTTTGTAAGAGACATAATTGGTATTGTAGAAATTGTGATGATTATGGTCACCAAAATACATTTATGTCTCCTGAAGTTGCTGGCGAGCTCTCTGAAAAGCTTAAGCGCCATGTTAAACCTACAGCATACGCTTACCACGTTGTGGATGAGGCATGCTTAGTTGATGATTTTGTCAATTTAAAATATAGAGCTGCAACTCCTGGTAAGGATAGTGCATCTTCAGCTGTTAAGTGTTTCAGTGTTACAGATTTCTTGAAGAAAGCTGTTTTTCTTAAGGAAGCACTGAAATGTGAACAAATATCTAATGATGGTTTTATAGTGTGTAATACACAGAGTGCTCATGCATTAGAGGAAGCAAAGAATGCAGCCATCTATTATGCGCAATATCTGTGTAAGCCAATACTTATACTTGACCAGGCACTTTATGAGCAATTAGTAGTAGAGCCTGTGTCTAAGAGTGTTATAGATAAAGCGTGTAGCATTTTGTCTAGTATAATATCTGTAGATACTGCAGCTTTAAATTATAAGGCAGGCACACTTCGTGATGCTCTGCTTTCTATTACTAAAGACGAAGAAGCCGTAGATATGGCTATATTCTGTCATAATCATGATGTGGATTACACTGGTGATGGTTTTACTAATGTGATACCGTCATATGGTATAGACACTGGCAAGTTAACACCTCGTGATAGAGGGTTTTTGATAAATGCAGATGCTTCTATTGCTAACTTAAGAGTTAAAAATGCTCCGCCGGTAGTATGGAAGTTTTCTGAGCTTATTAAGTTGTCTGACAGTTGTCTTAAATATTTAATTTCGGCTACTGTTAAGTCAGGTGTTCGTTTCTTTATAACAAAGTCTGGTGCTAAACAAGTTATTGCTTGTCATACCCAGAAGTTGTTAGTAGAGAAAAAGGCAGGTGGTATTGTTAGCGGCACCTTTAAGTGTTTTAAGAGTTATTTTAAATGGCTCTTGATCTTTTACATACTTTTTACAGCATGTTGTTCGGGTTATTACTATATGGAGGTGAGTAAAAGTTTTGTTCACCCCATGTATGATGTAAACTCCACACTGCATGTTGAAGGTTTTAAAGTTATAGATAAAGGTGTTCTTAGGGAAATTGTACCAGAAGATACATGTTTCTCTAATAAATTTGTTAATTTTGATGCTTTTTGGGGCAGACCATATGATAATAGTAGAAACTGTCCAATTGTCACAGCTGTTATAGATGGTGATGGGACAGTAGCTACAGGTGTTCCTGGTTTTGTGTCCTGGGTTATGGATGGTGTTATGTTTATACATATGACACTGACTGAGAGAAAACCGTGGTACATTCCTACTTGGTTTAATAGAGAAATTGTTGGTTACACTCAGGATTCAATTATTACTGAGGGTAGTTTTTATACATCTATAGCGTTATTTTCCGCTAGGTGTTTATATTTAACAGCCAGCAATACACCTCAATTGTATTGCTTTAATGGTGATAATGATGCACCTGGAGCCTTACCATTTGGTAGTATTATCCCTCATAGAGTTTACTTCCAACCCAATGGTGTTAGGCTTATAGTTCCACAACAAATACTGCACACACCCTACGTAGTAAAGTTTGTATCAGACAGCTATTGTAGGGGTAGTGTGTGTGAGTACACTAGACCAGGTTACTGTGTGTCATTAAACCCACAATGGGTTTTGTTTAATGACGAATACACAAGTAAACCCGGTGTTTTCTGTGGTTCTACTGTTAGAGAACTTATGTTTAGTATGGTTAGTACATTCTTTACTTGTGTTAACCCCAATATCTATATGCAATTAGCAACTATGTTTTTAATACTAGTTGTTGTTGTATTAATCTTTGCAATGGTTATAAAGTTTCAAGGTGTTTTTAAAGCTTATGCAACCACTGTTTTTATAACAATGTTAGTTTGGGTAATTAACGCATTTATTTTGTGTGTACATAGTTACAACAGTGTTTTAGCTGTTATATTACTAGTACTCTATTGCTATGCGTCATTGGTTACAAGTCGCAATACTGTTATAATAATGCATTGTTGGCTTGTTTTTACCTTTGGTTTAATAGTACCCACATGGTTGGCTTGTTGCTACCTGGGATTTATTATTTATATGTATACACCGTTGTTTTTATGGTGTTATGGTACTACAAAAAACACTCGTAAGCTGTATGATGGCAATGAGTTTGTTGGTAATTATGATCTTGCTGCGAAGAGCACTTTTGTTATTCGCGGCTCTGAATTTGTTAAGCTTACTAATGAGATAGGTGATAAATTTGAGGCCTACCTTTCAGCGTATGCTAGATTAAAGTACTATTCAGGCACTGGCAGTGAACAAGATTATTTGCAAGCTTGTCGTGCATGGTTAGCTTATGCTTTGGACCAATATAGAAATAGTGGTGTGGAAATTGTTTATACTCCGCCACGTTACTCTATTGGTGTTAGTAGATTACAATCTGGTTTTAAGAAACTGGTTTCTCCTAGTAGTGCTGTTGAAAAGTGCATTGTTAGTGTCTCTTATAGAGGTAATAATCTTAATGGACTGTGGCTAGGTGACACTATCTACTGTCCTCGTCATGTATTGGGTAAGTTTTCAGGTGACCAATGGAATGATGTACTTAATCTTGCTAATAATCATGAGTTTGAAGTTACAACTCAACATGGTGTTACTTTGAATGTTGTCAGTAGGCGTTTAAAAGGTGCAGTTTTAATTTTACAAACTGCTGTTGCTAATGCTGAAACTCCAAAGTATAAGTTTATTAAAGCTAATTGTGGTGATAGTTTCACTATAGCTTTTGCTTATGGTGGTACAGTTGTAGGACTCTACCCTGTTACTATGCGTTCTAATGGTACTATTAGAGCATCTTTTCTTGCGGGAGCCTGTGGTTCAGTTGGTTTTAATATAGAAAAGGGTGTAGTTAATTTCTTTTATATGCACCATCTTGAGTTACCTAATGCATTACACACTGGAACTGACCTAATGGGTGAATTCTATGGTGGTTATGTTGATGAAGAGGTTGCACAAAGAGTGCCACCAGATAATTTAGTTACTAACAATATTGTAGCATGGCTCTATGCGGCAATTATTAGTGTTAAGGAGAGTAGTTTCTCGCTGCCTAAATGGTTGGAGAGTACTACTGTTAGTGTTGATGATTATAATAAGTGGGCTGGTGACAATGGTTTTACACCATTTTCTACTAGTACCGCTATTACTAAATTAAGTGCTATAACTGGAGTTGATGTTTGTAAGCTCCTTCGCACTATTATGGTAAAAAATAGCCAGTGGGGTGGTGACCCCATTTTAGGGCAATATAATTTTGAAGATGAATTGACACCGGAGTCTGTATTTAATCAGATTGGTGGTGTTAGATTACAATCTTCTTTTGTAAGAAAAGCTACATCTTGGTTTTGGAGTAGATGTGTGTTAGCTTGCTTCTTATTTGTGTTGTGTGCTATTGTCTTGTTTACGGCAGTGCCACTTAAATTTTATGTATATGCAGCTGTTATTTTGTTAATGGCTGTACTTTTTATTTCTTTTACTGTTAAACATGTTATGGCATATATGGATACTTTTCTATTGCCAACATTGATTACAGTTATTATTGGAGTTTGTGCTGAAGTCCCTTTCATCTACAATACTCTAATTAGTCAAGTTGTTATTTTCTTAAGTCAATGGTATGACCCAGTAGTCTTTGATACTATGGTACCATGGATGTTCTTGCCACTAGTGTTGTATACTGCTTTTAAGTGTGTACAAGGTTGCTATATGAATTCTTTCAATACTTCTTTGTTAATGCTGTATCAGTTTGGGAAGTTAGGTTTTGTTATTTACACCTCTTCTAATACTCTTACTGCATACACAGAAGGTAATTGGGAGTTATTCTTCGAGTTGGTGCACACTACTGTGTTGGCTAATGTTAGTAGTAATTCTTTAATTGGTTTATTTGTTTTTAAGTGTGCTAAATGGATGTTGTATTATTGTAATGCAACATACTTAAACAATTATGTACTAATGGCAGTTATGGTTAACTGCATTGGCTGGCTCTGCACTTGTTACTTTGGGTTGTATTGGTGGGTTAATAAGGTTTTTGGTTTAACCTTAGGTAAATACAATTTTAAAGTTTCAGTAGATCAATATAGGTATATGTGTTTGCACAAGATAAACCCACCTAAAACTGTGTGGGAAGTCTTTTCGACAAATATACTTATACAAGGAATTGGTGGTGACCGTGTGTTGCCTATTGCTACAGTTCAAGCTAAATTGAGTGATGTAAAGTGTACAACTGTTGTTTTAATGCAGCTTTTGACTAAGCTTAATGTTGAAGCAAATTCAAAAATGCATGCTTATCTTGTTGAGTTACACAATAAAACTCTTGCTTCTGATGATGTTGGAGAGTGCATGGATAATTTGTTGGGTATGCTTATAACACTATTTTGTATAGATTCTACTATTGATTTGAGTGAGTATTGTGATGACATACTTAAGAGGTCAACTGTATTACAATCGGTTACTCAAGAATTCTCAAACATACCCTCTTATGCTGAATATGAAAGGGCTAAGAATCTTTATGAAAAGGTTTTAGTTGATTCTAAAAATGGTGGTGTTACACAGCAAGAGCTTGCTGCATATCGTAAAGCTGCCAATATTGCAAAGTCAGTTTTTGATAGAGACTTGGCTGTCCAAAAGAAGTTAGATAGCATGGCAGAGCGTGCTATGACAACAATGTATAAAGAGGCGCGTGTAACAGATAGACGAGCAAAATTAGTCTCATCACTACATGCGTTACTTTTCTCAATGCTTAAGAAAATAGATTCTGAAAAGCTTAATGTCTTGTTTGACCAGGCTAGTAGTGGTGTTGTGCCCCTAGCGACTGTTCCAATTGTTTGTAGTAATAGGCTTACACTTGTAATACCAGACCCAGAAACGTGGGTCAAGTGTGTGGAAGGTGTGCATGTTACATATTCAACAGTTGTTTGGAATATAGACACTGTTATTGATGCCGATGGCACAGAGTTACACCCAACTTCTACAGGTAGTGGATTGACATACTGTATAAGTGGTGCTAATATAGCATGGCCTTTAAAGGTTAACTTGACTAGGAGTGGGCATAATAAGGTTGATGTTGTTTTGCAAAATAATGAGCTTATGCCACATGGTGTTAAAACAAAGGCTTGCGTAGCAGGTGTAGATCAAGCACATTGTAGCGTAGAGTCTAAATGTTATTATACAAATATTAGTGGCAATTCAGTTGTAGCTGCTATTACTTCTTCAAATCCAAATCTGAAAGTAGCTTCGTTTTTGAATGAGGCAGGCAATCAGATTTATGTAGACTTAGACCCACCATGTAAATTTGGTATGAAAGTGGGTGATAAGGTTGAAGTTGTTTACTTGTATTTTATAAAGAATACAAGGTCGATTGTTAGAGGTATGGTACTTGGTGCTATATCTAATGTTGTTGTCTTACAGTCTAAAGGGCATGAAACAGAGGAAGTGGATGCTGTTGGCATTCTTTCACTATGTTCATTTGCAGTAGATCCCGCGGACACATATTGTAAATATGTGGCAGCAGGTAATCAACCTTTAGGTAACTGTGTTAAAATGTTGACAGTGCATAATGGTAGTGGTTTTGCTATAACTTCAAAGCCAAGTCCTACTCCTGACCAGGATTCTTATGGAGGAGCTTCTGTGTGTCTCTATTGTAGAGCACACATAGCACATCCAGGAGGTGTAGGAAATTTAGATGGACGTTGTCAATTTAAAGGTTCTTTTGTGCAAATACCTACTACGGAGAAAGACCCCGTTGGATTCTGTCTACGTAATAAGGTTTGCACTGTTTGTCAGTGTTGGATTGGTTATGGATGTCAGTGTGATTCACTTAGACAACCAAAATCTTCTGTTCAATCAGTTGCTGGAGCATCTGATTTTGATAAGAATTATTTAAACGGGTACGGGGTAGCAGTGAGGCTCGGCTGA
Protein
MASSLKQGVSPKPRDVILVSKDIPEQLCDALFFYTSHNPKDYADAFAVRQKFDRSLQTGKQFKFETVCGLFLLKGVDKITPGVPAKVLKATSKLADLEDIFGVSPLARKYRELLKTACQWSLTVEALDVRAQTLDEIFDPTEILWLQVAAKIHVSSMAMRRLVGEVTAKVMDALGSNLSALFQIVKQQIARIFQKALAIFENVNELPQRIAALKMAFAKCARSITVVVVEXTLVVKEFAGTCLASINGAVAKFFEELPNGFMGSKIFTTLAFFKEAAVRVVENIPNAPRGTKGFEVVGNAKGTQVVVRGMRNDLTLLDQKADIPVEPEGWSAILDGHLCYVFRSGDRFYAAPLSGNFALSDVHCCERVVCLSDGVTPEINDGLILAAIYSSFSVSELVTALKKGEPFKFLGHKFVYAKDAAVSFTLAKAATIADVLRLFQSARVIAEDVWSSFTEKSFEFWKLAYGKVRNLEEFVKTYVCKAQMSIVILAAVLGEGIWHLVSQVIYKLGVLFTKVVDFCDKHWKGFCVQLKRAKLIVTETFCVLKGVAQHCFQLLLDAIHSLYKSFKKCALGRIHGDLLFWKGGVHKIVQDGDEIWFDAIDSVDVEDLGVVQEKSIDFEVCDDVTLPENQPGHMVQIEDDGKNYMFFRFKKDENIYYTPMSQLGAINVVCKAGGKTVTFGETTVQEIPPPDVVPIKVSIECCGEPWNTIFKKAYKEPIEVDTDLTVEQLLSVIYEKMCDDLKLFPEAPEPPPFENVALVDKNGKDLDCIKSCHLIYRDYESDDAIEEEDAEECDTDSGEAEECDTNSECEEEDEDTKVLALIQDPASIKYPLPLDEDYSVYNGCIVHKDALDVVNLPSGEETFVVNNCFEGAVKPLPQKVVDVLGDWGEAVDAQEQLCQQEPLQHTFEEPVENSTGSSETMTEQVVVEDQEIPVVEQDQDVVVYTPTDLEVAKETAEEVDEFILIFDVPKEEVVSQKDGAQIKQEPIQVVKPQREKKAKKFKVKPATCEKPKFLEYKTCVGDLTVVIAKALDEFKEFCIVNAANEHMTHGSGVAKAIADFCGLDFVEYCEDYVKKHGPQQRLVTPSFVKGIQCVNNVVGPRHGDNNLHEKLVAAYKNVLVDGVVNYVVPVLSLGIFGVDFKMSIDAMREAFEGCTIRVLLFSLSQEHIDYFDVTCKQKTIYLTEDGVKYRSIVLKPGDSLGQFGQVYAKNKIVFTADDVEDKEILYVPTTDKSILEYYGLDAQKYVIYLQTLAQKWNVQYRDNFLILEWRDGNCWISSAIVLLQAAKIRFKGFLTEAWAKLLGGDPTDFVAWCYASCNAKVGDFSDANWLLANLAEHFDADYTNAFLKKRVSCNCGIKSYELRGLEACIQPVRATNLLHFKTQYSNCPTCGANNTDEVIEASLPYLLLFATDGPATVDCDEDAVGTVVFVGSTNSGHCYTQAAGQAFDNLAKDRKFGKKSPYITAMYTRFAFKNETSLPVAKQSKGKSKSVKEDVSNLATSSKASFDNLTDFEQWYDSNIYESLKVQESPDNFDKYVSFTTKEDSKLPLTLKVRGIKSVVDFRSKDGFIYKLTPDTDENSKAPVYYPVLDAISLKAIWVEGNANFVVGHPNYYSKSLHIPTFWENAENFVKMGDKIGGVTMGLWRAEHLNKPNLERIFNIAKKAIVGSSVVTTQCGKLIGKAATFIADKVGGGVVRNITDSIKGLCGITRGHFERKMSPQFLKTLMFFLFYFLKASVKSVVASYKTVLCKVVFATLLIVWFVYTSNPVMFTGIRVLDFLFEGSLCGPYKDYGKDSFDVLRYCADDFICRVCLHDKDSLHLYKHAYSVEQVYKDAASGFIFNWNWLYLVFLILFVKPVAGFVIICYCVKYLVLNSTVLQTGVCFLDWFVQTVFSHFNFMGAGFYFWLFYKIYIQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYTNSGYNFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVDEACLVDDFVNLKYRAATPGKDSASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHALEEAKNAAIYYAQYLCKPILILDQALYEQLVVEPVSKSVIDKACSILSSIISVDTAALNYKAGTLRDALLSITKDEEAVDMAIFCHNHDVDYTGDGFTNVIPSYGIDTGKLTPRDRGFLINADASIANLRVKNAPPVVWKFSELIKLSDSCLKYLISATVKSGVRFFITKSGAKQVIACHTQKLLVEKKAGGIVSGTFKCFKSYFKWLLIFYILFTACCSGYYYMEVSKSFVHPMYDVNSTLHVEGFKVIDKGVLREIVPEDTCFSNKFVNFDAFWGRPYDNSRNCPIVTAVIDGDGTVATGVPGFVSWVMDGVMFIHMTLTERKPWYIPTWFNREIVGYTQDSIITEGSFYTSIALFSARCLYLTASNTPQLYCFNGDNDAPGALPFGSIIPHRVYFQPNGVRLIVPQQILHTPYVVKFVSDSYCRGSVCEYTRPGYCVSLNPQWVLFNDEYTSKPGVFCGSTVRELMFSMVSTFFTCVNPNIYMQLATMFLILVVVVLIFAMVIKFQGVFKAYATTVFITMLVWVINAFILCVHSYNSVLAVILLVLYCYASLVTSRNTVIIMHCWLVFTFGLIVPTWLACCYLGFIIYMYTPLFLWCYGTTKNTRKLYDGNEFVGNYDLAAKSTFVIRGSEFVKLTNEIGDKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYRNSGVEIVYTPPRYSIGVSRLQSGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPRHVLGKFSGDQWNDVLNLANNHEFEVTTQHGVTLNVVSRRLKGAVLILQTAVANAETPKYKFIKANCGDSFTIAFAYGGTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFYMHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFSLPKWLESTTVSVDDYNKWAGDNGFTPFSTSTAITKLSAITGVDVCKLLRTIMVKNSQWGGDPILGQYNFEDELTPESVFNQIGGVRLQSSFVRKATSWFWSRCVLACFLFVLCAIVLFTAVPLKFYVYAAVILLMAVLFISFTVKHVMAYMDTFLLPTLITVIIGVCAEVPFIYNTLISQVVIFLSQWYDPVVFDTMVPWMFLPLVLYTAFKCVQGCYMNSFNTSLLMLYQFGKLGFVIYTSSNTLTAYTEGNWELFFELVHTTVLANVSSNSLIGLFVFKCAKWMLYYCNATYLNNYVLMAVMVNCIGWLCTCYFGLYWWVNKVFGLTLGKYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQAKLSDVKCTTVVLMQLLTKLNVEANSKMHAYLVELHNKTLASDDVGECMDNLLGMLITLFCIDSTIDLSEYCDDILKRSTVLQSVTQEFSNIPSYAEYERAKNLYEKVLVDSKNGGVTQQELAAYRKAANIAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLFDQASSGVVPLATVPIVCSNRLTLVIPDPETWVKCVEGVHVTYSTVVWNIDTVIDADGTELHPTSTGSGLTYCISGANIAWPLKVNLTRSGHNKVDVVLQNNELMPHGVKTKACVAGVDQAHCSVESKCYYTNISGNSVVAAITSSNPNLKVASFLNEAGNQIYVDLDPPCKFGMKVGDKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCSFAVDPADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAHPGGVGNLDGRCQFKGSFVQIPTTEKDPVGFCLRNKVCTVCQCWIGYGCQCDSLRQPKSSVQSVAGASDFDKNYLNGYGVAVRLG
Summary
Function
The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity).
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK.
The peptide p16 might be involved in the EGF signaling pathway.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK.
The peptide p16 might be involved in the EGF signaling pathway.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
Subunit
3CL-PRO exists as monomer and homodimer. The three peptides nsp2, nsp3 and nsp4 may form a complex. Nsp9 is a dimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp10 forms a dodecamer (By similarity).
Miscellaneous
Produced by conventional translation.
Similarity
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
Activation of host autophagy by virus
Host cytoplasm
Host membrane
Host-virus interaction
Hydrolase
Membrane
Metal-binding
Protease
Repeat
Ribosomal frameshifting
RNA-binding
Thiol protease
Transmembrane
Transmembrane helix
Zinc
Zinc-finger
Feature
chain Replicase polyprotein 1a
Uniprot
EMBL
Proteomes
Pfam
Interpro
IPR018995
RNA_synth_NSP10_coronavirus
IPR036499 NSP9_sf
IPR014829 NSP8
IPR009003 Peptidase_S1_PA
IPR014822 NSP9
IPR014827 Viral_protease
IPR013016 Peptidase_C30/C16
IPR002589 Macro_dom
IPR037230 NSP8_sf
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR040795 Nsp1a_N
IPR036333 NSP10_sf
IPR032505 Corona_NSP4_C
IPR037204 NSP7_sf
IPR008740 Peptidase_C30
IPR036499 NSP9_sf
IPR014829 NSP8
IPR009003 Peptidase_S1_PA
IPR014822 NSP9
IPR014827 Viral_protease
IPR013016 Peptidase_C30/C16
IPR002589 Macro_dom
IPR037230 NSP8_sf
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR040795 Nsp1a_N
IPR036333 NSP10_sf
IPR032505 Corona_NSP4_C
IPR037204 NSP7_sf
IPR008740 Peptidase_C30
SUPFAM
Gene 3D
ProteinModelPortal
PDB
3LD1
E-value=0.0 Score= 667 Identity=92.46%
Cov(Q)=9.06% Cov(P)=99.72%
3D Structure
Ontologies
GO
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0019082 P:viral protein processing
GO:0008270 F:zinc ion binding
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0003723 F:RNA binding
GO:0008242 F:omega peptidase activity
GO:0016021 C:integral component of membrane
GO:0004197 F:cysteine-type endopeptidase activity
GO:0039520 P:induction by virus of host autophagy
GO:0033644 C:host cell membrane
GO:0019079 P:viral genome replication
GO:0019082 P:viral protein processing
GO:0008270 F:zinc ion binding
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0003723 F:RNA binding
GO:0008242 F:omega peptidase activity
GO:0016021 C:integral component of membrane
GO:0004197 F:cysteine-type endopeptidase activity
GO:0039520 P:induction by virus of host autophagy
GO:0033644 C:host cell membrane
GO:0019079 P:viral genome replication
Subcellular Location
From MSLVP
Capsid
From Uniprot
Host membrane
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 1 publications.
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 1 publications.
Topology
Length:
3951
Number of predicted TMHs:
18
Exp number of AAs in TMHs:
417.83869
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00574
outside
1 - 1724
TMhelix
1725 - 1744
inside
1745 - 1750
TMhelix
1751 - 1773
outside
1774 - 1841
TMhelix
1842 - 1864
inside
1865 - 1868
TMhelix
1869 - 1888
outside
1889 - 1897
TMhelix
1898 - 1920
inside
1921 - 2276
TMhelix
2277 - 2299
outside
2300 - 2557
TMhelix
2558 - 2580
inside
2581 - 2584
TMhelix
2585 - 2607
outside
2608 - 2610
TMhelix
2611 - 2630
inside
2631 - 2642
TMhelix
2643 - 2665
outside
2666 - 2887
TMhelix
2888 - 2905
inside
2906 - 3095
TMhelix
3096 - 3118
outside
3119 - 3122
TMhelix
3123 - 3140
inside
3141 - 3152
TMhelix
3153 - 3175
outside
3176 - 3189
TMhelix
3190 - 3212
inside
3213 - 3223
TMhelix
3224 - 3246
outside
3247 - 3255
TMhelix
3256 - 3278
inside
3279 - 3297
TMhelix
3298 - 3320
outside
3321 - 3951
