Coronavirus Database

Strain

Harrisii_MK521914 (Region: Australia: wukalina/Mt William National Park, Tasmania; Strain: Torovirus sp. isolate Tasmania/Sarcophilus_harrisii/2016/DN128115, complete genome.; Date: 2017)

Gene

spike protein

Description

Annotated in NCBI, spike protein

Location

MK521914(+):20961-25715

GenBank Accession

QBJ04615.1

Full name

Spike glycoprotein

Alternative Name

E2
Peplomer protein

CDS

ATGTTTTTATGTTTCTGTACCGCGGCAATTTTGTGCCTCTGGGTTAATTCAGGAGGTGCCGTTGTTGTGTCAAATGAAACATTAGTGGTTTGTGAGCCAGTACTCTACCCTTACTCCCTACAAGTTCTTCGCTCTTTTTCACAGCGTCTTAATTTAAGAACAAAGAGATCTGTTACTACTGATGCCTGGTCTTTTGCCTACCAAATTTCAACTAATTCTTTGAATGTTAATGGTTGGTATGTTAATTTTACATCTCCTTTAGGTTGGAGTTATCCAAATGGTAAATTGGTTGGTGTTGTTTTGAGTTCTGATGCCATGATGAGAGCATCCCAGTCATTTTTTACATATGATGTTATTTCATATGTAGGGCAAAGACCAAATCTTGATTGTCAAATAAATGATTTAGTAAATGGTGGGTTGGAGGGTTGGCATAGCACTGTTAGAGTGGATAATTGTGGTAATTACCCATGCCATGGTGGGGGTAAACCTGGTTGTTCTATTGGACAGCCCTATATGGCTAATGGTGTGTGTACCCGCGTTTTGTCCACCATCCAGTCTCCAGGCATTCAGTATGAGATATATTCTGGTCAAGATTATGCTGTGTACCAAATTACACCTTATACACAGTACACTATTACCATGCCATCTGGAACCCCTGGCTACTGCCAACAGACACCGCTCTATGTAGAGTGTGGTTCTTGGACACCATACAGAGTCCATGCATATGGTTGTGATAAGGCAACTCAGAGCTGTAAGTATACTATTTCATCAGATTGGGTTGTCGCTTTTAAGAGCAAGATTACAGCGGTAACCCTACCACCAGATTTGAAGGTTCCAGTTGTACAAAAGGTTACTAAACGGCTTGGTGTTACATCTCCAGATTATTTTTGGCTAATAAAGCAGGCCTACCAGTATCTCTCACAGGCAGCAATTTCACCAAACTATGCATTGTTTTCGATACTTTCAAATTCACTCTATCAACAGTCTCTTGTTTTGACAGATCTGTGCTATGGTTCTCCATTTTTTGTGGCTCAGGAGTGCTATAATAATGCATTGTATTTGCCTGATGCTGTTTTTACTACTTTGTTTTCAATCTTGTTTAGCTGGGATTATCAGGTGAATTATCCAGTGAATAATGTTTTACAAGCAAATGAGACCTTTTTACAATTACCAACAACTGGATATTTGGGCCAGACAGTTTCCCAAGGACGCATGTTGAACCTTTTTAAGGATGCCATAGTGTTTCTTGATTTTTACGATACCAAGTTTTACCGTACGAATGATGGACCTGGTGGTGACATTTTTGCTGTTGTTGTGAAGCAAGTACCAGTCATCGCATATAGTGCATTTAGAATTGAACAACAGACTGGTGACTACCTTGCTGTTAAGTGTAACGGCGTTACACAGGCAACACTAGCACCACACTCATCTCGTGTTGTTTTGCTTGCTAGACACATGTCTATGTGGTCTATTGCAGCAGCTAACTCCACCACTATCTATTGTCCAATTTATACCTTGACACAGTTTGGTTCGCTTGATATTTCCACATCTTGGTATTTTCACACCTTGGCACAGCCGTCTGGCCCAATACAACAGGTTTCCATGCCTCTTCTTTCTACCGCCGCTGCTGGTGTTTATATGCATCCTATGGTTGAACATTGGGTTACTTTATTGACACAAACCCAAGATGTTTATCAGCCTAGTATGTTTAATATGGGTGTTAATAAGTCTGTTACTTTGACAACACAGTTGCAGGCTTATGCTCAGGTTTATACTGCTTGGTTTTTGTCCATTATATACACCCGGCTCCCCGAGTCTAGAAGATTGACATTGGGGGCACAGTTGACACCCTTTATCCAAGCACTTTTATCATTTAAGCAGGCTGATATTGATGCTACTGATGTTGATACAGTGGCCCGTTATAATGTTTTATCTTTGATGTGGGGTAGAAAGTATGCTGTTGTTTCTTATAACCAATTACCTGAGTGGTCATATCCCCTCTTTAAGGGTGGTGTTGGTGATTCTATGTGGTTTAGAAAAGAAATTTCTTGTACTAATCAAAATCCATCAACACCATCACATTTCCCCTTTATAGCGGGTTATTTGGATTTTTTAGATTATAAGTATATTCCTAAGTATAAAGATGTTGCATGTCCTACCACAATGGTAACACCTACATTATTGCAAGTTTATGAAACACCACAGCTGTTTGTTATAATTGTTCAATGTGTTTCAACTACATATTCATGGTACCCAGGACTTCGAAACCCACACACAATTTACCGTTCATATAAACTTGGCACAATCTGTGTTTTGGTGCCATACTCAAGTCCGACCAGTGTTTATTCATCATTTGGGTTCTTTTTTCAGTCTGCACTTACAATACCTACAGTGCAAACGACCGATGACATTTTACCTGGTTGTGTGGGTTTTGTACAAGATAGTGTTTTTACGCCATGTCATCCATCTGGTTGTCCTGTTCGGAATTCTTATGACAATTATATTATTTGTCCTGGTTCTAGTGCGTCAAACTATACCTTACGCAACTATTACAGGACAACTATTCCAGTTACGAATGTACCAATTGAGGAAGTGCCTTTACAGCTTGAAATACCAACAGTAAGTTTAACATCATATGAACTTAAACAATCTGAGTCTGTTTTGTTGCAGGACATTGAGGGGGGCATTGTTGTTGACCACAACACTGGTTCAATTTGGTATCCTGGTGGTCAGGCCTATGATGTCTCTTTCTATGTTTCTGTAATTATACGTTATGCTCCACCTAAGCTTGAGTTGCCATCTACACTTGCTAATTTTACATCGTGTCTTGATTACATTTGTTTTGGTAATCAACAGTGTAGAGGTGAGGCACAGACTTTTTGCACTTCAATGGATTATTTTGAACAAGTTTTTAATAAGAGTTTAACATCTTTGATAACAGCTTTGCAAGACCTGCATTATGTTTTAAAACTTGTGTTACCAGAAACAACCCTTGAACTTACTGAGGATACACGTCGTAGGCGACGTGCTGTAGATGAGTTTTCAGACACAATATCACTTTTGTCAGAGTCATTTGAGAGGTTTATGTCACCAGCTTCACAGGCCTATATGGCAAACATGATGTGGTGGGATGAAGCATTTGATGGTATAAGTTTGCCGCAGAGAACTGGCTCTATACTATCTAGGACACCTTCGCTGTCATCCATGTCTTCCTGGCATTCATATTCTTCACGAACACCACTTATTTCAAATGTCAAAACACCAAAGACTACTTTTAATGTGAAGTTATCTATGCCAAAGTTACCTAAGGCATCCACCCTCTCCACTATTGGGTCTGTACTATCATCCGGTCTCTCTATTGCTTCTTTGGGGTTGTCTATTTTTTCAATTATAGAGGACAGAAGAGTTACAGAGCTTACACAACAGCAAATTATGGCTCTTGAGAATCAGATTACTATTCTTACTGATTATACAGAAAAGAATTTTAAGGAAATACAATCCTCCTTGAATACTTTGGGACAGCAAGTTCAGGATTTTTCACAACAAGTGACATTGTCATTACAGCAGCTGTCTAATGGGTTAGAGCAAATTACCCAGCAGTTGGATAAGAGTATTTATTATGTTATGGCAGTACAGCAGTATGCCACCTATATGTCATCTCTTGTAAATCAGCTTAATGAGCTGTCCCAAGCTGTGTATAAGACACAAGATATGTATATAACATGTATACATTCTTTACAATCTGGTGTACTTTCACCCAATTGTATTACTCCTTCACAAATGTTTCAGTTGTATCAAGTGGCAAAAAATTTGAGCGGAGAATGTCAACCAATTTTTTCAGAGCGCGAGATTTCACGCTTTTATTCCCTTCCACTTGTTACTGATGCTATGGTGCATAATGATACTTATTGGTTTTCATGGTCAATTCCTATTACATGTTCCAACATCTTGGGCTCAGTTTATAAGGTTCAACCAGGTTACATAGTAAATCCCTACCACCCCACCAGCTTACAATATGATGTTCCTATTCATGTTGTTACGTCAAATGCTGGTGCGTTGATATTTGATGAGCATTATTGCGATAGGTATAACCAGGTTTACCTATGCACAAAGTCTGCATTTGATCTTACAGAATCTAGTTATCTTACAATGCTCTATTCTAATCAAACAGATAATAGTAGCCTGACATTTCATCCAGCACCAAAACCTGACCCTTGTGTTTATTTGTCAGCATCAGCCCTTTACTGCTATTATTCAGATGAATGTCATCAATGTGTTATAGCAGTTGGTAATTGTACTAATCGTACTGTTACCTATGAAAACTATACTTACCCAATTATGGATCCACAGTGTAGAGGTTTTGACCAGATAACCATATCATCACCAATTGCTATTGGTGCTGACTTTACAGCTTTACCATCTCGGCCACCTTTGCCTTTGCATCTGTCATATGTGAATGTTACATTTAATGTCACTTTACCCAATGGAGTTAATTGGACCGATTTGGTTTTAGATTATAGTTTTAAAGATAAAGTTTATGAAATTTCAAAGAATATAACCCAGTTACATGAGCAGATACTTCAAGTTTCCAATTGGGCTTCTGGATGGTTCCAGCGTTTAAGAGACTTTCTTTATGGTTTAATTCCTGCTTGGATTACTTGGCTTACTTTAGGTTTTAGTTTGTTTAGTATATTAATAAGTGGTGTAAATATTATATTGTTTTTTGAGATGAATGGCAAGGTTAAGAAAAGCTAG

Protein

MFLCFCTAAILCLWVNSGGAVVVSNETLVVCEPVLYPYSLQVLRSFSQRLNLRTKRSVTTDAWSFAYQISTNSLNVNGWYVNFTSPLGWSYPNGKLVGVVLSSDAMMRASQSFFTYDVISYVGQRPNLDCQINDLVNGGLEGWHSTVRVDNCGNYPCHGGGKPGCSIGQPYMANGVCTRVLSTIQSPGIQYEIYSGQDYAVYQITPYTQYTITMPSGTPGYCQQTPLYVECGSWTPYRVHAYGCDKATQSCKYTISSDWVVAFKSKITAVTLPPDLKVPVVQKVTKRLGVTSPDYFWLIKQAYQYLSQAAISPNYALFSILSNSLYQQSLVLTDLCYGSPFFVAQECYNNALYLPDAVFTTLFSILFSWDYQVNYPVNNVLQANETFLQLPTTGYLGQTVSQGRMLNLFKDAIVFLDFYDTKFYRTNDGPGGDIFAVVVKQVPVIAYSAFRIEQQTGDYLAVKCNGVTQATLAPHSSRVVLLARHMSMWSIAAANSTTIYCPIYTLTQFGSLDISTSWYFHTLAQPSGPIQQVSMPLLSTAAAGVYMHPMVEHWVTLLTQTQDVYQPSMFNMGVNKSVTLTTQLQAYAQVYTAWFLSIIYTRLPESRRLTLGAQLTPFIQALLSFKQADIDATDVDTVARYNVLSLMWGRKYAVVSYNQLPEWSYPLFKGGVGDSMWFRKEISCTNQNPSTPSHFPFIAGYLDFLDYKYIPKYKDVACPTTMVTPTLLQVYETPQLFVIIVQCVSTTYSWYPGLRNPHTIYRSYKLGTICVLVPYSSPTSVYSSFGFFFQSALTIPTVQTTDDILPGCVGFVQDSVFTPCHPSGCPVRNSYDNYIICPGSSASNYTLRNYYRTTIPVTNVPIEEVPLQLEIPTVSLTSYELKQSESVLLQDIEGGIVVDHNTGSIWYPGGQAYDVSFYVSVIIRYAPPKLELPSTLANFTSCLDYICFGNQQCRGEAQTFCTSMDYFEQVFNKSLTSLITALQDLHYVLKLVLPETTLELTEDTRRRRRAVDEFSDTISLLSESFERFMSPASQAYMANMMWWDEAFDGISLPQRTGSILSRTPSLSSMSSWHSYSSRTPLISNVKTPKTTFNVKLSMPKLPKASTLSTIGSVLSSGLSIASLGLSIFSIIEDRRVTELTQQQIMALENQITILTDYTEKNFKEIQSSLNTLGQQVQDFSQQVTLSLQQLSNGLEQITQQLDKSIYYVMAVQQYATYMSSLVNQLNELSQAVYKTQDMYITCIHSLQSGVLSPNCITPSQMFQLYQVAKNLSGECQPIFSEREISRFYSLPLVTDAMVHNDTYWFSWSIPITCSNILGSVYKVQPGYIVNPYHPTSLQYDVPIHVVTSNAGALIFDEHYCDRYNQVYLCTKSAFDLTESSYLTMLYSNQTDNSSLTFHPAPKPDPCVYLSASALYCYYSDECHQCVIAVGNCTNRTVTYENYTYPIMDPQCRGFDQITISSPIAIGADFTALPSRPPLPLHLSYVNVTFNVTLPNGVNWTDLVLDYSFKDKVYEISKNITQLHEQILQVSNWASGWFQRLRDFLYGLIPAWITWLTLGFSLFSILISGVNIILFFEMNGKVKKS

Function

Mediates the binding of virions to the host cell receptor and is involved in membrane fusion.

Subunit

Homotrimer.

Similarity

Belongs to the torovirinae spike protein family.
Belongs to the toroviruses spike protein family.

Keywords

Fusion of virus membrane with host membrane Glycoprotein Host-virus interaction Membrane Reference proteome Signal Transmembrane Transmembrane helix Viral attachment to host cell Viral envelope protein Viral penetration into host cytoplasm Virion Virulence Virus entry into host cell

Feature

chain Spike glycoprotein

Uniprot

A0A481W6L2 D4QEZ6 A0A0U5B0A6 D4QEZ2 D4QEZ5 A0A0U4MWV7 + More
Q70KN4 A0A3G4S8L5 D4QEZ4 A0A3G4S8T0 D4QEZ3 A0A1X9H825 O90304 A0A3G1RFS9 P23052 A0A097P9K3 U5IJ97 A0A481ZGV7 A0A239QQX7 Q70KN5 D7PC11

Pubmed

20220164 26708248 12915570 9879765 16137782 2219698 + More
24122107

EMBL

MK521914 QBJ04615.1 AB526866 BAJ04618.1 LC088094 BAU21406.1 + More
AB526862 BAJ04614.1 AB526865 BAJ04617.1 LC088095 BAU21412.1 AJ575373 CAE01339.1 MG957146 AYU75161.1 AB526864 BAJ04616.1 MG957145 AYU75157.1 AB526863 BAJ04615.1 KR527150 ANA57416.1 AF076621 AY427798 MG996765 AWV66922.1 X52506 KM403390 AIU41585.1 JQ740195 JQ860350 AFZ75471.1 AGB05582.1 MH603532 QBK95468.1 LT900503 SNT95684.1 AJ575372 CAE01338.1 GU196786 ADI16212.1

Proteomes

UP000102793 UP000138412 UP000207672 UP000000355 UP000006571 UP000119381 + More
UP000111898 UP000269215

PRIDE

O90304 P23052

Pfam

PF17072 Spike_torovirin

Interpro

IPR031412 S_torovirinae

ProteinModelPortal

A0A481W6L2 D4QEZ6 A0A0U5B0A6 D4QEZ2 D4QEZ5 A0A0U4MWV7 + More
Q70KN4 A0A3G4S8L5 D4QEZ4 A0A3G4S8T0 D4QEZ3 A0A1X9H825 O90304 A0A3G1RFS9 P23052 A0A097P9K3 U5IJ97 A0A481ZGV7 A0A239QQX7 Q70KN5 D7PC11

KEGG

vg:3707766 vg:17603137

GO

GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane
GO:0019062  P:virion attachment to host cell
GO:0039663  P:membrane fusion involved in viral entry into host cell
GO:0009405  P:pathogenesis
GO:0019031  C:viral envelope

From MSLVP

Single-Pass Membrane

From Uniprot

Virion membrane

Length:

1584

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

26.91551

Exp number, first 60 AAs:

2.2708

Total prob of N-in:

0.10244

outside

1 - 1550

TMhelix

1551 - 1573

inside

1574 - 1584

Sequence

Summary

Ontologies

Subcellular Location

Topology