Coronavirus Database

Strain

Porcine_KM403390 (Region: USA; Strain: Porcine torovirus strain PToV/NPL/2014, complete genome.; Date: 2-Jan-14)

Gene

spike glycoprotein

Description

Annotated in NCBI, spike glycoprotein

Location

KM403390(+):20826-25547

GenBank Accession

AIU41585.1

Full name

Spike glycoprotein

Alternative Name

E2
Peplomer protein

CDS

ATGTTTTTATTGTTCTGTACCACGTCAATTTTGTGCTTCTGGATTAGTTCAGGAGGTGCCTATGTTGTGTCAAATGAATCATTAAGTTTAAGTGAGCCAGTATCTTATCCCTTTTCTTTAGCTGTTCTTCGTTCTTTTACACAGCATGTTACAGGTAGGTTTAGGAGAGATGTTGTTAAACAAGTTTGGGATTTTGCTTACCAAATTTCTACAAACCGTATAAGTGTTAATGGATGGGATGTAGTTTTTAAGTCACCTTTTATTCTTAGTTATTCTAATGGCATGTTAAATACATCTGTTTTGCCATTTGATGCATATATGAAGTCATCAATTGCAAAGTTTAGTTATACAGTTACAGCTTATACGGGTCAGCGCCCATATCTTAACACCCAGGTTAATGATTTAGTTAATGGTGGTTATAGTGGTTGGTCAGATAATGTTAGAGTTGATAACTGTGGTAATTATGCATGTCATCCTGGAGGTAAGCCTGGGTGTTCCATTGGCCAGCCCCGTATGTTACAAGGTGTTTGTACAAGAGTTTTACCTACCACCCAGTCACCTGGTGTACAATTTTCAGGTGTTAACTACCAACTAACCCCTTATACTGATTACACCCTATCTATGCCATCAACGCAATCTGGTTATTGTCAAAACAGTCCTGTTTATGTTCAGTGTGGTGCTTGGACACCATATCGCTTACACTCTTTTGGATGTGATAGGGTTAGTTGTAATTATAATTTAACAACGGACTGGGTTGTTGGCTTTAAGTCAAAAGTACCACCTGTTACTTTACCTCAAGAACTTCGGCTGCCAATAGCTCAGAAAGTTTCGAGGAGGCTGGGTGTTAATGTACCTGATTATTTTTGGTTGGTTAAGCAATCTTATTTTTATTTGGCACAGTCTTTTAAGTCTCCTAATTACTCTTTGTTTGCTGCATTGCTTAATTCTATTTTTCAACAGTCTCGGTTTTTGACTGATTTGTGTTATTCACAACCTTTTTTTCAACTTCAGCAGTGCTATGATAATGCTTTATATTTACCTGATGCTGTGTTTTCAACTTTATTTTCTACACTTTTTCAATGGGATTATCAAGTTAAGTTTCCAAATAATAATAGGTTACAAGTTAATGAAACTTTTTTACAATTACCACCATATGAGTATGTTGGACAAACAATTTCACAGGGCCAGATTTTAAATTTGTTTAAAGATGCAATGGTTTTTTTGGATTTTTTTGATACTAAATTTTATAGAGTTAATGATGGACCTGGTGGTGATGTTTTTGCTGTTGTTGTTAAGCAAATGGAAGAGATAAAGTATAGTGATTTTAAGGTTAAGTTAGTTAATGGGTTTTTAGAGATTAGTTGCAAAAATGTTGTTAATGCAACACTTCAGCCACATGCCTCACAAGTTATTTTGTTAGCTAGACATATGTCAATGTGGTCTGTTGCTGCAGCTAACTCAACAACAATTTATTGTCCAATTTACACACTTACTCATTTTGGAACACTTGATATTTCTTCTTCTTGGTTTTTTCACACTTTAGCTAAACCATCTGGTCCTCTTAAAGAGATTTCTATGCCTATTTTATCAACTGCAGCTGCTGGTGTTTATATGTATGCTATGCCTGAACATTGGCTTTCTTTTTTACAACAGTTGCAACAAGTTTATCAGCCAAGTCTTTTTAGTTTGGGTATTAATATGACATCTGCTAACTCGTCTCAACTCCAGGCTTATGTTCAAAGTTATACAGCTTGGTATCTGTCTATTATTTACACCAGGCTGCCTGAGAGTCGGAGATTGAGTTTTGGTTCTCACTTGGTGCCATATATGCAGGCGTTGTTGTCATTTAGACAGTCAGATATTGATGCCACTGATGTTGATACTGTTGCTCGTTATAATACTTTATGTCTTATGTGGGGTAGAAAGTATGCTGTTGTTTCATATAATCAATTACCTGAATGGTCTTTACCTCTTTTTAGGGGTGACGTGGGTAGTTCTATGTGGTTTAGAAAAACCATTACTTGTGAAAATACACCTGCACATTTTTATCCCATAGTTGGCTATTTAGATTTTTTGGATTATAAATATATACCTAAGTATAATTCTGTACAGTGTCCTAATACTAATGTTCAACCGACACTGTTGCAAGTTTATGAAGTGCCTAATCTGTTTGTTATTATTGTTCAGTGTGTTTTTGGTTCATATTCTTGGTTTTCTGGTTTAACAGATAGACGGGCCTATACTTTTTATAGATCTTATAAAATTGGAACTATTTGCATTTTGTTACCATATAAAAAACCTTTTGGCAGTATTAGTACCATTGGTTTTTATAAACAGGAGTCCCTAAATATTCCAGTGGTTACCGTTACACAAGATTTGTTACCTAATTGTACTGGTATTATTATGGATGGCATTTTTACACCTTGCCATCCTTCTGGGTGTCCTGTGCGTAGTTCTTATGATAATTACATTGTTTGTAGAGGTGATAGTGGTTCTAATTACACTTTAAGGAATTATCACCGTGTATCTCCACCTGTTTATAATGTACCCTTATCTGAGGTTTCCTTAAACTTAACTGTACCAACAGTTGATTTTACATCATATAGTTTAAGCCCGTCAAATTCTGTGTTACTTCAAGATATTGATGGAGGAATTGTTGTAGATCATAATACAGGTTCTATTTGGTATCCTGATGGTCAAGCATATGATGTTTCATTTTATATTTCTGTTATTATACGTTATGCTCCTCCTAAGCTAGAATTACCATCTTCATTAGCTAATTTTACATCATGTTTAGACTATGTTTGTTTTGGAAACCAACAGTGTAGAGGTGAAGCACAAACTTTTTGTGCTTCAATGGATTATTTTGAACAGGTGTTTAATAAAAGTTTGACATCATTGGTAACGGCGTTAACAGATTTACATCATGTTTTAAAGTTAATATTACCAGAAACCACACTAGAACTCACTGACTCTTCACGCAGACAACGTCGCTCTGTGGATGAGTTTGCTGATAGTATTTCATTATTGTCTGAGTCATTTGAGAGGTACATGTCACCTGCTTCACAGGCCTATATGGCTAATATGATGTGGTGGGATGAAGCCTTTGATGGTATAAGTTTACCGCAAAGGTCTGGTTCTATTTTGTCACGGTCTCCATCTATTTCGTCAACATCTTCTTGGAGATCATATTCATCCCGTACACCACTAATTTCAAATGTAAGAACACCTAAAACTACATTTAATGTGAAGCTATCTATGCCTAAATTACCTAAGGCATCGACACTCTCAACTATTGGTTCTGTACTTTCATCTGGACTTTCTATTGCATCTCTTGGTTTATCTATTTTTTCAATCATTCAGGATAGACAAGTTACAGAACTTACTCAGCAACAAATTATGGCACTTGAGAATCAAGTAACAATTTTAACAGATTATACTGAGAAGAATTTTAAGGAAATACAATCTTCCTTGAATACATTGGGTCAACAGGTTCAGGATTTTTCACAACAGGTAACTTTGTCATTACAACAACTTTCAAATGGTTTAGAGCAGATTACACAACAGTTAGACAAAAGTCTTTATTATGTTACTGCCACTCAACAGTATTCTATATATATGTCATCTTTGATAAATCAGTTGAATGAATTGTCACAGGCTGTTTATAAGACGCAGGATATGTATATAACATGCATACATTCTTTGCAATCTGGAGTTCTTTCACCTACATGTATAACACCATCCCAAATATTGCAGCTTTATCAAGTGGCTAAAAATTTGGGTGGCAACTGTCAACCTATATTTTCTGAACGGGAGATTTCTCGGTTCTATTCGTTGCCACTTGTGACAGATGCTATGGTGCATAATGATACCTATTGGTTTTCTTGGTCAATTCCAATTACTTGTTCAAATATATTAGGTTCTGTTTTTAAGGTACAACCTGGGTACATAGTTAATCCATACCATCAAACAAGCTTACAATATGATTTACCAACACATGTTGTTACATCAAATGCAGGTGCATTGGTATTTAATAATCATTACTGTGACAGGTATAACCAGGTTTACTTGTGTACTAAGTCAGCTTTTGATCTTGCTGAATCTAACTACCTAACCATGATATATTCAAATGTTACTGGTAATGGTAGTCTGACTTTCCATCCAGAACCAAAACCTGATCCATGTGTTTACTTGTCAGCATCAACACTTTATTGTTTTTATTCCGATGTTTGTCATCAATGTGTTATTACTGTTGGTAATTGCACAAATCGTACTGTTACCTATGAGAATTATACCTACTTTATAATGGATCAGCAGTGTAGGGGTTTTGACCAAGTTACAATTTCATCACCAATAGATATTAGGTATGATTTTACAGCAATACCATCTAAACCCCCTTTACCATTGCATTTGTCATATATTAATGTTACTTTTAATGTAACTTTACCCAATGGTATGAATTGGACAGATTTGGTGTTAGATTATAGTTTTAAAGATAAAGTTTATGAGATATCAAAAAATATAACACAGTTGCATGAACAAATATTACAAGTGTCAAGTTGGGCTTCAGGATGGTTTCAACGTTTAAGGGATTTTCTTTATGGTTTACTTCCTGCTTGGATAACCTGGCTTACTTTAGGATTTAGTTTATTTAGTATTGTTATTAGTGGTGTAAATATTATATTATTTTTTGAAGTTAATGGTAAGGCTAAGAGAAGTTAG

Protein

MFLLFCTTSILCFWISSGGAYVVSNESLSLSEPVSYPFSLAVLRSFTQHVTGRFRRDVVKQVWDFAYQISTNRISVNGWDVVFKSPFILSYSNGMLNTSVLPFDAYMKSSIAKFSYTVTAYTGQRPYLNTQVNDLVNGGYSGWSDNVRVDNCGNYACHPGGKPGCSIGQPRMLQGVCTRVLPTTQSPGVQFSGVNYQLTPYTDYTLSMPSTQSGYCQNSPVYVQCGAWTPYRLHSFGCDRVSCNYNLTTDWVVGFKSKVPPVTLPQELRLPIAQKVSRRLGVNVPDYFWLVKQSYFYLAQSFKSPNYSLFAALLNSIFQQSRFLTDLCYSQPFFQLQQCYDNALYLPDAVFSTLFSTLFQWDYQVKFPNNNRLQVNETFLQLPPYEYVGQTISQGQILNLFKDAMVFLDFFDTKFYRVNDGPGGDVFAVVVKQMEEIKYSDFKVKLVNGFLEISCKNVVNATLQPHASQVILLARHMSMWSVAAANSTTIYCPIYTLTHFGTLDISSSWFFHTLAKPSGPLKEISMPILSTAAAGVYMYAMPEHWLSFLQQLQQVYQPSLFSLGINMTSANSSQLQAYVQSYTAWYLSIIYTRLPESRRLSFGSHLVPYMQALLSFRQSDIDATDVDTVARYNTLCLMWGRKYAVVSYNQLPEWSLPLFRGDVGSSMWFRKTITCENTPAHFYPIVGYLDFLDYKYIPKYNSVQCPNTNVQPTLLQVYEVPNLFVIIVQCVFGSYSWFSGLTDRRAYTFYRSYKIGTICILLPYKKPFGSISTIGFYKQESLNIPVVTVTQDLLPNCTGIIMDGIFTPCHPSGCPVRSSYDNYIVCRGDSGSNYTLRNYHRVSPPVYNVPLSEVSLNLTVPTVDFTSYSLSPSNSVLLQDIDGGIVVDHNTGSIWYPDGQAYDVSFYISVIIRYAPPKLELPSSLANFTSCLDYVCFGNQQCRGEAQTFCASMDYFEQVFNKSLTSLVTALTDLHHVLKLILPETTLELTDSSRRQRRSVDEFADSISLLSESFERYMSPASQAYMANMMWWDEAFDGISLPQRSGSILSRSPSISSTSSWRSYSSRTPLISNVRTPKTTFNVKLSMPKLPKASTLSTIGSVLSSGLSIASLGLSIFSIIQDRQVTELTQQQIMALENQVTILTDYTEKNFKEIQSSLNTLGQQVQDFSQQVTLSLQQLSNGLEQITQQLDKSLYYVTATQQYSIYMSSLINQLNELSQAVYKTQDMYITCIHSLQSGVLSPTCITPSQILQLYQVAKNLGGNCQPIFSEREISRFYSLPLVTDAMVHNDTYWFSWSIPITCSNILGSVFKVQPGYIVNPYHQTSLQYDLPTHVVTSNAGALVFNNHYCDRYNQVYLCTKSAFDLAESNYLTMIYSNVTGNGSLTFHPEPKPDPCVYLSASTLYCFYSDVCHQCVITVGNCTNRTVTYENYTYFIMDQQCRGFDQVTISSPIDIRYDFTAIPSKPPLPLHLSYINVTFNVTLPNGMNWTDLVLDYSFKDKVYEISKNITQLHEQILQVSSWASGWFQRLRDFLYGLLPAWITWLTLGFSLFSIVISGVNIILFFEVNGKAKRS

Function

Mediates the binding of virions to the host cell receptor and is involved in membrane fusion.

Subunit

Homotrimer.

Similarity

Belongs to the torovirinae spike protein family.
Belongs to the toroviruses spike protein family.

Keywords

Fusion of virus membrane with host membrane Glycoprotein Host-virus interaction Membrane Reference proteome Signal Transmembrane Transmembrane helix Viral attachment to host cell Viral envelope protein Viral penetration into host cytoplasm Virion Virulence Virus entry into host cell

Feature

chain Spike glycoprotein

Uniprot

A0A097P9K3 U5IJ97 A0A481ZGV7 A0A239QQX7 D7PC11 Q70KN5 + More
A0A3G4S8T0 A0A481W6L2 A0A0U4MWV7 A0A3G4S8L5 D4QEZ6 D4QEZ5 Q70KN4 D4QEZ4 D4QEZ3 A0A1X9H825 A0A0U5B0A6 D4QEZ2 O90304 A0A3G1RFS9 P23052

Pubmed

24122107 12915570 26708248 20220164 9879765 16137782 + More
2219698

EMBL

KM403390 AIU41585.1 JQ740195 JQ860350 AFZ75471.1 AGB05582.1 + More
MH603532 QBK95468.1 LT900503 SNT95684.1 GU196786 ADI16212.1 AJ575372 CAE01338.1 MG957145 AYU75157.1 MK521914 QBJ04615.1 LC088095 BAU21412.1 MG957146 AYU75161.1 AB526866 BAJ04618.1 AB526865 BAJ04617.1 AJ575373 CAE01339.1 AB526864 BAJ04616.1 AB526863 BAJ04615.1 KR527150 ANA57416.1 LC088094 BAU21406.1 AB526862 BAJ04614.1 AF076621 AY427798 MG996765 AWV66922.1 X52506

Proteomes

UP000119381 UP000111898 UP000269215 UP000138412 UP000207672 UP000102793 + More
UP000000355 UP000006571

PRIDE

O90304 P23052

Pfam

PF17072 Spike_torovirin

Interpro

IPR031412 S_torovirinae

ProteinModelPortal

A0A097P9K3 U5IJ97 A0A481ZGV7 A0A239QQX7 D7PC11 Q70KN5 + More
A0A3G4S8T0 A0A481W6L2 A0A0U4MWV7 A0A3G4S8L5 D4QEZ6 D4QEZ5 Q70KN4 D4QEZ4 D4QEZ3 A0A1X9H825 A0A0U5B0A6 D4QEZ2 O90304 A0A3G1RFS9 P23052

KEGG

vg:17603137 vg:3707766

GO

GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane
GO:0019062  P:virion attachment to host cell
GO:0039663  P:membrane fusion involved in viral entry into host cell
GO:0009405  P:pathogenesis
GO:0019031  C:viral envelope

From MSLVP

Single-Pass Membrane

From Uniprot

Virion membrane

Length:

1573

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

30.9980599999999

Exp number, first 60 AAs:

5.87265

Total prob of N-in:

0.26100

outside

1 - 1539

TMhelix

1540 - 1562

inside

1563 - 1573

Sequence

Summary

Ontologies

Subcellular Location

Topology