Strain

CHINA_HS_2004_NC_006577 (Region: China: Hong Kong;  Strain: Human coronavirus HKU1, complete genome.;  Date: 2004)

Gene

nucleocapsid phosphoprotein

Description

Annotated in NCBI,  nucleocapsid phosphoprotein

Location

NC_006577(+):28320-29645

GenBank Accession

YP_173242.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGTCTTATACTCCCGGTCATTATGCTGGAAGTAGAAGCTCCTCTGGAAATCGTTCAGGAATCCTCAAGAAAACTTCTTGGGCTGACCAATCTGAGCGAAATTACCAAACCTTTAATAGAGGCAGAAAAACCCAACCTAAATTCACTGTGTCTACTCAACCACAAGGAAATACTATCCCACATTATTCCTGGTTCTCCGGGATCACTCAATTTCAAAAAGGTAGAGACTTTAAATTTTCAGATGGTCAAGGAGTTCCCATTGCTTTCGGAGTACCCCCTTCTGAAGCAAAAGGATATTGGTATAGACACAGCCGGCGTTCTTTTAAAACAGCTGATGGTCAACAAAAGCAGTTGTTACCGAGATGGTATTTCTACTATCTCGGTACCGGCCCATATGCCAATGCATCCTATGGTGAATCCCTCGAAGGGGTCTTCTGGGTTGCTAATCACCAAGCTGACACTTCTACTCCCTCCGATGTTTCGTCAAGGGATCCTACTACTCAAGAAGCTATCCCTACTAGGTTTCCGCCTGGTACGATTTTGCCTCAAGGCTATTATGTTGAAGGCTCAGGAAGGTCTGCTTCTAATAGTCGACCAGGTTCACGTTCTCAATCACGTGGACCCAATAATCGTTCATTAAGTAGAAGTAATTCTAATTTTAGACATTCAGATTCTATAGTAAAACCTGATATGGCTGATGAGATCGCTAATCTTGTTTTAGCCAAGCTTGGTAAAGATTCTAAACCTCAGCAAGTCACTAAGCAAAATGCCAAGGAAATCAGGCATAAAATTTTAACAAAACCTCGCCAAAAGCGAACTCCTAATAAACATTGTAATGTTCAACAGTGTTTTGGTAAAAGAGGACCTTCTCAAAATTTTGGTAATGCTGAAATGTTAAAGCTTGGTACTAATGATCCTCAGTTTCCTATTCTTGCAGAATTAGCTCCTACACCAGGTGCTTTTTTCTTTGGTTCTAAATTAGACTTGGTTAAAAGAGATTCCGAGGCTGACTCACCTGTTAAAGATGTTTTTGAACTTCATTATTCTGGTTCTATTAGGTTTGATAGTACTTTACCAGGCTTTGAGACAATTATGAAAGTTCTTGAAGAGAATTTAAATGCTTACGTTAATTCTAATCAGAACACTGATTCTGATTCGTTGAGTTCTAAACCTCAGCGTAAAAGAGGTGTTAAACAATTACCAGAACAGTTTGACTCTCTTAATTTAAGTGCTGGTACTCAGCACATTTCAAATGATTTTACTCCTGAGGATCATAGTTTACTTGCTACTCTTGATGATCCTTATGTAGAAGACTCTGTTGCTTAA

Protein

MSYTPGHYAGSRSSSGNRSGILKKTSWADQSERNYQTFNRGRKTQPKFTVSTQPQGNTIPHYSWFSGITQFQKGRDFKFSDGQGVPIAFGVPPSEAKGYWYRHSRRSFKTADGQQKQLLPRWYFYYLGTGPYANASYGESLEGVFWVANHQADTSTPSDVSSRDPTTQEAIPTRFPPGTILPQGYYVEGSGRSASNSRPGSRSQSRGPNNRSLSRSNSNFRHSDSIVKPDMADEIANLVLAKLGKDSKPQQVTKQNAKEIRHKILTKPRQKRTPNKHCNVQQCFGKRGPSQNFGNAEMLKLGTNDPQFPILAELAPTPGAFFFGSKLDLVKRDSEADSPVKDVFELHYSGSIRFDSTLPGFETIMKVLEENLNAYVNSNQNTDSDSLSSKPQRKRGVKQLPEQFDSLNLSAGTQHISNDFTPEDHSLLATLDDPYVEDSVA

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Similarity

Belongs to the betacoronavirus nucleocapsid protein family.

Keywords

ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion  

Feature

chain  Nucleoprotein

Uniprot

Q19U25   Q5MQC6   A0A127ASW7   A0A127ASW6   A0A127ATV4   A0A127ASZ8   + More
A0A127AT34   A0A127AT73   Q19U29   Q0ZJE5   Q19U34   Q19U36   Q0ZJD7   Q19U24   S5ZBQ7   Q0PRK0   U3NAH8   A0A1Y0EV09   E0YJ48   A0A127AWE0   A0A127ASV8   A0A127AT49   A0A127ATT6   A0A127ASY7   A0A127AT66   A0A127AUB1   Q19U26   Q0ZME3   Q14EA6   A0A127AT27   A0A127AT59   A0A127AW89   A0A127AU98   A0A127ASV7   A0A127ATF4   Q0ZJH7   A0A127ATU5   A0A3Q9JNH6   A0A127AUC1   A0A127ATF0   A0A4P2V418   E5RPZ1   A0A4P2V3N3   R4WKE3   A0A0K2RVN9   A8R4D8   Q9DQX6   A0A0M5NBL9   I2FKH0   H9AA48   H9AA59   A0A410UD36   A0A410UD67   A0A3S7GYG0   A0A142D800   B7U2N9   B7U2M8   B7U2L7   B9TXU6   A7BKC8   A0A142D7Z2   A0A3S7H0D9   A0A142D7Z3   A0A142D801   D0EY89   D0EY99   A0A142D7Z9   C6GHR6   B9TXU8   A0A5J6NU34   P26020   B7TYH5   A0A5J6NRV2   A0A2H4MZ40   B8YPE5   Q9QAR8   P59712   P10527   A0A191URC9   A0A0U2GMC1   A0A2R4STY7   B9TXU7   A0A142D803   A8HB22   A0A5J6NS08   Q2QKM8   Q9QAR1   A0A191URZ1   B7U2S1   C6GHL9   Q0PL33   B7U2R0   A0A142D7Z1   A0A142D7Z4   A0A451ETZ8   D0EY79   A0A481SB66   A2ICF7   A0A2R4STX2   A0A5J6NRW3  

Pubmed

16757599    16809319    15613317    24394697    16447108    18191362    + More
20719951    21273011    26271151    23648375    26395082    17706262    11101590    22398294    26969241    18842722    17374765    23405345    31534035    1856695    9778786    30285857    11774548    3029965    27274850    26678874    17916374    16809333   

EMBL

DQ415900    DQ415903    DQ437631    ABD75533.1    ABD75557.1    ABD96210.1    + More
AY597011    KR055547    AMM42391.1    KR055546    AMM42390.1    KR055552    AMM42396.1    KR055548    AMM42392.1    KR055551    AMM42395.1    KR055549    AMM42393.1    DQ415896    DQ415904    DQ415905    DQ415909    DQ415914    DQ437621    DQ437626    DQ437627    KF686344    KT779555    KT779556    ABD75501.1    ABD75565.1    ABD75573.1    ABD75605.1    ABD75645.1    ABD96200.1    ABD96205.1    ABD96206.1    AGW27876.1    AMN88690.1    AMN88698.1    DQ415906    ABD75581.1    DQ415910    DQ437622    ABD75613.1    ABD96201.1    DQ415908    DQ437620    ABD75597.1    ABD96199.1    DQ415907    ABD75589.1    DQ415901    DQ437632    ABD75541.1    ABD96211.1    KF430201    KF686341    KF686342    KF686343    KF686346    KY674941    KY674942    KY674943    AGT17773.1    AGW27849.1    AGW27858.1    AGW27867.1    AGW27885.1    ARB07603.1    ARB07612.1    ARB07621.1    DQ778921    ABG77571.1    KF686340    AGW27840.1    KY983584    ARU07581.1    HM034837    ADN03343.1    KR055550    AMM42394.1    KR055536    AMM42380.1    KR055534    AMM42378.1    KR055532    AMM42376.1    KR055538    AMM42382.1    KR055539    AMM42383.1    KR055543    AMM42387.1    DQ415897    DQ415898    DQ415899    DQ415911    DQ415912    DQ415913    DQ437623    DQ437624    DQ437625    DQ437628    DQ437629    DQ437630    KY674921    MH940245    ABD75509.1    ABD75517.1    ABD75525.1    ABD75621.1    ABD75629.1    ABD75637.1    ABD96202.1    ABD96203.1    ABD96204.1    ABD96207.1    ABD96208.1    ABD96209.1    ARB07442.1    AYN64565.1    DQ339101    AY884001    KR055541    AMM42385.1    KR055544    AMM42388.1    KR055540    AMM42384.1    KR055533    AMM42377.1    KR055537    AMM42381.1    KR055545    AMM42389.1    DQ415902    ABD75549.1    KR055542    AMM42386.1    MK167038    AZS52622.1    KR055553    AMM42397.1    KR055535    AMM42379.1    LC149486    BBD43533.1    AB555559    LC061272    BAJ52884.1    BAS18850.1    LC149485    BBD43532.1    AB775893    LC061274    LC054263    BAN18702.1    BAS18870.1    BAS53429.1    LC061273    BAS18860.1    EF446615    ABP87995.1    AF251144    LC054264    BAS53430.1    AB671298    BAM15655.1    JN874560    AFE48809.1    JN874559    JN874561    AFE48799.1    AFE48821.1    MH475352    QAU20980.1    MH475353    QAU20981.1    MG757138    AVI15006.1    KT318093    AMQ23469.1    FJ425186    ACJ66964.1    FJ425185    ACJ66963.1    FJ425184    ACJ66950.1    EU401983    ACB30192.1    AB354579    BAF75637.1    KT318085    AMQ23461.1    MG757139    AVI15017.1    KT318086    KT318088    AMQ23462.1    AMQ23464.1    KT318089    KT318090    KT318091    KT318094    KT318095    KX982264    MG757140    MG757141    MG757142    AMQ23465.1    AMQ23466.1    AMQ23467.1    AMQ23470.1    AMQ23471.1    ARD06005.1    AVI15028.1    AVI15039.1    AVI15050.1    GQ918142    JX860640    ACX46856.1    AFW97366.1    GQ918143    ACX46866.1    KT318092    AMQ23468.1    FJ938067    ACT11036.1    EU401985    ACB30194.1    MN514963    QEY10637.1    AF058944    FJ415324    ACJ35489.1    MN514966    QEY10661.1    KY370052    ATP66782.1    FJ556872    ACL80212.1    AF058942    AF220295    U00735    KU558922    KU558923    ANJ04723.1    ANJ04734.1    KT368891    ALA50084.1    MH043955    AVZ61135.1    EU401984    ACB30193.1    KT318096    AMQ23472.1    EU019216    ABV74060.1    MN514964    MN514965    MN514967    QEY10645.1    QEY10653.1    QEY10669.1    DQ011855    AAY68302.1    AF058943    KU886219    ANJ04980.1    FJ425189    ACJ67006.1    FJ938063    ACT10989.1    DQ811784    ABG89284.1    FJ425188    FJ425190    ACJ66985.1    KT318084    AMQ23460.1    KT318087    AMQ23463.1    MK095161    MK095162    AZS64208.1    AZS64209.1    GQ918141    ACX46846.1    MH475915    QBH22433.1    EF193074    ABM66809.1    MH043953    AVZ61115.1    MN514962    QEY10629.1   

Proteomes

UP000120443    UP000148743    UP000008170    UP000102058    UP000103177    UP000118444    + More
UP000122230    UP000127413    UP000134208    UP000161305    UP000174991    UP000123677    UP000168247    UP000164754    UP000107950    UP000147573    UP000098016    UP000098607    UP000139452    UP000143896    UP000173897    UP000173725    UP000108760    UP000107997    UP000134743    UP000143869    UP000156925    UP000162514    UP000168964    UP000001985    UP000006551    UP000124867    UP000166748    UP000155347    UP000130220    UP000103372    UP000124585    UP000107676    UP000125269    UP000140344    UP000104294    UP000174569    UP000168103    UP000137675    UP000164707    UP000158296    UP000008572    UP000007554    UP000158231    UP000125924    UP000133443    UP000172225    UP000147981    UP000102696    UP000148210   

PRIDE

Q9QAR8   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037179   Nucleocapsid_C
IPR001218   Corona_nucleocap
IPR037195   Nucleocapsid_N

SUPFAM

SSF110304   SSF110304
SSF103068   SSF103068

ProteinModelPortal

Q19U25   Q5MQC6   A0A127ASW7   A0A127ASW6   A0A127ATV4   A0A127ASZ8   + More
A0A127AT34   A0A127AT73   Q19U29   Q0ZJE5   Q19U34   Q19U36   Q0ZJD7   Q19U24   S5ZBQ7   Q0PRK0   U3NAH8   A0A1Y0EV09   E0YJ48   A0A127AWE0   A0A127ASV8   A0A127AT49   A0A127ATT6   A0A127ASY7   A0A127AT66   A0A127AUB1   Q19U26   Q0ZME3   Q14EA6   A0A127AT27   A0A127AT59   A0A127AW89   A0A127AU98   A0A127ASV7   A0A127ATF4   Q0ZJH7   A0A127ATU5   A0A3Q9JNH6   A0A127AUC1   A0A127ATF0   A0A4P2V418   E5RPZ1   A0A4P2V3N3   R4WKE3   A0A0K2RVN9   A8R4D8   Q9DQX6   A0A0M5NBL9   I2FKH0   H9AA48   H9AA59   A0A410UD36   A0A410UD67   A0A3S7GYG0   A0A142D800   B7U2N9   B7U2M8   B7U2L7   B9TXU6   A7BKC8   A0A142D7Z2   A0A3S7H0D9   A0A142D7Z3   A0A142D801   D0EY89   D0EY99   A0A142D7Z9   C6GHR6   B9TXU8   A0A5J6NU34   P26020   B7TYH5   A0A5J6NRV2   A0A2H4MZ40   B8YPE5   Q9QAR8   P59712   P10527   A0A191URC9   A0A0U2GMC1   A0A2R4STY7   B9TXU7   A0A142D803   A8HB22   A0A5J6NS08   Q2QKM8   Q9QAR1   A0A191URZ1   B7U2S1   C6GHL9   Q0PL33   B7U2R0   A0A142D7Z1   A0A142D7Z4   A0A451ETZ8   D0EY79   A0A481SB66   A2ICF7   A0A2R4STX2   A0A5J6NRW3  

PDB

3HD4     E-value=1.63683e-72,     Score=694