Strain

USA_HS_2004_AY585228 (Region: USA;  Strain: Human coronavirus OC43 strain ATCC VR-759, complete genome.;  Date: 2004)

Gene

nucleocapsid protein

Description

Annotated in NCBI,  nucleocapsid protein

Location

AY585228(+):29079-30425

GenBank Accession

AAT84358.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGTCTTTTACTCCTGGTAAGCAATCCAGTAGTAGAGCGTCCTCTGGAAATCGTTCTGGTAATGGCATCCTCAAGTGGGCCGATCAGTCCGACCAGTTTAGAAATGTTCAAACCAGGGGTAGAAGAGCTCAACCCAAGCAAACTGCTACCTCTCAGCAACCATCAGGAGGGAATGTTGTACCCTACTATTCTTGGTTCTCTGGAATTACTCAGTTTCAAAAGGGAAAGGAGTTTGAGTTTGTAGAAGGACAAGGTGTGCCTATTGCACCAGGAGTCCCAGCTACTGAAGCTAAGGGGTACTGGTACAGACACAACAGACGTTCTTTTAAAACAGCCGATGGCAACCAGCGTCAACTGCTGCCACGATGGTATTTTTACTATCTGGGAACAGGACCGCATGCTAAAGACCAGTACGGCACCGATATTGACGGAGTCTACTGGGTCGCTAGCAACCAGGCTGATGTCAATACCCCGGCTGACATTGTCGATCGGGACCCAAGTAGCGATGAGGCTATTCCGACTAGGTTTCCGCCTGGCACGGTACTCCCTCAGGGTTACTATATTGAAGGCTCAGGAAGGTCTGCTCCTAATTCCAGATCTACTTCGCGCACATCCAGCAGAGCCTCTAGTGCAGGATCGCGTAGTAGAGCCAATTCTGGCAATAGAACCCCTACCTCTGGTGTAACACCTGACATGGCTGATCAAATTGCTAGTCTTGTTCTGGCAAAACTTGGCAAGGATGCCACTAAACCTCAGCAAGTAACTAAGCATACTGCCAAAGAAGTCAGACAGAAAATTTTGAATAAGCCCCGCCAGAAGAGGAGCCCCAATAAACAATGCACTGTTCAGCAGTGTTTTGGTAAGAGAGGCCCTAATCAGAATTTTGGTGGTGGAGAAATGTTAAAACTTGGAACTAGTGACCCACAGTTCCCCATTCTTGCAGAACTCGCACCCACAGCTGGTGCGTTTTTCTTTGGATCAAGATTAGAGTTGGCCAAAGTGCAGAATTTATCTGGGAATCCTGACGAGCCCCAGAAGGATGTTTATGAATTGCGCTATAACGGCGCAATTAGGTTTGACAGTACACTTTCAGGTTTTGAGACCATAATGAAGGTGCTGAATGAGAATTTGAATGCCTATCAACAACAAGATGGTATGATGAATATGAGTCCAAAACCACAGCGTCAGCGTGGTCATAAGAATGGACAAGGAGAAAATGATAATATAAGTGTTGCAGTGCCCAAAAGCCGCGTGCAGCAAAATAAGAGTAGAGAGTTGACTGCAGAGGACATCAGCCTTCTTAAGAAGATGGATGAGCCCTATACTGAAGACACCTCAGAAATATAA

Protein

MSFTPGKQSSSRASSGNRSGNGILKWADQSDQFRNVQTRGRRAQPKQTATSQQPSGGNVVPYYSWFSGITQFQKGKEFEFVEGQGVPIAPGVPATEAKGYWYRHNRRSFKTADGNQRQLLPRWYFYYLGTGPHAKDQYGTDIDGVYWVASNQADVNTPADIVDRDPSSDEAIPTRFPPGTVLPQGYYIEGSGRSAPNSRSTSRTSSRASSAGSRSRANSGNRTPTSGVTPDMADQIASLVLAKLGKDATKPQQVTKHTAKEVRQKILNKPRQKRSPNKQCTVQQCFGKRGPNQNFGGGEMLKLGTSDPQFPILAELAPTAGAFFFGSRLELAKVQNLSGNPDEPQKDVYELRYNGAIRFDSTLSGFETIMKVLNENLNAYQQQDGMMNMSPKPQRQRGHKNGQGENDNISVAVPKSRVQQNKSRELTAEDISLLKKMDEPYTEDTSEI

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Similarity

Belongs to the betacoronavirus nucleocapsid protein family.

Keywords

3D-structure   ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Reference proteome   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion  

Feature

chain  Nucleoprotein

Uniprot

Q696P4   U3M7Z6   A0A0G2RC83   U3M822   U3M820   U3M7K1   + More
U3M7Z8   U3M828   U3M7I5   A0A0B4N684   U3M6V0   U3M804   A0A127AT53   U3M7Z4   A0A0K0KPA1   P33469   A0A0G2RCY1   A0A0G2RCZ3   A0A0G2RCA8   A0A0G2RC64   U3M6V7   A0A0B4Q8L7   A0A127ATA9   A0A127AT23   A0A127AWK6   A0A127ATB4   A0A127AT99   A0A127AT45   A0A127ATA6   A0A127AT35   A0A127ATJ2   G5CJB5   A0A0B4N6W6   A0A0B4N7G3   A0A0B4UFS5   A0A385H6V0   A0A482KB57   A0A0G2RC66   A0A1S5VGJ0   A0A0K0KPQ5   A0A127AUM9   A0A0G2RC94   A0A0B4Q800   A0A0B4N7F3   A0A482KEV8   A0A0B4UEK7   A0A0B4N5V5   A0A127ATC1   A0A1S5VGI5   A0A0K0KQ87   U3M7J7   A0A0B4N6G8   A0A127AWJ2   A0A127AU02   A0A127ATK0   A0A127ATA3   A0A127AWL7   A0A127AT26   A0A127ATA7   A0A127ATB6   A0A0G2RC60   A0A127ATZ8   A0A0K0L9S6   U3M816   A0A1S5VGD1   A0A0B4N6G5   A0A482K8S6   Q4VIE0   A0A2D1QW28   A0A0G2RC68   A0A1W6DZX0   A0A385H5Z4   G5CJC3   A0A386BY28   A0A482KFL3   A0A1W6DZV4   A0A0B4N7G5   A0A1S5VG93   A0A0G2RCB5   A0A3S6FHP7   A0A127AUL9   A0A0K0KPA2   A0A385H5X1   A0A5J6NU34   A0A127AT13   A0A5B9MUK4   A0A1L7H9A3   A0A0G2RC86   A0A0B4N5U7   A0A0K0KQA8   Q4VID1   A0A0K0KPB1   A0A1V0PKZ6   A0A140E069   A0A3S6FHN9   A0A2D1CLX3   A0A3S6FH50   U3M826   A0A1W6DZW0   A0A0A0YP48  

Pubmed

15280490    26008694    25530469    26916286    2541577    15650185    + More
21849456    28050020    15914223    31534035    29950583   

EMBL

AY585229    AAT84366.1    KF530067    KF530076    KF530079    KF530082    + More
KF530088    KF530089    KF530091    AGT51485.1    AGT51574.1    AGT51604.1    AGT51634.1    AGT51694.1    AGT51704.1    AGT51724.1    KF963197    AIX10716.1    KF530095    KF530096    AGT51764.1    AGT51774.1    KF530094    AGT51754.1    KF530071    AGT51525.1    KF530077    KF530083    KF530087    KF530093    AGT51584.1    AGT51644.1    AGT51684.1    AGT51744.1    KF530084    KF530098    AGT51654.1    AGT51794.1    KF530063    KF530099    AGT51445.1    AGT51804.1    KF572794    AIL49474.1    KF530060    AGT51416.1    KF530086    AGT51674.1    KR055618    AMM42462.1    KF530068    KF530070    KF530081    KF572740    KF572743    KF572744    KF572756    KF923886    KF923887    AGT51495.1    AGT51515.1    AGT51624.1    AIL49420.1    AIL49423.1    AIL49424.1    AIL49436.1    AIV41778.1    AIV41784.1    KF572754    AIL49434.1    AY585228    AY391777    KF963201    KY014281    AIX10720.1    ATP16761.1    KF963211    AIX10730.1    KF963200    AIX10719.1    KF963204    AIX10723.1    KF530059    KF530061    KF530062    KF530064    KF530065    KF530066    KF530072    KF530073    KF530074    KF530075    KF530078    KF530080    KF530085    KF530090    AGT51406.1    AGT51426.1    AGT51435.1    AGT51455.1    AGT51465.1    AGT51475.1    AGT51535.1    AGT51545.1    AGT51555.1    AGT51565.1    AGT51594.1    AGT51614.1    AGT51664.1    AGT51714.1    KF572746    KF572747    KF923896    AIL49426.1    AIL49427.1    AIV41838.1    KR055611    AMM42455.1    KR055616    AMM42460.1    KR055610    AMM42454.1    KR055609    AMM42453.1    KR055604    AMM42448.1    KR055608    AMM42452.1    KR055614    AMM42458.1    KR055617    AMM42461.1    KR055605    AMM42449.1    JN129834    KF572708    KF572711    KF572712    KF572713    KF572714    KF572717    KF572718    KF572719    KF572720    KF572722    KF572723    KF572726    KF572728    KF572731    KF572732    KF572733    KF572734    KF572736    KF572737    KF572751    KF572753    KF572757    KF572758    KF572759    KF572760    KF572761    KF572762    KF572763    KF572764    KF572765    KF572766    KF572767    KF572768    KF572769    KF572770    KF572771    KF572772    KF572773    KF572774    KF572775    KF572776    KF572777    KF572778    KF572779    KF572780    KF572781    KF572782    KF572783    KF572784    KF572785    KF572786    KF572787    KF572788    KF572789    KF572791    KF572792    KF572793    KF572795    KF572796    KF572797    KF572798    KF572800    KF572801    KF572803    KF923890    KF923891    KF923892    KF923893    KF923894    KF923895    KF923897    KF923899    KF923900    KF923901    KF923903    KF923905    KF923907    KF923908    KF923909    KF923910    KF923911    KF923912    KF923913    KF923914    KF923915    KF923916    KF923917    KF923919    KF923920    KF923921    KF923923    KF923924    KF963208    KX538968    KX538969    KX538971    KX538973    KX538977    KY674920    KY554974    KY554975    AEN19362.1    AIL49388.1    AIL49391.1    AIL49392.1    AIL49393.1    AIL49394.1    AIL49397.1    AIL49398.1    AIL49399.1    AIL49400.1    AIL49402.1    AIL49403.1    AIL49406.1    AIL49408.1    AIL49411.1    AIL49412.1    AIL49413.1    AIL49414.1    AIL49416.1    AIL49417.1    AIL49431.1    AIL49433.1    AIL49437.1    AIL49438.1    AIL49439.1    AIL49440.1    AIL49441.1    AIL49442.1    AIL49443.1    AIL49444.1    AIL49445.1    AIL49446.1    AIL49447.1    AIL49448.1    AIL49449.1    AIL49450.1    AIL49451.1    AIL49452.1    AIL49453.1    AIL49454.1    AIL49455.1    AIL49456.1    AIL49457.1    AIL49458.1    AIL49459.1    AIL49460.1    AIL49461.1    AIL49462.1    AIL49463.1    AIL49464.1    AIL49465.1    AIL49466.1    AIL49467.1    AIL49468.1    AIL49469.1    AIL49471.1    AIL49472.1    AIL49473.1    AIL49475.1    AIL49476.1    AIL49477.1    AIL49478.1    AIL49480.1    AIL49481.1    AIL49483.1    AIV41802.1    AIV41808.1    AIV41814.1    AIV41820.1    AIV41826.1    AIV41832.1    AIV41844.1    AIV41856.1    AIV41862.1    AIV41868.1    AIV41880.1    AIV41892.1    AIV41904.1    AIV41910.1    AIV41916.1    AIV41922.1    AIV41928.1    AIV41934.1    AIV41940.1    AIV41946.1    AIV41952.1    AIV41958.1    AIV41964.1    AIV41976.1    AIV41982.1    AIV41988.1    AIV42000.1    AIV42006.1    AIX10727.1    AQN78692.1    AQN78700.1    AQN78716.1    AQN78732.1    AQN78764.1    ARB07435.1    ARE30012.1    ARE30021.1    KF572741    AIL49421.1    KF572738    KF572742    KF923889    KF963205    AIL49418.1    AIL49422.1    AIV41796.1    AIX10724.1    KF572745    KF963206    KF963207    KP198610    MF314143    AIL49425.1    AIX10725.1    AIX10726.1    AJC98131.1    AVQ05268.1    MG197717    AXX83347.1    MK303621    QBP84726.1    KF963198    AIX10717.1    KX538975    AQN78748.1    KF572735    AIL49415.1    KR055613    AMM42457.1    KF963212    MK303623    MK303624    AIX10731.1    QBP84744.1    QBP84753.1    KF572750    KF923888    AIL49430.1    AIV41790.1    KF572716    KF923925    AIL49396.1    AIV42012.1    MK327281    QBP84763.1    KP198611    AJC98139.1    KF572749    AIL49429.1    KR055619    AMM42463.1    KX538974    AQN78740.1    KF572721    AIL49401.1    KF530069    AGT51505.1    KF572739    AIL49419.1    KR055600    AMM42444.1    KR055612    AMM42456.1    KR055615    AMM42459.1    KR055601    AMM42445.1    KR055620    AMM42464.1    KR055607    AMM42451.1    KR055599    AMM42443.1    KR055621    AMM42465.1    KF963199    AIX10718.1    KR055602    AMM42446.1    KF923922    AIV41994.1    KF530092    AGT51734.1    KX538965    AQN78668.1    KF572724    KF572725    KF572727    KF572729    KF572730    KF923902    KF923904    KU745566    KU745567    KU745568    KX538964    KX538966    KX538972    KX538976    KX538978    KX538979    MG197713    AIL49404.1    AIL49405.1    AIL49407.1    AIL49409.1    AIL49410.1    AIV41874.1    AIV41886.1    ANZ78867.1    ANZ78868.1    ANZ78869.1    AQN78660.1    AQN78676.1    AQN78724.1    AQN78756.1    AQN78772.1    AQN78780.1    AXX83323.1    MK303619    QBP84708.1    AY903459    AAX85673.1    KY014282    ATP16771.1    KF963209    AIX10728.1    KY967359    ARK08665.1    KU745565    KU745575    KU745576    KU745577    KU745580    MG197712    MG197715    MG197716    MG197722    ANZ78866.1    ANZ78876.1    ANZ78877.1    ANZ78878.1    ANZ78881.1    AXX83317.1    AXX83335.1    AXX83341.1    AXX83377.1    JN129835    KF572715    KF572755    KF572799    KJ958218    AEN19370.1    AIL49395.1    AIL49435.1    AIL49479.1    AIX09803.1    MH685718    AYC76640.1    MK303620    QBP84717.1    KY967360    MN026165    ARK08674.1    QDH43730.1    KF572748    KF923906    AIL49428.1    AIV41898.1    KX538967    AQN78684.1    KF963210    AIX10729.1    KU745579    ANZ78880.1    KR055603    AMM42447.1    KF572710    KF572752    AIL49390.1    AIL49432.1    KU745574    MG197710    ANZ78875.1    AXX83305.1    MN514963    QEY10637.1    KR055606    AMM42450.1    MN310478    QEG03818.1    KY369905    KY369906    KY369907    KX538970    KY967361    KY983588    MF374984    MF374985    MG977451    MG197723    MH121121    MN306036    MN306041    MN306042    MN306053    APU51924.1    APU51934.1    APU51935.1    AQN78708.1    ARK08683.1    ARU07614.1    ATN39876.1    ATN39883.1    AWW13570.1    AXX83383.1    AZP73844.1    QEG03744.1    QEG03761.1    QEG03771.1    QEG03798.1    KF963202    AIX10721.1    KF572709    KF923918    AIL49389.1    AIV41970.1    KF572802    AIL49482.1    AY903460    AAX85682.1    KF572790    AIL49470.1    KY674917    KY674918    KY554972    KY554973    ARB07416.1    ARB07422.1    ARE29994.1    ARE30003.1    KU131570    AMK59681.1    KU745569    ANZ78870.1    MF374983    MG977444    MG977445    MG977446    MG977447    MG977448    MG977449    MG977450    MG977452    MN026164    ATN39868.1    AWW13515.1    AWW13523.1    AWW13531.1    AWW13539.1    AWW13546.1    AWW13555.1    AWW13563.1    AWW13579.1    QDH43715.1    KU745570    KU745571    MK303622    ANZ78871.1    ANZ78872.1    QBP84735.1    KF530097    AGT51784.1    KY967358    ARK08655.1    KJ958219    AIX09811.1   

Proteomes

UP000100580    UP000109543    UP000114034    UP000119922    UP000122365    UP000143194    + More
UP000150595    UP000160021    UP000140040    UP000158566    UP000104124    UP000097333    UP000105266    UP000136788    UP000159503    UP000100004    UP000168290    UP000109321    UP000172586    UP000167348    UP000096360    UP000114688    UP000117387    UP000119762    UP000140401    UP000143341    UP000007552    UP000180344    UP000100971    UP000106834    UP000115705    UP000143333    UP000147052    UP000147585    UP000149702    UP000154668    UP000165173    UP000165185    UP000168172    UP000170317    UP000174077    UP000107048    UP000108500    UP000112072    UP000115343    UP000115819    UP000116223    UP000117554    UP000119058    UP000119882    UP000119993    UP000121854    UP000123825    UP000128148    UP000128782    UP000130040    UP000130067    UP000132146    UP000136483    UP000136628    UP000137532    UP000142623    UP000149793    UP000150164    UP000152870    UP000154332    UP000161839    UP000162080    UP000166197    UP000173822    UP000137844    UP000134871    UP000104994    UP000173555    UP000133796    UP000155676    UP000114169    UP000126877    UP000101116    UP000165756    UP000161137    UP000126267    UP000130586    UP000173306    UP000143152    UP000159995    UP000147591    UP000149594    UP000099221   

PRIDE

P33469   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037195   Nucleocapsid_N
IPR001218   Corona_nucleocap
IPR037179   Nucleocapsid_C

SUPFAM

SSF110304   SSF110304
SSF103068   SSF103068

ProteinModelPortal

Q696P4   U3M7Z6   A0A0G2RC83   U3M822   U3M820   U3M7K1   + More
U3M7Z8   U3M828   U3M7I5   A0A0B4N684   U3M6V0   U3M804   A0A127AT53   U3M7Z4   A0A0K0KPA1   P33469   A0A0G2RCY1   A0A0G2RCZ3   A0A0G2RCA8   A0A0G2RC64   U3M6V7   A0A0B4Q8L7   A0A127ATA9   A0A127AT23   A0A127AWK6   A0A127ATB4   A0A127AT99   A0A127AT45   A0A127ATA6   A0A127AT35   A0A127ATJ2   G5CJB5   A0A0B4N6W6   A0A0B4N7G3   A0A0B4UFS5   A0A385H6V0   A0A482KB57   A0A0G2RC66   A0A1S5VGJ0   A0A0K0KPQ5   A0A127AUM9   A0A0G2RC94   A0A0B4Q800   A0A0B4N7F3   A0A482KEV8   A0A0B4UEK7   A0A0B4N5V5   A0A127ATC1   A0A1S5VGI5   A0A0K0KQ87   U3M7J7   A0A0B4N6G8   A0A127AWJ2   A0A127AU02   A0A127ATK0   A0A127ATA3   A0A127AWL7   A0A127AT26   A0A127ATA7   A0A127ATB6   A0A0G2RC60   A0A127ATZ8   A0A0K0L9S6   U3M816   A0A1S5VGD1   A0A0B4N6G5   A0A482K8S6   Q4VIE0   A0A2D1QW28   A0A0G2RC68   A0A1W6DZX0   A0A385H5Z4   G5CJC3   A0A386BY28   A0A482KFL3   A0A1W6DZV4   A0A0B4N7G5   A0A1S5VG93   A0A0G2RCB5   A0A3S6FHP7   A0A127AUL9   A0A0K0KPA2   A0A385H5X1   A0A5J6NU34   A0A127AT13   A0A5B9MUK4   A0A1L7H9A3   A0A0G2RC86   A0A0B4N5U7   A0A0K0KQA8   Q4VID1   A0A0K0KPB1   A0A1V0PKZ6   A0A140E069   A0A3S6FHN9   A0A2D1CLX3   A0A3S6FH50   U3M826   A0A1W6DZW0   A0A0A0YP48  

PDB

3HD4     E-value=1.63683e-72,     Score=694