Strain
Bat_MH687940
(Region: Viet Nam; Strain: Alphacoronavirus sp. strain VZ_AlphaCoV_16715_45, complete genome.; Date: 10-Jun-14)
Gene
replicase polyprotein
Description
Annotated in NCBI,
replicase polyprotein
Location
GenBank Accession
Full name
Replicase polyprotein 1ab
Alternative Name
ORF1ab polyprotein
Sequence
CDS
ATGTCCAGCAACCATATTTCGTTGGCCTTTGCCAATGATACTGAAATTTCATCCATAGGCTTTGGTACCTACGATGAGGCCGTCTCATTTTACAGTGAGGCCGCCGCCCGTGGATTCGTCCAATGCCGCTTTGTGTCCTTTGGGCTCCAGCAAGCAGTCACTGGTCTTGAAGATGACGATATTGTTATGCTCGTGACTGGTGTTACTCAGCTACGCGCTTATTTGGGCACTTTTAATGATCGGCCTCCAAATTTGAGAGGTTGGATCGTTTTTTCAAATTGCAACTACTTCTTAGAAGAGTTGGATTTGATTTTTGGTCGTCAAGGTGGTACAACTATCCCTGTAGACCAATATATGTGTGGTTCTGATGGTTTGCCTGTCCTTCAGGAATGTGATTGGGAGTATACCGATTACTTTACAGAAGGTAATCAATTTACCCGTAATGGCATCACTTATGTGAAGGCCTGGGATGTTGATAGAAAGGCTGTGCCATATGAAAAGCAGAACCTTACTTGCATACGTAGAATTACGTATGTTACAGACAACCGTCATACTCTTGCTGATGGTACTGTCATGAAGACAGCTAAACACCCTAAAATTAACAAGAGTGTGGTACTTACACCTCCTTTTGACAAAATTTACATGGAAGTTGGCTCACCATTCATGGGTAATGGTGAAACTTTCGTAGAAATGGTCAAGGACCCAGTTTTCTTTCATGCTCTTATCACATGTCAATGCGGTAGAAGCGAATGGACTGTGGGTGATTGGAAGAGTTATAACTCACTTTGTTGTAACATCAAGTGTAAGCCTATTACAATTGTTGCCCCAAAGGCTGTCCCAGGTGCTGTGCTTGTCACCAAAGCTGACGTTGGTTCTGGTTTGAAATGTTACAGTAACGTGTTTATTAAGCATGTTACTGACATCACGGTGCCTGGGACAAAGTTGGGTTGGGGGATATGGCGTATTATGAAGGTACAAGCCAAGAATGATATAGCCATGTCAGGTAACCCACTAGTTGACGACCCGGATGACAAGTTAGACCCTTGTTATTTCGAGAATGATGGCCATTTTTCGACTAAATTCAAAATTCAGTTGCTCTCAAACTCCTTTGATGATGAAGTGAAGGGTGCCATCATGCAGGGCATTTTGAAAGTCAACACCGTTATATGTGACCTGGTCAAAGACATGTTGGGCATTCCTTGGTTCATTAAGAAATTGGGCACCTTAGCCGTTAATTTGTGGAACCAGTTTGTCTCAACAGTTAGAGGCATGAAGCTTTGTAGTTCCAAGGTTTTGGAGCTGGCAAAGGCTATTTCTTGTGCTTCTATGTCTGTTGTCAATGGTGCTTTGCGAGTTGTTGCTGATGTACCCTTGCTTTTTAAGGGTGCGTTTGACACGCTTGTTGGCGCTATTGGTTGCATTTTTACTAGTACGTGTGACACTTTAGCTGTGGCTGGTAGAGCTTTTGCTAGAGTTGGTGACATGGTTATTATGCCTAAGTCGCTTGTCCGTCTTGTTAAATCTAAAGTTAAAGGACCAAGACAGGCTGGTTTGAAGCAGTTGCAATTTGCCACTGTCGTTCTTGGAGACACACAGAAGGTCCGCTCATCTAGAGTGGAATTCTCTACAGTCAACCTTAAAATGGTAGACGAAGACGTGCCTTTGAACCCTGATGGGTACACAGTGGCGGTTGGAGACCAGGCGTTCTTTTGCAGTGACGGTGTCTACAGATTTATGTCTGATTTGGATGCTGTGTTACTCGAGCCTGTTTTCAAACCAGAGCTTGATTTGGAACCTATTTTTGACTGCCAACCAATTCCAGGCTTTCCTAAGGTTGCTGCCTCAAATGTTGCAGAACTTTGTGTAAAAGTGGACAGTCTTCTTTTTAATTATGACAAACCTTATAAGAAGTATAGTACCATCATAAGAGGTGATAGGTGCTGCGTACAGTGTTCTTACACTTTTAAGGCACCATACTATTACTTTGAAGAAGAAGAGTTTGTTGACAACTGTCAAAAGTATCATGACACTCCAGGGTTTGAATCTTTCTATAATGCAGCGCTGCAAGCTCCTGACATGGAGGCGTTTTGTGGACTTTGCGTTGGAGACTTTGATAGTTTTCTGCCAAAGATTCCAGAATGTCCTCCTGTATTGTTTGAACTAGATGGTGGTTCCATTTGGTATTCATTCATAGCAGGTGTTCGTAGCGTTAAGGATTTTATTTTGAGTCTTAAAGTAAACCTTGATTTAAATGGTGTAAAAGTGGCAGTTGCTAAAAGATTTAAAAAGTTTGGTGTGATGTTGCAACAGTTGTATAATACGTTTTTGGACACTGTTAGTAGTGTTGTGAGTGTGGCCGGTGTTGCATTCAAGTACTATGCTACTACTGTTCCAAAGATTGTTGTTAACGGTTGCTTTCATACTGTTACAAGGCTGTTTTCAAAAGATTTTGCGTTACCGGTTGAGGATGGTATTACGGAGTTTAATGCTTTTAACCACTGTACATTTCCAGTCAATCCTACTAAGATTGAGAAGGATGAAATAGAATTGGAGGAAGTGCATTACGTCGAACCTGCAACTAATGGTAAACTTGTTGTTTGTGACGATTATGCTTTCTACAATTATGGTGATAAGTACTATCCTTCTGATGGCAAAGGTATTGTGCCAGTTTGCTATAAGAAGAAAGGTGGTGGGTTGGTTTCTATATCTGATGATGTCAAGATTCATACCATAGATCCTGTTTACAGGGTCAAAGTTGAGTATGAGTTTGAAAATGAAACCATTGTTAAAGTCTGTGAAAAAGCCATTGGTACTAGACTTAAAGTCACAGGTGGTTGGGATCAGTTGTTAGAAACTGTTGACATTTCTATGAATGCTGTAAAACAGCATCTTGATGTACCCAACTACTATGTCTACGATGAAGAAGGTGGTACTGATATTAACCTTCACATCATAGTTTCTCAGTGGCCGCTTGCTAGTGGTGCCCAAGGTGACGATTTTGAATGTGTCAATGACTCAGAGCTAGAAGAGGTCGAGTCTGTATGCGACTTAATAACCCAAGCTGTTGCAGATGCCGACAATGACTGTGGTGATGTAGTGGAGACTGTCGAAGCAAAGTCTAATGAGCAGCTTGAAGTTGAAGCTGCACTTGCTTTTATGAAACCACAACCTATACAACGACCGGTTACTAATAAACAGCACGATTTGTTTTCGTTTGAGTTTTTTAGTTACGGTGGTTTGAAGGTTTTAAAACAGTCTAGTAATAATTGTTGGGTTAGTGCAACTATGATTCAATTGCAGCTTACTGGCCTGGATGACAGCGACGAAATGAAACTTTTCGAAGCTGGAAGGGTGGGCCCAATGGTTAAGCGTTGTTATGAAGCACAAAAAGCAATAGTTGGTTCTTTGGGTGATGTTTCAGCTTGCCTGGAGTCATTACTTAAGGACAAGGACGGTTTGAGTCTGACCTGTAATGTTCAATGTGCTTGTGGTGTTGGTGTTCGTGTTTATGAAAACGCAGTTTTTCGTTTTACACCAACTAAAGAACCTTTTCCTATGGGTTGCTGCCCTATTTGTTCTAAAGTCCTCATGCACAGTATTACACAGTTAAAGGGTACTGGTATCTTTTGCCGAGATCCAACTCAGTTGGATGTGGAATCATTGGTTGTAAAACCATTGTGTGCTGCTGTGTATGTAGGAGACAGAGATGGTGGACATTATGTTACAAACATGTATGACTGTAATATGGCCGTTGATGGTAATGGTAGACACCCTTTAAGATACGATACGGTTAACACATTGTGCTACCGTAACGTGGATTGGGAATTGGTTGAAACTCCTATTGTTGAGACACCAAAGCCTTTTGTTGTCTTCAAAAATGTTGAGTTCTACCAAGGTGAGTTCACCAAGTTGGTGTGTCTTCAGCACGATTTTGTTGTTAATGCTGCAAATGAGAATCTTGCTCATGGTGGTGGCATTGCGAAAGTGTTGAATGATTACACAAATGGTGAATTACAGATTAAGTCTAACAGTTACATTAAGGCCAATGGTCCTGTTAAAGTTGGTTCTGGTGCTTTTGTTAAATGTGGCAATTGCAACATTTTAAATGTTGTTGGTCCTCGTAAGGGTAAACATGCACCAGAGCTCTTGACTAAGGCTTACACTTTTATTTTTAAACAGAAGGGCGTTCCATTGACGCCACTGCTTAGTGTTGGCATTTTTAAAGTTCCAATTGAAGAGTCTTTGGCTGCGTTGCTTGCTTGTGCTGGAGACAGTGTCTGCCGGTGCTTCTGCTATAGTGATGTCGAAAGGCAAGCTATTGAAAAGTTTGTTTCCAATGCAGTTCAGGTTCCTGTTACTGTTGTAGATGACAAACCCAAAGAAGTTGTTAAAGTCAAGCAATCAGTTCAGCCTTTTAGAGTTGAAGGTGCCTCAAAGTTTTATGAGCCCAAACCTGATCTTATACGTCATGTTGGTGCTGACAAAATCGTTTCGTTCACGTCTAGTGACTTTGAACTGTCTGATTTTTTCAAAAGTTGTGACGTCTATTTGGACAAACAACTTACTAAGGCCATACAGGAGTATAGAAAGGTTAACACTAATGTCCCTGCTGGTAACTGCGTTACACTTAAGTGTGACGGGTTTACTTCTTTTACATTTGTTGTGTTACCTAAGGCTGATGAAAAGGGCTATGAAAAGAACTTTAATAGAGCCATCACTAAGTTTTTTAAACTTAAAGGTACATTATTAGTTGTTGTTGATGATGTCAACATTTTTTCGAAAATCTCACATTTTGCTGTTTTGGGCTATGTTGCAAGCCATGTCCTAGTTGACAAATTGTTTGAAGTGAAACCTGTGCAGGTGGTTGTGACAAAGGATCAGCGTACCTTTGACACAGTTGAACTTTCCACTGACAAAACCTTTGGCGATCAATTAGGTTCTTGTGTTGTGGAGGGTAAAAATGTTACAGACTTGAAGCCTGTGTCCAGTGATAAGGTCGTAAGTGTTGTTCCAAATGTTGATTGGGATAAGCATTACGGTTTTAAGGATGCTGGTGTTTTCCATTCCATGGACCACTCAAGTTTTACATTTGACAACAATGTTGTTGCTGGTAAGCGTGTTTTGCGTACCAGTGATAATAATTGTTGGGTTAATGCCACTTGTTTACAATTGCAGTTTGCAAATGCTAAGTTCATTTCTAGGGGCTTGCAGAGTATATGGGACTCTTATTGCACTGGTGATGTCGCTCTTTTCACGCACTGGTTGTATTTTATGACTGGCGTGGAAAAGGGCCAACCCAGTGATGCAGAGAATGCACTTAATGTCATCTCCAAATATCTTAAACCACAGGGTTCTGTTGAAATGATTCGATCCACAGCCACTGGATGTGACGGTTCTTGTGTTTCTAAGAGAACCGTTTCAACTCCTGTCGTCAATGCAAGTCTTCTTAAGGTGGGTCTTGATGACGGTAATTGCGTCCATGGTATGCCTCTTATTGATCGCGTTGTCTCTGTTAAGGGTAACGTGATTTTAACAGGTGTGGGTGAATCAGTTGGTAAGCCCGTTGTTGCAACAGAAAGTCTTTTGTTAGATGGTGTTTCGTACACAGTCTTTCAAGACAGTGCATCTGGTGTCGGTCACTACACAGTTTATGATAAGTGTGGTAAGTTGGCATTTGATGGTGACATGCTTAAACCATGTGACTTGAATGTCGCACCTGTTACCAGTATGGTTGTTAACAACGTGGAAAGGGTTGTAGTTCAGGACCCAGTGAAAAGAGTTGAATTAGATGCTAGTAAATTGTTAGATACAATGAATTTGGCATCTGATAAGTTTTTCACATTTGGCGATTTTGTTTCTAGAAATATCATAGTACTTATAGTACACATCTTTAGCCTTCTTTCTTTATGTTATAGAGCTTTTAAAAAGCAGGATATAAAGGTAATGGCTGGTGTACCACAACGTACAGGTATAATATTGAGGCGAAGTTTGAAGTACAATTATAAAGCTTTAAAGTTTTTCTTTAAGTTGAAATTTTACTACGTTAAGTTTTTCTTAAAGTTGTGCTTGTTGCTTTATACTATATACGCTCTCACCTTTATGTTTATACGTTTTACACCTGTAGGTACGCCAATCTGTAGAAGTTATGTGGATGGTTACTCTAATTCTACTTTTGATAAGAACTCCTACTGCGGTGGCGTTCTTTGCAAGATTTGCCTTTTTGGTTATGATGAACTAGCGGACTTTGCCCACACCAAGGTTGTTTGGCAGCATTTAAAAGACCCATTAATTGGTAATGTGATGCCTTTCTTCTATATGGCTTTTCTCATTATCTTTGGTGGTTTTTATGTTAGGTCCATGGTTATGTACTTTTTGTTGCAGTACCTCAACGCAGCAGGTGCAGCGTTGGGCTACCAGGAGAGAGTCTGGCTTTTGCACCTGTTACCGTTCAGTACTGTTGGTAACATAGTGGTTGTGGCTTTTATAGTTGTCCGTGCACTACTCTTTTTGAAGCATGTGTTGTTTGGTTGTGATAAACCGTCATGCATAGCTTGTTCTAAAAGTGCTAAACTAACGAGGGTCCCCTTACAAACTATTATGCAAGGTGTTACCAAGTCCTTTTATGTTAATGCCAATGGTGGTAAAAAGTTTTGCAAGAAACACAATTTCTTTTGTGTTGAGTGCGACTCTTATGGTCCAGGCTGCACTTTTATTAATGATGTTATAGCACCAGAAGTTAGCAATGTCATGAAACTTAATGTCATGCCCACTGGTCCTGCTACTATAACCATTGATAAAGTTGAGTTCAGTAATGGTTTTTATTACCTCCATAGTGGTTCCACGTTCTGGAAATATAACTATGACATTACAGACAGCAAATACTCATGTAAAGATGTGCTTAAGAATGGCAACATAGTTTCAGATTTTGTTGTTTTTAACAACAGTGGTAGTAATATAACGCAGGTTAGGAATGCTTGTGTTTATTTCTCGCAGTTGTTATGTAAACCTATCAAGATTGTTGATTCTGCACTCTTGGCTTCTCTGAATGTTGACTTTTCTGCCAACTTGCACAAGGCTTTTGTTGAAGTCCTCAGCAATAGCTTTGGCAAGGATTTGTCTGGTTGTTCCAATATGAACGAATGTAAAGAGGCTCTTGGACTTGGTGATGTCTCCGAAGAAGAGTTCACAGGTGCTGTGTCAGAGGCCCATCGTTATGATGTGCTTATTTCTGACGTTTCATTTAATAACTTGGTTACCTCTTATGCCAAACCTGAAGAAAAACTGCCTGTTCATGATATAGCAAATTGTATGCGTGTAGGCGCTAAAATTGCTAATCATAATGTGCTTACTAAAGACAATGTGCCTGTTGTCTGGTTAGCTAAAGACTTCATAGCATTGTCTGAAGAAGCCCGTAAGTACATAGTCAGGACTACTAAGACTAAGGGGTTGAATTTTATGCTAACGTTTAATGATAGACGTATGCATTTGACCATACCTACTGTTAACATTGCAAACAAGAAAGGTGCTGGTTTGCCCTCTATTCTTAGTAATTTATATAAATTCTTATGGTATGTTTGTTGTTTTATAGTCGTTGTCTTTTTGGCTACTAGTTTGCTTGATTTTTCAGCTCAAGTTTCTAGTAACATGGATTACGACTTTAAGTACATTGAAAATGGCGTTCTGAAGGCTTTTGAAAAATCACTTGACTGTGTACATAATGGTTTTGTTAACTTTGACTCCTGGCATAATGCCAAGTTTGGCAGTGTACCTGTGAAGAGTCGTAGTTGTCCCATTGTAGTTGGTACCTCGGATGAAGTTCGTGCTGTACCAGGTGTGCCATCAGGTGTTTTTCTTTATGGTAAGTCACTCATTTTTGCCATGAGTACCATTTTTGGAACATCAGGTTTGTGTTTTGATGAAAGAGGTCTTACAGACCCTGATTCTTGCACCTTTAACTCTGCTTGTACTACTTTGAAAGGTATTGGTGGTTCTGCTGTTTATTGTTACCGTGACGGCATTGTGGAAGGTTCTAGACTATACAGTGATTTACTACCACATAGTTTTTATAGGTTAGTTGATGGTAATCATATTGTTTTACCTGAAATAATCTCACGTGGTTTTGGTTTTAGGACAATTAAAACGCAGGCCATGACCTATTGCAGAACTGGCGAGTGTATTGATTCAGAAGCTGGTGTCTGTGTTGGTCTGGATAAGTTTTTTGTCTTTAGCAAAACCCCTGGTAATGACTATGTTTGTGGTAGTGGGTTTGTGTCTTTAATTGGCAACATTATTGGTATGTTTTCCAATTCTATACCTGTCACTGTGCTGTCGGGCCAAATATTGTTTAACTGTATGGTTGCTTTCATGGCAGTCATGCTGTGCTTTGCTTTTACCAAGTTTAAACGTATGTTTGGTGACATGTCTATGGGTGTTTTTAGTGTTGGTTTGTGTACTGTTGTTAATAACATCTCATATGTAATCACACAAAATTCACTTGGTATGTTGGCTTATGCCACTTTATACTTTCTATGTACAAAAGGTGTTAGGTATGCTTGGATTTGGCACTTTGGTTTTGTCGTTTCATACCTATTTATGGCACCATGGTGGGTTGTTGTATCCTACTTTTTGTGTTCTATTGTTGAGTTTTTGCCCAACTTGTTCAAGCTTAAAGTATCTACCCAGCTTTTTGATGGTGATAAATTTGTTGGCTCTTTTGAAGATGCTGCTGCTGGCACATTTGTGCTTGACATGCATTCCTATCAAAAATTAGCAAACTCTATTACCACTGAAAAGCTTAAACAGTATGCCGCATCTTATAATAAATATAAATATTATAGTGGTGCAGCTAGTGAAGCGGATTATCGTTTGGCTTGTTTTGCGCATCTTGCTAAAGCAATGGGTGACTTCTCAACTGACCACATGGACAAATTGTACACGCCACCCACCATTAGTTACAACACAACCTTGCAGGCTGGCTTACGTAAAATGGCACAACCTTCGGGTGTGGTTGAACGGTGCATAGTGCGTGTCACTTATGGAAATTTGACACTTAATGGCCTTTGGCTGGGTGATGTAGTTATTTGTCCTAGACATGTTATAGCTAGTAATACTACTACTGTGATAGATTACGACCATGCTATGTCACTTGTTAGGTTGCATAACTTTTCAATTTCTTATGGTAACATGTTTTTAGGTGTTGTTAGCGTTTCAATGCGTGGCACCTTATTGCATGTTAAAGTTAACCAGAGCAATGTGAACACACCAAATTATTCATACAAGACTTTGAGACCAGGTGATTCATTTAACATCTTAGCTTGCTATGATGGTAGTGCCGCAGGTGTTTATGGTGTTAATTTACGCACCAATTACACCATTCGTGGCTCTTTTATAAATGGCGCATGTGGCTCTCCAGGTTACAACATCAACAAAGGGGTTGTTGAATTTTGCTACATGCACCACCTTGAACTAGGTTCGGGTTGTCATGTTGGTAGTGACATGGACGGTTCTATGTATGGTAATTATGATGATCAACCGACATTGCAGATTGAGGGTTCTAGTAACCTGGTTACTGAAAATGTTTGTTCGTGGCTTTATGCAGCTCTTATTAATGGTTGCAATTGGTGGTTAGTCTCTGCTAGTATGGGACTCGAAACTTTTAACGAATGGGCCCTTCGTAATGGCATGACCCCATTGCAAAATACAGATTGTTTCTCACTGTTGGTAGCCAAAACTGGTGTTGATGTTGGTAGAATACTAGCATCGATTCAGAAGTTGAGTAACAATTTTGGTGGTAAGAGCATTTTAGGTTGTTCAACGTTGAATGATGAGTTTACATTGCCTGAAGTTGTCAAGCAAATGTATGGTGTTACATTGCAAAGCAGCAAAGTTTCACGTGCTTTTAGAAACACTTTTATTGTTTGTTGCTTCTTGTTTTTGTTTTTGTCAGAGGTGTTAACTCATTCGCAATTCTTTTGGGTACATCCAGGTTATGTTACTCCAGTGTTTTTGTTATTGTTGTTCGTCGCAACGTGTTTGATGTTTTTGGTTAAGCATAAATTGTTGTTCTTGCAACTATATTTGCTTCCTTCTGTTTGCATTGTAGCTGGTTATAATGTAGTGCTGGATTATGAGTTGTATGTGCGCCTCTTAGAAGAGTTTGACTATAAAATGCCTGTTAGTGGTTTTAATATGCAAGGTTTATTGAGTATTGTGCTCTGTTGTTTTGTGATGGCATTACACACATACAGGTTTGTTAAAGCACCTAGTAGGTTTACCTCTTACATTGTGGCACTTGTCACTGTTGGTTACACTTACTATTATTCTTTTGACATTGTGGGTTTGTTGCTTACTGTTGCATCAAGCTTTACAAGTCATTGGTTTATAGGTGCAGCTACCTATAAATTAGTAGTCTACGTTTTGCCTTACGTCTCTGTTTTATCGCCCTTTGGCCAGGTGAAAAGCGCAGTTTTGTTGTACTTGTTTGTTGGATACTTTAACTGTGTGTTCTATGGCACTTTGTACTGGGTTAATAGGTTTTGTAAATTAACTTTGGGTTGTTATGACTTTAAAGTTAGCCCAGTAGAATTTAAATACATGGTTGCTAATGGCCTTAGAGCTCCAACAGGTGTTTTTGATGCCCTTTGGTTGTCATTAAAACTAGTAGGAGTTGGTGGCAAACGTACCATTAAGATTTCATCTGTGCAGTCTAAACTCACAGATCTTAAGTGTACTAATGTTGTTTTATTAGGCTGTTTGACTAATATGAACATTAGTGCTAATTCTGCTGAGTGGGCTTATTGTGTTGATTTGCACAACAAAATTAACCTTTGTAGTGACCCAGAGTTGGCTCAAGAGATGCTTCTTGCACTGTTAGCCTTCTTTCTTAGTAAGAATAGTGCCTTTGGTATTGAGGATTTATTGGAATCGTATTTCAACGATAGTTCCATTTTACAGAGTGTTGCAGCTACTTATGTTAATTTGCCTTCATATATGGCTTACGAAAATGCTCGTCAAAGTTATGAAGACGCTTTGGCTAATGGTTCTCCCCCCCAATTAGTTAAACAACTTAGACATGCTATGAATGTCGCAAAGAGTGAGTTTGACAGGGAAGCTTCTACGCAACGTAAGTTAGACAGAATGGCTGAACAAGCTGCTTCTCAAATGTATAAGGAGGCACGCGCTGTTAACCGTAAGTCCAAAGTTGTAAGTGCTATGCATTCATTGCTTTTTGGTATGCTTAGGCGCTTGGATATGTCATCTATTGACACCATTCTTAACTTAGCTAAAGATGGTGTTGTGCCGCTCTCAATCATCCCCGCTGTTAGTGCTACTAAGCTCAATATCGTTGTTTCTGATATTGATTCTTATGTTAAGATTCAGCGTGAAGGATGCGTGCACTATGCTGGTGTCATTTGGTCAGTTGTTGACATTAAAGATAATGACGGAAAACCAGTGCATGCTAAGGAGGTGGTTGCTAATAATGTTGAAGCCCTTGCTTGGCCTTTGTTCTTGAACTGTGAACGTATTATTAAGTTGCAGAATAATGAAATTATTCCTAGCAAACTTAAACAACGACCAGTTAAGGCAGAAGGTGAAGGCTTTACGGCAGATGGCAATGCTCTTTATAGTACAGAAGGTGGACGTACATTTATGTATGCATTCATCTCTGATAAGGCAGACCTTAAAGTTGTTAAATGGGAATTTGATGGTGGTTCTAACGCTATAGAATTGGAACCACCAAGGAAATTTCTGGTGGATTCTTCTAGTGGTCCTGTTGTTAAATACTTGTACTTTGTGCGCAACTTGAATAACTTGCGCAGAGGTGCAGTCTTAGGTTTTATCGGTGCAACAGTACGTTTGCAGGCTGGTAAACAGACAGAGCAGGCTGTTAATTCACCTCTTTTAACACTATGTGCATTCGCCGTAGACCCCGCTAAAACTTACTTAGATGCCGTTAAGGGTGGTCAAAAACCAGTTGGCAATTGTATTAAGATGCTTGCTAATGGATCTGGTAATGGTCAAGCCATTACTAATGGTGTTGAGGCCAGTACTAACCAAGATTCATATGGTGGTGCTTCTGTGTGTCTTTATTGTAGAGCACATGTGGAACACCCGGATATGGACGGTTTTTGTAAACTTAAAGGCAAGTATGTTCAAGTCCCGTTGGGTACTTTAGATCCTATACGGTTTGTACTTGAAAATACAGTATGTAAGGTTTGTGGGTGTTGGCAGGCTAATGGTTGTGTTTGTGACAGGTCTGTTGTGCAGAGTGTGGACACAGGTTATTTAAACGAGTGCGGGGCTCTAGTGCAGCTCGACTAGAGCCCATAAATGGTTCGGACACACATCATGTGTGCCGTGCTTTTGATATATACAATCGTGATGCTGCATGTATTAGTAAATTCTTGAAGGTGAACTGTGTTCGTCTCAGGAATTTGGACAAACATGACGCCTTTTGGGTTGTTAAAAAGTGCACGAAGTCAGTTATGGAACACGAGCAATCCATATATGAACTGATTTCAGATTGTGGTGCAGTTGCTAAGCATGACTTTTTCACATGGAAAGAGGGTAGGTCTATCTATGGCAATGTCTGTAGACAAGATCTTACCGAGTATACCATGATGGATTTGTGTTATGCTTTGCGCAACTTTGATGAGAATAATTGTCAAACACTTAAAGACATTCTTGTTGTAGTAGGGGCTTGTGATGTCTCTTACTTTGAGAACAAGTTGTGGTTTGATCCTGTTGAAAATGAAGATATTCACCGTGTTTATGCCAAACTTGGTACCGTGGTTGCTAGAGCAATGCTTAAGTGTGTTAAACTCTGTGACGCCATGGTTGACAAGGGCATAGTCGGTGTTATAACCTTAGACAATCAGGACCTTAATGGTGATTTCTATGATTTTGGAGACTTTGTTACTAGTGTTAAAGGGATGGGTGTGCCTATATGTACGTCATATTATTCATATATGATGCCGATTATGGGTATGACCAATTGCTTAGCTAGTGAATGTTTTATTAAGAGTGATATTTTTGGTGAAGATTTTAAGACTTTTGATCTTTTGGCGTATGACTTCACAGAGCACAAAGTCAATCTTTTCAATAAATATTTTAAACATTGGGGTCAGGTTTATCACCCAAATTGTGAGGACTGTTATGATGAACATTGTATAGTTCATTGTGCAAACTTTAACACTTTGTTTGCGACCACTATACCTATTACCGCTTTCGGCCCGCTGTGTCGTAAGTGTTGGATTGATGGTGTGCCGCTAGTTACAACAGCTGGCTATCATTTCAAACAATTGGGTATTGTGTGGAACAAAGATCTTAATTTACATTCAAGCAGGTTGACGATCAACGAACTCCTGCAGTTTTGTGCTGATCCGTCACTGCTTATAGCGTCGTCTCCAGCTTTAGTAGACAAACGCACTGTGTGCTTCTCTGTGGCTGCTCTGGGTACTGGCATGACTAATCAAACTGTAAAGCCAGGCCATTTTAACAAAGATTTTTATGACTTCTTGAGAAGTCAGGGATTCTTTGAGGAAGGCTCAGATTTGACATTGAAGCATTTTTTCTTTGCACAAAAAGGTGATGCTGCTGTTGAAGATTTTAACTATTACCGATATAACCGTACTACTGTTTTAGATATTTGCCAAGCTCGTGTTGTGTACCAAATAGTGCAATGCTATTTTAGTGTATACGAAGGTGGTTGTATAACTGCCAAAGAGGTTATTGTTAACAACCTTAACAAGAGTGCTGGTTATCCGTTTAACAAGTTTGGTAAGGCGGGTCTTTATTATGACTCATTGTCCTATGAAGAACAAGATGAGTTGTACGCTTATACCAAGCGTAATATAATTCCCACCATGACCCAGTTAAATCTTAAGTATGCAATCAGTGGTAAGGCCCGTGCACGCACTGTCGGTGGTGTTTCTCTTCTGTCAACTATGACTACTAGGCAGTATCACCAAAAGCATTTAAAATCCATAGTTAATACAAGAGGTGCTTCTGTTGTCATTGGTACAACCAAATTCTATGGTGGCTGGGACAACATGCTTAAAACACTTATTAAGGATGTAGACAACCCTAATCTTATGGGTTGGGATTATCCTAAGTGTGATAGAGCGTTGCCCAACATGATTAGAATGATTTCTGCTATGATTCTTGGTTCCAAGCACGTTAACTGCTGCAATGCCACGGATCGGTATTACAGGCTTTGTAATGAGCTGGCCCAAGTTCTTACGGAAGTGGTTTATTCTAATGGTGGTTTTTATATTAAGCCAGGTGGCACAACTTCTGGTGATGCAACCACAGCTTACGCCAATTCAGTTTTTAACATCTTTCAGGCTACTAGTGCTAATGTTAACAGGTTGTTGAGTGTTGATAGTAACACTTGTAACAACATAGAGGTTAAACAGTTACAGCGCAAGTTGTATGATTGTTGTTATAGGTCATCCAATGTTGACCCAAGTTTTGTTGAAGAGTACTTCAGTTACTTGCGTAAACATTTTTCAATGATGATCCTTTCCGATGATGGTGTTGTTTGCTACAACAGTGAATATGCATCTCTGGGTTATGTTGCCGACCTTAGTGCATTTAAGGCAGTTTTGTATTATCAAAATAATGTCTTTATGAGTGCGTCTAAGTGTTGGATTGAGCCCGATATTAACAAAGGCCCACATGAGTTTTGTTCACAGCACACTATGCAGATAGTTGATAAGGATGGAACTTATTACCTTCCTTACCCGGATCCCTCTAGAATTTTATCTGCCGGTGTGTTTGTTGATGACATTGTAAAGACAGACCCTGTTATACTCCTAGAACGTTATGTTTCTTTGGCTATAGATGCTTATCCATTGTCAAAACATGACAATCCAGAATACCGTCGTGTATTCTATGTAATGTTGGACTGGGTTAAGCATCTTTACAAGACACTTAACCAAGGGGTTTTGGAGTCTTTTTCTGTTACTTTGTTGGAAGACGCCACAGCCAAATTTTGGGATGAGAGTTTTTATGCTAATATGTACGAGCGTTCAGCTGTTTTGCAATCTGCTGGTCTTTGCGTCGTTTGTTCTTCACAAACTGTGCTAAGATGCGGTGACTGCATACGCAGACCCATGCTCTGTACTAAGTGTGCATATGACCACGTTGTAGGCACTAGTCATAAGTTCATCTTGGCCATTACACCCTATGTGTGTTGTTCATCAGGTTGCGGTGTTTCTGACGTTACAAAACTTTACCTTGGTGGTCTCAGTTATTGGTGTGTTGACCACAAACCACGCCTCGCGTTTCCACTTTGTTCTAGTGGTAACGTTTTTGGTCTTTACAAGAATTCGGCTACTGGTTCCCCAGACGTTGACGAGTTCAACATTCTAGCAACTTCCGATTGGACAGATGTTAGAGATTACAAGTTGGCAAATGACGTTAAAGATTCTTTACGCTTGTTTGCAGCTGAAACAATAAAGGCCAAAGAAGAGAGTGTTAAATCGGCTTATGCTTGTGCCACAATTCATGAGATAGTTGGACCTAAAGAACTAGTTTTGAAATGGGAAGCTGGTAAACCAAGACCACCTCTCAACCGTAATTCAGTTTTCACTTGTTATCACATAACCAAGAACACTAAGTTCCAGGTGGGTGAATTTACGTTTGAAAAACTGGATTATGATAACGATGCAGTTAGTTTTAAATCTACTGCTACTACTAAGTTAGTTCCAGGCATGGTTTTTGTGCTGACTTCACATAATGTTCAGCCTTTGCGTGCTCCAACTTTGATAAACCAAGAAAGGTATTCCACTTTGCACAAGCTTCGACCTGCTTTCAACGTACATGAAGACTATTCCAGTTTGATACCCTACTATCAATTAATAGGTAAGCAGAGAATTACTACTATTCAAGGTCCCCCTGGAAGTGGTAAATCTCATTGTGTTATTGGTTTAGGTCTTTATTTTCCAGGAGCTAGAATCGTGTTTACGGCTTGTTCTCATGCAGCTGTAGATTCTTTGTGTGTTAAAGCAGCCACAGCATATAGTGTGGACAAGTGCTCACGGATCATCCCCCAAAAGGCACGTATTGAGTGCTATGATGGTTTTAAACCAAATAATACTGGTGCTCAATACTTGTTCTCCACTGTTAATGCTCTGCCTGAAGTCAATGCAGACATTTGTGTGGTGGATGAAGTGTCTATGTGTACCAATTACGATTTGTCTGTTATTAACCAACGTGTTAATTACAAACACATTGTTTATGTAGGTGACCCGCAGCAACTGCCTGCCCCTAGAGTTATGATAACCAAGGGTGTTTTGTCACCGGGGGATTATAATGTCGTCACAAGACGTATGTGTGCACTTAAGCCTGACATCTTTCTGCACAAGTGTTATCGTTGTCCAGCTGAAATCGTTAATACGGTTTCAGAGATGGTTTACGAAAACCAATTCAAGCCTGTCAAGTCTGAAAGTAAGGAGTGCTTTAAGATTTATTGTCGTGGCAATGTGCAGGTTGATAATGGTTCCAGTATTAATAGACGGCAACTTGATGTTGTTCGTATGTTTTTGGCTAAGAACCCAAAGTGGGCAAAGGCTGTCTTTATTTCTCCTTACAATAGTCAAAATTATGTTGCAGGCAGAGTTTTGGGTTTGCAAATTCAAACCGTGGATTCTTCCCAGGGTAGCGAGTATGATTACGTCATTTACACACAGACTTCTGACACGGCACATGCTAGCAACGTTAATCGTTTTAACGTTGCTATAACTAGGGCTAAGAAGGGTATCTTGTGTGTTATGTGTGATCGCGAGTTGTTTGACATACTTAAGTTTTATGAACTTAAGTTGTCTGATTTGCAAGCAGGTGATGGTTGTGGTTTGTTTAAAGATTGTTATAAAGGCGATGACAACTTACCACCATCACATGCAGCTACCTATATGTCTCTGTCTGACAATTTTAAAACTGATAAGGATTTGGCTGTCCAAATTGGTGTTAATGTGCCCATTAAATATGAACACGTCATATCTTTTATGGGCTTTAGATTTGACATCAATGTACCTAACCAGCACACATTGTTTTGTACAAGAGATTTTGCTATGAGAAATGTTAGAGGTTGGCTAGGTTTCGATGTGGAAGGTGCACATGTTATTGGCAGCAATGTAGGCACTAATGTACCTCTTCAATTAGGGTTTTCTAATGGTGTTGATTTTGTTGTACGCCCTGAAGGTTGTGTTTCAACTGAGAGTGGTGATTCAATTCAACCGGTTAGAGCTCGTGCTCCTCCTGGCGATCAATTTACACATTTGTTGCCTTTATTACGTAAAGGACAACCTTGGAGTGTGGTCCGTCGTCGTATTGTGCAAATGTGTAGTGATTACCTAGTAAACCTGTCAGATACACTTATATTTGTGTTGTGGGCAGGTGGTTTGGAGCTAACTACGATGAGGTACTTTGTTAAATTAGGACCATTCAAAGCCTGTGAGTGTGGTAATAAGGCAACTTGTTACAACAGTGTTAATCACACCTTTACATGTTTTAAACATGCATTGGGTTGTGACTATTTGTATAACCCCTATTGTATTGATGTTCAACAATGGGGTTACACGGGCTCTCTTAGCATGAACCATCATGAATTTTGCAACATTCATCGTAATGAACATGTAGCATCGGGTGATGCTGCTATGACACGCTGTCTAGCTGTGCATGATTGTTTTGTTAAGAATGTTGATTGGTCTATCACCTATCCATTTATTGCCAATGAACAAGCCATCAATAAGAGTGGCAGGGTTGTGCAGTCACACGTTATGCGTGCTGTTTTAAAGTTGTATAATCCACGTGCTGTTCATGACATTGGTAATCCTAAGGGCATACGTTGTGTTGCCGCTGATGTTAGTTGGTTTTGTTATGATAAAAACCCTACTAATAACAATGTCAAAAGGTTAGAGTACGATTATATAACACATGGTCAGATGGAAGGTTTGTGCCTATTTTGGAATTGTAATGTTGATATGTACCCGGAATTTTCTGTGGTTTGCAGGTTTGACACTAGATTACGTTCCAATCTCAATCTGGAAGGTTGCAACGGTGGTTCGCTCTATGTTAACAACCATGCATTCCACACACCAGCCTTTGACAAACGCGCATTTGCCAAATTGAAGGCAATGCCGTTTTTCTTTTATGATGACAGTGATTGTGAAAAACTTCAAGACTCCATCAATTATGTGCCATTGCATGCTTCCAATTGCATAACTAAGTGCAATGTGGGAGGTGCTGTTTGTAGTAAGCATTGTGCATTGTACCACAATTATGTCAATGCTTATAATACCTTCACCACGGCTGGTTTTACTATCTGGGTACCTACCACCTTTGACACTTTTAACCTTTGGCAAACTTTTAAAAATTCAACTGTCCAGGGCTTAGAGAATATAGCCTATAATGTTGTAAAAAAAGGTTCTTATGTAGGTGTTGAGGGTGAGTTGCCTGTAGCCATAGTGCATGACAAGGTTATGGTGCGTGATGGTGTTTCTGACAACGTTGTTTTTGTTAACAGCACGTCTCTACCTACAAATATTGCTTTTGAACTTTATGCAAAACGTAAAGTAGGTTTGACACCACCACTTACAATTTTGAAAAACCTTGGTGTTGTTTGCACTAGTAAATGTGTTTTGTGGGATTATGAAGCAGCAAGGCCGCTCACTACTTTTACAAAGGATGTTTGTAAATATACTGATTTTGACGGTGACGTTTGTACTCTTTTTGACAATAGTGTACCTGGTTCTTTCGAACGATTCACTATGGCAAAAGATGCTGTTTTGATTTCTTTAACTGCAGTTAAGAAACTCACCGCTATCAAAATTACTTATGGTTATCTGAATGGTGTACCAGTTTCTACACATGAAGACAAACCTTTTACATGGTATATTTACACCAGAAAGAATGGCAACTTTGAGGACTATCCTGACGGTTATTTCACTCAAGGTCGCACTGTTTCTGATTTCAAACCACGTAGTATCATGGAAGAAGATTTTCTTAACATGGACACTGGTTTGTTCATAAGTAAATATGGTTTGGAGGATTTTGGATTTGAACATGTTGTGTATGGTGATGTGTCTAAAACCACTCTTGGTGGTTTACACTTACTCATTTCACAAATACGATTATCTAAAATAGGTGTGCTGAAAGTAGAAGATTTTGTTTCTAGTTCAGACAGCACTCTTAAATCATGTACCGTTACTTATGTTGACAATCCTAGTAGTAAAATGGTTTGTACTTATGTTGATTTGTTGCTTGATGACTTTGTTTGTATTTTGAAGTCTGTGGACCTTAGTGTTGTTTCTAAGGTTCATGAAGTTGTTATTGATTGTAGGGTTTGGCGTTGGATGTTATGGTGTAAGGACCACAAAGTTCAGACCTTTTATCCCCAACTTCAGTCTGCAGAATGGAAGTGTGGATACTCCATGCCCTCCATTTATAAGATTCAACGTATGTGTTTAGAACCATGTAATTTGTATAATTATGGTAGTGGTTTAAAGCTTCCTGATGGCATCATGTTTAATGTTGTTAAATACACTCAGTTGTGCCAATTTTTGAATAGTACCACTATGTGCGTCCCTCATCATATGAGAGTGCTGCACTTAGGTGCTGGTTCTGATAAGGGTGTGGCCCCTGGTACAGCTGTGTTACGTAGGTGGCTGCCTATGGATGCAGTTATTGTGGATAATGATGTCAATGACTATGTTAGTGATGCTGATTTTAGTTACACAGGTGATTGTGCTTCTATGTACCTCACTGATAAATTTGACCTTGTCATTTCAGACATGTACGATGGTCGTACTAAGTCGTGTGATGGTGACAATGTGTCTAAAGAGGGTTTCTTCCCTTACATTAATGGTGTTATCACTGAGAAGTTAGCTCTCGGTGGAACTATTGCCATTAAAATTACAGAGTTTAGCTGGAATAAAAAGCTTTACGAGCTTGTTCAAAAGTTTGAGTATTGGACAATGTTTTGTACTAGTGTCAATACTTCATCATCTGAAGCTTTTATCGTTGGCGTGCATTACCTGGGCGATTTTGCGAACAAAGCAATAATTGACGGTAATACCATGCATGCCAACTATATATTCTGGCGCAATTCCACTATTATGGCTATGTCCTATAATAGCGTACTAGATTTAAGTAAGTTTAATTGTAAGCATAAGGCTACAGTTGTTGTTAATTTGAAAGAAAGTGCGGTTTCAGACGTTGTGCTGGGATTGTTGAAAAATGGTAAGTTGTTGATTAGAAATAATGGTGTTGTTTGTGGGTTTTCTAACCACTTGGTAAATTCAACCAAATGA
Protein
MSSNHISLAFANDTEISSIGFGTYDEAVSFYSEAAARGFVQCRFVSFGLQQAVTGLEDDDIVMLVTGVTQLRAYLGTFNDRPPNLRGWIVFSNCNYFLEELDLIFGRQGGTTIPVDQYMCGSDGLPVLQECDWEYTDYFTEGNQFTRNGITYVKAWDVDRKAVPYEKQNLTCIRRITYVTDNRHTLADGTVMKTAKHPKINKSVVLTPPFDKIYMEVGSPFMGNGETFVEMVKDPVFFHALITCQCGRSEWTVGDWKSYNSLCCNIKCKPITIVAPKAVPGAVLVTKADVGSGLKCYSNVFIKHVTDITVPGTKLGWGIWRIMKVQAKNDIAMSGNPLVDDPDDKLDPCYFENDGHFSTKFKIQLLSNSFDDEVKGAIMQGILKVNTVICDLVKDMLGIPWFIKKLGTLAVNLWNQFVSTVRGMKLCSSKVLELAKAISCASMSVVNGALRVVADVPLLFKGAFDTLVGAIGCIFTSTCDTLAVAGRAFARVGDMVIMPKSLVRLVKSKVKGPRQAGLKQLQFATVVLGDTQKVRSSRVEFSTVNLKMVDEDVPLNPDGYTVAVGDQAFFCSDGVYRFMSDLDAVLLEPVFKPELDLEPIFDCQPIPGFPKVAASNVAELCVKVDSLLFNYDKPYKKYSTIIRGDRCCVQCSYTFKAPYYYFEEEEFVDNCQKYHDTPGFESFYNAALQAPDMEAFCGLCVGDFDSFLPKIPECPPVLFELDGGSIWYSFIAGVRSVKDFILSLKVNLDLNGVKVAVAKRFKKFGVMLQQLYNTFLDTVSSVVSVAGVAFKYYATTVPKIVVNGCFHTVTRLFSKDFALPVEDGITEFNAFNHCTFPVNPTKIEKDEIELEEVHYVEPATNGKLVVCDDYAFYNYGDKYYPSDGKGIVPVCYKKKGGGLVSISDDVKIHTIDPVYRVKVEYEFENETIVKVCEKAIGTRLKVTGGWDQLLETVDISMNAVKQHLDVPNYYVYDEEGGTDINLHIIVSQWPLASGAQGDDFECVNDSELEEVESVCDLITQAVADADNDCGDVVETVEAKSNEQLEVEAALAFMKPQPIQRPVTNKQHDLFSFEFFSYGGLKVLKQSSNNCWVSATMIQLQLTGLDDSDEMKLFEAGRVGPMVKRCYEAQKAIVGSLGDVSACLESLLKDKDGLSLTCNVQCACGVGVRVYENAVFRFTPTKEPFPMGCCPICSKVLMHSITQLKGTGIFCRDPTQLDVESLVVKPLCAAVYVGDRDGGHYVTNMYDCNMAVDGNGRHPLRYDTVNTLCYRNVDWELVETPIVETPKPFVVFKNVEFYQGEFTKLVCLQHDFVVNAANENLAHGGGIAKVLNDYTNGELQIKSNSYIKANGPVKVGSGAFVKCGNCNILNVVGPRKGKHAPELLTKAYTFIFKQKGVPLTPLLSVGIFKVPIEESLAALLACAGDSVCRCFCYSDVERQAIEKFVSNAVQVPVTVVDDKPKEVVKVKQSVQPFRVEGASKFYEPKPDLIRHVGADKIVSFTSSDFELSDFFKSCDVYLDKQLTKAIQEYRKVNTNVPAGNCVTLKCDGFTSFTFVVLPKADEKGYEKNFNRAITKFFKLKGTLLVVVDDVNIFSKISHFAVLGYVASHVLVDKLFEVKPVQVVVTKDQRTFDTVELSTDKTFGDQLGSCVVEGKNVTDLKPVSSDKVVSVVPNVDWDKHYGFKDAGVFHSMDHSSFTFDNNVVAGKRVLRTSDNNCWVNATCLQLQFANAKFISRGLQSIWDSYCTGDVALFTHWLYFMTGVEKGQPSDAENALNVISKYLKPQGSVEMIRSTATGCDGSCVSKRTVSTPVVNASLLKVGLDDGNCVHGMPLIDRVVSVKGNVILTGVGESVGKPVVATESLLLDGVSYTVFQDSASGVGHYTVYDKCGKLAFDGDMLKPCDLNVAPVTSMVVNNVERVVVQDPVKRVELDASKLLDTMNLASDKFFTFGDFVSRNIIVLIVHIFSLLSLCYRAFKKQDIKVMAGVPQRTGIILRRSLKYNYKALKFFFKLKFYYVKFFLKLCLLLYTIYALTFMFIRFTPVGTPICRSYVDGYSNSTFDKNSYCGGVLCKICLFGYDELADFAHTKVVWQHLKDPLIGNVMPFFYMAFLIIFGGFYVRSMVMYFLLQYLNAAGAALGYQERVWLLHLLPFSTVGNIVVVAFIVVRALLFLKHVLFGCDKPSCIACSKSAKLTRVPLQTIMQGVTKSFYVNANGGKKFCKKHNFFCVECDSYGPGCTFINDVIAPEVSNVMKLNVMPTGPATITIDKVEFSNGFYYLHSGSTFWKYNYDITDSKYSCKDVLKNGNIVSDFVVFNNSGSNITQVRNACVYFSQLLCKPIKIVDSALLASLNVDFSANLHKAFVEVLSNSFGKDLSGCSNMNECKEALGLGDVSEEEFTGAVSEAHRYDVLISDVSFNNLVTSYAKPEEKLPVHDIANCMRVGAKIANHNVLTKDNVPVVWLAKDFIALSEEARKYIVRTTKTKGLNFMLTFNDRRMHLTIPTVNIANKKGAGLPSILSNLYKFLWYVCCFIVVVFLATSLLDFSAQVSSNMDYDFKYIENGVLKAFEKSLDCVHNGFVNFDSWHNAKFGSVPVKSRSCPIVVGTSDEVRAVPGVPSGVFLYGKSLIFAMSTIFGTSGLCFDERGLTDPDSCTFNSACTTLKGIGGSAVYCYRDGIVEGSRLYSDLLPHSFYRLVDGNHIVLPEIISRGFGFRTIKTQAMTYCRTGECIDSEAGVCVGLDKFFVFSKTPGNDYVCGSGFVSLIGNIIGMFSNSIPVTVLSGQILFNCMVAFMAVMLCFAFTKFKRMFGDMSMGVFSVGLCTVVNNISYVITQNSLGMLAYATLYFLCTKGVRYAWIWHFGFVVSYLFMAPWWVVVSYFLCSIVEFLPNLFKLKVSTQLFDGDKFVGSFEDAAAGTFVLDMHSYQKLANSITTEKLKQYAASYNKYKYYSGAASEADYRLACFAHLAKAMGDFSTDHMDKLYTPPTISYNTTLQAGLRKMAQPSGVVERCIVRVTYGNLTLNGLWLGDVVICPRHVIASNTTTVIDYDHAMSLVRLHNFSISYGNMFLGVVSVSMRGTLLHVKVNQSNVNTPNYSYKTLRPGDSFNILACYDGSAAGVYGVNLRTNYTIRGSFINGACGSPGYNINKGVVEFCYMHHLELGSGCHVGSDMDGSMYGNYDDQPTLQIEGSSNLVTENVCSWLYAALINGCNWWLVSASMGLETFNEWALRNGMTPLQNTDCFSLLVAKTGVDVGRILASIQKLSNNFGGKSILGCSTLNDEFTLPEVVKQMYGVTLQSSKVSRAFRNTFIVCCFLFLFLSEVLTHSQFFWVHPGYVTPVFLLLLFVATCLMFLVKHKLLFLQLYLLPSVCIVAGYNVVLDYELYVRLLEEFDYKMPVSGFNMQGLLSIVLCCFVMALHTYRFVKAPSRFTSYIVALVTVGYTYYYSFDIVGLLLTVASSFTSHWFIGAATYKLVVYVLPYVSVLSPFGQVKSAVLLYLFVGYFNCVFYGTLYWVNRFCKLTLGCYDFKVSPVEFKYMVANGLRAPTGVFDALWLSLKLVGVGGKRTIKISSVQSKLTDLKCTNVVLLGCLTNMNISANSAEWAYCVDLHNKINLCSDPELAQEMLLALLAFFLSKNSAFGIEDLLESYFNDSSILQSVAATYVNLPSYMAYENARQSYEDALANGSPPQLVKQLRHAMNVAKSEFDREASTQRKLDRMAEQAASQMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSIDTILNLAKDGVVPLSIIPAVSATKLNIVVSDIDSYVKIQREGCVHYAGVIWSVVDIKDNDGKPVHAKEVVANNVEALAWPLFLNCERIIKLQNNEIIPSKLKQRPVKAEGEGFTADGNALYSTEGGRTFMYAFISDKADLKVVKWEFDGGSNAIELEPPRKFLVDSSSGPVVKYLYFVRNLNNLRRGAVLGFIGATVRLQAGKQTEQAVNSPLLTLCAFAVDPAKTYLDAVKGGQKPVGNCIKMLANGSGNGQAITNGVEASTNQDSYGGASVCLYCRAHVEHPDMDGFCKLKGKYVQVPLGTLDPIRFVLENTVCKVCGCWQANGCVCDRSVVQSVDTGYLNRVRGSSAARLEPINGSDTHHVCRAFDIYNRDAACISKFLKVNCVRLRNLDKHDAFWVVKKCTKSVMEHEQSIYELISDCGAVAKHDFFTWKEGRSIYGNVCRQDLTEYTMMDLCYALRNFDENNCQTLKDILVVVGACDVSYFENKLWFDPVENEDIHRVYAKLGTVVARAMLKCVKLCDAMVDKGIVGVITLDNQDLNGDFYDFGDFVTSVKGMGVPICTSYYSYMMPIMGMTNCLASECFIKSDIFGEDFKTFDLLAYDFTEHKVNLFNKYFKHWGQVYHPNCEDCYDEHCIVHCANFNTLFATTIPITAFGPLCRKCWIDGVPLVTTAGYHFKQLGIVWNKDLNLHSSRLTINELLQFCADPSLLIASSPALVDKRTVCFSVAALGTGMTNQTVKPGHFNKDFYDFLRSQGFFEEGSDLTLKHFFFAQKGDAAVEDFNYYRYNRTTVLDICQARVVYQIVQCYFSVYEGGCITAKEVIVNNLNKSAGYPFNKFGKAGLYYDSLSYEEQDELYAYTKRNIIPTMTQLNLKYAISGKARARTVGGVSLLSTMTTRQYHQKHLKSIVNTRGASVVIGTTKFYGGWDNMLKTLIKDVDNPNLMGWDYPKCDRALPNMIRMISAMILGSKHVNCCNATDRYYRLCNELAQVLTEVVYSNGGFYIKPGGTTSGDATTAYANSVFNIFQATSANVNRLLSVDSNTCNNIEVKQLQRKLYDCCYRSSNVDPSFVEEYFSYLRKHFSMMILSDDGVVCYNSEYASLGYVADLSAFKAVLYYQNNVFMSASKCWIEPDINKGPHEFCSQHTMQIVDKDGTYYLPYPDPSRILSAGVFVDDIVKTDPVILLERYVSLAIDAYPLSKHDNPEYRRVFYVMLDWVKHLYKTLNQGVLESFSVTLLEDATAKFWDESFYANMYERSAVLQSAGLCVVCSSQTVLRCGDCIRRPMLCTKCAYDHVVGTSHKFILAITPYVCCSSGCGVSDVTKLYLGGLSYWCVDHKPRLAFPLCSSGNVFGLYKNSATGSPDVDEFNILATSDWTDVRDYKLANDVKDSLRLFAAETIKAKEESVKSAYACATIHEIVGPKELVLKWEAGKPRPPLNRNSVFTCYHITKNTKFQVGEFTFEKLDYDNDAVSFKSTATTKLVPGMVFVLTSHNVQPLRAPTLINQERYSTLHKLRPAFNVHEDYSSLIPYYQLIGKQRITTIQGPPGSGKSHCVIGLGLYFPGARIVFTACSHAAVDSLCVKAATAYSVDKCSRIIPQKARIECYDGFKPNNTGAQYLFSTVNALPEVNADICVVDEVSMCTNYDLSVINQRVNYKHIVYVGDPQQLPAPRVMITKGVLSPGDYNVVTRRMCALKPDIFLHKCYRCPAEIVNTVSEMVYENQFKPVKSESKECFKIYCRGNVQVDNGSSINRRQLDVVRMFLAKNPKWAKAVFISPYNSQNYVAGRVLGLQIQTVDSSQGSEYDYVIYTQTSDTAHASNVNRFNVAITRAKKGILCVMCDRELFDILKFYELKLSDLQAGDGCGLFKDCYKGDDNLPPSHAATYMSLSDNFKTDKDLAVQIGVNVPIKYEHVISFMGFRFDINVPNQHTLFCTRDFAMRNVRGWLGFDVEGAHVIGSNVGTNVPLQLGFSNGVDFVVRPEGCVSTESGDSIQPVRARAPPGDQFTHLLPLLRKGQPWSVVRRRIVQMCSDYLVNLSDTLIFVLWAGGLELTTMRYFVKLGPFKACECGNKATCYNSVNHTFTCFKHALGCDYLYNPYCIDVQQWGYTGSLSMNHHEFCNIHRNEHVASGDAAMTRCLAVHDCFVKNVDWSITYPFIANEQAINKSGRVVQSHVMRAVLKLYNPRAVHDIGNPKGIRCVAADVSWFCYDKNPTNNNVKRLEYDYITHGQMEGLCLFWNCNVDMYPEFSVVCRFDTRLRSNLNLEGCNGGSLYVNNHAFHTPAFDKRAFAKLKAMPFFFYDDSDCEKLQDSINYVPLHASNCITKCNVGGAVCSKHCALYHNYVNAYNTFTTAGFTIWVPTTFDTFNLWQTFKNSTVQGLENIAYNVVKKGSYVGVEGELPVAIVHDKVMVRDGVSDNVVFVNSTSLPTNIAFELYAKRKVGLTPPLTILKNLGVVCTSKCVLWDYEAARPLTTFTKDVCKYTDFDGDVCTLFDNSVPGSFERFTMAKDAVLISLTAVKKLTAIKITYGYLNGVPVSTHEDKPFTWYIYTRKNGNFEDYPDGYFTQGRTVSDFKPRSIMEEDFLNMDTGLFISKYGLEDFGFEHVVYGDVSKTTLGGLHLLISQIRLSKIGVLKVEDFVSSSDSTLKSCTVTYVDNPSSKMVCTYVDLLLDDFVCILKSVDLSVVSKVHEVVIDCRVWRWMLWCKDHKVQTFYPQLQSAEWKCGYSMPSIYKIQRMCLEPCNLYNYGSGLKLPDGIMFNVVKYTQLCQFLNSTTMCVPHHMRVLHLGAGSDKGVAPGTAVLRRWLPMDAVIVDNDVNDYVSDADFSYTGDCASMYLTDKFDLVISDMYDGRTKSCDGDNVSKEGFFPYINGVITEKLALGGTIAIKITEFSWNKKLYELVQKFEYWTMFCTSVNTSSSEAFIVGVHYLGDFANKAIIDGNTMHANYIFWRNSTIMAMSYNSVLDLSKFNCKHKATVVVNLKESAVSDVVLGLLKNGKLLIRNNGVVCGFSNHLVNSTK
Summary
Function
The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity).
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).
The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G) (By similarity).
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).
The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G) (By similarity).
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.
Catalytic Activity
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
ATP + H2O = ADP + H(+) + phosphate
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
ATP + H2O = ADP + H(+) + phosphate
Subunit
3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer (By similarity).
Miscellaneous
Bat coronavirus 512/2005 is highly similar to porcine epidemic diarrhea virus (PEDV).
Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Similarity
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
Activation of host autophagy by virus
ATP-binding
Endonuclease
Exonuclease
Helicase
Host cytoplasm
Host membrane
Host-virus interaction
Hydrolase
Inhibition of host innate immune response by virus
Inhibition of host IRF3 by virus
Inhibition of host RLR pathway by virus
Membrane
Metal-binding
Methyltransferase
Modulation of host ubiquitin pathway by viral deubiquitinase
Modulation of host ubiquitin pathway by virus
Nuclease
Nucleotide-binding
Nucleotidyltransferase
Protease
Reference proteome
Repeat
Ribosomal frameshifting
RNA-binding
RNA-directed RNA polymerase
Thiol protease
Transferase
Transmembrane
Transmembrane helix
Ubl conjugation pathway
Viral immunoevasion
Viral RNA replication
Zinc
Zinc-finger
Feature
chain Non-structural protein 1
Uniprot
Pubmed
EMBL
Proteomes
PRIDE
Pfam
Interpro
IPR014829
NSP8
IPR014827 Viral_protease
IPR002589 Macro_dom
IPR009461 Coronavirus_NSP16
IPR042515 Nsp15_N
IPR027351 (+)RNA_virus_helicase_core_dom
IPR007094 RNA-dir_pol_PSvirus
IPR036499 NSP9_sf
IPR009466 NSP11
IPR037227 EndoU-like
IPR014822 NSP9
IPR009003 Peptidase_S1_PA
IPR013016 Peptidase_C30/C16
IPR038123 NSP4_C_sf
IPR037230 NSP8_sf
IPR027417 P-loop_NTPase
IPR029063 SAM-dependent_MTases
IPR018995 RNA_synth_NSP10_coronavirus
IPR041679 DNA2/NAM7-like_AAA
IPR009469 RNA_pol_N_coronovir
IPR032505 Corona_NSP4_C
IPR037204 NSP7_sf
IPR008740 Peptidase_C30
IPR014828 NSP7
IPR027352 CV_ZBD
IPR036333 NSP10_sf
IPR014827 Viral_protease
IPR002589 Macro_dom
IPR009461 Coronavirus_NSP16
IPR042515 Nsp15_N
IPR027351 (+)RNA_virus_helicase_core_dom
IPR007094 RNA-dir_pol_PSvirus
IPR036499 NSP9_sf
IPR009466 NSP11
IPR037227 EndoU-like
IPR014822 NSP9
IPR009003 Peptidase_S1_PA
IPR013016 Peptidase_C30/C16
IPR038123 NSP4_C_sf
IPR037230 NSP8_sf
IPR027417 P-loop_NTPase
IPR029063 SAM-dependent_MTases
IPR018995 RNA_synth_NSP10_coronavirus
IPR041679 DNA2/NAM7-like_AAA
IPR009469 RNA_pol_N_coronovir
IPR032505 Corona_NSP4_C
IPR037204 NSP7_sf
IPR008740 Peptidase_C30
IPR014828 NSP7
IPR027352 CV_ZBD
IPR036333 NSP10_sf
SUPFAM
ProteinModelPortal
PDB
6NUS
E-value=0.0 Score=1165 Identity=60.13%
Cov(Q)=13.71% Cov(P)=97.17%
3D Structure
Ontologies
KEGG
GO
GO:0039694 P:viral RNA genome replication
GO:0033644 C:host cell membrane
GO:0036459 F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016021 C:integral component of membrane
GO:0016896 F:exoribonuclease activity, producing 5'-phosphomonoesters
GO:0019082 P:viral protein processing
GO:0008270 F:zinc ion binding
GO:0039548 P:suppression by virus of host IRF3 activity
GO:0005524 F:ATP binding
GO:0003724 F:RNA helicase activity
GO:0039520 P:induction by virus of host autophagy
GO:0039648 P:modulation by virus of host protein ubiquitination
GO:0044172 C:host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0004197 F:cysteine-type endopeptidase activity
GO:0008168 F:methyltransferase activity
GO:0004519 F:endonuclease activity
GO:0003678 F:DNA helicase activity
GO:0032259 P:methylation
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0008242 F:omega peptidase activity
GO:0003723 F:RNA binding
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0006351 P:transcription, DNA-templated
GO:0033644 C:host cell membrane
GO:0036459 F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016021 C:integral component of membrane
GO:0016896 F:exoribonuclease activity, producing 5'-phosphomonoesters
GO:0019082 P:viral protein processing
GO:0008270 F:zinc ion binding
GO:0039548 P:suppression by virus of host IRF3 activity
GO:0005524 F:ATP binding
GO:0003724 F:RNA helicase activity
GO:0039520 P:induction by virus of host autophagy
GO:0039648 P:modulation by virus of host protein ubiquitination
GO:0044172 C:host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0004197 F:cysteine-type endopeptidase activity
GO:0008168 F:methyltransferase activity
GO:0004519 F:endonuclease activity
GO:0003678 F:DNA helicase activity
GO:0032259 P:methylation
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0008242 F:omega peptidase activity
GO:0003723 F:RNA binding
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0006351 P:transcription, DNA-templated
Subcellular Location
From MSLVP
Capsid
From Uniprot
Host membrane
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 1 publications.
Host endoplasmic reticulum-Golgi intermediate compartment The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA. With evidence from 1 publications.
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 1 publications.
Host endoplasmic reticulum-Golgi intermediate compartment The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA. With evidence from 1 publications.
Topology
Length:
6771
Number of predicted TMHs:
16
Exp number of AAs in TMHs:
379.236569999995
Exp number, first 60 AAs:
0.000790000000000001
Total prob of N-in:
0.00025
outside
1 - 1951
TMhelix
1952 - 1974
inside
1975 - 2016
TMhelix
2017 - 2039
outside
2040 - 2094
TMhelix
2095 - 2117
inside
2118 - 2141
TMhelix
2142 - 2164
outside
2165 - 2520
TMhelix
2521 - 2543
inside
2544 - 2749
TMhelix
2750 - 2771
outside
2772 - 2774
TMhelix
2775 - 2797
inside
2798 - 2809
TMhelix
2810 - 2827
outside
2828 - 2849
TMhelix
2850 - 2872
inside
2873 - 3303
TMhelix
3304 - 3326
outside
3327 - 3329
TMhelix
3330 - 3349
inside
3350 - 3353
TMhelix
3354 - 3373
outside
3374 - 3392
TMhelix
3393 - 3415
inside
3416 - 3426
TMhelix
3427 - 3449
outside
3450 - 3458
TMhelix
3459 - 3481
inside
3482 - 3487
TMhelix
3488 - 3510
outside
3511 - 6771
