Strain

CHINA_MURINE_2012_NC_026011 (Region: China;  Strain: Betacoronavirus HKU24 strain HKU24-R05005I, complete genome.;  Date: 2012)

Gene

nucleocapsid protein

Description

Annotated in NCBI,  nucleocapsid protein

Location

NC_026011(+):29613-30944

GenBank Accession

YP_009113031.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGTCTCATACGCCAGGCAAAGCTGGTAGCAGATCATCCTCTGGTAACCGTAATGGCGGCATTCTTAAGTGGGCCGACCAGACGGAACCTAATAATGTTAATAGCAGAGGTAGAAGAGCCCAACCTAAGCAAACAGCTAATACCCAGGCTTCAGGAGGAAATGTTGTACCATTTTACTCCTGGTTCTCTGGAATTACTCAGTTTCAAAAAGGGCAAGAATTTGGATTTGAACAAGGACAAGGTGTGCCCCTTACCAATGGAGTCCCTCCCTCAGAAGAAAAGGGATACTGGTATAGGCACAACAGAAAGTCCTATAGAACTGCAGATGGACAACAACGGCAGCTGCTACCCAGATGGTATTTTTACTATCTCGGAACAGGGCCGTATGCGAACAAACAATACGGGTCGGACATCGACGGTGTTGTTTGGGTTGCTAGTCCAAATGTTGATGTACGTTCCCCAGCGGACGTTCCAGATAGGGATCCTACTAGCCACCAAGCTGAGCCGACTAGGTTTGCGCCTGGCACGGTTCTGCCTAAAGGCTATTATGTTGAAGGCTCAGGAAGGTCTGCTCCTAGCTCGCGATCTAGCTCTCGTGCATCCAGCAGAGCATCTAGTGTCGGCGGAAGCAGAAGCAGAAACAACTCAGCTTCTAGAAATAATACCTCTGAAGTGACACCTGATATGGCTGATCAAATTGCTTCCCTTGTGCTGGCCAAGCTGAACAAAGAGTCCGGCAAACCAGTGCAAGTTACAAAGCAGACAGCCAAGGAAATAAAGCAGAAAATTCTCAACAAACCCCGCCAAAAGAGGACGCCCAACAAGCAGTGCACTGTTCAACAGTGTTTCGGCAAAAGGGGCCCCAGCCAGAATTTTGGTGGTGGTAGTATGCTCAAATTGGGAACTAGTGACCCACAGTTCCCCATCCTTGCTGAATTGGCCCCCACAGCGGGAGCCTTTTTCTTTGGATCCAAGCTGGAATTGGCCAAAGTCAACAACATGTCTGGGGCTGCTGATGAGCCGCAGAAGGATGTTTATGAGCTGCGCTATTCTGGTGCAATAAGATTTGATAGCACCCTACCCGGGTTTGAGACTATCATGAAAGTTATGAATGAAAATCTGGATGCGTACCAACATACAGAAGAGGGTGCGCAATTGTTGAGCCCAAAATTTCAGCGCAAGCAGAAGAAAGGGCAAGTTGAAAAGGATAATGTGAGTGCTGCAACGCCCAAGAGTCGTGTGCAGCAAAATGTAAGAAGAGAGCTAACGCCCCAGGACCTCAGCATTCTCGCGCAGATTGATGATGATACCCAGGGAAGCTCAGAAATATAA

Protein

MSHTPGKAGSRSSSGNRNGGILKWADQTEPNNVNSRGRRAQPKQTANTQASGGNVVPFYSWFSGITQFQKGQEFGFEQGQGVPLTNGVPPSEEKGYWYRHNRKSYRTADGQQRQLLPRWYFYYLGTGPYANKQYGSDIDGVVWVASPNVDVRSPADVPDRDPTSHQAEPTRFAPGTVLPKGYYVEGSGRSAPSSRSSSRASSRASSVGGSRSRNNSASRNNTSEVTPDMADQIASLVLAKLNKESGKPVQVTKQTAKEIKQKILNKPRQKRTPNKQCTVQQCFGKRGPSQNFGGGSMLKLGTSDPQFPILAELAPTAGAFFFGSKLELAKVNNMSGAADEPQKDVYELRYSGAIRFDSTLPGFETIMKVMNENLDAYQHTEEGAQLLSPKFQRKQKKGQVEKDNVSAATPKSRVQQNVRRELTPQDLSILAQIDDDTQGSSEI

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Similarity

Belongs to the betacoronavirus nucleocapsid protein family.

Keywords

ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion   Reference proteome  

Feature

chain  Nucleoprotein

Uniprot

A0A0A7UXF2   A0A3G3NHS1   A0A3G3NH17   A0A3G3NHG7   A0A096XNF1   A0A2H4MZ43   + More
A0A2H4MWZ7   A0A410UD36   A0A410UD67   A0A410UD39   A0A410UD43   Q2QKM8   A0A166MX98   Q8JSP4   Q8BB23   A0A1V0IG43   B5M8W1   A0A410UD61   A0A1V0IG80   B9TXU8   B9TXU6   A0A1V0IG51   B9TXU7   A0A410UD35   A0A410UD32   A0A410UD49   A0A410UD40   A0A191URC9   D0EY89   A8HB22   A0A3S7GYG0   B7TYH5   A0A142D7Z2   A0A2R4STX2   P26020   Q91A22   B7U2S1   C6GHR6   C6GHL9   Q0PL33   B8YPE5   A7BKC8   A0A142D7Z3   A0A142D801   A0A5J6NS08   B7U2R0   Q9QAR8   A4ZU25   A4ZU80   A4ZU69   A4ZTY1   B7U2P9   A4ZU47   A4ZTZ2   Q06BD4   A4ZU58   A0A142D800   A0A3S7H0D9   A0A2R4STY0   A0A451ETZ8   P59712   P10527   A0A2P1IQ86   A0A5J6NRV2   A0A4P2V418   A0A142D803   B9TXU3   A0A5J6NU34   Q6W358   A0A3T0IBL9   A2ICF6   A0A142D7Z9   A0A142D7Z1   A2ICF7   A0A142D7Z4   A0A0C5AYI0   A0A3Q9K420   A0A4P2V3N3   A0A0U2GMC1   D0EY99   A3E2F7   A0A2R4STW5   A0A142D7Z0   A0A451EU00   Q9QAR1   C6GHN1   A0A5J6NRW3   C6GHP3   A4ZU14   B7U2N9   B7U2M8   A4ZU36   B7U2L7   A0A291L0T4   A4ZU03   A0A481SB66   X2JHN2   C6GHQ4   H9AA69   B8RIR3  

Pubmed

25552712    25463600    30285857    16809333    12237422    24756345    + More
27274850    23405345    17916374    26969241    1856695    9778786    11714968    18842722    17374765    31534035    17434558    17344285    17459444    11774548    3029965    29508550    26678874    17092595    24655427    22398294    19162098   

EMBL

KM349742    KM349743    KM349744    AJA91202.1    AJA91213.1    AJA91223.1    + More
MH687974    MH687977    AYR18657.1    AYR18684.1    MH687969    MH687971    MH687972    MH687973    MH687976    MH687978    AYR18612.1    AYR18630.1    AYR18639.1    AYR18648.1    AYR18675.1    AYR18693.1    MH687975    AYR18666.1    KF294357    AID16634.1    KY370047    ATP66753.1    KY370046    ATP66747.1    MH475352    QAU20980.1    MH475353    QAU20981.1    MH475354    QAU20982.1    MH475356    QAU20984.1    DQ011855    AAY68302.1    KU127229    KY994645    MF083115    ANA52021.1    AUF40280.1    AVV64339.1    AF481863    AY078417    KY419104    KY419105    KY419110    KY419112    ARC95215.1    ARC95223.1    ARC95255.1    ARC95271.1    FJ009234    ACH72650.1    MH475355    QAU20983.1    KY419106    KY419107    KY419109    KY419111    KY419113    ARC95231.1    ARC95239.1    ARC95247.1    ARC95263.1    ARC95278.1    EU401985    ACB30194.1    EU401983    ACB30192.1    KY419103    ARC95207.1    EU401984    ACB30193.1    MH475349    QAU20977.1    MH475350    QAU20978.1    MH475347    QAU20975.1    MH475351    QAU20979.1    KU558922    KU558923    ANJ04723.1    ANJ04734.1    GQ918142    JX860640    ACX46856.1    AFW97366.1    EU019216    ABV74060.1    MG757138    AVI15006.1    FJ415324    ACJ35489.1    KT318085    AMQ23461.1    MH043953    AVZ61115.1    AF058944    AF391541    FJ425189    ACJ67006.1    FJ938067    ACT11036.1    FJ938063    ACT10989.1    DQ811784    ABG89284.1    FJ556872    ACL80212.1    AB354579    BAF75637.1    KT318086    KT318088    AMQ23462.1    AMQ23464.1    KT318089    KT318090    KT318091    KT318094    KT318095    KX982264    MG757140    MG757141    MG757142    AMQ23465.1    AMQ23466.1    AMQ23467.1    AMQ23470.1    AMQ23471.1    ARD06005.1    AVI15028.1    AVI15039.1    AVI15050.1    MN514964    MN514965    MN514967    QEY10645.1    QEY10653.1    QEY10669.1    FJ425188    FJ425190    ACJ66985.1    AF058942    EF424619    ABP38276.1    EF424624    ABP38330.1    EF424623    ABP38321.1    EF424615    ABP38232.1    FJ425187    ACJ66983.1    EF424621    ABP38302.1    EF424616    ABP38247.1    DQ915164    ABI94003.2    EF424622    ABP38310.1    KT318093    AMQ23469.1    MG757139    AVI15017.1    MH043954    AVZ61125.1    MK095161    MK095162    AZS64208.1    AZS64209.1    AF220295    U00735    MG518518    AVN88326.1    MN514966    QEY10661.1    LC149486    BBD43533.1    KT318096    AMQ23472.1    EU401980    EU401981    EU401982    ACB30189.1    ACB30190.1    ACB30191.1    MN514963    QEY10637.1    AY316299    AAQ67202.1    MH810163    AZU96330.1    EF193073    ABM66808.1    KT318092    AMQ23468.1    KT318084    AMQ23460.1    EF193074    ABM66809.1    KT318087    AMQ23463.1    KM985634    AJL33725.1    MK095163    MK095167    MK095168    MK095169    MK095170    AZS64210.1    AZS64214.1    AZS64215.1    AZS64216.1    AZS64217.1    LC149485    BBD43532.1    KT368891    ALA50084.1    GQ918143    ACX46866.1    DQ682406    ABG78753.1    MH043952    AVZ61105.1    KT318083    AMQ23459.1    MK095166    AZS64213.1    AF058943    FJ938064    ACT11001.1    MN514962    QEY10629.1    FJ938065    ACT11013.1    EF424618    ABP38273.1    FJ425186    ACJ66964.1    FJ425185    ACJ66963.1    EF424620    ABP38294.1    FJ425184    ACJ66950.1    MF593476    ATI09453.1    EF424617    ABP38259.1    MH475915    QBH22433.1    KF906249    KF906250    KF906251    AHN64778.1    AHN64787.1    AHN64796.1    FJ938066    ACT11024.1    JN874562    AFE48831.1    EU999954    ACL13001.1   

Proteomes

UP000144342    UP000153628    UP000174571    UP000125924    UP000007543    UP000007546    + More
UP000137675    UP000158296    UP000008570    UP000133443    UP000164707    UP000172225    UP000147981    UP000168103    UP000102696    UP000148210    UP000134650    UP000147178    UP000163913    UP000121953    UP000158327    UP000136116    UP000127099    UP000154814    UP000139235    UP000008572    UP000007554    UP000158231    UP000136745    UP000139966    UP000173415    UP000140344    UP000104294    UP000170940    UP000174569    UP000151273    UP000121258    UP000145507    UP000149260    UP000162935    UP000145001   

PRIDE

Q91A22    Q9QAR8   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037195   Nucleocapsid_N
IPR001218   Corona_nucleocap
IPR037179   Nucleocapsid_C

SUPFAM

SSF103068   SSF103068
SSF110304   SSF110304

ProteinModelPortal

A0A0A7UXF2   A0A3G3NHS1   A0A3G3NH17   A0A3G3NHG7   A0A096XNF1   A0A2H4MZ43   + More
A0A2H4MWZ7   A0A410UD36   A0A410UD67   A0A410UD39   A0A410UD43   Q2QKM8   A0A166MX98   Q8JSP4   Q8BB23   A0A1V0IG43   B5M8W1   A0A410UD61   A0A1V0IG80   B9TXU8   B9TXU6   A0A1V0IG51   B9TXU7   A0A410UD35   A0A410UD32   A0A410UD49   A0A410UD40   A0A191URC9   D0EY89   A8HB22   A0A3S7GYG0   B7TYH5   A0A142D7Z2   A0A2R4STX2   P26020   Q91A22   B7U2S1   C6GHR6   C6GHL9   Q0PL33   B8YPE5   A7BKC8   A0A142D7Z3   A0A142D801   A0A5J6NS08   B7U2R0   Q9QAR8   A4ZU25   A4ZU80   A4ZU69   A4ZTY1   B7U2P9   A4ZU47   A4ZTZ2   Q06BD4   A4ZU58   A0A142D800   A0A3S7H0D9   A0A2R4STY0   A0A451ETZ8   P59712   P10527   A0A2P1IQ86   A0A5J6NRV2   A0A4P2V418   A0A142D803   B9TXU3   A0A5J6NU34   Q6W358   A0A3T0IBL9   A2ICF6   A0A142D7Z9   A0A142D7Z1   A2ICF7   A0A142D7Z4   A0A0C5AYI0   A0A3Q9K420   A0A4P2V3N3   A0A0U2GMC1   D0EY99   A3E2F7   A0A2R4STW5   A0A142D7Z0   A0A451EU00   Q9QAR1   C6GHN1   A0A5J6NRW3   C6GHP3   A4ZU14   B7U2N9   B7U2M8   A4ZU36   B7U2L7   A0A291L0T4   A4ZU03   A0A481SB66   X2JHN2   C6GHQ4   H9AA69   B8RIR3  

PDB

3HD4     E-value=1.63683e-72,     Score=694